Bradley J. Backes

6.8k total citations · 3 hit papers
45 papers, 5.0k citations indexed

About

Bradley J. Backes is a scholar working on Molecular Biology, Cell Biology and Organic Chemistry. According to data from OpenAlex, Bradley J. Backes has authored 45 papers receiving a total of 5.0k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Molecular Biology, 13 papers in Cell Biology and 12 papers in Organic Chemistry. Recurrent topics in Bradley J. Backes's work include Endoplasmic Reticulum Stress and Disease (12 papers), Chemical Synthesis and Analysis (9 papers) and Peptidase Inhibition and Analysis (7 papers). Bradley J. Backes is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (12 papers), Chemical Synthesis and Analysis (9 papers) and Peptidase Inhibition and Analysis (7 papers). Bradley J. Backes collaborates with scholars based in United States, United Kingdom and Japan. Bradley J. Backes's co-authors include Jonathan A. Ellman, Jennifer L. Harris, Feroz R. Papa, Charles S. Craik, Francesco Leonetti, Scott A. Oakes, Alana G. Lerner, Sami Mahrus, Lieselotte Vande Walle and John-Paul Upton and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Bradley J. Backes

44 papers receiving 4.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

2012 696 citations Alana G. Lerner, Paurush Praveen et al. Cell Metabolism profile →
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

2009 654 citations Dan Han, Alana G. Lerner et al. Cell profile →
Fmoc-Based Synthesis of Peptide-^αThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation

1999 320 citations Bradley J. Backes, Jonathan A. Ellman et al. profile →

Peers

Countries citing papers authored by Bradley J. Backes

Since Specialization

Citations

This map shows the geographic impact of Bradley J. Backes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bradley J. Backes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bradley J. Backes more than expected).

Fields of papers citing papers by Bradley J. Backes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bradley J. Backes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bradley J. Backes. The network helps show where Bradley J. Backes may publish in the future.

Co-authorship network of co-authors of Bradley J. Backes

This figure shows the co-authorship network connecting the top 25 collaborators of Bradley J. Backes. A scholar is included among the top collaborators of Bradley J. Backes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bradley J. Backes. Bradley J. Backes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice 2025 ·Journal of Clinical Investigation ·Vincent C. Auyeung, Thorsten Steinberg, (unknown), (unknown), Mary E. Moreno, Imran S. Khan, Michael S. Downey, Maike Thamsen, Lu Guo, Dustin J. Maly, Bradley J. Backes, Dean Sheppard, Feroz R. Papa	0
2	IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis 2022 ·American Journal of Physiology-Lung Cellular and Molecular Physiology ·Vincent C. Auyeung, Michael S. Downey, Maike Thamsen, (unknown), Bradley J. Backes, Dean Sheppard, Feroz R. Papa	27
3	ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR 2021 ·Nature Chemical Biology ·Hannah C. Feldman, Rajarshi Ghosh, Vincent C. Auyeung, James L. Mueller, Jae‐Hong Kim, Zachary E. Potter, Vidadala V. Narayana, B. Gayani K. Perera, (unknown), Bradley J. Backes, Julie Zikherman, Feroz R. Papa, Dustin J. Maly	14
4	A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome 2020 ·The Journal of Experimental Medicine ·(unknown), Zhenlu Chong, Christopher S. Law, Kojiro Mukai, (unknown), Tereza Martinu, Bradley J. Backes, Walter L. Eckalbar, Tomohiko Taguchi, Anthony K. Shum	139
5	Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival 2019 ·Cancer Research ·(unknown), (unknown), Maike Thamsen, Rajarshi Ghosh, Justin Peng, Micah J. Gliedt, Rosa Meza-Acevedo, (unknown), Annie Hiniker, Grace Kim, Dustin J. Maly, Bradley J. Backes, Feroz R. Papa, Scott A. Oakes	25
6	Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung 2019 ·PLoS ONE ·Maike Thamsen, Rajarshi Ghosh, Vincent C. Auyeung, Alexis Brumwell, Harold A. Chapman, Bradley J. Backes, (unknown), Dustin J. Maly, Dean Sheppard, Feroz R. Papa	52
7	Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes 2017 ·Cell Metabolism ·Shuhei Morita, S. Armando Villalta, Hannah C. Feldman, Ames C. Register, Wendy Rosenthal, Ingeborg T. Hoffmann‐Petersen, Morvarid Mehdizadeh, Rajarshi Ghosh, Likun Wang, (unknown), Rosa Meza-Acevedo, Bradley J. Backes, Dustin J. Maly, Jeffrey A. Bluestone, Feroz R. Papa	139
8	IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress breakdown → 2012 ·Cell Metabolism ·Alana G. Lerner, (unknown), Paurush Praveen, Rajarshi Ghosh, Yoshimi Nakagawa, Aeid Igbaria, (unknown), Vinh Nguyen, Bradley J. Backes, Myriam Heiman, Nathaniel Heintz, Paul Greengard, Simon T. Hui, Qizhi Tang, Ala Trusina, Scott A. Oakes, Feroz R. Papa	696
9	Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors 2012 ·Nature Chemical Biology ·Likun Wang, B. Gayani K. Perera, Sanjay B. Hari, Barun Bhhatarai, Bradley J. Backes, Markus A. Seeliger, Stephan C. Schürer, Scott A. Oakes, Feroz R. Papa, Dustin J. Maly	158
10	IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates breakdown → 2009 ·Cell ·Dan Han, Alana G. Lerner, Lieselotte Vande Walle, John-Paul Upton, Weihong Xu, Andrew Hagen, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa	654
11	Synthesis of C-11 modified mifepristone analog libraries 2007 ·Molecular Diversity ·Gregory L. Hamilton, Bradley J. Backes	2
12	A strategy to profile prime and non-prime proteolytic substrate specificity 2005 ·Bioorganic & Medicinal Chemistry Letters ·H. Michael Petrassi, Jennifer Williams, Jun Li, Christine Tumanut, (unknown), Takashi Nakai, (unknown), Bradley J. Backes, Jennifer L. Harris	39
13	Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays 2004 ·Chemistry & Biology ·Jennifer L. Harris, Daniel E. Mason, Jun Li, Keith W. Burdick, Bradley J. Backes, Teresa C. Chen, Aaron Shipway, Gino Van Heeke, Lucy Gough, Amir M. Ghaemmaghami, Farouk Shakib, François Debaene, Nicolas Winssinger	94
14	Biochemical characterization of prostasin, a channel activating protease 2004 ·Biochemical and Biophysical Research Communications ·Aaron Shipway, Henry Danahay, Jennifer Williams, David C. Tully, Bradley J. Backes, Jennifer L. Harris	64
15	Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei 2003 ·Journal of Biological Chemistry ·Ching C. Wang, Zbynek Bozdech, (unknown), Aaron Shipway, Bradley J. Backes, Jennifer L. Harris, Matthew Bogyo	35
16	Substrate specificity of the human proteasome 2001 ·Chemistry & Biology ·Jennifer L. Harris, Phil B. Alper, Jun Li, Martin Rechsteiner, Bradley J. Backes	90
17	Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II 2001 ·Journal of Biological Chemistry ·Jennifer L. Harris, Andrew L. Niles, Keith W. Burdick, (unknown), Bradley J. Backes, Jonathan A. Ellman, Irwin D. Kuntz, Mary Haak‐Frendscho, Charles S. Craik	50
18	From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling 2001 ·Angewandte Chemie International Edition ·Nicolas Winssinger, Jennifer L. Harris, Bradley J. Backes, Peter G. Schultz	92
19	Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 2000 ·Nature Biotechnology ·Bradley J. Backes, Jennifer L. Harris, Francesco Leonetti, Charles S. Craik, Jonathan A. Ellman	212
20	Solid support linker strategies 1997 ·Current Opinion in Chemical Biology ·Bradley J. Backes	67

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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