Sarah Spiegel

53.3k total citations · 17 hit papers
399 papers, 44.9k citations indexed

About

Sarah Spiegel is a scholar working on Molecular Biology, Cell Biology and Physiology. According to data from OpenAlex, Sarah Spiegel has authored 399 papers receiving a total of 44.9k indexed citations (citations by other indexed papers that have themselves been cited), including 365 papers in Molecular Biology, 158 papers in Cell Biology and 63 papers in Physiology. Recurrent topics in Sarah Spiegel's work include Sphingolipid Metabolism and Signaling (304 papers), Lipid Membrane Structure and Behavior (110 papers) and Cellular transport and secretion (75 papers). Sarah Spiegel is often cited by papers focused on Sphingolipid Metabolism and Signaling (304 papers), Lipid Membrane Structure and Behavior (110 papers) and Cellular transport and secretion (75 papers). Sarah Spiegel collaborates with scholars based in United States, Japan and Germany. Sarah Spiegel's co-authors include Sheldon Milstien, Michael Maceyka, Ana Olivera, Lisa C. Edsall, Nitai C. Hait, Olivier Cuvillier, Kazuaki Takabe, Shawn G. Payne, Alfred H. Merrill and Jeremy C. Allegood and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Sarah Spiegel

396 papers receiving 44.1k citations

Hit Papers

Sphingosine-1-phosphate: ... 1991 2026 2002 2014 2003 1996 2014 1998 2011 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Sphingosine-1-phosphate: an enigmatic signalling lipid
    2003 1.8k citations Sarah Spiegel, Sheldon Milstien Nature Reviews Molecular Cell Biology profile →
  2. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    1996 1.3k citations Sarah Spiegel et al. profile →
  3. Sphingolipid metabolites in inflammatory disease
    2014 1.0k citations Michael Maceyka, Sarah Spiegel profile →
  4. Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
    1998 882 citations Sarah Spiegel et al. Science profile →
  5. Sphingosine-1-phosphate signaling and its role in disease
    2011 830 citations Michael Maceyka, Kuzhuvelil B. Harikumar et al. profile →
  6. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
    2009 802 citations Nitai C. Hait, Jeremy C. Allegood et al. Science profile →
  7. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
    1993 792 citations Ana Olivera, Sarah Spiegel profile →
  8. The outs and the ins of sphingosine-1-phosphate in immunity
    2011 652 citations Sarah Spiegel, Sheldon Milstien profile →
  9. Sphingolipid metabolism and cell growth regulation
    1996 634 citations Sarah Spiegel et al. profile →
  10. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    2010 615 citations Kuzhuvelil B. Harikumar, Nitai C. Hait et al. profile →
  11. Essential Role for Sphingosine Kinases in Neural and Vascular Development
    2005 593 citations Ana Olivera, Sarah Spiegel et al. profile →
  12. “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
    2008 580 citations Kazuaki Takabe, Steven W. Paugh et al. profile →
  13. Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform
    2000 558 citations Sheldon Milstien, Sarah Spiegel et al. profile →
  14. Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology
    1997 558 citations Sarah Spiegel et al. profile →
  15. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.
    1991 544 citations Ana Olivera, Sarah Spiegel et al. profile →
  16. SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism
    2005 530 citations Michael Maceyka, Heidi Sankala et al. profile →
  17. Sphingolipids in metabolic disease: The good, the bad, and the unknown
    2021 194 citations Christopher D. Green, Michael Maceyka et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Sarah Spiegel United States 113 38.6k 14.0k 6.8k 6.2k 3.0k 399 44.9k
Lina M. Obeid United States 94 26.4k 0.7× 7.4k 0.5× 5.3k 0.8× 3.3k 0.5× 1.9k 0.6× 291 30.5k
Michael N. Hall Switzerland 108 34.3k 0.9× 6.7k 0.5× 3.9k 0.6× 3.7k 0.6× 3.1k 1.0× 246 44.9k
Timothy Hla United States 99 23.6k 0.6× 6.7k 0.5× 4.0k 0.6× 4.8k 0.8× 2.7k 0.9× 245 35.3k
Jerold Chun United States 99 23.9k 0.6× 6.7k 0.5× 4.2k 0.6× 3.9k 0.6× 1.5k 0.5× 334 31.6k
Sheldon Milstien United States 88 20.5k 0.5× 7.3k 0.5× 4.8k 0.7× 3.7k 0.6× 1.5k 0.5× 237 26.6k
Joseph Avruch United States 95 29.1k 0.8× 8.6k 0.6× 3.2k 0.5× 3.8k 0.6× 4.5k 1.5× 189 38.2k
Peter J. Parker United Kingdom 95 25.3k 0.7× 7.6k 0.5× 3.0k 0.4× 3.5k 0.6× 3.9k 1.3× 406 33.7k
Dario R. Alessi United Kingdom 124 50.6k 1.3× 10.1k 0.7× 6.8k 1.0× 4.9k 0.8× 7.7k 2.5× 313 65.6k
John Blenis United States 101 39.2k 1.0× 6.3k 0.5× 4.7k 0.7× 6.5k 1.0× 8.2k 2.7× 222 51.9k
Brian A. Hemmings Switzerland 102 33.2k 0.9× 7.2k 0.5× 3.0k 0.4× 3.8k 0.6× 5.1k 1.7× 313 42.4k

Countries citing papers authored by Sarah Spiegel

Since Specialization
Citations

This map shows the geographic impact of Sarah Spiegel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sarah Spiegel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sarah Spiegel more than expected).

Fields of papers citing papers by Sarah Spiegel

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sarah Spiegel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sarah Spiegel. The network helps show where Sarah Spiegel may publish in the future.

Co-authorship network of co-authors of Sarah Spiegel

This figure shows the co-authorship network connecting the top 25 collaborators of Sarah Spiegel. A scholar is included among the top collaborators of Sarah Spiegel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sarah Spiegel. Sarah Spiegel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Green, Christopher D., Cynthia Weigel, Clément Oyeniran, et al.. (2021). CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism. Journal of Lipid Research. 62. 100082–100082. 24 indexed citations
2.
Ma, Yibao, Wei Wang, Huiping Zhou, et al.. (2020). Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. Scientific Reports. 10(1). 1450–1450. 52 indexed citations
3.
Yamada, Akimitsu, Masayuki Nagahashi, Tomoyoshi Aoyagi, et al.. (2018). ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Molecular Cancer Research. 16(6). 1059–1070. 61 indexed citations
4.
Nagahashi, Masayuki, Akimitsu Yamada, Eriko Katsuta, et al.. (2018). Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis. Cancer Research. 78(7). 1713–1725. 165 indexed citations
5.
Liakath‐Ali, Kifayathullah, Valerie E. Vancollie, Christopher J. Lelliott, et al.. (2016). Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole‐body energy expenditure. The Journal of Pathology. 239(3). 374–383. 33 indexed citations
6.
Temkin, Sarah M., Sarah Spiegel, Simeon E. Goldblum, et al.. (2016). VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells. Clinical Cancer Research. 22(16). 4249–4258. 30 indexed citations
7.
Lu, Junyan, Hanlin Zeng, Zhongjie Liang, et al.. (2015). Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets. Scientific Reports. 5(1). 14739–14739. 38 indexed citations
8.
Nagahashi, Masayuki, Subramaniam Ramachandran, Eugene Y. Kim, et al.. (2012). Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis. Cancer Research. 72(3). 726–735. 265 indexed citations
9.
Yacoub, Adly, Hossein A. Hamed, Jeremy C. Allegood, et al.. (2010). PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells. Cancer Research. 70(3). 1120–1129. 89 indexed citations
10.
Oskeritzian, Carole A., Megan M. Price, Nitai C. Hait, et al.. (2010). Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. The Journal of Experimental Medicine. 207(3). 465–474. 101 indexed citations
11.
Park, Margaret A., Clint Mitchell, Guo Zhang, et al.. (2010). Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+- De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway. Cancer Research. 70(15). 6313–6324. 86 indexed citations
12.
Kapitonov, Dmitri, Jeremy C. Allegood, Clint Mitchell, et al.. (2009). Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts. Cancer Research. 69(17). 6915–6923. 154 indexed citations
13.
Park, Margaret A., Teneille Walker, Aditi Pandya Martin, et al.. (2009). MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism. Molecular Cancer Therapeutics. 8(5). 1280–1291. 40 indexed citations
14.
Hait, Nitai C., Jeremy C. Allegood, Michael Maceyka, et al.. (2009). Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate. Science. 325(5945). 1254–1257. 802 indexed citations breakdown →
15.
Sankala, Heidi, Nitai C. Hait, Steven W. Paugh, et al.. (2007). Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin. Cancer Research. 67(21). 10466–10474. 132 indexed citations
16.
Oskeritzian, Carole A., Sheldon Milstien, & Sarah Spiegel. (2007). Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacology & Therapeutics. 115(3). 390–399. 81 indexed citations
17.
Watterson, Kenneth R., David A. Lanning, Robert F. Diegelmann, & Sarah Spiegel. (2007). Regulation of fibroblast functions by lysophospholipid mediators: Potential roles in wound healing. Wound Repair and Regeneration. 15(5). 607–616. 97 indexed citations
18.
Spiegel, Sarah & Sheldon Milstien. (2003). Sphingosine-1-phosphate: an enigmatic signalling lipid. Nature Reviews Molecular Cell Biology. 4(5). 397–407. 1761 indexed citations breakdown →
19.
González‐Espinosa, Claudia, Sandra Odom, Ana Olivera, et al.. (2003). Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells. The Journal of Experimental Medicine. 197(11). 1453–1465. 132 indexed citations
20.
Olivera, Ana, et al.. (2000). [25] Assaying sphingosine kinase activity. Methods in enzymology on CD-ROM/Methods in enzymology. 311. 215–223. 68 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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