Christian Gilissen

27.9k total citations · 4 hit papers
135 papers, 8.5k citations indexed

About

Christian Gilissen is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Christian Gilissen has authored 135 papers receiving a total of 8.5k indexed citations (citations by other indexed papers that have themselves been cited), including 79 papers in Molecular Biology, 70 papers in Genetics and 17 papers in Cancer Research. Recurrent topics in Christian Gilissen's work include Genomics and Rare Diseases (45 papers), Genomic variations and chromosomal abnormalities (32 papers) and Genetics and Neurodevelopmental Disorders (20 papers). Christian Gilissen is often cited by papers focused on Genomics and Rare Diseases (45 papers), Genomic variations and chromosomal abnormalities (32 papers) and Genetics and Neurodevelopmental Disorders (20 papers). Christian Gilissen collaborates with scholars based in Netherlands, United States and Germany. Christian Gilissen's co-authors include Joris A. Veltman, Alexander Hoischen, Lisenka E.L.M. Vissers, Han G. Brunner, Bert B.A. de Vries, Petra de Vries, Joep de Ligt, Bregje W.M. van Bon, Marisol del Rosario and Helger G. Yntema and has published in prestigious journals such as New England Journal of Medicine, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Christian Gilissen

133 papers receiving 8.3k citations

Hit Papers

Diagnostic Exome Sequencing in Persons with Severe Intell... 2010 2026 2015 2020 2012 2010 2015 2011 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability
    2012 987 citations Tjitske Kleefstra, Helger G. Yntema et al. profile →
  2. A de novo paradigm for mental retardation
    2010 526 citations Lisenka E.L.M. Vissers, Christian Gilissen et al. Nature Genetics profile →
  3. Genetic studies in intellectual disability and related disorders
    2015 448 citations Lisenka E.L.M. Vissers, Christian Gilissen et al. profile →
  4. STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis
    2011 436 citations Alexander Hoischen, Christian Gilissen et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Christian Gilissen Netherlands 47 4.6k 4.4k 944 703 570 135 8.5k
Alexander Hoischen Netherlands 46 3.9k 0.9× 4.0k 0.9× 940 1.0× 1.0k 1.5× 544 1.0× 142 8.2k
Brian J. O’Roak United States 27 4.6k 1.0× 4.7k 1.1× 951 1.0× 352 0.5× 340 0.6× 36 8.3k
Mark Lathrop France 25 3.2k 0.7× 2.9k 0.7× 509 0.5× 486 0.7× 616 1.1× 48 7.2k
Fowzan S. Alkuraya Saudi Arabia 59 6.8k 1.5× 4.6k 1.0× 814 0.9× 1.0k 1.4× 448 0.8× 385 11.5k
Betsy Hirsch United States 42 3.4k 0.8× 2.4k 0.5× 735 0.8× 461 0.7× 270 0.5× 179 7.3k
Colette Dib France 11 3.1k 0.7× 2.5k 0.6× 593 0.6× 342 0.5× 749 1.3× 23 6.0k
Daniel G. MacArthur United States 47 3.9k 0.9× 4.7k 1.1× 589 0.6× 319 0.5× 306 0.5× 118 8.5k
Alessandra Renieri Italy 46 4.1k 0.9× 4.2k 1.0× 352 0.4× 291 0.4× 297 0.5× 246 8.2k
Mariano Rocchi Italy 55 7.4k 1.6× 4.3k 1.0× 783 0.8× 1.4k 2.0× 417 0.7× 321 11.6k
Bernhard Zabel Germany 50 7.2k 1.6× 4.7k 1.1× 1.1k 1.1× 567 0.8× 332 0.6× 166 11.0k

Countries citing papers authored by Christian Gilissen

Since Specialization
Citations

This map shows the geographic impact of Christian Gilissen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christian Gilissen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christian Gilissen more than expected).

Fields of papers citing papers by Christian Gilissen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christian Gilissen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christian Gilissen. The network helps show where Christian Gilissen may publish in the future.

Co-authorship network of co-authors of Christian Gilissen

This figure shows the co-authorship network connecting the top 25 collaborators of Christian Gilissen. A scholar is included among the top collaborators of Christian Gilissen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christian Gilissen. Christian Gilissen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
McKibbin, Martin, Suzanne E. de Bruijn, Andrea L. Vincent, et al.. (2025). Expansion of the ABCA4-Associated Retinopathy Spectrum: Severe Variants Can be Associated With Early-Onset Severe Retinal Dystrophy. Investigative Ophthalmology & Visual Science. 66(6). 19–19.
2.
Höps, Wolfram, Marjan M. Weiss, Ronny Derks, et al.. (2025). HiFi long-read genomes for difficult-to-detect, clinically relevant variants. The American Journal of Human Genetics. 112(2). 450–456. 6 indexed citations
3.
Steyaert, Wouter, Lonneke Haer‐Wigman, Rolph Pfundt, et al.. (2023). Systematic analysis of paralogous regions in 41,755 exomes uncovers clinically relevant variation. Nature Communications. 14(1). 6845–6845. 5 indexed citations
4.
Šablauskas, Karolis, Wouter Steyaert, Michael Kwint, et al.. (2022). DeNovoCNN: a deep learning approach to de novo variant calling in next generation sequencing data. Nucleic Acids Research. 50(17). e97–e97. 11 indexed citations
5.
Schieving, Jolanda, Helger G. Yntema, Maartje Pennings, et al.. (2022). Reanalysis of exome negative patients with rare disease: a pragmatic workflow for diagnostic applications. Genome Medicine. 14(1). 66–66. 25 indexed citations
6.
Khan, Mubeen, Stéphanie S. Cornelis, Riccardo Sangermano, et al.. (2020). In or Out? New Insights on Exon Recognition through Splice-Site Interdependency. International Journal of Molecular Sciences. 21(7). 2300–2300. 9 indexed citations
7.
Wiel, Laurens, et al.. (2019). MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains. Human Mutation. 40(8). 1030–1038. 115 indexed citations
8.
Khan, Mubeen, Stéphanie S. Cornelis, Muhammad Imran Khan, et al.. (2019). Cost‐effective molecular inversion probe‐based ABCA4 sequencing reveals deep‐intronic variants in Stargardt disease. Human Mutation. 40(10). 1749–1759. 37 indexed citations
9.
Goldmann, Jakob M., Vladimir B. Seplyarskiy, Wendy S.W. Wong, et al.. (2018). Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence. Nature Genetics. 50(4). 487–492. 46 indexed citations
10.
Goldmann, Jakob M., Vladimir B. Seplyarskiy, Wendy S.W. Wong, et al.. (2018). Germline De Novo Mutation Clusters Arise During Oocyte Aging in Genomic Regions With High Double-Strand-Break Incidence. Obstetrical & Gynecological Survey. 73(9). 531–532. 4 indexed citations
11.
Oud, Manon S., Liliana Ramos, Moira K. O’Bryan, et al.. (2017). Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia. Human Mutation. 38(11). 1592–1605. 44 indexed citations
12.
Wiel, Laurens, Hanka Venselaar, Joris A. Veltman, Gert Vriend, & Christian Gilissen. (2017). Aggregation of population‐based genetic variation over protein domain homologues and its potential use in genetic diagnostics. Human Mutation. 38(11). 1454–1463. 20 indexed citations
13.
Goldmann, Jakob M., Wendy S.W. Wong, Michele Pinelli, et al.. (2016). Parent-of-origin-specific signatures of de novo mutations. Nature Genetics. 48(8). 935–939. 196 indexed citations
14.
Maijenburg, Marijke W., Christian Gilissen, Marion Kleijer, et al.. (2016). Different Balance of Wnt Signaling in Adult and Fetal Bone Marrow-Derived Mesenchymal Stromal Cells. Stem Cells and Development. 25(12). 934–947. 8 indexed citations
15.
Berk, Lieke C. J. van den, Bas Jansen, Stuart G. Snowden, et al.. (2014). Cord Blood Mesenchymal Stem Cells Suppress DC-T Cell Proliferation via Prostaglandin B2. Stem Cells and Development. 23(14). 1582–1593. 14 indexed citations
16.
Szklarczyk, Radek, Bas F.J. Wanschers, Leo Nijtmans, et al.. (2012). A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia. Human Molecular Genetics. 22(4). 656–667. 69 indexed citations
17.
Maijenburg, Marijke W., Christian Gilissen, Sara M. Melief, et al.. (2011). Nuclear Receptors Nur77 and Nurr1 Modulate Mesenchymal Stromal Cell Migration. Stem Cells and Development. 21(2). 228–238. 56 indexed citations
18.
Gilissen, Christian, Heleen H. Arts, Alexander Hoischen, et al.. (2010). Exome Sequencing Identifies WDR35 Variants Involved in Sensenbrenner Syndrome. The American Journal of Human Genetics. 87(3). 418–423. 197 indexed citations
19.
Jansen, Bas, Christian Gilissen, Helene Roelofs, et al.. (2009). Functional Differences Between Mesenchymal Stem Cell Populations Are Reflected by Their Transcriptome. Stem Cells and Development. 19(4). 481–490. 114 indexed citations
20.
Oziemlak, Aneta, Reinier Raymakers, Saskia M. Bergevoet, et al.. (2009). MicroRNA hsa-miR-135b Regulates Mineralization in Osteogenic Differentiation of Human Unrestricted Somatic Stem Cells. Stem Cells and Development. 19(6). 877–885. 83 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Alexander Hoischen Breakdown of academic impact, for papers by Brian J. O’Roak Breakdown of academic impact, for papers by Mark Lathrop Breakdown of academic impact, for papers by Fowzan S. Alkuraya Breakdown of academic impact, for papers by Betsy Hirsch Breakdown of academic impact, for papers by Colette Dib Breakdown of academic impact, for papers by Daniel G. MacArthur Breakdown of academic impact, for papers by Alessandra Renieri Breakdown of academic impact, for papers by Mariano Rocchi Breakdown of academic impact, for papers by Bernhard Zabel
Rankless by CCL
2026