Alexei Brooun

6.0k total citations · 1 hit paper
37 papers, 3.0k citations indexed

About

Alexei Brooun is a scholar working on Molecular Biology, Oncology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Alexei Brooun has authored 37 papers receiving a total of 3.0k indexed citations (citations by other indexed papers that have themselves been cited), including 29 papers in Molecular Biology, 9 papers in Oncology and 7 papers in Cellular and Molecular Neuroscience. Recurrent topics in Alexei Brooun's work include Protein Kinase Regulation and GTPase Signaling (4 papers), Bacterial Genetics and Biotechnology (4 papers) and Photoreceptor and optogenetics research (3 papers). Alexei Brooun is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (4 papers), Bacterial Genetics and Biotechnology (4 papers) and Photoreceptor and optogenetics research (3 papers). Alexei Brooun collaborates with scholars based in United States, Switzerland and Austria. Alexei Brooun's co-authors include Kim Lewis, Peter Kühn, Songhua Liu, Raymond C. Stevens, Clifford D. Mol, Ruben Abagyan, Ellen Y. T. Chien, Gustavo Fenalti, Peter G. Wells and Vsevolod Katritch and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Alexei Brooun

35 papers receiving 2.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

2010 1.5k citations Beili Wu, Ellen Y. T. Chien et al. Science profile →

Peers

Alexei Brooun

CMN

ONCOL

IMMUN

RNMI

Roger Dawson Switzerland

Erik Procko United States

Minyong Chen United States

Ganesh M. Sathe United States

Karen L. White Australia

N. Burgess-Brown United Kingdom

Brock F. Binkowski United States

Pamela J. Focia United States

Christopher T. Eggers United States

Matthias Müller Germany

Roger Dawson Switzerland

Alexei Brooun

2.4k ×1.1

571 ×0.7

CMN

1.4k ×2.5

ONCOL

142 ×0.4

IMMUN

351 ×0.9

RNMI

Citations per year, relative to Alexei Brooun Alexei Brooun (= 1×) peers Roger Dawson

Countries citing papers authored by Alexei Brooun

Since Specialization

Citations

This map shows the geographic impact of Alexei Brooun's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexei Brooun with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexei Brooun more than expected).

Fields of papers citing papers by Alexei Brooun

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexei Brooun. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexei Brooun. The network helps show where Alexei Brooun may publish in the future.

Co-authorship network of co-authors of Alexei Brooun

This figure shows the co-authorship network connecting the top 25 collaborators of Alexei Brooun. A scholar is included among the top collaborators of Alexei Brooun based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexei Brooun. Alexei Brooun is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Bae, Jae Hyun, et al.. (2025). Abstract 4367: ERAS-4001 is a pan-KRAS inhibitor with robust anti-tumor activity in KRAS altered solid tumors. Cancer Research. 85(8_Supplement_1). 4367–4367.

Zhang, Xin‐Jun, Richard L. Kraus, Vincent P. Santarelli, et al.. (2023). Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels. Proceedings of the National Academy of Sciences. 120(42). e2220029120–e2220029120. 7 indexed citations

Byrne, Noel, et al.. (2023). A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression. Protein Expression and Purification. 215. 106406–106406. 1 indexed citations

Brooun, Alexei, Jingchuan Zhang, Richard Y. Lam, et al.. (2023). The pharmacologic and toxicologic characterization of the potent and selective KRAS G12D inhibitors ERAS-4693 and ERAS-5024. Toxicology and Applied Pharmacology. 474. 116601–116601. 2 indexed citations

Byrne, Noel, John C. Reid, Sung‐Sau So, et al.. (2020). Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy. Protein Expression and Purification. 179. 105796–105796. 6 indexed citations

Long, Yicheng, Ben Bolaños, Wei Liu, et al.. (2017). Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. eLife. 6. 78 indexed citations

Brooun, Alexei, K.S. Gajiwala, Ya‐Li Deng, et al.. (2016). Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nature Communications. 7(1). 11384–11384. 117 indexed citations

Maegley, Karen A., et al.. (2015). Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay the Protein Methyltransferase PRMT5. Assay and Drug Development Technologies. 13(4). 235–240. 10 indexed citations

Love, Robert A., Carol L. Nilsson, Simon Bergqvist, et al.. (2012). Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction. Protein Science. 21(12). 1885–1896. 66 indexed citations

10.

Wu, Beili, Ellen Y. T. Chien, Clifford D. Mol, et al.. (2010). Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 330(6007). 1066–1071. 1462 indexed citations breakdown →

11.

Moore, Cathy D., Haihong Wu, Ben Bolaños, et al.. (2009). Structural and Biophysical Characterization of XIAP BIR3 G306E Mutant: Insights in Protein Dynamics and Application for Fragment‐Based Drug Design. Chemical Biology & Drug Design. 74(3). 212–223. 14 indexed citations

12.

Chrencik, Jill, Alexei Brooun, Hui Zhang, et al.. (2008). Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1. Journal of Molecular Biology. 380(5). 828–843. 49 indexed citations

13.

Chrencik, Jill, Alexei Brooun, Michael I. Recht, et al.. (2007). Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition. Journal of Biological Chemistry. 282(50). 36505–36513. 49 indexed citations

14.

Hanson, Michael A., Alexei Brooun, Kent A. Baker, et al.. (2007). Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expression and Purification. 56(1). 85–92. 34 indexed citations

15.

Chrencik, Jill, Alexei Brooun, Michael I. Recht, et al.. (2006). Structure and Thermodynamic Characterization of the EphB4/Ephrin-B2 Antagonist Peptide Complex Reveals the Determinants for Receptor Specificity. Structure. 14(2). 321–330. 75 indexed citations

16.

Brooun, Alexei, Scott A. Foster, Jill Chrencik, et al.. (2006). Remedial strategies in structural proteomics: Expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expression and Purification. 53(1). 51–62. 7 indexed citations

17.

Chrencik, Jill, Alexei Brooun, Michelle L. Kraus, et al.. (2006). Structural and Biophysical Characterization of the EphB4·EphrinB2 Protein-Protein Interaction and Receptor Specificity. Journal of Biological Chemistry. 281(38). 28185–28192. 79 indexed citations

18.

Ye, Sheng, F. von Delft, Alexei Brooun, et al.. (2003). The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode. Journal of Bacteriology. 185(14). 4144–4151. 41 indexed citations

19.

Brooun, Alexei, Douglas D. Richman, & Richard S. Kornbluth. (2001). HIV-1 Preintegration Complexes Preferentially Integrate into Longer Target DNA Molecules in Solution as Detected by a Sensitive, Polymerase Chain Reaction-based Integration Assay. Journal of Biological Chemistry. 276(50). 46946–46952. 10 indexed citations

20.

Brooun, Alexei, John J. Tomashek, & Kim Lewis. (1999). Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter. Journal of Bacteriology. 181(16). 5131–5133. 68 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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