Tom C. Freeman

20.6k citations

151 papers · 9.2k · 4 hit papers · h-index 51

Impact in

Neurology top 0.5%
- Neuroinflammation and Neurodegeneration Mechanisms
Physiology top 0.5%
- Adenosine and Purinergic Signaling

Papers in

Molecular Biology 74
- Bioinformatics and Genomic Networks 13
- Gene expression and cancer classification 8
- Epigenetics and DNA Methylation 6
Immunology 32
- T-cell and B-cell Immunology 9
- Immune cells in cancer 9
- Immune Cell Function and Interaction 7
- Immune Response and Inflammation 6

Co-authors: J. Kenneth Baillie (6 shared papers)David Hume (15 shared papers)Peter J. Richardson (6 shared papers)Barry W. McColl (3 shared papers)Kim Summers (5 shared papers)Anton J. Enright (5 shared papers)Kathleen Grabert (2 shared papers)Amelie K. Gubitz (2 shared papers)
Journals: BMC Genomics (6 papers)Scientific Reports (5 papers)European Journal of Immunology (4 papers)PLoS ONE (4 papers)Journal of Crohn s and Colitis (4 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

Tom C. Freeman

147 papers receiving 9.0k citations

Tom C. Freeman's Hit Papers

align trajectories log scale

Microglial brain region−dependent diversity and selective regional sensitivities to aging 2016 · 898 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 Nature Neuroscience
2016 PLoS Genetics
1998 Cell
1996 British Journal of Pharmacology

Peers

Countries citing papers authored by Tom C. Freeman

Since Specialization

Citations

This map shows the geographic impact of Tom C. Freeman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tom C. Freeman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tom C. Freeman more than expected).

Fields of papers citing papers by Tom C. Freeman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tom C. Freeman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tom C. Freeman. The network helps show where Tom C. Freeman may publish in the future.

Co-authors

The 25 scholars most cited alongside Tom C. Freeman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tom C. Freeman Line = papers co-authored together Tom C. Freeman links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 151 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Microglial brain region−dependent diversity and selective regional sensitivities to aging Nature Neuroscience ·Kathleen Grabert, Tom Michoel, Michail H. Karavolos, Sara Clohisey, J. Kenneth Baillie, Mark P. Stevens, Tom C. Freeman, Kim Summers, Barry W. McColl Hit paper breakdown →	2016	898
2	Tissue distribution of adenosine receptor mRNAs in the rat British Journal of Pharmacology ·Alistair K. Dixon, Amelie K. Gubitz, D.J.S. Sirinathsinghji, Peter J. Richardson, Tom C. Freeman Hit paper breakdown →	1996	506
3	Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice Cell ·Toby G. Bush, Tor Savidge, Tom C. Freeman, Hilary J. Cox, Elizabeth A. Campbell, Lennart Mucke, Martin H. Johnson, Michael V. Sofroniew Hit paper breakdown →	1998	504
4	Network visualization and analysis of gene expression data using BioLayout Express3D Nature Protocols ·Athanasios Theocharidis, Stjin van Dongen, Anton J. Enright, Tom C. Freeman	2009	327
5	The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9 European Journal of Immunology ·Marc‐André Wurbel, Jean‐Marc Philippe, Catherine Nguyen, Geneviève Victoréro, Tom C. Freeman, Peter Wooding, Arkadiusz Miążek, Marie‐Geneviève Mattéi, Marie Malissen, Bertrand Jordan, Bernard MALISSEN, Alice Carrier, Philippe Naquet	2000	312
6	An expression atlas of human primary cells: inference of gene function from coexpression networks BMC Genomics ·Neil A. Mabbott, J. Kenneth Baillie, Helen Brown, Tom C. Freeman, David Hume	2013	302
7	Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression Breast Cancer Research ·Richard Clarkson, Matthew T. Wayland, Jennifer Lee, Tom C. Freeman, Christine J. Watson	2003	290
8	Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance PLoS Genetics ·R. Roehe, R.J. Dewhurst, Carol-Anne Duthie, John A. Rooke, Nest McKain, D.W. Ross, Jimmy J. Hyslop, A. Waterhouse, Tom C. Freeman, Mick Watson, R. J. Wallace Hit paper breakdown →	2016	265
9	Mapping macrophage polarization over the myocardial infarction time continuum Basic Research in Cardiology ·Alan J. Mouton, Kristine Y. DeLeon‐Pennell, O. J. Gonzalez, Elizabeth R. Flynn, Tom C. Freeman, Jeffrey J. Saucerman, Michael R. Garrett, Yonggang Ma, Romain Harmancey, Merry L. Lindsey	2018	250
10	Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12 Current Biology ·Shuji Takada, Maxine Tevendale, J. Baker, Pantelis Georgiades, Elizabeth A. Campbell, Tom C. Freeman, Martin H. Johnson, Martina Paulsen, Anne C. Ferguson‐Smith	2000	201
11	Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets The Journal of Immunology ·Tim Willinger, Tom C. Freeman, Hitoshi Hasegawa, Andrew J. McMichael, Margaret Callan	2005	187
12	Construction, Visualisation, and Clustering of Transcription Networks from Microarray Expression Data PLoS Computational Biology ·Tom C. Freeman, Leon Goldovsky, Markus Brosch, Stijn van Dongen, Pierre Mazière, Russell Grocock, Shiri Freilich, Janet M. Thornton, Anton J. Enright	2007	184
13	The rumen microbiome as a reservoir of antimicrobial resistance and pathogenicity genes is directly affected by diet in beef cattle Microbiome ·Marc Auffret, R.J. Dewhurst, Carol-Anne Duthie, John A. Rooke, R. J. Wallace, Tom C. Freeman, Robert Stewart, Mick Watson, R. Roehe	2017	146
14	Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo The Journal of Immunology ·Tim Willinger, Tom C. Freeman, Mark Herbert, Hitoshi Hasegawa, Andrew J. McMichael, Margaret Callan	2006	141
15	Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors Cancer Immunology Research ·Ajit J. Nirmal, Tim Regan, Barbara Shih, David Hume, Andrew H. Sims, Tom C. Freeman	2018	137
16	Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis Basic Research in Cardiology ·Alan J. Mouton, Yonggang Ma, O. J. Gonzalez, Michael J. Daseke, Elizabeth R. Flynn, Tom C. Freeman, Michael R. Garrett, Kristine Y. DeLeon‐Pennell, Merry L. Lindsey	2019	131
17	A gene expression atlas of the domestic pig BMC Biology ·Tom C. Freeman, Alasdair Ivens, J. Kenneth Baillie, Dario Beraldi, Mark Barnett, David A. Dorward, Alison Downing, Lynsey Fairbairn, Ronan Kapétanovic, Sobia Raza, Andru Tomoiu, Ramiro Alberio, Chunlei Wu, Andrew I. Su, Kim Summers, Christopher K. Tuggle, Alan Archibald, David Hume	2012	130
18	Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis PLoS ONE ·Diane Rebourcet, Peter J. O’Shaughnessy, Ana Monteiro, Laura Milne, Lyndsey Cruickshanks, N. Weitzel Jeffrey, Florian Guillou, Tom C. Freeman, Rod T. Mitchell, Lee B. Smith	2014	119
19	Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis Development ·Diane Rebourcet, Peter J. O’Shaughnessy, Jean-Luc Pitetti, Ana Monteiro, Laura O’Hara, Laura Milne, Yi Ting Tsai, Lyndsey Cruickshanks, Dieter Riethmacher, Florian Guillou, Rod T. Mitchell, Rob vanʼt Hof, Tom C. Freeman, Serge Nef, Lee B. Smith	2014	118
20	Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance Biochemical Journal ·L. Lescale-Matys, Jane Dyer, D. Scott, Tom C. Freeman, Ernest M. Wright, Soraya P. Shirazi‐Beechey	1993	111

About Tom C. Freeman

Tom C. Freeman is a scholar working on Molecular Biology, Immunology, Genetics, Oncology and Surgery, having authored 151 papers that have together received 9.2k indexed citations. Recurring topics across this work include Bioinformatics and Genomic Networks (13 papers), T-cell and B-cell Immunology (9 papers), Immune cells in cancer (9 papers), Gene expression and cancer classification (8 papers), Neuroinflammation and Neurodegeneration Mechanisms (8 papers), Immune Cell Function and Interaction (7 papers), Epigenetics and DNA Methylation (6 papers) and Immune Response and Inflammation (6 papers). The work is most often cited by research in Neurology (1.2k citations), Physiology (482 citations), Immunology (2.1k citations), Biological Psychiatry (165 citations) and Developmental Neuroscience (260 citations). Tom C. Freeman has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include J. Kenneth Baillie, David Hume, Peter J. Richardson, Barry W. McColl, Kim Summers, Anton J. Enright, Kathleen Grabert, Amelie K. Gubitz, Sara Clohisey and D.J.S. Sirinathsinghji. Their work appears in journals such as BMC Genomics, Scientific Reports, European Journal of Immunology, PLoS ONE and Journal of Crohn s and Colitis.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Tom C. Freeman

Impact in

Papers in i

In The Last Decade

Tom C. Freeman

Tom C. Freeman's Hit Papers

Peers

Countries citing papers authored by Tom C. Freeman

Fields of papers citing papers by Tom C. Freeman

All Works

About Tom C. Freeman

Explore authors with similar magnitude of impact

Papers in