Anne Hakem

7.5k citations

36 papers · 6.1k indexed · 4 hit papers · h-index 26

Impact in

Immunology top 2%
- interferon and immune responses
Molecular Biology top 1%
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways

Papers in

Oncology 16
- Cancer-related Molecular Pathways 13
Molecular Biology 34
- DNA Repair Mechanisms 16
- Cell death mechanisms and regulation 12
- Ubiquitin and proteasome pathways 5
- Genomics and Chromatin Dynamics 4
- Epigenetics and DNA Methylation 3
- CRISPR and Genetic Engineering 3

Co-authors: Razqallah Hakem Josef Penninger Andrew Elia Tak W. Mak Minna Woo Gordon S. Duncan David Kägi Stephen A. Kaufman
Journals: Cell (4 papers)Genes & Development (4 papers)PLoS Genetics (3 papers)The Journal of Cell Biology (2 papers)The Journal of Experimental Medicine (2 papers)
Partner nations: Canada United States Singapore

In The Last Decade

Anne Hakem

36 papers receiving 6.0k citations

Hit Papers

align trajectories log scale

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo 1998 · 1.1k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1998 Cell
1998 Cell
1998 Genes & Development
1996 Cell

Peers

Countries citing papers authored by Anne Hakem

Since Specialization

Citations

This map shows the geographic impact of Anne Hakem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Anne Hakem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Anne Hakem more than expected).

Fields of papers citing papers by Anne Hakem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Anne Hakem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Anne Hakem. The network helps show where Anne Hakem may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Anne Hakem, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Anne Hakem Line = papers co-authored together Anne Hakem links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity iScience ·Hsiang-Chou Liao, Krista Sapronova, Jie Wu, Eric Cartignies, B. Rieger, Rehna Krishnan, Anne Hakem, Dalia Baršytė-Lovejoy, Razqallah Hakem, Steven A. Narod, Joanne Kotsopoulos, Leonardo Salmena	2024	1
2	DNA double-strand break–capturing nuclear envelope tubules drive DNA repair Nature Structural & Molecular Biology ·Radhiga Chandran, Sithokoza Mbokazi, 李怀庆, Janet N.Y. Chan, 余达, T. J. Cullen, Anne Hakem, Roderic Espín, Jun Hao, Rehna Krishnan, Philipp G. Maass, Brendan C. Dickson, M. Prakash Hande, Miguel Ángel Pujana, Razqallah Hakem, Karim Mekhail	2024	26
3	Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation Diabetes ·Cynthia T. Luk, 治雄田宮, Christine Kranich, Sally Yu Shi, M Suhela Thasleem, Facultad De Pedagogía, Siu-Siu Ha, Stephanie A. Schroer, Harsh R. Desai, Tharini Sivasubramaniyam, Erica P. Cai, Mansa Krishnamurthy, Ying Wu, Apu Chowdhury, Rukhsana Aslam, Darren A. Yuen, Anne Hakem, Razqallah Hakem, Minna Woo	2023	12
4	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation Nature Communications ·Kevin Nichols, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, 信一隈元, Ramya Kumareswaran, Samah El Ghamrasni, E. Cotterill, Parasvi S. Patel, T.T. Kakuchaya, Robert G. Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem, Razqallah Hakem	2016	41
5	INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia Leukemia ·Irakli Dzneladze, María Rosa Randazzo, John F. Woolley, Meong Hi Son, 闫咏梅, F. Vazeille, Zakhar Rozlach, Doron Goldbarsht, Anooshiravan Hami, Anne Hakem, Narmin Ibrahimova, Andrea Arruda, Bob Löwenberg, Peter J.M. Valk, Mark D. Minden, Leonardo Salmena	2015	43
6	Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression Oncogene ·Samah El Ghamrasni, Frank Pace, Ji Yin, 温景林, Shane M. Harding, Ramanan Kumareswaran, Roy Haines-Young, Kruy Kroeun, Andrea Jurisicova, Yumvihoze Emmanuel, M. Prakash Hande, Robert G. Bristow, Razqallah Hakem, Anne Hakem	2014	15
7	Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis PLoS Genetics ·Robert A. Cord, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, M. Prakash Hande, Otto Sánchez, Razqallah Hakem	2013	17
8	The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover Cell Death and Differentiation ·Miyuki Bohgaki, Anne Hakem, Ji Yin, Toshiyuki Bohgaki, Zhadyra Konurbayeva, Bruna dos Santos Willges, Jorge Manuel da Silva Ribeiro, Thomas Kislinger, Yumvihoze Emmanuel, Yi Sheng, Razqallah Hakem	2013	41
9	Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome PLoS Genetics ·Toshiyuki Bohgaki, Miyuki Bohgaki, José Vieira Coutinho Júnior, Stephanie Panier, 温景林, Li Li, Grant S. Stewart, Otto Sánchez, M. Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem	2011	64
10	Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer PLoS Genetics ·Samah El Ghamrasni, 直之北村, Marie Jo Halaby, Miyuki Bohgaki, José Vieira Coutinho Júnior, Li Li, Shriram Venkatesan, Swaminathan Sethu, Atsushi Hirao, Tak W. Mak, M. Prakash Hande, Anne Hakem, Razqallah Hakem	2011	18
11	Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer Cancer Research ·直之北村, José Vieira Coutinho Júnior, Anne Hakem, Elzbieta Matysiak‐Zablocki, Anuradha Poonepalli, Laura Tamblyn, Bayardo Perez‐Ordoñez, M. Prakash Hande, Otto Sánchez, Razqallah Hakem	2007	25
12	Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling Journal of Biological Chemistry ·Bénédicte Lemmers, Leonardo Salmena, Nicolas Bidère, Helen C. Su, Elzbieta Matysiak‐Zablocki, Kiichi Murakami, Pamela S. Ohashi, Andrea Jurisicova, Michael J. Lenardo, Razqallah Hakem, Anne Hakem	2007	147
13	RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis Genes & Development ·Anne Hakem, Otto Sanchez-Sweatman, Annick You-Ten, Gordon S. Duncan, Andrew Wakeham, Rama Khokha, Tak W. Mak	2005	240
14	Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity Nature Immunology ·Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S. Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E. Wu, Christopher J. Paige, Tak W. Mak	2003	144
15	Brca1 required for T cell lineage development but not TCR loci rearrangement Nature Immunology ·Tak W. Mak, Anne Hakem, PonceletPascal, Amro Shehabeldin, MariaMatteis, Eva Migon, Gordon S. Duncan, Denis Bouchard, Andrew Wakeham, Alison Cheung, Jana Karásková, Ildiko Sarosi, Jeremy A. Squire, Jamey D. Marth, Razqallah Hakem	2000	61
16	Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes Genes & Development ·Minna Woo, Razqallah Hakem, Marı́a S. Soengas, G S Duncan, Arda Shahinian, David Kägi, Anne Hakem, Mila E. McCurrach, Wilson Khoo, Stephen A. Kaufman, Giorgio Senaldi, Tina Howard, Scott W. Lowe, Tak W. Mak Hit paper breakdown →	1998	747
17	Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo Cell ·Razqallah Hakem, Anne Hakem, Gordon S. Duncan, Jeffrey T. Henderson, Minna Woo, Marı́a S. Soengas, Andrew Elia, José Luís de la Pompa, David Kägi, Wilson Khoo, Julia M. Potter, 啓介當山, Stephen A. Kaufman, Scott W. Lowe, Josef Penninger, Tak W. Mak Hit paper breakdown →	1998	1103
18	Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development Cell ·Hiroki Yoshida, Young‐Yun Kong, 啓介當山, Andrew Elia, Anne Hakem, Razqallah Hakem, Josef Penninger, Tak W. Mak Hit paper breakdown →	1998	938
19	Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice Cell ·Ryuichi Amakawa, Anne Hakem, Thomas M. Kündig, T. Matsuyama, John Simard, Emma Timms, Andrew Wakeham, Sai Nei Lim, Henrik Griesser, Hiroaki Takimoto, Rudolf Schmits, Arda Shahinian, Pamela S. Ohashi, Josef Penninger, Tak W. Mak	1996	266
20	The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse Cell ·Razqallah Hakem, José Luís de la Pompa, Christian Sirard, Rong Mo, Minna Woo, Anne Hakem, Andrew Wakeham, Julia M. Potter, Armin Reitmair, Filio Billia, Eduardo Firpo, Chi Chung Hui, Jim Roberts, Janet Rossant, Tak W. Mak Hit paper breakdown →	1996	530

About Anne Hakem

Anne Hakem is a scholar working on Oncology, Molecular Biology, Immunology, Cancer Research and Cell Biology, having authored 36 papers that have together received 6.1k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (16 papers), Cancer-related Molecular Pathways (13 papers), Cell death mechanisms and regulation (12 papers), Ubiquitin and proteasome pathways (5 papers), Genomics and Chromatin Dynamics (4 papers), Epigenetics and DNA Methylation (3 papers), Microtubule and mitosis dynamics (3 papers) and CRISPR and Genetic Engineering (3 papers). The work is most often cited by research in Immunology (1.4k citations), Molecular Biology (4.6k citations), Cancer Research (986 citations), Oncology (1.4k citations) and Cell Biology (685 citations). Anne Hakem has collaborated with scholars based in Canada, United States and Singapore. Frequent co-authors include Razqallah Hakem, Josef Penninger, Andrew Elia, Tak W. Mak, Minna Woo, Tak W. Mak, Gordon S. Duncan, David Kägi, Stephen A. Kaufman and Wilson Khoo. Their work appears in journals such as Cell, Genes & Development, PLoS Genetics, The Journal of Cell Biology and The Journal of Experimental Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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