Tak W. Mak

24.8k total citations · 9 hit papers
115 papers, 16.9k citations indexed

About

Tak W. Mak is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Tak W. Mak has authored 115 papers receiving a total of 16.9k indexed citations (citations by other indexed papers that have themselves been cited), including 80 papers in Immunology, 34 papers in Molecular Biology and 17 papers in Oncology. Recurrent topics in Tak W. Mak's work include T-cell and B-cell Immunology (55 papers), Immune Cell Function and Interaction (54 papers) and Immunotherapy and Immune Responses (25 papers). Tak W. Mak is often cited by papers focused on T-cell and B-cell Immunology (55 papers), Immune Cell Function and Interaction (54 papers) and Immunotherapy and Immune Responses (25 papers). Tak W. Mak collaborates with scholars based in Canada, United States and Germany. Tak W. Mak's co-authors include Pamela S. Ohashi, Andrew Wakeham, Josef Penninger, Arda Shahinian, Thomas M. Kündig, Kenji Kishihara, Klaus Pfeffer, T. Matsuyama, Valerie A. Wallace and Guido Kroemer and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Tak W. Mak

113 papers receiving 16.5k citations

Hit Papers

Mice deficient for the 55 kd tumor necrosis factor recept... 1993 2026 2004 2015 1993 2001 1993 2000 1995 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    1993 1.5k citations T. Matsuyama, Thomas M. Kündig et al. Cell profile →
  2. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
    2001 1.1k citations Santos A. Susín, Éric Daugas et al. profile →
  3. Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
    1993 1.1k citations Arda Shahinian, Thomas M. Kündig et al. Science profile →
  4. Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
    2000 889 citations Andrew Wakeham, I. Kozieradzki et al. Science profile →
  5. Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β
    1995 727 citations Haruhiko Suzuki, Thomas M. Kündig et al. Science profile →
  6. Heat-shock protein 70 antagonizes apoptosis-inducing factor
    2001 714 citations L Ravagnan, Santos A. Susín et al. profile →
  7. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
    2002 650 citations Gordon S. Duncan, Christine Mirtsos et al. profile →
  8. Two Distinct Pathways Leading to Nuclear Apoptosis
    2000 610 citations Santos A. Susín, Éric Daugas et al. The Journal of Experimental Medicine profile →
  9. T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
    2001 463 citations Toshiaki Ohteki, Andrew Wakeham et al. Immunity profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Tak W. Mak Canada 57 9.9k 6.7k 3.0k 1.6k 1.3k 115 16.9k
Kazuo Sugamura Japan 78 12.2k 1.2× 4.9k 0.7× 4.0k 1.3× 1.5k 0.9× 1.4k 1.0× 304 20.8k
Klaus Pfizenmaier Germany 69 7.5k 0.8× 7.9k 1.2× 3.1k 1.0× 2.1k 1.3× 1.4k 1.0× 253 17.3k
Shin Yonehara Japan 66 9.0k 0.9× 10.3k 1.6× 3.3k 1.1× 1.7k 1.0× 1.9k 1.4× 172 18.7k
Pamela L. Schwartzberg United States 72 11.2k 1.1× 4.9k 0.7× 3.7k 1.2× 1.0k 0.6× 1.2k 0.9× 153 17.7k
Pierre Golstein France 48 10.1k 1.0× 8.4k 1.3× 3.3k 1.1× 1.5k 0.9× 2.5k 1.8× 138 18.9k
Thomas A. Hamilton United States 70 9.7k 1.0× 4.4k 0.7× 4.0k 1.3× 2.0k 1.3× 1.4k 1.1× 218 16.3k
Stephen Μ. Hedrick United States 66 10.6k 1.1× 7.3k 1.1× 2.9k 1.0× 1.2k 0.7× 1.1k 0.8× 166 17.0k
Bernd Arnold Germany 59 6.6k 0.7× 4.5k 0.7× 2.0k 0.6× 1.2k 0.8× 1.2k 0.9× 167 15.1k
Jonathan D. Ashwell United States 67 7.9k 0.8× 7.0k 1.1× 2.9k 0.9× 2.3k 1.4× 1.0k 0.8× 166 14.5k
Doreen A. Cantrell United Kingdom 81 12.6k 1.3× 10.0k 1.5× 5.1k 1.7× 2.2k 1.4× 1.0k 0.8× 217 21.7k

Countries citing papers authored by Tak W. Mak

Since Specialization
Citations

This map shows the geographic impact of Tak W. Mak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tak W. Mak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tak W. Mak more than expected).

Fields of papers citing papers by Tak W. Mak

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tak W. Mak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tak W. Mak. The network helps show where Tak W. Mak may publish in the future.

Co-authorship network of co-authors of Tak W. Mak

This figure shows the co-authorship network connecting the top 25 collaborators of Tak W. Mak. A scholar is included among the top collaborators of Tak W. Mak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tak W. Mak. Tak W. Mak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Campos, Cecília Bonolo de, Zhihua Li, Daniel K.C. Lee, et al.. (2025). PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism. Blood. 147(6). 650–661. 1 indexed citations
2.
Campos, Cecília Bonolo de, Zhihua Li, Michael St. Paul, et al.. (2025). Autophagy/lysosome disruption via pikfyve inhibition in multiple myeloma. Blood. 146(Supplement 1). 3316–3316.
3.
Tran, Charles W., Samuel D. Saibil, Thierry Le Bihan, et al.. (2017). Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. The Journal of Immunology. 199(12). 4056–4065. 13 indexed citations
4.
Rahbar, Ramtin, Albert Lin, Magar Ghazarian, et al.. (2014). B7-H4 Expression by Nonhematopoietic Cells in the Tumor Microenvironment Promotes Antitumor Immunity. Cancer Immunology Research. 3(2). 184–195. 38 indexed citations
5.
McIlwain, David R., Philipp A. Lang, Thorsten Maretzky, et al.. (2012). iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS. Science. 335(6065). 229–232. 259 indexed citations
6.
Pellegrini, Marc, Thomas Calzascia, Jesse G. Toe, et al.. (2011). IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology. Cell. 144(4). 601–613. 249 indexed citations
7.
Pellegrini, Marc, Thomas Calzascia, Alisha R. Elford, et al.. (2009). Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nature Medicine. 15(5). 528–536. 171 indexed citations
8.
Lin, Amy E. & Tak W. Mak. (2007). The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells. Current Opinion in Immunology. 19(6). 665–673. 56 indexed citations
9.
Chau, Hien, Veronica Wong, Nien‐Jung Chen, et al.. (2005). Cellular FLICE-inhibitory protein is required for T cell survival and cycling. The Journal of Experimental Medicine. 202(3). 405–413. 72 indexed citations
10.
Hao, Zhenyue, Gordon S. Duncan, Chia‐Che Chang, et al.. (2005). Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis. Cell. 121(4). 579–591. 213 indexed citations
11.
Suh, Woong‐Kyung, Agostino Tafuri, Arda Shahinian, et al.. (2004). The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28. The Journal of Immunology. 172(10). 5917–5923. 47 indexed citations
12.
Muto, Akihiro, Jürgen Ruland, Linda M. McAllister‐Lucas, et al.. (2002). Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-κB Activation Induced by Phorbol Ester. Journal of Biological Chemistry. 277(35). 31871–31876. 35 indexed citations
13.
Susín, Santos A., Éric Daugas, L Ravagnan, et al.. (2000). Two Distinct Pathways Leading to Nuclear Apoptosis. The Journal of Experimental Medicine. 192(4). 571–580. 610 indexed citations breakdown →
14.
Oliveira-dos-Santos, Antonio, Alexandra Ho, Yoshifumi Tada, et al.. (1999). CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis. The Journal of Immunology. 162(8). 4490–4495. 70 indexed citations
15.
Yoshida, Hiroki, Hiroshi Nishina, Hiroaki Takimoto, et al.. (1998). The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production. Immunity. 8(1). 115–124. 300 indexed citations
16.
Marengère, Luc E. M., Christine Mirtsos, I. Kozieradzki, et al.. (1997). Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. The Journal of Immunology. 159(1). 70–76. 94 indexed citations
17.
Penninger, Josef, et al.. (1995). The role of transgenic knockout models in defining the pathogenesis of viral heart disease. European Heart Journal. 16(suppl O). 25–27. 17 indexed citations
18.
Suzuki, Haruhiko, Thomas M. Kündig, Caren Furlonger, et al.. (1995). Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β. Science. 268(5216). 1472–1476. 727 indexed citations breakdown →
19.
Wallace, Valerie A., Amin Rahemtulla, Emma Timms, Josef Penninger, & Tak W. Mak. (1992). CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.. The Journal of Experimental Medicine. 176(5). 1459–1463. 36 indexed citations
20.
Iwamoto, Aikichi, Pamela S. Ohashi, Hanspeter Pircher, et al.. (1987). T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.. The Journal of Experimental Medicine. 165(3). 591–600. 63 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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