Dirk J. Lefeber

10.8k total citations · 1 hit paper
157 papers, 4.9k citations indexed

About

Dirk J. Lefeber is a scholar working on Molecular Biology, Organic Chemistry and Immunology. According to data from OpenAlex, Dirk J. Lefeber has authored 157 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 118 papers in Molecular Biology, 37 papers in Organic Chemistry and 36 papers in Immunology. Recurrent topics in Dirk J. Lefeber's work include Glycosylation and Glycoproteins Research (82 papers), Carbohydrate Chemistry and Synthesis (35 papers) and Lysosomal Storage Disorders Research (26 papers). Dirk J. Lefeber is often cited by papers focused on Glycosylation and Glycoproteins Research (82 papers), Carbohydrate Chemistry and Synthesis (35 papers) and Lysosomal Storage Disorders Research (26 papers). Dirk J. Lefeber collaborates with scholars based in Netherlands, United States and Germany. Dirk J. Lefeber's co-authors include Éva Morava, Ron A. Wevers, Monique van Scherpenzeel, Floris L. van Delft, Gert Matthijs, Floris P. J. T. Rutjes, Samuel Schmidt, Rinske P. Temming, Jan C. M. van Hest and Linda Hendriks and has published in prestigious journals such as Science, Journal of Biological Chemistry and Angewandte Chemie International Edition.

In The Last Decade

Dirk J. Lefeber

150 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three‐Dimensional Imaging of Living Cells

2010 594 citations Dirk J. Lefeber et al. profile →

Peers

Countries citing papers authored by Dirk J. Lefeber

Since Specialization

Citations

This map shows the geographic impact of Dirk J. Lefeber's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk J. Lefeber with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk J. Lefeber more than expected).

Fields of papers citing papers by Dirk J. Lefeber

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk J. Lefeber. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk J. Lefeber. The network helps show where Dirk J. Lefeber may publish in the future.

Co-authorship network of co-authors of Dirk J. Lefeber

This figure shows the co-authorship network connecting the top 25 collaborators of Dirk J. Lefeber. A scholar is included among the top collaborators of Dirk J. Lefeber based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Dirk J. Lefeber. Dirk J. Lefeber is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	New treatment for pyridoxine-dependent epilepsy due to ALDH7A1 deficiency: first proof-of-principle of upstream enzyme inhibition in the mouse 2025 ·Brain Communications ·Clara D.M. van Karnebeek, Valérie Gailus‐Durner, Udo F. H. Engelke, Claudia Seisenberger, Susan Marschall, Nathalia Romanelli Vicente Dragano, Patricia da Silva‐Buttkus, Stefanie Leuchtenberger, Helmut Fuchs, Martin Hrabě de Angelis, Ron A. Wevers, Curtis R. Coughlin, Dirk J. Lefeber	1
2	Untargeted Metabolomics for Diagnosis, Monitoring, and Understanding the Pathophysiology of Inherited Metabolic Disorders 2025 ·Journal of Inherited Metabolic Disease ·Jonathan Martens, Udo F. H. Engelke, Ron A. Wevers, Dirk J. Lefeber, Purva Kulkarni	0
3	Structure Elucidation for MALDI Mass Spectrometry Imaging Using Infrared Ion Spectroscopy 2025 ·Analytical Chemistry ·(unknown), (unknown), Kas J. Houthuijs, (unknown), Valerie Gailus-Durner, Stefanie Leuchtenberger, Helmut Fuchs, Martin Hrabě de Angelis, Udo F. H. Engelke, Dirk J. Lefeber, Clara van Karnebeek, Ron A. Wevers, (unknown), (unknown), Michiel Vandenbosch, Rob J. Vreeken, Ron M. A. Heeren, Giel Berden, Jos Oomens, Jonathan Martens	1
4	Mixed-phase weak anion-exchange/reversed-phase LC–MS/MS for analysis of nucleotide sugars in human fibroblasts 2024 ·Analytical and Bioanalytical Chemistry ·M. Rahm, (unknown), Hans J. C. T. Wessels, Marek Noga, Dirk J. Lefeber	0
5	N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma 2024 ·Clinical Chemistry and Laboratory Medicine (CCLM) ·(unknown), (unknown), Purva Kulkarni, Simon Nadal, (unknown), (unknown), (unknown), Martijn M. VanDuijn, Irma Joosten, Thomas Dejoie, Alain J. van Gool, Jolein Gloerich, Dirk J. Lefeber, Hans J. C. T. Wessels, Joannes F.M. Jacobs	6
6	Oral sialic acid supplementation inNANS‐CDG: Results of a single center, open‐label, observational pilot study 2023 ·Journal of Inherited Metabolic Disease ·(unknown), Marion M. Brands, Lonneke de Boer, Charlotte A. Haaxma, Anna Lengyel, (unknown), (unknown), (unknown), Willemijn M. Klein, Karlien L. M. Coene, Dirk J. Lefeber, Clara van Karnebeek	1
7	Isotopic Tracing of Nucleotide Sugar Metabolism in Human Pluripotent Stem Cells 2023 ·Cells ·Federica Conte, Marek Noga, Monique van Scherpenzeel, (unknown), (unknown), (unknown), (unknown), (unknown), Christian Freund, Eduardo V. Soares, Huiqing Zhou, Dirk J. Lefeber	6
8	Glycoproteomics in Cerebrospinal Fluid Reveals Brain-Specific Glycosylation Changes 2023 ·International Journal of Molecular Sciences ·(unknown), (unknown), (unknown), Karin Huijben, Fokje Zijlstra, Joannes F.M. Jacobs, Marcel M. Verbeek, Hans J. C. T. Wessels, Dirk J. Lefeber	11
9	Development of tools to facilitate the diagnosis of hereditary fructose intolerance 2023 ·JIMD Reports ·(unknown), (unknown), Dirk J. Lefeber, Nynke Simons, M. Estela Rubio‐Gozalbo, Martijn C.G.J. Brouwers	2
10	Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC‐derived excitatory neurons 2023 ·Journal of Neurochemistry ·(unknown), Chantal Schoenmaker, (unknown), Sam J. Moons, Thomas J. Boltje, Nael Nadif Kasri, Dirk J. Lefeber	1
11	Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism 2023 ·Analytical Chemistry ·Rianne E. van Outersterp, (unknown), Jona Merx, Udo F. H. Engelke, Nematollah Omidikia, (unknown), Kas J. Houthuijs, Giel Berden, (unknown), Dirk J. Lefeber, Michèl A.A.P. Willemsen, Jasmin Mecinović, Jeroen J. Jansen, Karlien L. M. Coene, Ron A. Wevers, Thomas J. Boltje, Jos Oomens, Jonathan Martens	3
12	In Vitro Skeletal Muscle Model of PGM1 Deficiency Reveals Altered Energy Homeostasis 2023 ·International Journal of Molecular Sciences ·Federica Conte, Angel Ashikov, (unknown), (unknown), Monique van Scherpenzeel, (unknown), (unknown), (unknown), Karin Huijben, (unknown), Richard J. Rodenburg, Nicol C. Voermans, Alejandro Garanto, Werner J.H. Koopman, Hans J. C. T. Wessels, Marek Noga, Dirk J. Lefeber	6
13	Loss of the AMD-associated B3GLCT gene affects glycosylation of TSP1 without impairing secretion in retinal pigment epithelial cells 2021 ·Experimental Eye Research ·(unknown), (unknown), (unknown), Eiko K. de Jong, Hans J. C. T. Wessels, Anneke I. den Hollander, Dirk J. Lefeber	3
14	Fluorinated rhamnosides inhibit cellular fucosylation 2021 ·Nature Communications ·Johan F. A. Pijnenborg, (unknown), Jona Merx, Marek Noga, (unknown), (unknown), (unknown), Paul B. White, Dirk J. Lefeber, Thomas J. Boltje	28
15	Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation 2020 ·International Journal of Molecular Sciences ·Agnes L. Hipgrave Ederveen, Noortje de Haan, (unknown), Dirk J. Lefeber, Manfred Wuhrer	17
16	Screening for abnormal glycosylation in a cohort of adult liver disease patients 2020 ·Journal of Inherited Metabolic Disease ·Jos C. Jansen, Bart van Hoek, Herold J. Metselaar, Aad P. van den Berg, Fokje Zijlstra, Karin Huijben, Monique van Scherpenzeel, Joost P.H. Drenth, Dirk J. Lefeber	8
17	Variants in NGLY1 lead to intellectual disability, myoclonus epilepsy, sensorimotor axonal polyneuropathy and mitochondrial dysfunction 2020 ·Clinical Genetics ·(unknown), Saskia B. Wortmann, Charlotte A. Haaxma, Peter M. van Hasselt, Nicole I. Wolf, Yvonne Hendriks, Benno Küsters, (unknown), (unknown), Werner J.H. Koopman, Liesbeth T. Wintjes, (unknown), Maaike de Vries, Dirk J. Lefeber, Jan Smeıtınk, Richard J. Rodenburg	23
18	A Multiplex Assay for the Diagnosis of Mucopolysaccharidoses and Mucolipidoses 2015 ·PLoS ONE ·Eveline J. Langereis, Tom Wagemans, Wim Kulik, Dirk J. Lefeber, Henk van Lenthe, Esmée Oussoren, Ans T. van der Ploeg, George J. G. Ruijter, Ron A. Wevers, Frits A. Wijburg, Naomi van Vlies	30
19	Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2 2007 ·Nature Genetics ·(unknown), Uwe Kornak, Ellen Reynders, Aikaterini Dimopoulou, Jeroen van Reeuwijk, Bjoern Fischer, Anna Rajab, Birgit Budde, Peter Nürnberg, François Foulquier, Dirk J. Lefeber, Zsolt Urbán, (unknown), Wim Annaert, Han G. Brunner, Hans van Bokhoven, Ron A. Wevers, Éva Morava, Gert Matthijs, Lionel Van Maldergem, Stefan Mundlos	259
20	O -Acetylation of Cryptococcal Capsular Glucuronoxylomannan Is Essential for Interference with Neutrophil Migration 2004 ·The Journal of Immunology ·Pauline M. Ellerbroek, Dirk J. Lefeber, Richard van Veghel, Jelle Scharringa, Ellen C. Brouwer, Gerrit J. Gerwig, Guilhem Janbon, Andy I. M. Hoepelman, Frank E. J. Coenjaerts	50

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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