Alan Sher

72.2k total citations · 23 hit papers
449 papers, 57.2k citations indexed

About

Alan Sher is a scholar working on Parasitology, Immunology and Epidemiology. According to data from OpenAlex, Alan Sher has authored 449 papers receiving a total of 57.2k indexed citations (citations by other indexed papers that have themselves been cited), including 233 papers in Parasitology, 202 papers in Immunology and 158 papers in Epidemiology. Recurrent topics in Alan Sher's work include Parasites and Host Interactions (129 papers), Toxoplasma gondii Research Studies (102 papers) and Immune Cell Function and Interaction (88 papers). Alan Sher is often cited by papers focused on Parasites and Host Interactions (129 papers), Toxoplasma gondii Research Studies (102 papers) and Immune Cell Function and Interaction (88 papers). Alan Sher collaborates with scholars based in United States, United Kingdom and Brazil. Alan Sher's co-authors include Sara Hieny, Ricardo T. Gazzinelli, Kenneth M. Murphy, Abul K. Abbas, Allen W. Cheever, Dragana Janković, Júlio Aliberti, Patricia Caspar, Carl G. Feng and Robert L. Coffman and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Alan Sher

447 papers receiving 55.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Functional diversity of helper T lymphocytes

1996 3.7k citations Alan Sher et al. profile →
Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 2.0k citations Júlio Aliberti, Alan Sher et al. profile →
Type I interferons in infectious disease

2015 1.9k citations Katrin D. Mayer-Barber, Alan Sher et al. profile →
Vaccine Adjuvants: Putting Innate Immunity to Work

2010 1.4k citations Alan Sher, Robert A. Seder et al. profile →
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

2012 1.1k citations Alan Sher et al. profile →
Cooperation of Toll-like receptor signals in innate immune defence

2007 1.1k citations Giorgio Trinchieri, Alan Sher profile →
A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 786 citations Katsutoshi Ozaki, Rosanne Spolski et al. Science profile →
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

2005 772 citations Felix Yarovinsky, Dekai Zhang et al. Science profile →
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α

1996 760 citations Ricardo T. Gazzinelli, Maria Wysocka et al. The Journal of Immunology profile →
In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 752 citations Caetano Reis e Sousa, Sara Hieny et al. The Journal of Experimental Medicine profile →
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 741 citations Júlio Aliberti, Alan Sher et al. The Journal of Experimental Medicine profile →
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 702 citations Ricardo T. Gazzinelli, Sara Hieny et al. profile →
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 664 citations Patricia Caspar, Alan Sher et al. The Journal of Experimental Medicine profile →
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 618 citations Dragana Janković, Júlio Aliberti et al. profile →
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 609 citations Phillip Scott, Alan Sher et al. The Journal of Experimental Medicine profile →
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages

1992 592 citations Ricardo T. Gazzinelli, Alan Sher et al. The Journal of Immunology profile →
Parasite-induced IL-12 stimulates early IFN- gamma synthesis and resistance during acute infection with Toxoplasma gondii .

1994 588 citations Ricardo T. Gazzinelli, Maria Wysocka et al. The Journal of Immunology profile →
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

2014 567 citations Katrin D. Mayer-Barber, Sandra D. Oland et al. profile →
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine

1991 517 citations Ricardo T. Gazzinelli, Sara Hieny et al. The Journal of Immunology profile →
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii

1992 475 citations Ricardo T. Gazzinelli, Sara Hieny et al. The Journal of Immunology profile →
Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 402 citations Alan Sher, Ricardo T. Gazzinelli et al. profile →
A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

2019 310 citations Diego L. Costa, Sivaranjani Namasivayam et al. The Journal of Experimental Medicine profile →
Host-directed immunotherapy of viral and bacterial infections: past, present and future

2022 151 citations Alan Sher et al. profile →

Peers

Countries citing papers authored by Alan Sher

Since Specialization

Citations

This map shows the geographic impact of Alan Sher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alan Sher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alan Sher more than expected).

Fields of papers citing papers by Alan Sher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alan Sher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alan Sher. The network helps show where Alan Sher may publish in the future.

Co-authorship network of co-authors of Alan Sher

This figure shows the co-authorship network connecting the top 25 collaborators of Alan Sher. A scholar is included among the top collaborators of Alan Sher based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alan Sher. Alan Sher is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model 2023 ·Antimicrobial Agents and Chemotherapy ·(unknown), (unknown), Styliani Karanika, Stefanie Krug, (unknown), Andrew Garcia, Samuel K. Ayeh, (unknown), Diego L. Costa, Alan Sher, Nader Fotouhi, Natalya V. Serbina, Petros C. Karakousis	4
2	Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge 2021 ·The Journal of Experimental Medicine ·Kerry L. Hilligan, Sivaranjani Namasivayam, Chad S. Clancy, (unknown), Sandra D. Oland, Shelly J. Robertson, Paul J. Baker, Ehydel Castro, Nicole L. Garza, Bernard A. P. Lafont, Reed F. Johnson, Franca Ronchese, Katrin D. Mayer-Barber, Sonja M. Best, Alan Sher	69
3	The Microbiome and Tuberculosis: Early Evidence for Cross Talk 2018 ·mBio ·Sivaranjani Namasivayam, Alan Sher, Michael S. Glickman, Matthew F. Wipperman	65
4	Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes 2016 ·The Journal of Experimental Medicine ·David Kugler, Francis A. Flomerfelt, Diego L. Costa, Karen Laky, Olena Kamenyeva, Paul R. Mittelstadt, Ronald E. Gress, Stephan P. Rosshart, Barbara Rehermann, Jonathan D. Ashwell, Alan Sher, Dragana Janković	25
5	Integrated Bioinformatic and Targeted Deletion Analyses of the SRS Gene Superfamily Identify SRS29C as a Negative Regulator of Toxoplasma Virulence 2012 ·mBio ·James D. Wasmuth, Viviana Pszenny, Simon Haile, Emily Jansen, (unknown), Alan Sher, Jon P. Boyle, Martin J. Boulanger, John Parkinson, Michael E. Grigg	65
6	Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii –infected dendritic cells 2009 ·The Journal of Experimental Medicine ·Romina S. Goldszmid, Isabelle Coppens, Avital Lev, Pat Caspar, Ira Mellman, Alan Sher	124
7	The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1) 2009 ·The Journal of Experimental Medicine ·Svenja Steinfelder, John F. Andersen, Jennifer L. Cannons, Carl G. Feng, Manju B. Joshi, Dennis M. Dwyer, Pat Caspar, Pamela L. Schwartzberg, Alan Sher, Dragana Janković	241
8	Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection 2007 ·The Journal of Experimental Medicine ·Dragana Janković, Marika C. Kullberg, Carl G. Feng, Romina S. Goldszmid, Carmen M. Collazo, Mark Wilson, Thomas A. Wynn, Masahito Kamanaka, Richard A. Flavell, Alan Sher	469
9	TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein breakdown → 2005 ·Science ·Felix Yarovinsky, Dekai Zhang, John F. Andersen, Gerard Bannenberg, Charles N. Serhan, Matthew S. Hayden, Sara Hieny, Fayyaz S. Sutterwala, Richard A. Flavell, Sankar Ghosh, Alan Sher	772
10	Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites 2003 ·Blood ·Damien Chaussabel, Roshanak Tolouei Semnani, Mary Ann McDowell, David L. Sacks, Alan Sher, Thomas B. Nutman	257
11	Relationships Among Murine CD11chigh Dendritic Cell Subsets as Revealed by Baseline Gene Expression Patterns 2003 ·The Journal of Immunology ·Alexander D. Edwards, Damien Chaussabel, Simon R. Tomlinson, Oliver Schulz, Alan Sher, Caetano Reis e Sousa	102
12	Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent 2003 ·The Journal of Immunology ·Liyun Huang, Júlio Aliberti, Cynthia A. Leifer, David M. Segal, Alan Sher, Douglas T. Golenbock, Basil Golding	61
13	Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization 2003 ·The Journal of Immunology ·Júlio Aliberti, João P. B. Viola, Adriana Vieira‐de‐Abreu, Patrı́cia T. Bozza, Alan Sher, Júlio Scharfstein	91
14	A Critical Role for IL-21 in Regulating Immunoglobulin Production breakdown → 2002 ·Science ·Katsutoshi Ozaki, Rosanne Spolski, Carl G. Feng, Chen‐Feng Qi, Jun Cheng, Alan Sher, Herbert C. Morse, Chengyu Liu, Pamela L. Schwartzberg, Warren J. Leonard	786
15	In Vivo CD40-CD154 (CD40 Ligand) Interaction Induces Integrated HIV Expression by APC in an HIV-1-Transgenic Mouse Model 2001 ·The Journal of Immunology ·Claire Chougnet, (unknown), Marco Schito, Elaine K. Thomas, Alan Sher, Gene M. Shearer	16
16	A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. II. Effect on Acute Resistance to Toxoplasma gondii and Rescue by IL-18 Treatment 2001 ·The Journal of Immunology ·George Yap, Robert Ortmann, Ethan M. Shevach, Alan Sher	42
17	Recombinant Attenuated Toxoplasma gondii Expressing the Plasmodium yoelii Circumsporozoite Protein Provides Highly Effective Priming for CD8+ T Cell-Dependent Protective Immunity Against Malaria 2000 ·The Journal of Immunology ·Hugues Charest, Martha Sedegah, George Yap, Ricardo T. Gazzinelli, Patricia Caspar, Stephen L. Hoffman, Alan Sher	31
18	Induction and regulation of IL-15 expression in murine macrophages 1996 ·The Journal of Immunology ·T. Mark Doherty, Robert A. Seder, Alan Sher	289
19	Parasite-induced IL-12 stimulates early IFN- gamma synthesis and resistance during acute infection with Toxoplasma gondii . breakdown → 1994 ·The Journal of Immunology ·Ricardo T. Gazzinelli, Maria Wysocka, Seiji Hayashi, Eric Denkers, Sara Hieny, Patricia Caspar, Giorgio Trinchieri, Alan Sher	588
20	Genetic Factors Influencing the Interaction of Parasites with the Immune System 1982 ·Alan Sher, Phillip Scott	7

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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