Bradley J. Backes

6.8k total citations · 3 hit papers
45 papers, 5.0k citations indexed

About

Bradley J. Backes is a scholar working on Molecular Biology, Cell Biology and Organic Chemistry. According to data from OpenAlex, Bradley J. Backes has authored 45 papers receiving a total of 5.0k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Molecular Biology, 13 papers in Cell Biology and 12 papers in Organic Chemistry. Recurrent topics in Bradley J. Backes's work include Endoplasmic Reticulum Stress and Disease (12 papers), Chemical Synthesis and Analysis (9 papers) and Peptidase Inhibition and Analysis (7 papers). Bradley J. Backes is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (12 papers), Chemical Synthesis and Analysis (9 papers) and Peptidase Inhibition and Analysis (7 papers). Bradley J. Backes collaborates with scholars based in United States, United Kingdom and Japan. Bradley J. Backes's co-authors include Jonathan A. Ellman, Jennifer L. Harris, Feroz R. Papa, Charles S. Craik, Francesco Leonetti, Scott A. Oakes, Alana G. Lerner, Sami Mahrus, Lieselotte Vande Walle and John-Paul Upton and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Bradley J. Backes

44 papers receiving 4.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

2012 696 citations Alana G. Lerner, Paurush Praveen et al. Cell Metabolism profile →
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

2009 654 citations Dan Han, Alana G. Lerner et al. Cell profile →
Fmoc-Based Synthesis of Peptide-^αThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation

1999 320 citations Bradley J. Backes, Jonathan A. Ellman et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Bradley J. Backes United States	30	2.9k	1.4k	1.3k	871	588	45	5.0k
Consuelo Gajate Spain	43	3.7k 1.3×	1.0k 0.7×	567 0.4×	477 0.5×	619 1.1×	82	5.3k
Ching‐Shih Chen United States	44	4.7k 1.6×	651 0.5×	915 0.7×	521 0.6×	1.0k 1.7×	144	6.8k
Gÿorgý Kéri Hungary	41	3.5k 1.2×	486 0.3×	592 0.4×	540 0.6×	1.7k 2.9×	162	6.1k
Richard J. Stockert United States	36	2.3k 0.8×	917 0.6×	294 0.2×	527 0.6×	720 1.2×	91	4.4k
Cristiano Ferlini Italy	41	3.0k 1.0×	997 0.7×	512 0.4×	263 0.3×	1.7k 3.0×	136	5.3k
Dirk J. Lefeber Netherlands	37	3.4k 1.2×	660 0.5×	1.2k 0.9×	359 0.4×	173 0.3×	157	4.9k
Stig Linder Sweden	49	4.8k 1.7×	1.0k 0.7×	335 0.3×	1.0k 1.2×	2.0k 3.4×	151	7.1k
Daniel A. Bachovchin United States	34	4.1k 1.4×	354 0.2×	1.1k 0.8×	283 0.3×	1.0k 1.8×	54	5.5k
Claudio Pisano Italy	48	4.0k 1.4×	1.2k 0.8×	1.3k 1.0×	131 0.2×	1.3k 2.1×	169	6.0k
Nancy E. Kohl United States	42	5.2k 1.8×	820 0.6×	757 0.6×	355 0.4×	2.4k 4.1×	97	8.0k

Countries citing papers authored by Bradley J. Backes

Since Specialization

Citations

This map shows the geographic impact of Bradley J. Backes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bradley J. Backes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bradley J. Backes more than expected).

Fields of papers citing papers by Bradley J. Backes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bradley J. Backes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bradley J. Backes. The network helps show where Bradley J. Backes may publish in the future.

Co-authorship network of co-authors of Bradley J. Backes

This figure shows the co-authorship network connecting the top 25 collaborators of Bradley J. Backes. A scholar is included among the top collaborators of Bradley J. Backes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bradley J. Backes. Bradley J. Backes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Auyeung, Vincent C., Thorsten Steinberg, Mary E. Moreno, et al.. (2025). Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice. Journal of Clinical Investigation. 135(20).

Auyeung, Vincent C., Michael S. Downey, Maike Thamsen, et al.. (2022). IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. American Journal of Physiology-Lung Cellular and Molecular Physiology. 322(4). L564–L580. 27 indexed citations

Feldman, Hannah C., Rajarshi Ghosh, Vincent C. Auyeung, et al.. (2021). ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nature Chemical Biology. 17(11). 1148–1156. 14 indexed citations

Chong, Zhenlu, Christopher S. Law, Kojiro Mukai, et al.. (2020). A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. The Journal of Experimental Medicine. 217(11). 139 indexed citations

Thamsen, Maike, Rajarshi Ghosh, Justin Peng, et al.. (2019). Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Research. 79(24). 6190–6203. 25 indexed citations

Thamsen, Maike, Rajarshi Ghosh, Vincent C. Auyeung, et al.. (2019). Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS ONE. 14(1). e0209824–e0209824. 52 indexed citations

Morita, Shuhei, S. Armando Villalta, Hannah C. Feldman, et al.. (2017). Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metabolism. 25(4). 883–897.e8. 139 indexed citations

Lerner, Alana G., Paurush Praveen, Rajarshi Ghosh, et al.. (2012). IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress. Cell Metabolism. 16(2). 250–264. 696 indexed citations breakdown →

Wang, Likun, B. Gayani K. Perera, Sanjay B. Hari, et al.. (2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology. 8(12). 982–989. 158 indexed citations

10.

Han, Dan, Alana G. Lerner, Lieselotte Vande Walle, et al.. (2009). IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates. Cell. 138(3). 562–575. 654 indexed citations breakdown →

11.

Hamilton, Gregory L. & Bradley J. Backes. (2007). Synthesis of C-11 modified mifepristone analog libraries. Molecular Diversity. 11(2). 107–111. 2 indexed citations

12.

Petrassi, H. Michael, Jennifer Williams, Jun Li, et al.. (2005). A strategy to profile prime and non-prime proteolytic substrate specificity. Bioorganic & Medicinal Chemistry Letters. 15(12). 3162–3166. 39 indexed citations

13.

Harris, Jennifer L., Daniel E. Mason, Jun Li, et al.. (2004). Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays. Chemistry & Biology. 11(10). 1361–1372. 94 indexed citations

14.

Shipway, Aaron, Henry Danahay, Jennifer Williams, et al.. (2004). Biochemical characterization of prostasin, a channel activating protease. Biochemical and Biophysical Research Communications. 324(2). 953–963. 64 indexed citations

15.

Wang, Ching C., Zbynek Bozdech, Aaron Shipway, et al.. (2003). Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei. Journal of Biological Chemistry. 278(18). 15800–15808. 35 indexed citations

16.

Harris, Jennifer L., Phil B. Alper, Jun Li, Martin Rechsteiner, & Bradley J. Backes. (2001). Substrate specificity of the human proteasome. Chemistry & Biology. 8(12). 1131–1141. 90 indexed citations

17.

Harris, Jennifer L., Andrew L. Niles, Keith W. Burdick, et al.. (2001). Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II. Journal of Biological Chemistry. 276(37). 34941–34947. 50 indexed citations

18.

Winssinger, Nicolas, Jennifer L. Harris, Bradley J. Backes, & Peter G. Schultz. (2001). From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. Angewandte Chemie International Edition. 40(17). 3152–3155. 92 indexed citations

19.

Backes, Bradley J., Jennifer L. Harris, Francesco Leonetti, Charles S. Craik, & Jonathan A. Ellman. (2000). Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18(2). 187–193. 212 indexed citations

20.

Backes, Bradley J.. (1997). Solid support linker strategies. Current Opinion in Chemical Biology. 1(1). 86–93. 67 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact