Han G. Brunner

50.1k total citations · 10 hit papers
278 papers, 20.9k citations indexed

About

Han G. Brunner is a scholar working on Molecular Biology, Genetics and Surgery. According to data from OpenAlex, Han G. Brunner has authored 278 papers receiving a total of 20.9k indexed citations (citations by other indexed papers that have themselves been cited), including 141 papers in Molecular Biology, 134 papers in Genetics and 27 papers in Surgery. Recurrent topics in Han G. Brunner's work include Genomic variations and chromosomal abnormalities (46 papers), Genomics and Rare Diseases (45 papers) and Genetics and Neurodevelopmental Disorders (32 papers). Han G. Brunner is often cited by papers focused on Genomic variations and chromosomal abnormalities (46 papers), Genomics and Rare Diseases (45 papers) and Genetics and Neurodevelopmental Disorders (32 papers). Han G. Brunner collaborates with scholars based in Netherlands, United States and United Kingdom. Han G. Brunner's co-authors include Joris A. Veltman, Lisenka E.L.M. Vissers, Hans‐Hilger Ropers, Christian Gilissen, Alexander Hoischen, Bernard A. van Oost, Bert B.A. de Vries, Ad Geurts van Kessel, Marc A. van Driel and Marcel Nelen and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

Han G. Brunner

273 papers receiving 20.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 1.2k citations Han G. Brunner et al. profile →
Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 1.1k citations Han G. Brunner et al. profile →
Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

2012 987 citations Marjolein H. Willemsen, Helger G. Yntema et al. profile →
Mutations in a new member of the chromodomain gene family cause CHARGE syndrome

2004 876 citations Lisenka E.L.M. Vissers, Bert B.A. de Vries et al. profile →
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

2008 546 citations Han G. Brunner et al. profile →
Heterozygous Germline Mutations in the p53 Homolog p63 Are the Cause of EEC Syndrome

1999 536 citations Han G. Brunner et al. profile →
A de novo paradigm for mental retardation

2010 526 citations Lisenka E.L.M. Vissers, Christian Gilissen et al. profile →
PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 522 citations Ineke van der Burgt, Han G. Brunner et al. The American Journal of Human Genetics profile →
De novo mutations in human genetic disease

2012 514 citations Han G. Brunner et al. profile →
Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders

2019 367 citations Helen V. Firth, Han G. Brunner et al. Genetics in Medicine profile →

Peers

Countries citing papers authored by Han G. Brunner

Since Specialization

Citations

This map shows the geographic impact of Han G. Brunner's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Han G. Brunner with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Han G. Brunner more than expected).

Fields of papers citing papers by Han G. Brunner

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Han G. Brunner. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Han G. Brunner. The network helps show where Han G. Brunner may publish in the future.

Co-authorship network of co-authors of Han G. Brunner

This figure shows the co-authorship network connecting the top 25 collaborators of Han G. Brunner. A scholar is included among the top collaborators of Han G. Brunner based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Han G. Brunner. Han G. Brunner is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Systematic analysis of paralogous regions in 41,755 exomes uncovers clinically relevant variation 2023 ·Nature Communications ·Wouter Steyaert, Lonneke Haer‐Wigman, Rolph Pfundt, Debby M.E.I. Hellebrekers, Marloes Steehouwer, (unknown), Elke de Boer, Alexander P.A. Stegmann, Helger G. Yntema, Erik‐Jan Kamsteeg, Han G. Brunner, Alexander Hoischen, Christian Gilissen	5
2	Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy 2023 ·Circulation Genomic and Precision Medicine ·(unknown), Ida G. Lunde, Debby M.E.I. Hellebrekers, Godelieve R.F. Claes, Hiroko Wakimoto, Joshua Gorham, Ingrid P.C. Krapels, Els K. Vanhoutte, Arthur van den Wijngaard, Michiel T.H.M. Henkens, Anne G. Raafs, (unknown), Jos L. V. Broers, Miranda Nabben, Elizabeth A. V. Jones, Stéphane Heymans, Han G. Brunner, Job A.J. Verdonschot	10
3	A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes 2023 ·The American Journal of Human Genetics ·Erica Harris, Vincent Roy, Martin Montagne, (unknown), Helen Livesey, Margot R.F. Reijnders, Emma Hobson, Francis H. Sansbury, Marjolein H. Willemsen, Rolph Pfundt, Daniel Warren, Vernon Long, Ian Carr, Han G. Brunner, Eamonn Sheridan, Helen V. Firth, Pierre Lavigne, James A. Poulter	4
4	Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort 2023 ·Scientific Reports ·(unknown), Job A.J. Verdonschot, Kasper Derks, Han G. Brunner, Theo M. de Kok, Ilja C.W. Arts, Stéphane Heymans, Martina Kutmon, Michiel Adriaens	3
5	Embryo tracking system for high-throughput sequencing-based preimplantation genetic testing 2022 ·Human Reproduction ·(unknown), Kasper Derks, Marion Drüsedau, (unknown), (unknown), (unknown), J. Dreesen, Edith Coonen, Christine de Die‐Smulders, Servi J.C. Stevens, Han G. Brunner, Arthur van den Wijngaard, Aimée Paulussen, Masoud Zamani Esteki	3
6	Methylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences 2022 ·npj Genomic Medicine ·(unknown), Florence Busato, Jörg Tost, D. Consten, Jannie van Echten‐Arends, Sebastiaan Mastenbroek, (unknown), Sylvie Rémy, Sabine A. S. Langie, Tim S. Nawrot, Michelle Plusquin, Rossella Alfano, Esmée M. Bijnens, Marij Gielen, Ron van Golde, John C.M. Dumoulin, Han G. Brunner, Aafke P.A. van Montfoort, Masoud Zamani Esteki	4
7	The broader phenotypic spectrum of congenital caudal abnormalities associated with mutations in the caudal type homeobox 2 gene 2021 ·Clinical Genetics ·Servi J.C. Stevens, Constance T. R. M. Stumpel, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mary‐Alice Abbott, (unknown), Jorune Balciuniene, Louise C. Pyle, Jacqueline Leonard, Jill R. Murrell, (unknown), Iris A.L.M. van Rooij, Alexander Hoischen, Paul Lasko, Han G. Brunner	6
8	Contribution of Intellectual Disability–Related Genes to ADHD Risk and to Locomotor Activity in Drosophila 2020 ·American Journal of Psychiatry ·Marieke Klein, (unknown), (unknown), Ditte Demontis, Anders D. Børglum, Nina Roth Mota, Anna Castells‐Nobau, Lambertus A. Kiemeney, Han G. Brunner, Alejandro Arias Vásquez, Annette Schenck, Monique van der Voet, Barbara Franke	17
9	Cardiac Inflammation Impedes Response to Cardiac Resynchronization Therapy in Patients With Idiopathic Dilated Cardiomyopathy 2020 ·Circulation Arrhythmia and Electrophysiology ·Job A.J. Verdonschot, Jort J. Merken, Antonius van Stipdonk, (unknown), Kasper Derks, Ping Wang, Michiel T.H.M. Henkens, Pieter van Paassen, Myrurgia Abdul Hamid, Vanessa van Empel, Christian Knackstedt, Justin Luermans, Harry J.G.M. Crijns, Hans‐Peter Brunner‐La Rocca, Han G. Brunner, Gerhard Poelzl, Kevin Vernooy, Stéphane Heymans, Mark R. Hazebroek	6
10	Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences 2020 ·European Heart Journal ·Job A.J. Verdonschot, Marco Merlo, Fernándo Domínguez, Ping Wang, Michiel T.H.M. Henkens, Michiel Adriaens, Mark R. Hazebroek, Marco Masè, Luis Escobar-López, Rafael Cobas Paz, Kasper Derks, Arthur van den Wijngaard, Ingrid P.C. Krapels, Han G. Brunner, Gianfranco Sinagra, Pablo García‐Pavía, Stéphane Heymans	69
11	Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers 2019 ·Molecular Genetics & Genomic Medicine ·Job A.J. Verdonschot, Emma Robinson, Kiely N. James, (unknown), Godelieve R.F. Claes, Kari Casas, Els K. Vanhoutte, Mark R. Hazebroek, (unknown), (unknown), Arthur van den Wijngaard, Jan F. C. Glatz, Stéphane Heymans, Ingrid P.C. Krapels, Shareef Nahas, Han G. Brunner, Radek Szklarczyk	12
12	Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene 2019 ·Genes ·Iris A.L.M. van Rooij, Kerstin U. Ludwig, (unknown), Nina Ishorst, (unknown), Tessel E. Galesloot, Edwin M. Ongkosuwito, Stefaan Bergé, Khalid Aldhorae, Augusto Rojas-Martı́nez, Lambertus A. Kiemeney, Joris Vermeesch, Han G. Brunner, Nel Roeleveld, Koenraad Devriendt, Titiaan Dormaar, Greet Hens, Michael Knapp, Carine Carels, Elisabeth Mangold	13
13	Diagnostic exome sequencing in 100 consecutive patients with both epilepsy and intellectual disability 2018 ·Epilepsia ·Francesca M. Snoeijen‐Schouwenaars, (unknown), Judith Verhoeven, Petra van Mierlo, Hilde M. H. Braakman, Eric Smeets, Joost Nicolai, Jeroen Schoots, (unknown), Rob P.W. Rouhl, Francis Tan, Helger G. Yntema, Han G. Brunner, Rolph Pfundt, Alexander P.A. Stegmann, Erik‐Jan Kamsteeg, Helenius J. Schelhaas, Marjolein H. Willemsen	60
14	Next-generation phenotyping using computer vision algorithms in rare genomic neurodevelopmental disorders 2018 ·Genetics in Medicine ·(unknown), Sandra Jansen, Janneke Schuurs-Hoeijmakers, David A. Koolen, (unknown), Alexander Hoischen, Han G. Brunner, Patrick Kemmeren, Christoffer Nellåker, Lisenka E.L.M. Vissers, Bert B.A. de Vries, Jayne Y. Hehir‐Kwa	13
15	Rare novel variants in the ZIC3 gene cause X-linked heterotaxy 2016 ·European Journal of Human Genetics ·Aimée Paulussen, Anja Steyls, Jo Vanoevelen, (unknown), Ingrid P.C. Krapels, Godelieve R.F. Claes, Sonja Chocron, (unknown), Gita Tan-Sindhunata, Catarina Lundin, Irene Valenzuela, Bálint Nagy, Iben Bache, Lisa Leth Maroun, Kristiina Avela, Han G. Brunner, Hubert J.M. Smeets, Jeroen Bakkers, Arthur van den Wijngaard	16
16	Genomic Cloning and Characterization of the Human Homeobox Gene SIX6 Reveals a Cluster of SIX Genes in Chromosome 14 and Associates SIX6 Hemizygosity with Bilateral Anophthalmia and Pituitary Anomalies 1999 ·Genomics ·M. Esther Gallardo, Javier López-Rı́os, Isabel Fernaud-Espinosa, Begoña Granadino, Raúl Sanz, Carmen Ramos, Carmen Ayuso, Mary J. Seller, Han G. Brunner, Paola Bovolenta, Santiago Rodrı́guez de Córdoba	126
17	Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes. 1996 ·Journal of Clinical Investigation ·Jacques W.M. Lenders, Graeme Eisenhofer, N.G.G.M. Abeling, Wolfgang Berger, Dennis L. Murphy, (unknown), L. Wagemakers, Irwin J. Kopin, Farouk Karoum, A. H. van Gennip, Han G. Brunner	114
18	Further delineation of the branchio‐oculo‐facial syndrome 1995 ·American Journal of Medical Genetics ·Angela E. Lin, Robert J. Gorlin, Iosif W. Lurie, Han G. Brunner, Ineke van der Burgt, (unknown), (unknown), S. Stengel‐Rutkowski, Kenneth N. Rosenbaum, Peter Meinecke, Dietmar Müller	60
19	Absent thumb, immune disorder, and congenital anemia presenting with hydrops fetalis 1992 ·American Journal of Medical Genetics ·Ben A. Semmekrot, Ásgeir Haraldsson, Corry M.R. Weemaes, Dominique Smeets, Wil B. Geven, Han G. Brunner	2
20	[Dialyzability of possible "uremia toxins"]. 1976 ·PubMed ·Han G. Brunner, (unknown)	1

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