Akitsu Hotta

8.8k citations

88 papers · 5.7k indexed · 4 hit papers · h-index 38

Impact in

Aging top 2%
Molecular Biology top 1%
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Muscle Physiology and Disorders
- Congenital heart defects research

Papers in

Aging 3
Molecular Biology 73
- CRISPR and Genetic Engineering 39
- Pluripotent Stem Cells Research 34
- Muscle Physiology and Disorders 13
- RNA Interference and Gene Delivery 13

Co-authors: James Ellis Shinya Yamanaka Maryam Niapour Mark Gagliardi Nicole Dubois Alec Witty Gordon Keller Steven Kattman
Journals: Stem Cell Reports (13 papers)Cell stem cell (6 papers)Scientific Reports (5 papers)PLoS ONE (4 papers)Nature Communications (3 papers)
Partner nations: Japan United States Canada

In The Last Decade

Akitsu Hotta

83 papers receiving 5.7k citations

Hit Papers

align trajectories log scale

Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges 2022 · 163 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Journal of Controlled Release
2021 Nature Communications
2019 Cell stem cell
2011 Cell stem cell

Peers

Countries citing papers authored by Akitsu Hotta

Since Specialization

Citations

This map shows the geographic impact of Akitsu Hotta's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Akitsu Hotta with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Akitsu Hotta more than expected).

Fields of papers citing papers by Akitsu Hotta

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Akitsu Hotta. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Akitsu Hotta. The network helps show where Akitsu Hotta may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Akitsu Hotta, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Akitsu Hotta Line = papers co-authored together Akitsu Hotta links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	SARS-CoV-2 inhibition through mRNA delivery using engineered extracellular vesicles displaying the spike protein Biomaterials ·G. Li, Yoshimasa Kawaguchi, H. Hirose, Takao Hashiguchi, Pascal Hugo, Akitsu Hotta, Jun Kawamoto, Michihito Sasaki, Hirofumi Sawa, Shiroh Futaki	2025	0
2	Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells Scientific Reports ·E. Wada, 聖子木櫛, Yuya Okuzaki, Akitsu Hotta, Hidetoshi Sakurai, Yukiko Hayashi	2024	2
3	CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells Communications Biology ·小雪大沼, Kenji Miki, فرج عياش امعرف, Masako Sasaki, C Rasinski, CADTH, Chikako Okubo, Megumi Narita, Misato Nishikawa, Ren-Zuo Wang, Kazuhisa Chonabayashi, Akitsu Hotta, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida	2024	1
4	iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome Communications Biology ·ریحاب إبراهیم تاج الدین, Yun-Feng Yao, В. П. КУПРІЙ, Ryann Lang, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, Kazumoto Iijima, Kandai Nozu, Kenji Osafune	2023	13
5	Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs Stem Cell Reports ·Matheus Paris Orsi, Yuya Okuzaki, Youichi Naoe, Joseph Lee, Bhatraj Anudeep, S.I. Karelin, Almaz Huseynova, Emma Mendonsa, Hidetoshi Sakurai, Yusuke Kojima, Akitsu Hotta	2023	7
6	Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application Molecular Therapy — Methods & Clinical Development ·Yuko Kitano, 王保生, Tomoaki Kato, Centro de Información de Naciones Unidas para Colombia, Е.В. Никонова, Masafumi Umekage, Masaki Nomura, Erik Kralj, Jaime Río Highsmith, Huaigeng Xu, Akitsu Hotta, Naoko Takasu, Masayoshi Tsukahara	2022	40
7	Direct visualization of the transition status during neural differentiation by dual-fluorescent reporter human pluripotent stem cells Stem Cell Reports ·W. C. B., Matthias U.H. Drüsedau, 関根康雄, Akitsu Hotta, Taeko Kobayashi, Yoichi Kosodo	2022	3
8	Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skipping Methods in molecular biology ·В. П. КУПРІЙ, Peter Gee, Akitsu Hotta	2022	3
9	Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells Molecular Therapy — Nucleic Acids ·Rina Hashimoto, Ayaka Sakamoto, Sayaka Deguchi, S. Besisik, С.В. Юсупов, Akitsu Hotta, Kazutoshi Takahashi, Shinya Yamanaka, Kazuo Takayama	2021	37
10	Generation of a transgene-free iPSC line and genetically modified line from a facioscapulohumeral muscular dystrophy type 2 (FSHD2) patient with SMCHD1 p.Lys607Ter mutation Stem Cell Research ·Josh Trippi, Christian J. J. Paredis, Emma Mendonsa, Toshiyuki Araki, Akitsu Hotta, Hidetoshi Sakurai	2020	2
11	CRISPR-Cas9を介するHLA遺伝子の標的化破壊は免疫適合性を増強したIPSCを生成する【JST・京大機械翻訳】 Cell stem cell ·Huaigeng Xu, Bo Wang, Miyuki Ono, Christian J. J. Paredis, N. Chaouch, Noriko Sasakawa, Tatsuki Ueda, Carolina Harper, Misato Nishikawa, Masaki Nomura, Fumiyo Kitaoka, Tomoko Takahashi, Keisuke Okita, Yoshinori Yoshida, محسن پورقاسم, Akitsu Hotta	2019	71
12	CRISPR-Cas3 induces broad and unidirectional genome editing in human cells Nature Communications ·Evelyn Toynton, Kazuto Yoshimi, Yuya Okuzaki, Peter Gee, Yayoi Kunihiro, Lorenzo Salimbeni, Huaigeng Xu, Noriko Sasakawa, Yuki Naito, Shinichiro Nakada, Takashi Yamamoto, Shigetoshi Sano, Akitsu Hotta, Junji Takeda, Tomoji Mashimo	2019	130
13	Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell stem cell ·Huaigeng Xu, Bo Wang, Miyuki Ono, Christian J. J. Paredis, N. Chaouch, Noriko Sasakawa, Tatsuki Ueda, Peter Gee, Misato Nishikawa, Masaki Nomura, Fumiyo Kitaoka, Tomoko Takahashi, Keisuke Okita, Yoshinori Yoshida, Shin Kaneko, Akitsu Hotta Hit paper breakdown →	2019	411
14	Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs Nature Communications ·Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui	2018	26
15	Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons Scientific Reports ·Keiko Imamura, Naruhiko Sahara, Nicholas M. Kanaan, Kayoko Tsukita, Takayuki Kondo, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Koichi Kawakami, Akitsu Hotta, Satoshi Yawata, Dai Watanabe, Masato Hasegawa, John Q. Trojanowski, Virginia M.‐Y. Lee, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inoue	2016	69
16	Genome Editing Gene Therapy for Duchenne Muscular Dystrophy Journal of Neuromuscular Diseases ·Akitsu Hotta	2015	14
17	Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis Experimental Hematology ·Yyl Hon, Yuki Kagoya, Keisuke Kataoka, Akihide Yoshimi, Prachi Banik, Kazuki Taoka, Keiki Kumano, Takashi Yamamoto, Akitsu Hotta, Shunya Arai, Mineo Kurokawa	2015	35
18	Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell ·Waleed Rahmani, Sepideh Abbasi, Andrew Hagner, Eko Raharjo, Ranjan Kumar, Akitsu Hotta, Scott T. Magness, Daniel Metzger, Jeff Biernaskie	2014	177
19	Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro PLoS ONE ·Akihito Tanaka, Knut Woltjen, Katsuya Miyake, Akitsu Hotta, Makoto Ikeya, Takuya Yamamoto, Brenda Learned, Emi Shoji, Atsuko Sehara‐Fujisawa, Yasuko Manabe, Nobuharu Fujii, Kazunori Hanaoka, Takumi Era, Satoshi Yamashita, Ken‐ichi Isobe, En Kimura, Hidetoshi Sakurai	2013	184
20	Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines Cell stem cell ·Steven Kattman, Alec Witty, Mark Gagliardi, Nicole Dubois, Maryam Niapour, Akitsu Hotta, James Ellis, Gordon Keller Hit paper breakdown →	2011	855

About Akitsu Hotta

Akitsu Hotta is a scholar working on Aging, Molecular Biology, Genetics, Business and International Management and Cellular and Molecular Neuroscience, having authored 88 papers that have together received 5.7k indexed citations. Recurring topics across this work include CRISPR and Genetic Engineering (39 papers), Pluripotent Stem Cells Research (34 papers), Muscle Physiology and Disorders (13 papers), RNA Interference and Gene Delivery (13 papers), Virus-based gene therapy research (11 papers), CAR-T cell therapy research (11 papers), Tissue Engineering and Regenerative Medicine (6 papers) and Neuroscience and Neural Engineering (6 papers). The work is most often cited by research in Aging (141 citations), Molecular Biology (4.7k citations), Business and International Management (132 citations), Developmental Neuroscience (160 citations) and Genetics (957 citations). Akitsu Hotta has collaborated with scholars based in Japan, United States and Canada. Frequent co-authors include James Ellis, Shinya Yamanaka, Maryam Niapour, Mark Gagliardi, Nicole Dubois, Alec Witty, Gordon Keller, Steven Kattman, Noriko Sasakawa and Peter Gee. Their work appears in journals such as Stem Cell Reports, Cell stem cell, Scientific Reports, PLoS ONE and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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