William D. Shrader

1.6k citations

30 papers · 1.2k indexed · h-index 18

Impact in

Clinical Biochemistry top 2%
- Metabolism and Genetic Disorders
Hematology top 5%
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research

Papers in

Hematology 17
- Blood Coagulation and Thrombosis Mechanisms 17
- Hemophilia Treatment and Research 6
Genetics 13
- Coagulation, Bradykinin, Polyphosphates, and Angioedema 13

Co-authors: Guy Miller Paul A. Sprengeler Barbara Imperiali Viktoria Kheifets Wendy B. Young Martin Thoolen Akiko Amagata B.A. Katz
Journals: Bioorganic & Medicinal Chemistry Letters (16 papers)Tetrahedron Letters (2 papers)Molecular Genetics and Metabolism (2 papers)Journal of Molecular Biology (2 papers)Science Translational Medicine (1 paper)
Partner nations: United States Switzerland United Kingdom

In The Last Decade

William D. Shrader

30 papers receiving 1.2k citations

Peers

Countries citing papers authored by William D. Shrader

Since Specialization

Citations

This map shows the geographic impact of William D. Shrader's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William D. Shrader with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William D. Shrader more than expected).

Fields of papers citing papers by William D. Shrader

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William D. Shrader. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William D. Shrader. The network helps show where William D. Shrader may publish in the future.

Co-authorship network

The 25 scholars most cited alongside William D. Shrader, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William D. Shrader Line = papers co-authored together William D. Shrader links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson’s disease Science Translational Medicine ·Matthew T. Keeney, Emily M. Rocha, Eric K. Hoffman, Kyle Farmer, Roberto Di Maio, Sophia Tziraki, Sen Lê Thị Hoa, Xiao Hu, Yevgeniy Kosaretskyi, Sandra L. Castro, S Vasylevskyi, Marco Fazzari, Briana R. De Miranda, Osvaldo Mário Serra Truzzi, William D. Shrader, Patrick J. Pagano, Teresa G. Hastings, J. Timothy Greenamyre	2024	13
2	Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase PLoS ONE ·A. Scott Hinman, Charles R. Holst, Joey C. Latham, Joel Bruegger, Gözde Ulas, Kevin P. McCusker, Akiko Amagata, Dana M. Davis, Kevin G. Hoff, Amanda Kahn-Kirby, Shima Shayestehfar, 重夫森, Edgar Lee, Risalah Damar Ratri, R. Rhoden, Ingegerd Michel, H S Chen, Guy Miller, Jeffrey K. Trimmer, William D. Shrader	2018	149
3	A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial Movement Disorders ·David R. Lynch, Steven M. Willi, Robert B. Wilson, M. Grazia Cotticelli, Karlla W. Brigatti, Éric Deutsch, Olena Kucheruk, William D. Shrader, Patrice Rioux, Guy Miller, Amale Hawi, Thomas Sciascia	2012	66
4	EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome Molecular Genetics and Metabolism ·Diego Martinelli, Michela Catteruccia, Fiorella Piemonte, Anna Pastore, Giulia Tozzi, Carlo Dionisi‐Vici, Giuseppe Pontrelli, Tiziana Corsetti, Susanna Livadiotti, Viktoria Kheifets, A. Scott Hinman, William D. Shrader, Martin Thoolen, Matthew B. Klein, Enrico Bertini, Guy Miller	2012	149
5	α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging Bioorganic & Medicinal Chemistry Letters ·William D. Shrader, Akiko Amagata, Marius Lazurca, Gregory M. Enns, A. Scott Hinman, Chi Zhang, Viktoria Kheifets, M. S. Silva Yonara, Edgar Lee, Z. Nordatul Akmar, Katsuyuki Murase, Alfredo A. Sadun, Martin Thoolen, Ünal Bulut, Guy Miller	2011	70
6	Initial experience in the treatment of inherited mitochondrial disease with EPI-743 Molecular Genetics and Metabolism ·Gregory M. Enns, Stephen L. Kinsman, Susan Perlman, Kenneth Spicer, José E. Abdenur, Bruce H. Cohen, Akiko Amagata, Marius Lazurca, Viktoria Kheifets, William D. Shrader, Martin Thoolen, Francis G. Blankenberg, Guy Miller	2011	148
7	Towards a modern definition of vitamin E—evidence for a quinone hypothesis Bioorganic & Medicinal Chemistry Letters ·William D. Shrader, Akiko Amagata, Marius Lazurca, A. Scott Hinman, Chi Zhang, Edgar Lee, Viktoria Kheifets, M. S. Silva Yonara, Z. Nordatul Akmar, Katsuyuki Murase, Patrice Rioux, Ünal Bulut, Guy Miller	2011	11
8	Factor VIIa inhibitors: Gaining selectivity within the trypsin family Bioorganic & Medicinal Chemistry Letters ·William D. Shrader, Aleksandr Kolesnikov, Брагин А. Н., Луцкий Г. Л., Маханьков Е. П., Roopa Rai, PTS, Huiyong Hu, Mohammad R. Hemmati, G. Beckett, Wendy B. Young, B.A. Katz, Christine Yu, Jie Tang, Daniela De Lorenzo, Estefany Lopez Velazquez, James W. Janc, Paul A. Sprengeler	2006	12
9	Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model Bioorganic & Medicinal Chemistry Letters ·Wendy B. Young, Joyce Mordenti, М.А. Скворцов, William D. Shrader, Aleksandr Kolesnikov, Roopa Rai, Liang Liu, Huiyong Hu, Ellen M. Leahy, Michael J. Green, Paul A. Sprengeler, B.A. Katz, Christine Yu, James W. Janc, Kyle Elrod, Ulla M. Marzec, Stephen R. Hanson	2006	24
10	Efforts toward oral bioavailability in factor VIIa inhibitors Bioorganic & Medicinal Chemistry Letters ·De Francesca Af, Roopa Rai, Michael B. Shaghafi, G. Beckett, Mohammad R. Hemmati, Ellen M. Leahy, Jennifer R. Riggs, Huiyong Hu, Paul A. Sprengeler, William D. Shrader, ka Rosa Zelonka, Stephen Gugu, Estefany Lopez Velazquez, Toshiaki Iwata, Liang Liu, Juthamas Sukbuntherng, Wendy B. Young	2006	5
11	Potent 4-amino-5-azaindole factor VIIa inhibitors Bioorganic & Medicinal Chemistry Letters ·Huiyong Hu, Aleksandr Kolesnikov, Jennifer R. Riggs, Ünal Bulut, Peter McCaldon, Ellen M. Leahy, William D. Shrader, Paul A. Sprengeler, Michael J. Green, Estefany Lopez Velazquez, Margaret Nguyen, Vásquez Ávila, Daniela De Lorenzo, Wendy B. Young	2006	26
12	Small molecule inhibitors of plasma kallikrein Bioorganic & Medicinal Chemistry Letters ·Wendy B. Young, Roopa Rai, William D. Shrader, Брагин А. Н., Луцкий Г. Л., Маханьков Е. П., Huiyong Hu, Kyle Elrod, Paul A. Sprengeler, B.A. Katz, Juthamas Sukbuntherng, Joyce Mordenti	2006	8
13	Factor VIIa inhibitors: Improved pharmacokinetic parameters Bioorganic & Medicinal Chemistry Letters ·Aleksandr Kolesnikov, Roopa Rai, Wendy B. Young, Joyce Mordenti, Liang Liu, М.А. Скворцов, William D. Shrader, Ellen M. Leahy, Huiyong Hu, Vásquez Ávila, James W. Janc, B.A. Katz, Paul A. Sprengeler	2006	9
14	Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation Bioorganic & Medicinal Chemistry Letters ·Wendy B. Young, Paul A. Sprengeler, William D. Shrader, Yong Li, Roopa Rai, Erik Verner, Thomas E. Jenkins, S. Yu. Obudovskii, Aleksandr Kolesnikov, James W. Janc, Lynne Cregar, Kyle Elrod, Theresa Gl�ckler	2005	9
15	Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors Journal of Molecular Biology ·B.A. Katz, Kyle Elrod, Erik Verner, Richard L. Mackman, Christine Luong, William D. Shrader, Martin Sendzik, Jeffrey R. Spencer, Paul A. Sprengeler, NA Malishev, Vincent W.‐F. Tai, Hon C. Hui, J. Guy Breitenbucher, Darin A. Allen, James W. Janc	2003	30
16	The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain Structure ·John R. Somoza, Joseph D. Ho, Christine Luong, Arif Ahammad, Paul A. Sprengeler, Kyle Mortara, William D. Shrader, David Sperandio, Regina Molchanova, Mary E. McGrath, B.A. Katz	2003	66
17	Optimization of a screening lead for factor VIIa/TF Bioorganic & Medicinal Chemistry Letters ·Wendy B. Young, Aleksandr Kolesnikov, Roopa Rai, Paul A. Sprengeler, Ellen M. Leahy, William D. Shrader, Joan Sangalang, Брагин А. Н., Луцкий Г. Л., Маханьков Е. П., 王焘 Wang Tao, Kyle Elrod, Lynne Cregar	2001	39
18	Development of potent and selective factor Xa inhibitors Bioorganic & Medicinal Chemistry Letters ·Roopa Rai, Aleksandr Kolesnikov, Yong Li, Wendy B. Young, Xun Hu, Paul A. Sprengeler, Erik Verner, William D. Shrader, Брагин А. Н., Луцкий Г. Л., Маханьков Е. П., Joan Sangalang, Darin A. Allen, Camille Duprez, B.A. Katz, Christine Luong, Kyle Elrod, Lynne Cregar	2001	7
19	Neutral inhibitors of the serine protease factor Xa Bioorganic & Medicinal Chemistry Letters ·William D. Shrader, Wendy B. Young, Paul A. Sprengeler, Joan Sangalang, Kyle Elrod, Grant Carr	2001	19
20	Substrate assistance in the mechanism of family 18 chitinases: theoretical studies of potential intermediates and inhibitors 1 1Edited by B. Honig Journal of Molecular Biology ·Ken A. Brameld, William D. Shrader, Barbara Imperiali, William A. Goddard	1998	91

About William D. Shrader

William D. Shrader is a scholar working on Hematology, Genetics, Cancer Research, Biochemistry and Clinical Biochemistry, having authored 30 papers that have together received 1.2k indexed citations. Recurring topics across this work include Blood Coagulation and Thrombosis Mechanisms (17 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (13 papers), Protease and Inhibitor Mechanisms (6 papers), Hemophilia Treatment and Research (6 papers), Mitochondrial Function and Pathology (5 papers), Chemical Synthesis and Analysis (4 papers), Carbohydrate Chemistry and Synthesis (2 papers) and Click Chemistry and Applications (2 papers). The work is most often cited by research in Clinical Biochemistry (180 citations), Hematology (193 citations), Genetics (167 citations), Molecular Biology (735 citations) and Cancer Research (139 citations). William D. Shrader has collaborated with scholars based in United States, Switzerland and United Kingdom. Frequent co-authors include Guy Miller, Paul A. Sprengeler, Barbara Imperiali, Viktoria Kheifets, Wendy B. Young, Martin Thoolen, Akiko Amagata, B.A. Katz, Ken A. Brameld and William A. Goddard. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Molecular Genetics and Metabolism, Journal of Molecular Biology and Science Translational Medicine.

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