César Milstein

44.8k total citations · 19 hit papers
202 papers, 36.0k citations indexed

About

César Milstein is a scholar working on Radiology, Nuclear Medicine and Imaging, Molecular Biology and Immunology. According to data from OpenAlex, César Milstein has authored 202 papers receiving a total of 36.0k indexed citations (citations by other indexed papers that have themselves been cited), including 139 papers in Radiology, Nuclear Medicine and Imaging, 129 papers in Molecular Biology and 81 papers in Immunology. Recurrent topics in César Milstein's work include Monoclonal and Polyclonal Antibodies Research (139 papers), Glycosylation and Glycoproteins Research (78 papers) and T-cell and B-cell Immunology (61 papers). César Milstein is often cited by papers focused on Monoclonal and Polyclonal Antibodies Research (139 papers), Glycosylation and Glycoproteins Research (78 papers) and T-cell and B-cell Immunology (61 papers). César Milstein collaborates with scholars based in United Kingdom, United States and Argentina. César Milstein's co-authors include Georges Köhler, G. Galfré, Claudia Berek, David S. Secher, Sebastian Howe, A. Claudio Cuello, Michael S. Neuberger, Timothy A. Springer, Greg Winter and Franco Calabi and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

César Milstein

202 papers receiving 32.3k citations

Hit Papers

Continuous cultures of fused cells secreting antibody of ... 1966 2026 1986 2006 1975 1976 1977 1979 1988 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Continuous cultures of fused cells secreting antibody of predefined specificity
    1975 13.0k citations César Milstein et al. Nature profile →
  2. Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion
    1976 1.6k citations César Milstein et al. European Journal of Immunology profile →
  3. Antibodies to major histocompatibility antigens produced by hybrid cell lines
    1977 1.5k citations César Milstein et al. Nature profile →
  4. Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody
    1979 1.0k citations César Milstein et al. European Journal of Immunology profile →
  5. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
    1988 776 citations Claude M. Wischik, César Milstein et al. profile →
  6. Man-made antibodies
    1991 719 citations Greg Winter, César Milstein Nature profile →
  7. Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes
    1977 687 citations César Milstein et al. Cell profile →
  8. Fusion between immunoglobulin‐secreting and nonsecreting myeloma cell lines
    1976 626 citations César Milstein et al. European Journal of Immunology profile →
  9. Detection of substance P in the central nervous system by a monoclonal antibody.
    1979 546 citations A. Claudio Cuello, César Milstein et al. profile →
  10. Mutation Drift and Repertoire Shift in the Maturation of the Immune Response
    1987 546 citations César Milstein et al. Immunological Reviews profile →
  11. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens
    1978 529 citations César Milstein et al. European Journal of Immunology profile →
  12. A Possible Precursor of Immunoglobulin Light Chains
    1972 467 citations César Milstein et al. profile →
  13. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
    1984 457 citations César Milstein et al. Nature profile →
  14. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody
    1979 427 citations César Milstein et al. European Journal of Immunology profile →
  15. Hybrid hybridomas and their use in immunohistochemistry
    1983 398 citations César Milstein, A. Claudio Cuello Nature profile →
  16. Rat × rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG
    1979 336 citations César Milstein et al. Nature profile →
  17. Reshaping Human Antibodies: Grafting an Antilysozyme Activity
    1988 269 citations César Milstein et al. profile →
  18. mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
    1983 259 citations César Milstein et al. Nature profile →
  19. Origin of Antibody Variation
    1966 252 citations César Milstein et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
César Milstein United Kingdom 77 18.4k 17.7k 13.9k 3.4k 2.3k 202 36.0k
Georges Köhler Germany 44 11.1k 0.6× 11.0k 0.6× 10.1k 0.7× 3.1k 0.9× 1.7k 0.7× 97 25.2k
Stuart F. Schlossman United States 99 8.2k 0.4× 10.3k 0.6× 22.1k 1.6× 6.4k 1.9× 1.7k 0.7× 338 35.6k
Ellis L. Reinherz United States 96 9.2k 0.5× 11.1k 0.6× 24.2k 1.7× 5.5k 1.6× 1.6k 0.7× 392 36.0k
Hilary Koprowski United States 105 16.7k 0.9× 8.7k 0.5× 10.1k 0.7× 6.5k 1.9× 5.4k 2.3× 811 41.4k
Sen‐itiroh Hakomori United States 109 34.0k 1.9× 7.7k 0.4× 10.7k 0.8× 3.2k 0.9× 2.1k 0.9× 493 42.9k
Jeffrey V. Ravetch United States 115 15.6k 0.8× 18.4k 1.0× 29.6k 2.1× 7.4k 2.2× 2.0k 0.8× 268 47.2k
Gideon Goldstein United States 72 5.8k 0.3× 6.4k 0.4× 11.7k 0.8× 2.7k 0.8× 1.3k 0.5× 296 22.3k
Dennis A. Carson United States 88 11.4k 0.6× 4.2k 0.2× 11.1k 0.8× 5.7k 1.7× 1.8k 0.8× 467 29.3k
Philippa Marrack United States 119 9.8k 0.5× 8.5k 0.5× 39.8k 2.9× 6.3k 1.9× 4.5k 1.9× 425 51.7k
Max D. Cooper United States 99 7.0k 0.4× 5.6k 0.3× 23.4k 1.7× 2.6k 0.8× 3.6k 1.5× 450 33.6k

Countries citing papers authored by César Milstein

Since Specialization
Citations

This map shows the geographic impact of César Milstein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by César Milstein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites César Milstein more than expected).

Fields of papers citing papers by César Milstein

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by César Milstein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by César Milstein. The network helps show where César Milstein may publish in the future.

Co-authorship network of co-authors of César Milstein

This figure shows the co-authorship network connecting the top 25 collaborators of César Milstein. A scholar is included among the top collaborators of César Milstein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with César Milstein. César Milstein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Calabi, Franco & César Milstein. (2000). The molecular biology of CD1. Seminars in Immunology. 12(6). 503–509. 26 indexed citations
2.
Milstein, César & Herman Waldmann. (1999). Optimism after much pessimism: what next?. Current Opinion in Immunology. 11(5). 589–591. 16 indexed citations
3.
Aoufouchi, Saïd, José Yélamos, & César Milstein. (1999). Inhibition of apoptosis of a PARP−/− cell line transfected with PARP DNA-binding domain mutants. Journal of Molecular Biology. 290(5). 943–949. 7 indexed citations
4.
Neuberger, Michael S., Michael R. Ehrenstein, Norman Klix, et al.. (1998). Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunological Reviews. 162(1). 107–116. 102 indexed citations
5.
Goyenechea, Beatriz, Norman Klix, José Yélamos, et al.. (1997). Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. The EMBO Journal. 16(13). 3987–3994. 93 indexed citations
6.
Betz, Alexander G., Michael S. Neuberger, & César Milstein. (1993). Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes. Immunology Today. 14(8). 405–411. 202 indexed citations
7.
Milstein, César, Jos Even, John M. Jarvis, África González‐Fernández, & Ermanno Gherardi. (1992). Non‐random features of the repertoire expressed by the members of one Vx gene family and of the V‐J recombination. European Journal of Immunology. 22(6). 1627–1634. 26 indexed citations
8.
Mena, Raúl, Claude M. Wischik, Michal Novák, César Milstein, & A. Claudio Cuello. (1991). A Progressive Deposition of Paired Helical Filaments (PHF) in the Brain Characterizes the Evolution of Dementia in Alzheimerʼs Disease.. Journal of Neuropathology & Experimental Neurology. 50(4). 474–490. 45 indexed citations
9.
Gherardi, Ermanno, et al.. (1991). Colony assays for antibody fragments expressed in bacteria. Journal of Immunological Methods. 139(2). 197–205. 35 indexed citations
10.
Winter, Greg & César Milstein. (1991). Man-made antibodies. Nature. 349(6307). 293–299. 719 indexed citations breakdown →
11.
Foote, Jefferson & César Milstein. (1991). Kinetic maturation of an immune response. Nature. 352(6335). 530–532. 236 indexed citations
12.
Milstein, César. (1990). The Croonian Lecture, 1989 Antibodies: a paradigm for the biology of molecular recognition. Proceedings of the Royal Society of London. Series B, Biological sciences. 239(1294). 1–16. 24 indexed citations
13.
Sitia, Roberto, Michael S. Neuberger, Cristina M. Alberini, et al.. (1990). Developmental regulation of IgM secretion: The role of the carboxy-terminal cysteine. Cell. 60(5). 781–790. 214 indexed citations
14.
Calabi, Franco, John M. Jarvis, Luis Martin, & César Milstein. (1989). Two classes of CD1 genes. European Journal of Immunology. 19(2). 285–292. 225 indexed citations
15.
Calabi, Franco, Katharina Belt, C. Yung Yu, et al.. (1989). The rabbitCD1 and the evolutionary conservation of theCD1 gene family. Immunogenetics. 30(5). 370–377. 51 indexed citations
16.
Girdlestone, John & César Milstein. (1988). Differential expression and interferon response of HLA class I genes in thymocyte lines and response variants. European Journal of Immunology. 18(1). 139–143. 30 indexed citations
17.
Milstein, César. (1982). General motors cancer research foundation awards. Cancer. 49(10). 1953–1957. 10 indexed citations
18.
Milstein, César. (1981). The Wellcome Foundation Lecture, 1980 - Monoclonal antibodies from hybrid myelomas. Proceedings of the Royal Society of London. Series B, Biological sciences. 211(1185). 393–412. 25 indexed citations
19.
Cohen, S. & César Milstein. (1967). Structure and biological properties of immunoglobulins. Advances in immunology. 7. 1–89. 128 indexed citations
20.
Crick, Francis, Leroy Hood, O. Smithies, et al.. (1967). General Discussion on Theories of Antibody Variability. Cold Spring Harbor Symposia on Quantitative Biology. 32(0). 169–172. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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