Richard L. Mackman

9.4k citations

66 papers · 3.6k indexed · 2 hit papers · h-index 29

Co-authors: Tomáš Cihlář Adrian S. Ray Dustin S. Siegel Michael O. Clarke Robert Jordan Hon C. Hui Joy Y. Feng Xiaotao Lu
Topics: HIV/AIDS drug development and treatment (20 papers)Respiratory viral infections research (11 papers)HIV Research and Treatment (11 papers)
Cited by: Infectious Diseases Virology Epidemiology
Journals: New England Journal of Medicine Journal of the American Chemical Society Journal of Biological Chemistry
Partner nations: United States Czechia United Kingdom

In The Last Decade

Richard L. Mackman

65 papers receiving 3.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

2018 1.0k citations Adrian S. Ray, Tomáš Cihlář et al. profile →
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

2017 361 citations Richard L. Mackman, Hon C. Hui et al. profile →

Peers

Countries citing papers authored by Richard L. Mackman

Since Specialization

Citations

This map shows the geographic impact of Richard L. Mackman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard L. Mackman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard L. Mackman more than expected).

Fields of papers citing papers by Richard L. Mackman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard L. Mackman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard L. Mackman. The network helps show where Richard L. Mackman may publish in the future.

Co-authorship network of co-authors of Richard L. Mackman

This figure shows the co-authorship network connecting the top 25 collaborators of Richard L. Mackman. A scholar is included among the top collaborators of Richard L. Mackman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard L. Mackman. Richard L. Mackman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Antiviral target compound profile for pandemic preparedness 2024 ·Nature Reviews Drug Discovery ·James F. Demarest,Ruxandra Draghia‐Akli,Tomáš Cihlář,Kenneth A. Bradley,John A. T. Young,Richa Chandra,Sujata Vaidyanathan,Margaret Y. Chu‐Moyer,Christopher J. Lynch,Andrew Campbell,Kumar Singh Saikatendu,John P. Bilello,Yoshihiko Murata,Marnix Van Loock,Aeron C. Hurt,Timothy L. Tellinghuisen,Luigi Ruggiero,Richard L. Mackman,(unknown),John C. Pottage,(unknown),(unknown)	1
2	Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection 2022 ·Antiviral Research ·Jared Pitts,Darius Babusis,Meghan S. Vermillion,Raju Subramanian,(unknown),Diane S. Lye,Bin Ma,(unknown),(unknown),Xuping Xie,Adriana E. Kajon,Xianghan Lu,Roy Bannister,Pei‐Yong Shi,Maria M. Toteva,Danielle Porter,Bill J. Smith,Tomáš Cihlář,Richard L. Mackman,John P. Bilello	5
3	Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study 2014 ·New England Journal of Medicine ·John P. DeVincenzo,Richard J. Whitley,Richard L. Mackman,(unknown),Lisa Harrison,(unknown),Stephen McBride,Rob Lambkin‐Williams,Robert Jordan,Yan Xin,Srini Ramanathan,Thomas G. O’Riordan,Sandra A. Lewis,Xiaoming Li,Seth Toback,Shao‐Lee Lin,Jason W. Chien	256
4	A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities 2011 ·European Journal of Medicinal Chemistry ·Petr Jansa,Ondřej Baszczyňski,Martin Dračínský,Ivan Votruba,Zdeňek Zı́dek,(unknown),George Stepan,Tomáš Cihlář,Richard L. Mackman,Antonı́n Holý,Zlatko Janeba	55
5	Visualizing the Molecular Interactions of a Nucleotide Analog, GS-9148, with HIV-1 Reverse Transcriptase–DNA Complex 2010 ·Journal of Molecular Biology ·E.B. Lansdon,Dharmaraj Samuel,Leanna Lagpacan,Katherine M. Brendza,Kirsten White,Magdeleine Hung,Xiaohong Liu,Constantine G. Boojamra,Richard L. Mackman,Tomáš Cihlář,Adrian S. Ray,Mary E. McGrath,S. Swaminathan	37
6	Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors 2008 ·Bioorganic & Medicinal Chemistry ·Constantine G. Boojamra,Jay P. Parrish,David Sperandio,Ying Gao,(unknown),(unknown),(unknown),Jennifer E. Vela,Geneviève Laflamme,James Chen,Adrian S. Ray,(unknown),(unknown),Manoj C. Desai,Choung U. Kim,Tomáš Cihlář,Richard L. Mackman	43
7	Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates 2007 ·Bioorganic & Medicinal Chemistry Letters ·Richard L. Mackman,Constantine G. Boojamra,(unknown),Lijun Zhang,Kuei‐Ying Lin,(unknown),Darius Babusis,James Chen,Janet L. Douglas,Deborah Grant,Hon C. Hui,Choung U. Kim,(unknown),Jennifer E. Vela,Adrian S. Ray,Tomáš Cihlář	27
8	Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148 2007 ·Bioorganic & Medicinal Chemistry Letters ·Richard L. Mackman,Kuei‐Ying Lin,Constantine G. Boojamra,Hon C. Hui,Janet L. Douglas,Deborah Grant,(unknown),(unknown),Adrian S. Ray,Tomáš Cihlář	22
9	Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides 2007 ·Bioorganic & Medicinal Chemistry ·Martin Kuchař,Michal Hocek,Radek Pohl,Ivan Votruba,I‐hung Shih,Eric Mabery,Richard L. Mackman	16
10	Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides 2007 ·Bioorganic & Medicinal Chemistry ·Peter Šilhár,Michal Hocek,Radek Pohl,Ivan Votruba,I‐hung Shih,Eric Mabery,Richard L. Mackman	21
11	Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs 2007 ·Bioorganic & Medicinal Chemistry ·Richard L. Mackman,Lijun Zhang,(unknown),Constantine G. Boojamra,Janet L. Douglas,Deborah Grant,Hon C. Hui,Choung U. Kim,Geneviève Laflamme,Jay P. Parrish,Antitsa Stoycheva,S. Swaminathan,Keyu Wang,Tomáš Cihlář	24
12	Synthesis And Anti-Hiv Activity Of Cyclic Pyrimidine Phosphonomethoxy Nucleosides And Their Prodrugs: A Comparison Of Phosphonates And Corresponding Nucleosides 2007 ·Nucleosides Nucleotides & Nucleic Acids ·Richard L. Mackman,Lijun Zhang,(unknown),Constantine G. Boojamra,James Chen,Janet L. Douglas,Deborah Grant,Geneviève Laflamme,Hon C. Hui,Choung U. Kim,Jay P. Parrish,Antitsa Stoycheva,S. Swaminathan,Keyu Wang,Tomáš Cihlář	17
13	Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine l-ribonucleosides 2006 ·Bioorganic & Medicinal Chemistry Letters ·Michal Hocek,Peter Šilhár,I‐hung Shih,Eric Mabery,Richard L. Mackman	39
14	Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA) 2004 ·Journal of Molecular Biology ·B.A. Katz,Christine Luong,Joseph D. Ho,John R. Somoza,(unknown),Jie Tang,Steven R. Williams,Erik Verner,Richard L. Mackman,Wendy B. Young,Paul A. Sprengeler,(unknown),Kyle Mortara,James W. Janc,Mary E. McGrath	29
15	Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors 2003 ·Journal of Molecular Biology ·B.A. Katz,Kyle Elrod,Erik Verner,Richard L. Mackman,Christine Luong,William D. Shrader,Martin Sendzik,Jeffrey R. Spencer,Paul A. Sprengeler,(unknown),Vincent W.‐F. Tai,Hon C. Hui,J. Guy Breitenbucher,Darin A. Allen,James W. Janc	30
16	4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors 2002 ·Bioorganic & Medicinal Chemistry Letters ·Jeffrey R. Spencer,D. P. C. MCGEE,Darin A. Allen,B.A. Katz,Christine Luong,Martin Sendzik,Neil Squires,Richard L. Mackman	22
17	Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets 2001 ·Chemistry & Biology ·B.A. Katz,Paul A. Sprengeler,Christine Luong,Erik Verner,Kyle Elrod,(unknown),James W. Janc,Jeffrey R. Spencer,J. Guy Breitenbucher,Hon C. Hui,D. P. C. MCGEE,Darin A. Allen,(unknown),Richard L. Mackman	51
18	A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site11Edited by D. Rees 2001 ·Journal of Molecular Biology ·B.A. Katz,Kyle Elrod,Christine Luong,Mark J. Rice,Richard L. Mackman,Paul A. Sprengeler,Jeffrey R. Spencer,Jason Hataye,James W. Janc,John O. Link,Joane Litvak,Roopa Rai,Kenneth Rice,Steve Sideris,Erik Verner,Wendy B. Young	61
19	Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator 2000 ·Chemistry & Biology ·B.A. Katz,Richard L. Mackman,Christine Luong,Kesavan Radika,(unknown),Paul A. Sprengeler,Jing Wang,(unknown),(unknown)	66
20	Active-Site Topology of Bovine Cholesterol Side-Chain Cleavage Cytochrome P450 (P450scc) and Evidence for Interaction of Tyrosine 94 with the Side Chain of Cholesterol 1995 ·Archives of Biochemistry and Biophysics ·Irina A. Pikuleva,Richard L. Mackman,Norio Kagawa,Michael R. Waterman,(unknown)	37

About Richard L. Mackman

Richard L. Mackman is a scholar working on Virology, Infectious Diseases and Hepatology, having authored 66 papers that have together received 3.6k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (20 papers), Respiratory viral infections research (11 papers) and HIV Research and Treatment (11 papers). The work is most often cited by research in Infectious Diseases (2.0k citations), Virology (189 citations) and Epidemiology (781 citations). Richard L. Mackman has collaborated with scholars based in United States, Czechia and United Kingdom. Frequent co-authors include Tomáš Cihlář, Adrian S. Ray, Dustin S. Siegel, Michael O. Clarke, Robert Jordan, Hon C. Hui, Joy Y. Feng, Xiaotao Lu, Rachel L. Graham and Maria L. Agostini. Their work appears in journals such as New England Journal of Medicine, Journal of the American Chemical Society and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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