Chris de Graaf

10.3k citations

139 papers · 6.7k indexed · 2 hit papers · h-index 46

Impact in

Computational Theory and Mathematics top 0.2%
- Computational Drug Discovery Methods
Cellular and Molecular Neuroscience top 1%
- Neuropeptides and Animal Physiology

Papers in

Computational Theory and Mathematics 48
- Computational Drug Discovery Methods 48
Cellular and Molecular Neuroscience 40
- Neuropeptides and Animal Physiology 35

Co-authors: Iwan J. P. de Esch Rob Leurs Albert J. Kooistra Raymond C. Stevens Nico Vermeulen Didier Rognan Miles Congreve Henry F. Vischer
Journals: Journal of Medicinal Chemistry (22 papers)Journal of Chemical Information and Modeling (11 papers)Molecular Pharmacology (6 papers)Nature Communications (4 papers)British Journal of Pharmacology (4 papers)
Partner nations: Netherlands United Kingdom United States

In The Last Decade

Chris de Graaf

138 papers receiving 6.5k citations

Hit Papers

align trajectories log scale

Impact of GPCR Structures on Drug Discovery 2020 · 245 citations

Peers

Countries citing papers authored by Chris de Graaf

Since Specialization

Citations

This map shows the geographic impact of Chris de Graaf's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Chris de Graaf with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Chris de Graaf more than expected).

Fields of papers citing papers by Chris de Graaf

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Chris de Graaf. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Chris de Graaf. The network helps show where Chris de Graaf may publish in the future.

Co-authors

The 25 scholars most cited alongside Chris de Graaf, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Chris de Graaf Line = papers co-authored together Chris de Graaf links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identification of nanomolar adenosine A2A receptor ligands using reinforcement learning and structure-based drug design Nature Communications ·Morgan Thomas, Pierre Matricon, Zachary Roelen, 今井啓子, Stephanie Webster, Jonathan S. Mason, Jason Brown, Ratul Hasan Ankon, Naiara C. Silva, Nigel A. Swain, Angeline B. Abrenica, Noel M. O’Boyle, Francesca Deflorian, Andreas Bender, Chris de Graaf	2025	2
2	Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3 ACS Omega ·U. S. Senate, 俊明宮地, Francesca Deflorian, Chris de Graaf, Julyanne Rodrigues de Medeiros Pontes, Martyna Szpakowska, Andy Chevigné, Iwan J. P. de Esch, Barbara Zarzycka, Henry F. Vischer, Maikel Wijtmans, Rob Leurs	2025	0
3	Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential Journal of Chemical Information and Modeling ·V. Guhan, Lydia Siragusa, Muthukurumbathevar Bose, Lisa P. Evans, Simon Cross, Noel M. O’Boyle, Dávid Bajusz, György G. Ferenczy, György M. Keserű, Giovanni Bottegoni, Brian J. Bender, I‐Jen Chen, Chris de Graaf	2024	8
4	Conformational dynamics underlying atypical chemokine receptor 3 activation Proceedings of the National Academy of Sciences ·E Ragab Adham, G Ramasarma, Philip L. Gibbard, Lisa Niederwimmer, Reggie Bosma, Barbara Zarzycka, منال بنت عبد الله المطيري, Cédric Leyrat, Chris de Graaf, Rob Leurs, Thierry Durroux, Sébastien Granier, Xiaojing Cong, Chérine Bechara	2024	14
5	Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3) ACS Medicinal Chemistry Letters ·李健飞 Li Jianfei, Sarat Ch. Borah, Vera Lúcia Branco Quaresma, Marta Arimont, Meritxell Canals, Mísia Joyner de Sousa Dias Monteiro, Chris de Graaf, Laura E. Kilpatrick, Rob Leurs, Barrie Kellam, Stephen J. Hill, Stephen J. Briddon, Michael J. Stocks	2023	3
6	The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling ACS Pharmacology & Translational Science ·M. Sommer, Jana Selent, Jens Carlsson, Chris de Graaf, David E. Gloriam, György M. Keserű, Mickey Kosloff, Stefan Mordalski, Aurélien Rizk, Mette M. Rosenkilde, Eddy Sotelo, Johanna K. S. Tiemann, Andrew B. Tobin, Nina Vardjan, Maria Waldhoer, Peter Kolb	2020	13
7	The Landscape of Atypical and Eukaryotic Protein Kinases Trends in Pharmacological Sciences ·Georgi K. Kanev, Chris de Graaf, Iwan J. P. de Esch, Rob Leurs, Thomas Würdinger, Bart A. Westerman, Albert J. Kooistra	2019	95
8	Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells Scientific Reports ·Leigh A. Stoddart, Andrea J. Vernall, Uta Jungmann, Reggie Bosma, Albert J. Kooistra, Chris de Graaf, Henry F. Vischer, Rob Leurs, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill	2018	51
9	CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry Biochemical Pharmacology ·Potapova Aa, A. Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, W.J. Weerheijm, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph Rucker, Kurt Vermeire, Tracy M. Handel, Tom Van Loy, Martine J. Smit, Dominique Schols	2018	43
10	Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists European Journal of Medicinal Chemistry ·H.-P Schultheiss, Shan‐Liang Sun, 篤子大澤, Luc Roumen, K. Brask, 玉婷李, Mísia Joyner de Sousa Dias Monteiro, Marta Arimont, Jan Paul Bebelman, Stephen J. Briddon, Carsten Hoffmann, Stephen J. Hill, Martine J. Smit, Henry F. Vischer, Maikel Wijtmans, Chris de Graaf, Iwan J. P. de Esch, Rob Leurs	2018	11
11	Chemical Diversity in the G Protein-Coupled Receptor Superfamily Trends in Pharmacological Sciences ·Márton Vass, Albert J. Kooistra, Dehua Yang, Raymond C. Stevens, Ming-Wei Wang, Chris de Graaf	2018	63
12	Structure and Function of Peptide-Binding G Protein-Coupled Receptors Journal of Molecular Biology ·Fan Wu, Gaojie Song, Chris de Graaf, Raymond C. Stevens	2017	60
13	Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes Pharmacological Reviews ·Chris de Graaf, Daniel J Donnelly, Denise Wootten, Jesper Lau, Patrick M. Sexton, Laurence J. Miller, Jung‐Mo Ahn, Jiayu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair Brown, Caihong Zhou, Jiejie Deng, Mingwei Wang Hit paper breakdown →	2016	288
14	Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H ₁ Receptor Journal of Medicinal Chemistry ·Chris de Graaf, Albert J. Kooistra, Henry F. Vischer, Vsevolod Katritch, Yunchi Han, Mitsunori Shiroishi, So Iwata, Tatsuro Shimamura, Raymond C. Stevens, Iwan J. P. de Esch, Rob Leurs	2011	162
15	: The Pitfalls and Challenges of Predicting GPCR-Ligand Interactions. Pharmaceuticals Policy and Law ·Luc Roumen, F Gerhardt, Bas Vroling, Hsiu-Huang Tsai, Tserendash Tumurkhuu, Rob Leurs, Pedro Bonet Planes, Δημήτριος Κουρέτας, Chris de Graaf	2011	1
16	Molecular Determinants of Selective Agonist and Antagonist Binding to the Histamine H4 Receptor Current Topics in Medicinal Chemistry ·Enade Perdana Istyastono, Chris de Graaf, Iwan J. P. de Esch, Rob Leurs	2011	12
17	Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A Bioorganic & Medicinal Chemistry Letters ·Mark H.P. Verheij, Chris de Graaf, Gerdien E. de Kloe, Saskia Nijmeijer, Henry F. Vischer, Rogier A. Smits, Obbe P. Zuiderveld, Saskia Hulscher, Elmira Roshani Asl, Andrew J. Thompson, Jacqueline E. van Muijlwijk‐Koezen, Sarah C. R. Lummis, Rob Leurs, Iwan J. P. de Esch	2011	24
18	Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations European Biophysics Journal ·Chris de Graaf, Chris Oostenbrink, Peter H. J. Keizers, Barbara M. A. van Vugt‐Lussenburg, Jan N. M. Commandeur, Nico Vermeulen	2007	15
19	The Role and Application of In Silico Docking in Chemical Genomics Research Methods in molecular biology ·Aldo Jongejan, Chris de Graaf, Nico Vermeulen, Rob Leurs, Iwan J. P. de Esch	2005	2
20	Abstracts (Continue in Part I) Chris J.G. Bakker, Chris de Graaf, Weigou Zhang, Roberto Toni, Francisco Estrogildo Costa, H. A. Pedrozo, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown)	1985	1

About Chris de Graaf

Chris de Graaf is a scholar working on Computational Theory and Mathematics, Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology and Radiology, Nuclear Medicine and Imaging, having authored 139 papers that have together received 6.7k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (78 papers), Computational Drug Discovery Methods (48 papers), Neuropeptides and Animal Physiology (35 papers), Chemical Synthesis and Analysis (30 papers), Monoclonal and Polyclonal Antibodies Research (24 papers), Chemokine receptors and signaling (17 papers), Pharmacogenetics and Drug Metabolism (16 papers) and Analytical Chemistry and Chromatography (14 papers). The work is most often cited by research in Computational Theory and Mathematics (1.8k citations), Cellular and Molecular Neuroscience (1.8k citations), Molecular Biology (5.0k citations), Pharmacology (511 citations) and Radiology, Nuclear Medicine and Imaging (881 citations). Chris de Graaf has collaborated with scholars based in Netherlands, United Kingdom and United States. Frequent co-authors include Iwan J. P. de Esch, Rob Leurs, Albert J. Kooistra, Raymond C. Stevens, Nico Vermeulen, Didier Rognan, Miles Congreve, Henry F. Vischer, Luc Roumen and Vsevolod Katritch. Their work appears in journals such as Journal of Medicinal Chemistry, Journal of Chemical Information and Modeling, Molecular Pharmacology, Nature Communications and British Journal of Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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