Ellen Y. T. Chien

7.1k total citations · 4 hit papers
20 papers, 5.9k citations indexed

About

Ellen Y. T. Chien is a scholar working on Molecular Biology, Cell Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Ellen Y. T. Chien has authored 20 papers receiving a total of 5.9k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Molecular Biology, 9 papers in Cell Biology and 5 papers in Cellular and Molecular Neuroscience. Recurrent topics in Ellen Y. T. Chien's work include Hemoglobin structure and function (9 papers), Protein Structure and Dynamics (7 papers) and Receptor Mechanisms and Signaling (6 papers). Ellen Y. T. Chien is often cited by papers focused on Hemoglobin structure and function (9 papers), Protein Structure and Dynamics (7 papers) and Receptor Mechanisms and Signaling (6 papers). Ellen Y. T. Chien collaborates with scholars based in United States, Netherlands and Mexico. Ellen Y. T. Chien's co-authors include Raymond C. Stevens, Vadim Cherezov, Michael A. Hanson, Veli‐Pekka Jaakola, Mark T. Griffith, Vsevolod Katritch, Peter Kühn, Adriaan P. IJzerman, J. Robert Lane and Clifford D. Mol and has published in prestigious journals such as Science, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Ellen Y. T. Chien

20 papers receiving 5.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist

2008 1.5k citations Veli‐Pekka Jaakola, Mark T. Griffith et al. Science profile →
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

2010 1.5k citations Beili Wu, Ellen Y. T. Chien et al. Science profile →
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

2010 956 citations Ellen Y. T. Chien, Wei Liu et al. Science profile →
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

2008 780 citations Michael A. Hanson, Vadim Cherezov et al. Structure profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Ellen Y. T. Chien United States	16	5.0k	2.4k	952	666	614	20	5.9k
Beili Wu China	33	3.6k 0.7×	1.5k 0.6×	811 0.9×	935 1.4×	386 0.6×	62	5.0k
Xavier Deupí Switzerland	39	5.5k 1.1×	3.4k 1.4×	857 0.9×	404 0.6×	503 0.8×	79	6.2k
Brian A. Fox United States	18	4.9k 1.0×	2.9k 1.2×	593 0.6×	630 0.9×	377 0.6×	45	6.4k
Arun K. Shukla India	37	5.3k 1.1×	3.1k 1.3×	738 0.8×	366 0.5×	601 1.0×	101	6.1k
J.J.G. Tesmer United States	48	7.2k 1.4×	2.3k 0.9×	357 0.4×	501 0.8×	328 0.5×	160	8.7k
Tetsuya Hori Japan	11	4.5k 0.9×	3.0k 1.2×	543 0.6×	228 0.3×	354 0.6×	15	5.2k
Aashish Manglik United States	38	9.4k 1.9×	5.6k 2.3×	1.8k 1.9×	507 0.8×	945 1.5×	57	10.8k
Daniel H. Arlow United States	17	5.4k 1.1×	2.2k 0.9×	657 0.7×	183 0.3×	720 1.2×	20	6.1k
Qiang Zhao China	35	3.7k 0.7×	1.5k 0.6×	516 0.5×	424 0.6×	401 0.7×	97	4.7k
Brian T. DeVree United States	13	5.4k 1.1×	3.0k 1.3×	1.0k 1.1×	206 0.3×	514 0.8×	17	5.8k

Countries citing papers authored by Ellen Y. T. Chien

Since Specialization

Citations

This map shows the geographic impact of Ellen Y. T. Chien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ellen Y. T. Chien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ellen Y. T. Chien more than expected).

Fields of papers citing papers by Ellen Y. T. Chien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ellen Y. T. Chien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ellen Y. T. Chien. The network helps show where Ellen Y. T. Chien may publish in the future.

Co-authorship network of co-authors of Ellen Y. T. Chien

This figure shows the co-authorship network connecting the top 25 collaborators of Ellen Y. T. Chien. A scholar is included among the top collaborators of Ellen Y. T. Chien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ellen Y. T. Chien. Ellen Y. T. Chien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

West, Graham M., Ellen Y. T. Chien, Vsevolod Katritch, et al.. (2011). Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX. Structure. 19(10). 1424–1432. 120 indexed citations

Wu, Beili, Ellen Y. T. Chien, Clifford D. Mol, et al.. (2010). Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 330(6007). 1066–1071. 1462 indexed citations breakdown →

Chien, Ellen Y. T., Wei Liu, Qiang Zhao, et al.. (2010). Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science. 330(6007). 1091–1095. 956 indexed citations breakdown →

Zhang, Xi, Ellen Y. T. Chien, Michael J. Chalmers, et al.. (2010). Dynamics of the β₂-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange. Analytical Chemistry. 82(3). 1100–1108. 108 indexed citations

Jaakola, Veli‐Pekka, Mark T. Griffith, Michael A. Hanson, et al.. (2008). The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist. Science. 322(5905). 1211–1217. 1475 indexed citations breakdown →

Alexandrov, Alexander I., Mauro Mileni, Ellen Y. T. Chien, Michael A. Hanson, & Raymond C. Stevens. (2008). Microscale Fluorescent Thermal Stability Assay for Membrane Proteins. Structure. 16(3). 351–359. 354 indexed citations

Hanson, Michael A., Vadim Cherezov, Mark T. Griffith, et al.. (2008). A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor. Structure. 16(6). 897–905. 780 indexed citations breakdown →

Hanson, Michael A., Alexei Brooun, Kent A. Baker, et al.. (2007). Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expression and Purification. 56(1). 85–92. 34 indexed citations

Brooun, Alexei, Scott A. Foster, Jill Chrencik, et al.. (2006). Remedial strategies in structural proteomics: Expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expression and Purification. 53(1). 51–62. 7 indexed citations

10.

Mol, Clifford D., Kheng B. Lim, Vandana Sridhar, et al.. (2003). Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation. Journal of Biological Chemistry. 278(34). 31461–31464. 193 indexed citations

11.

Mar, Gerd N. La, et al.. (2001). Solution¹H NMR Characterization of Axial Interactions of the Proximal and Distal His in the Cyanomet Complexes of the Isolated Chains and the 65 kDa Intact Tetramer of Human Hemoglobin A. Journal of the American Chemical Society. 123(18). 4266–4274. 6 indexed citations

12.

Szabo, Christina M., Lori K. Sanders, Hongbiao Le, Ellen Y. T. Chien, & Eric Oldfield. (2000). Expression of doubly labeled Saccharomyces cerevisiaeiso‐1 ferricytochrome c and ¹H, ¹³C and ¹⁵N chemical shift assignments by multidimensional NMR. FEBS Letters. 482(1-2). 25–30. 5 indexed citations

13.

Müller, Joachim D., Benjamin H. McMahon, Ellen Y. T. Chien, Stephen G. Sligar, & G. Ulrich Nienhaus. (1999). Connection between the Taxonomic Substates and Protonation of Histidines 64 and 97 in Carbonmonoxy Myoglobin. Biophysical Journal. 77(2). 1036–1051. 103 indexed citations

14.

Peterson, Eric S., et al.. (1998). Functional Implications of the Proximal Hydrogen-Bonding Network in Myoglobin: A Resonance Raman and Kinetic Study of Leu89, Ser92, His97, and F-Helix Swap Mutants. Biochemistry. 37(35). 12301–12319. 86 indexed citations

15.

Wu, Yuyang, Ellen Y. T. Chien, Stephen G. Sligar, & Gerd N. La Mar. (1998). Influence of Proximal Side Mutations on the Molecular and Electronic Structure of Cyanomet Myoglobin: An ¹H NMR Study. Biochemistry. 37(19). 6979–6990. 15 indexed citations

16.

Christian, James F., Masashi Unno, J. Timothy Sage, et al.. (1997). Spectroscopic Effects of Polarity and Hydration in the Distal Heme Pocket of Deoxymyoglobin. Biochemistry. 36(37). 11198–11204. 36 indexed citations

17.

Pearson, John G., et al.. (1997). Assignment and Analysis of Fluorine Nuclear Magnetic Resonance Spectra of 4-Fluorotryptophan Myoglobins and Hemoglobins. Biochemistry. 36(12). 3590–3599. 15 indexed citations

18.

Rector, K. D., Chris W. Rella, Jeffrey R. Hill, et al.. (1997). Mutant and Wild-Type Myoglobin-CO Protein Dynamics: Vibrational Echo Experiments. The Journal of Physical Chemistry B. 101(8). 1468–1475. 61 indexed citations

19.

Tian, Weidong, J. Timothy Sage, P. M. Champion, Ellen Y. T. Chien, & Stephen G. Sligar. (1996). Probing Heme Protein Conformational Equilibration Rates with Kinetic Selection. Biochemistry. 35(11). 3487–3502. 56 indexed citations

20.

Chien, Ellen Y. T., et al.. (1995). Ligand binding to heme proteins. V. Light-induced relaxation in proximal mutants L89I and H97F of carbonmonoxymyoglobin. Biophysical Journal. 68(6). 2497–2504. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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