April D. Pyle

7.3k citations

62 papers · 4.5k indexed · 2 hit papers · h-index 30

Impact in

Developmental Neuroscience top 2%
- Neurogenesis and neuroplasticity mechanisms
Aging top 2%

Papers in

Aging 3
Molecular Biology 54
- Pluripotent Stem Cells Research 31
- CRISPR and Genetic Engineering 22
- Muscle Physiology and Disorders 19
- RNA Interference and Gene Delivery 6
- DNA Repair Mechanisms 4

Co-authors: Peter J. Donovan Amander T. Clark William E. Lowry Kathrin Plath Jason Tchieu Rupa Sridharan Leslie F. Lock Andres A. Paucar
Journals: Stem Cells (6 papers)Cell stem cell (4 papers)PLoS ONE (3 papers)Development (2 papers)Nature Communications (2 papers)
Partner nations: United States China Germany

In The Last Decade

April D. Pyle

61 papers receiving 4.5k citations

Hit Papers

align trajectories log scale

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner 2011 · 634 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Cell stem cell
2008 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by April D. Pyle

Since Specialization

Citations

This map shows the geographic impact of April D. Pyle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by April D. Pyle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites April D. Pyle more than expected).

Fields of papers citing papers by April D. Pyle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by April D. Pyle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by April D. Pyle. The network helps show where April D. Pyle may publish in the future.

Co-authorship network

The 25 scholars most cited alongside April D. Pyle, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with April D. Pyle Line = papers co-authored together April D. Pyle links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion Cell Reports ·Pablo Álvarez, L Li, Seon-Hwa Baek, Fredy Hoyos Daza, Angélica Medina, Marta Nieto, Karolina Elżbieta Kaczor‐Urbanowicz, Frédéric Amant, Ana Beatriz do Nascimento Oliveira, Robyn M. Kaake, Oliver I. Fregoso, April D. Pyle, Mehdi Bouhaddou, Hengli Tang, Melody M. H. Li	2025	1
2	Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice Nature Communications ·Xiangsheng Liu, Michael R. Hicks, Rizqi Indira Febyanti, Jinhong Jiang, Yuting Li, Courtney S. Young, Tianyu Zhang, Jong Hyun Noh, Lalehan Özalp, Yanyan Liu, Mengmeng Qin, Jiulong Li, Alessio Cariboni, Honghong Yang, Melissa J. Spencer, April D. Pyle, Huan Meng	2025	0
3	Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle JCI Insight ·J. Poplett, Yingjie Zheng, 朝隆上野, Feiyang Ma, 胡玄, F. Hinman, Irina Kramerova, Raquel Jiménez, Brian N. Smith, Jesús A. Angulo, Rachelle H. Crosbie, Lihua Zhou, Masafumi Yano, Gérald Coulis, Oluwatayo Ikotun, April D. Pyle, Matteo Pellegrini, Elizabeth M. McNally, S. Armando Villalta, Melissa J. Spencer	2025	2
4	A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy Cell Reports Medicine ·Jian Liu, Jesus Campagna, Varghese John, Robert Damoiseaux, Ekaterina Mokhonova, Stavroula Theofili, Huan Meng, Elizabeth M. McNally, April D. Pyle, Irina Kramerova, Melissa J. Spencer	2020	5
5	Non–fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle JCI Insight ·Gina M. Mosich, Daibin Ge, 晁珊珊, Abhinav K. Sharma, Choi Bok Hee, M. Paikar, Dewi Afra Khairunnisa, 片岡慶太, डाॅ. राकेश कुमार नेहरा, 一武富, Haibin Xi, April D. Pyle, Bruno Péault, Frank A. Petrigliano, Ayelet Dar	2019	12
6	Polyrotaxane Nanocarriers Can Deliver CRISPR/Cas9 Plasmid to Dystrophic Muscle Cells to Successfully Edit the DMD Gene Advanced Therapeutics ·Lalehan Özalp, Courtney S. Young, Ying Ji, Xiangsheng Liu, Ekaterina Mokhonova, April D. Pyle, Huan Meng, Melissa J. Spencer	2019	13
7	Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells Molecular Therapy — Nucleic Acids ·Patrick Lee, 王怀茂, Agustin Vega-Crespo, Conticello, Kip Hermann, A. Patessio, V. N. Kutik, Bryan Wananda Winata, Afliwarni Rahmi, Andreas K. Oevlisen, Claire Rowlands, Stephen D. Cederbaum, April D. Pyle, James Byrne, Gerald S. Lipshutz	2016	29
8	A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells Cell stem cell ·Courtney S. Young, Michael R. Hicks, Natalia Ermolova, Haruko Nakano, Nguyen Phuc Hai, Shahab Younesi, Saravanan Karumbayaram, Yingjie Zheng, Derek Wang, Jerome A. Zack, Donald B. Kohn, Atsushi Nakano, Stanley F. Nelson, M. Carrie Miceli, Melissa J. Spencer, April D. Pyle	2016	282
9	Small Molecule Screening with Laser Cytometry Can Be Used to Identify Pro-Survival Molecules in Human Embryonic Stem Cells PLoS ONE ·Sean P. Sherman, April D. Pyle	2013	5
10	Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition Small ·Rolando E. Yanes, Derrick Tarn, Angela Hwang, Daniel P. Ferris, Sean P. Sherman, Courtney R. Thomas, Jie Lü, April D. Pyle, Jeffrey I. Zink, Fuyuhiko Tamanoi	2012	144
11	Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner Cell stem cell ·Janel E. Le Belle, Constantin Ghita, Andres A. Paucar, Jonathan P. Saxe, Jack Mottahedeh, April D. Pyle, Hong Wu, Harley I. Kornblum Hit paper breakdown →	2011	634
12	Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions Lab on a Chip ·Ken‐ichiro Kamei, Minori Ohashi, Eric H. Gschweng, Max McDonald, Glaydson De Farias Lima, Jinghua Tang, Zeta Tak For Yu, Amander T. Clark, April D. Pyle, Michael A. Teitell, Ki‐Bum Lee, Owen N. Witte, Hsian‐Rong Tseng	2010	41
13	Increased Lysis of Stem Cells but Not Their Differentiated Cells by Natural Killer Cells; De-Differentiation or Reprogramming Activates NK Cells PLoS ONE ·Mirella de Lemos Giglio, Мехтиев Сабир Насрединович, Avina Paranjpe, Antonia Teruel, Wendy Yang, E. Quignard, Jackelyn A. Alva, Gina Walter, Christian Head, Tomo‐o Ishikawa, Harvey R. Herschman, Nicholas A. Cacalano, April D. Pyle, No-Hee Park, Anahid Jewett	2010	125
14	Female Human iPSCs Retain an Inactive X Chromosome Cell stem cell ·Jason Tchieu, Edward Kuoy, Mark H. Chin, Pingsu Mao, Michaela Patterson, Sean P. Sherman, S.T. Alexander Rani Suryandono, Anne Lindgren, Shahrad Hakimian, Jerome A. Zack, Amander T. Clark, April D. Pyle, William E. Lowry, Kathrin Plath	2010	211
15	Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD) PLoS Genetics ·Weihua Zeng, Jessica C. de Greef, E.S. VASYUTKIN, Richard Chien, Xiangduo Kong, Heather C. Gregson, Sara T. Winokur, April D. Pyle, Keith D. Robertson, John A. Schmiesing, Virginia Kimonis, Judit Balog, Rune R. Frants, Alexander R. Ball, Leslie F. Lock, Peter J. Donovan, Silvère M. van der Maarel, Kyoko Yokomori	2009	214
16	Generation of human induced pluripotent stem cells from dermal fibroblasts Proceedings of the National Academy of Sciences ·William E. Lowry, Anna Wunsch, Carlos Aguilar Huerta, April D. Pyle, Jason Tchieu, Rupa Sridharan, Amander T. Clark, Kathrin Plath Hit paper breakdown →	2008	789
17	Neurotrophins mediate human embryonic stem cell survival Nature Biotechnology ·April D. Pyle, Leslie F. Lock, Peter J. Donovan	2006	204
18	Staining Embryonic Stem Cells Using Monoclonal Antibodies to Stage-Specific Embryonic Antigens Humana Press eBooks ·Bruce A. Fenderson, María P. De Miguel, April D. Pyle, Peter J. Donovan	2006	7
19	Etoposide exposure during male mouse pachytene has complex effects on crossing-over and causes nondisjunction Mutation Research/Genetic Toxicology and Environmental Mutagenesis ·Liane B. Russell, Patricia R. Hunsicker, Marilyn Kerley, April D. Pyle, Arnold M. Saxton	2004	13
20	Meiotic Prophase Abnormalities and Metaphase Cell Death in MLH1-Deficient Mouse Spermatocytes: Insights into Regulation of Spermatogenic Progress Developmental Biology ·Shannon Eaker, John Cobb, April D. Pyle, Mary Ann Handel	2002	90

About April D. Pyle

April D. Pyle is a scholar working on Aging, Molecular Biology, Genetics, Rehabilitation and Genetics, having authored 62 papers that have together received 4.5k indexed citations. Recurring topics across this work include Pluripotent Stem Cells Research (31 papers), CRISPR and Genetic Engineering (22 papers), Muscle Physiology and Disorders (19 papers), 3D Printing in Biomedical Research (7 papers), Tissue Engineering and Regenerative Medicine (6 papers), RNA Interference and Gene Delivery (6 papers), DNA Repair Mechanisms (4 papers) and Virus-based gene therapy research (4 papers). The work is most often cited by research in Developmental Neuroscience (253 citations), Aging (101 citations), Molecular Biology (3.6k citations), Genetics (342 citations) and Genetics (632 citations). April D. Pyle has collaborated with scholars based in United States, China and Germany. Frequent co-authors include Peter J. Donovan, Amander T. Clark, William E. Lowry, Kathrin Plath, Jason Tchieu, Rupa Sridharan, Leslie F. Lock, Andres A. Paucar, Jack Mottahedeh and Hong Wu. Their work appears in journals such as Stem Cells, Cell stem cell, PLoS ONE, Development and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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