Bruce A. Witthuhn

12.8k total citations · 10 hit papers
60 papers, 10.8k citations indexed

About

Bruce A. Witthuhn is a scholar working on Oncology, Immunology and Molecular Biology. According to data from OpenAlex, Bruce A. Witthuhn has authored 60 papers receiving a total of 10.8k indexed citations (citations by other indexed papers that have themselves been cited), including 31 papers in Oncology, 21 papers in Immunology and 20 papers in Molecular Biology. Recurrent topics in Bruce A. Witthuhn's work include Cytokine Signaling Pathways and Interactions (30 papers), Immune Cell Function and Interaction (13 papers) and Insect symbiosis and bacterial influences (7 papers). Bruce A. Witthuhn is often cited by papers focused on Cytokine Signaling Pathways and Interactions (30 papers), Immune Cell Function and Interaction (13 papers) and Insect symbiosis and bacterial influences (7 papers). Bruce A. Witthuhn collaborates with scholars based in United States, Japan and United Kingdom. Bruce A. Witthuhn's co-authors include Olli Silvennoinen, James N. Ihle, Frederick W. Quelle, Osamu Miura, J N Ihle, Bo Tang, William E. Thierfelder, Dmitry Guschin, Sandra Pellegrini and Taolin Yi and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Bruce A. Witthuhn

60 papers receiving 10.6k citations

Hit Papers

JAK2 associates with the erythropoietin receptor and is t... 1993 2026 2004 2015 1993 1994 1993 1993 1994 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    1993 1.0k citations Bruce A. Witthuhn, Frederick W. Quelle et al. Cell profile →
  2. Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
    1994 836 citations Bruce A. Witthuhn, Frederick W. Quelle et al. Science profile →
  3. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
    1993 821 citations Lawrence S. Argetsinger, George S. Campbell et al. Cell profile →
  4. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
    1993 669 citations Mathias Müller, James Briscoe et al. Nature profile →
  5. Signaling by the cytokine receptor superfamily: JAKs and STATs
    1994 572 citations James N. Ihle, Bruce A. Witthuhn et al. profile →
  6. Interaction of IL-2Rβ and γ c Chains with Jak1 and Jak3: Implications for XSCID and XCID
    1994 553 citations Sarah M. Russell, James A. Johnston et al. Science profile →
  7. Defective Lymphoid Development in Mice Lacking Jak3
    1995 544 citations Bruce A. Witthuhn, James N. Ihle et al. Science profile →
  8. Signaling Through the Hematopoietic Cytokine Receptors
    1995 539 citations Bruce A. Witthuhn, Frederick W. Quelle et al. profile →
  9. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    1994 538 citations Bruce A. Witthuhn, Olli Silvennoinen et al. Nature profile →
  10. Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits
    1994 502 citations Olli Silvennoinen, Bruce A. Witthuhn et al. Science profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bruce A. Witthuhn United States 32 6.5k 5.2k 3.6k 1.2k 1.2k 60 10.8k
Frederick W. Quelle United States 34 5.2k 0.8× 4.1k 0.8× 3.2k 0.9× 824 0.7× 982 0.8× 56 8.8k
Tracy A. Willson Australia 43 5.2k 0.8× 4.3k 0.8× 4.8k 1.3× 1.0k 0.8× 1.0k 0.8× 74 11.1k
Olli Silvennoinen Finland 63 8.5k 1.3× 6.6k 1.3× 7.0k 2.0× 1.3k 1.0× 1.6k 1.4× 159 16.7k
Ke Shuai United States 45 6.5k 1.0× 5.7k 1.1× 5.9k 1.6× 701 0.6× 1.6k 1.3× 62 12.2k
Andrew F. Wilks Australia 46 4.5k 0.7× 2.8k 0.5× 4.8k 1.3× 583 0.5× 973 0.8× 101 9.0k
Richard Moriggl Austria 57 4.4k 0.7× 3.5k 0.7× 3.9k 1.1× 302 0.2× 1.4k 1.2× 176 10.2k
Jacalyn H. Pierce United States 56 4.0k 0.6× 3.4k 0.7× 6.2k 1.7× 242 0.2× 957 0.8× 128 11.5k
Andrew Ziemiecki Switzerland 42 3.4k 0.5× 2.3k 0.4× 3.8k 1.1× 450 0.4× 785 0.7× 91 8.0k
Andrew C. Larner United States 47 4.6k 0.7× 3.8k 0.7× 3.9k 1.1× 437 0.4× 1.1k 1.0× 96 8.3k
D Metcalf Australia 35 3.0k 0.5× 4.4k 0.8× 2.0k 0.6× 373 0.3× 990 0.8× 72 8.1k

Countries citing papers authored by Bruce A. Witthuhn

Since Specialization
Citations

This map shows the geographic impact of Bruce A. Witthuhn's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce A. Witthuhn with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce A. Witthuhn more than expected).

Fields of papers citing papers by Bruce A. Witthuhn

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce A. Witthuhn. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce A. Witthuhn. The network helps show where Bruce A. Witthuhn may publish in the future.

Co-authorship network of co-authors of Bruce A. Witthuhn

This figure shows the co-authorship network connecting the top 25 collaborators of Bruce A. Witthuhn. A scholar is included among the top collaborators of Bruce A. Witthuhn based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bruce A. Witthuhn. Bruce A. Witthuhn is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Najt, Charles P., Salmaan Khan, Timothy D. Heden, et al.. (2019). Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. Molecular Cell. 77(4). 810–824.e8. 119 indexed citations
2.
Wendt, Chris H., et al.. (2016). Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease. International Journal of COPD. Volume 11. 2435–2446. 28 indexed citations
3.
Baldridge, Gerald D., Bruce A. Witthuhn, LeeAnn Higgins, et al.. (2015). Mosaic composition of ribA and wspB genes flanking the virB8-D4 operon in the Wolbachia supergroup B-strain, wStr. Archives of Microbiology. 198(1). 53–69. 3 indexed citations
4.
Lei, Ting, Junshu Yang, Zheng Li, et al.. (2012). The Essentiality of Staphylococcal Gcp Is Independent of Its Repression of Branched-Chain Amino Acids Biosynthesis. PLoS ONE. 7(10). e46836–e46836. 15 indexed citations
5.
Fallon, Ann M., Gerald D. Baldridge, L. A. Higgins, & Bruce A. Witthuhn. (2012). Wolbachia from the planthopper Laodelphax striatellus establishes a robust, persistent, streptomycin-resistant infection in clonal mosquito cells. In Vitro Cellular & Developmental Biology - Animal. 49(1). 66–73. 28 indexed citations
6.
Janagama, Harish K., John P. Bannantine, Abirami Kugadas, et al.. (2010). Iron-sparing Response of Mycobacterium avium subsp. paratuberculosis is strain dependent. BMC Microbiology. 10(1). 268–268. 18 indexed citations
7.
Witthuhn, Bruce A., et al.. (2010). The insect repellent DEET (N,N-diethyl-3-methylbenzamide) increases the synthesis of glutathione S-transferase in cultured mosquito cells. Cell Biology and Toxicology. 27(2). 149–157. 6 indexed citations
8.
Serrano, Jose A., LeeAnn Higgins, Bruce A. Witthuhn, et al.. (2010). In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors. Comparative Biochemistry and Physiology Part D Genomics and Proteomics. 5(2). 138–150. 11 indexed citations
9.
Smith, Jason P., et al.. (2006). Proteomic Comparison of Needles from Blister Rust-Resistant and Susceptible Pinus strobus Seedlings Reveals UpRegulation of Putative Disease Resistance Proteins. Molecular Plant-Microbe Interactions. 19(2). 150–160. 30 indexed citations
10.
Matsuda, Tadashi, Jian Feng, Bruce A. Witthuhn, Yuichi Sekine, & James N. Ihle. (2004). Determination of the transphosphorylation sites of Jak2 kinase. Biochemical and Biophysical Research Communications. 325(2). 586–594. 40 indexed citations
11.
12.
Kohlhuber, Franz, Neil C. Rogers, Diane Watling, et al.. (1997). A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses. Molecular and Cellular Biology. 17(2). 695–706. 180 indexed citations
13.
Witthuhn, Bruce A. & Charles Faust. (1995). Tissue-specific expression in mouse P815 mastocytoma cells of the cloned rat α-subunit gene of the high-affinity receptor for immunoglobulin E. Immunology Letters. 47(1-2). 39–43. 3 indexed citations
14.
Morella, Karen K., Chunfai Lai, Satoru Kumaki, et al.. (1995). The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts. Journal of Biological Chemistry. 270(14). 8298–8310. 28 indexed citations
15.
Yin, Tinggui, Susanne R. Keller, Frederick W. Quelle, et al.. (1995). Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases. Journal of Biological Chemistry. 270(35). 20497–20502. 128 indexed citations
16.
Quelle, Frederick W., Noriko Sato, Bruce A. Witthuhn, et al.. (1994). JAK2 Associates with the β c Chain of the Receptor for Granulocyte-Macrophage Colony-Stimulating Factor, and Its Activation Requires the Membrane-Proximal Region. Molecular and Cellular Biology. 14(7). 4335–4341. 83 indexed citations
17.
Russell, Sarah M., James A. Johnston, Masayuki Noguchi, et al.. (1994). Interaction of IL-2Rβ and γ c Chains with Jak1 and Jak3: Implications for XSCID and XCID. Science. 266(5187). 1042–1045. 553 indexed citations breakdown →
18.
Argetsinger, Lawrence S., et al.. (1993). Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell. 74(2). 237–244. 821 indexed citations breakdown →
19.
Witthuhn, Bruce A., Frederick W. Quelle, Olli Silvennoinen, et al.. (1993). JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 74(2). 227–236. 1030 indexed citations breakdown →
20.
Watling, Diane, Dmitry Guschin, Mathias Müller, et al.. (1993). Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway. Nature. 366(6451). 166–170. 472 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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