Richard O. Hynes

99.3k citations

365 papers · 73.6k indexed · 36 hit papers · h-index 132

Molecular Biology top 0.02%
Immunology and Allergy top 0.01%
Cell Biology top 0.01%
Immunology top 0.05%
Cancer Research top 0.02%

Co-authors: Helen Rayburn Alexandra Naba Denisa D. Wagner Jack Lawler John W. Tamkun Kenneth M. Yamada Joy T. Yang Antonia T. Destree
Topics: Cell Adhesion Molecules Research (217 papers)Cellular Mechanics and Interactions (66 papers)Protease and Inhibitor Mechanisms (55 papers)
Cited by: Immunology and Allergy Cell Biology Cancer Research
Journals: Nature Science Cell
Partner nations: United States United Kingdom France

In The Last Decade

Richard O. Hynes

362 papers receiving 71.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 8.4k citations Richard O. Hynes profile →
Integrins

2002 6.9k citations Richard O. Hynes profile →
Complete Replication of Hepatitis C Virus in Cell Culture

2005 1.9k citations Brett D. Lindenbach, Matthew J. Evans et al. Science profile →
Genomic analysis of metastasis reveals an essential role for RhoC

2000 1.2k citations Richard O. Hynes et al. Nature profile →
Fibronectins: multifunctional modular glycoproteins.

1982 1.2k citations Richard O. Hynes et al. profile →
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 1.0k citations Richard O. Hynes et al. profile →
Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 961 citations Richard O. Hynes et al. profile →
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

2011 903 citations Alexandra Naba, Karl R. Clauser et al. profile →
Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

2011 892 citations Richard O. Hynes, Alexandra Naba profile →
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 883 citations Richard O. Hynes et al. profile →
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 768 citations Richard O. Hynes et al. profile →
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 734 citations Richard O. Hynes et al. Nature profile →
The extracellular matrix: Tools and insights for the “omics” era

2015 729 citations Alexandra Naba, Karl R. Clauser et al. profile →
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 687 citations Richard O. Hynes et al. profile →
Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 660 citations Richard O. Hynes et al. profile →
Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 629 citations Richard O. Hynes et al. profile →
Cell surface proteins and malignant transformation

1976 626 citations Richard O. Hynes profile →
Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere

2002 592 citations Charles A. Whittaker, Richard O. Hynes profile →
β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 591 citations Denise Crowley, Richard O. Hynes et al. profile →
Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 586 citations Richard O. Hynes et al. profile →
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

2002 583 citations Richard O. Hynes et al. profile →
Embryonic mesodermal defects in α5 integrin-deficient mice

1993 582 citations Richard O. Hynes et al. profile →
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

1999 579 citations Richard O. Hynes et al. profile →
Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis

1973 574 citations Richard O. Hynes Proceedings of the National Academy of Sciences profile →
Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

2000 563 citations Richard O. Hynes et al. profile →
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 542 citations Richard O. Hynes et al. profile →
Self-complementary oligopeptide matrices support mammalian cell attachment

1995 540 citations Richard O. Hynes et al. profile →
Molecular Biology of Fibronectin

1985 539 citations Richard O. Hynes profile →
Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 516 citations Denise Crowley, Richard O. Hynes et al. profile →
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 513 citations Richard O. Hynes et al. profile →
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 505 citations Richard O. Hynes et al. profile →
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 502 citations Richard O. Hynes et al. profile →
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

2012 466 citations John M. Lamar, Patrick Stern et al. Proceedings of the National Academy of Sciences profile →
Platelets guide the formation of early metastatic niches

2014 423 citations Shahinoor Begum, Richard O. Hynes et al. Proceedings of the National Academy of Sciences profile →
10 nm filaments in normal and transformed cells

1978 415 citations Richard O. Hynes et al. profile →
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

2019 291 citations Chenxi Tian, Karl R. Clauser et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Richard O. Hynes

Since Specialization

Citations

This map shows the geographic impact of Richard O. Hynes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard O. Hynes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard O. Hynes more than expected).

Fields of papers citing papers by Richard O. Hynes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard O. Hynes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard O. Hynes. The network helps show where Richard O. Hynes may publish in the future.

Co-authorship network of co-authors of Richard O. Hynes

This figure shows the co-authorship network connecting the top 25 collaborators of Richard O. Hynes. A scholar is included among the top collaborators of Richard O. Hynes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard O. Hynes. Richard O. Hynes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases 2023 ·Cancer Research ·Noor Jailkhani,Karl R. Clauser,(unknown),Steffen Rickelt,Chenxi Tian,Charles A. Whittaker,Kenneth K. Tanabe,(unknown),Steven A. Carr,Richard O. Hynes	15
2	Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches 2020 ·Cancer Research ·Jess D. Hebert,Samuel A. Myers,Alexandra Naba,Genevieve Abbruzzese,John M. Lamar,Steven A. Carr,Richard O. Hynes	90
3	Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma 2020 ·Cancer Research ·Chenxi Tian,Daniel Öhlund,Steffen Rickelt,(unknown),Ying Huang,Liangliang Hao,Renee T. Zhao,Oskar Franklin,Sangeeta N. Bhatia,David A. Tuveson,Richard O. Hynes	128
4	Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions 2019 ·Clinical Cancer Research ·Steffen Rickelt,(unknown),Miyeko Mana,Charles A. Whittaker,Christina Pfirschke,Jatin Roper,Deepa T. Patil,Ian Brown,Anthony R. Mattia,Lawrence Zukerberg,Qing Zhao,Runjan Chetty,Gregory Y. Lauwers,Azfar Neyaz,Lieve G.J. Leijssen,(unknown),Ömer Yılmaz,Vikram Deshpande,Richard O. Hynes	11
5	Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice 2019 ·Proceedings of the National Academy of Sciences ·Yushu Joy Xie,Michael Dougan,Noor Jailkhani,Jessica R. Ingram,Tao Fang,Laura Kummer,Noor Momin,Novalia Pishesha,Steffen Rickelt,Richard O. Hynes,Hidde L. Ploegh	234
6	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression 2017 ·Nature ·Karl R. Clauser,D.R. Mani,Steven A. Carr,Alexandra Naba,Richard O. Hynes	1
7	Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways 2016 ·Cancer Research ·Ran Li,Jess D. Hebert,(unknown),Hao Xing,Alexandra Boussommier-Calleja,Richard O. Hynes,Douglas A. Lauffenburger,Roger D. Kamm	78
8	Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression 2016 ·Cancer Discovery ·Madeleine J. Oudin,Oliver Jonas,Tatsiana Kosciuk,Liliane C. Broye,Bruna C. Guido,Jeff Wyckoff,Daisy Riquelme,John M. Lamar,Sreeja B. Asokan,Charles A. Whittaker,Duanduan Ma,Róbert Langer,Michael J. Cima,Kari B. Wisinski,Richard O. Hynes,Douglas A. Lauffenburger,Patricia J. Keely,James E. Bear,Frank B. Gertler	155
9	Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade 2016 ·Cancer Research ·Michelle B. Chen,John M. Lamar,Ran Li,Richard O. Hynes,Roger D. Kamm	133
10	A Quantitative System for Studying Metastasis Using Transparent Zebrafish 2015 ·Cancer Research ·Silja Heilmann,Kajan Ratnakumar,Erin M. Langdon,Emily R. Kansler,Isabella S. Kim,Nathaniel R. Campbell,Elizabeth B. Perry,Amy McMahon,Charles K. Kaufman,Ellen van Rooijen,William Lee,Christine A. Iacobuzio–Donahue,Richard O. Hynes,Leonard I. Zon,João B. Xavier,Richard M. White	84
11	GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression 2011 ·Cancer Research ·Liquan Yang,Guangchun Chen,(unknown),Glynis Scott,Fabeha Fazal,Arshad Rahman,Shahinoor Begum,Richard O. Hynes,Lei Xu	3
12	CUB-domain–containing protein 1 (CDCP1) activates Src to promote melanoma metastasis 2011 ·Proceedings of the National Academy of Sciences ·Hui Liu,Shao‐En Ong,Kwabena Badu-Nkansah,Jeffrey W. Schindler,Forest M. White,Richard O. Hynes	79
13	Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors 2009 ·Cancer Research ·Olga Sobolev,Patrick Stern,Adam Lacy‐Hulbert,Richard O. Hynes	14
14	Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases 2008 ·Molecular Cancer Research ·Lei Xu,Steven S. Shen,Yujin Hoshida,Aravind Subramanian,Ken N. Ross,(unknown),Stephan N. Wagner,Sridhar Ramaswamy,Jill P. Mesirov,Richard O. Hynes	195
15	Abstract 2007 ·Journal of Thrombosis and Haemostasis ·Richard O. Hynes	0
16	GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis 2006 ·Proceedings of the National Academy of Sciences ·Lei Xu,Shahinoor Begum,(unknown),Richard O. Hynes	227
17	Fibrinogen and von Willebrand factor‐independent platelet aggregation in vitro and in vivo 2006 ·Journal of Thrombosis and Haemostasis ·Hai-Ling Yang,Reheman Adili,(unknown),Guangheng Zhu,Richard O. Hynes,John Freedman,Denisa D. Wagner,Heyu Ni	80
18	Complete Replication of Hepatitis C Virus in Cell Culturebreakdown → 2005 ·Science ·Brett D. Lindenbach,Matthew J. Evans,Andrew J. Syder,Benno Wölk,Timothy L. Tellinghuisen,(unknown),Toshiaki Maruyama,Richard O. Hynes,Dennis R. Burton,Jane A. McKeating,Charles M. Rice	1850
19	Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis 2005 ·Cancer Research ·Sunny Y. Wong,Herbert Haack,Denise Crowley,Marc Barry,Roderick T. Bronson,Richard O. Hynes	129
20	Plasma fibronectin promotes thrombus growth and stability in injured arterioles 2003 ·Proceedings of the National Academy of Sciences ·Heyu Ni,Peter S.T. Yuen,(unknown),Jane E. Trevithick,Takao Sakai,Reinhard Fässler,Richard O. Hynes,Denisa D. Wagner	165

About Richard O. Hynes

Richard O. Hynes is a scholar working on Immunology and Allergy, Cell Biology and Cancer Research, having authored 365 papers that have together received 73.6k indexed citations. Recurring topics across this work include Cell Adhesion Molecules Research (217 papers), Cellular Mechanics and Interactions (66 papers) and Protease and Inhibitor Mechanisms (55 papers). The work is most often cited by research in Immunology and Allergy (31.3k citations), Cell Biology (18.6k citations) and Cancer Research (11.4k citations). Richard O. Hynes has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Helen Rayburn, Alexandra Naba, Denisa D. Wagner, Jack Lawler, John W. Tamkun, Kenneth M. Yamada, Joy T. Yang, Antonia T. Destree, Charles A. Whittaker and Jun‐Lin Guan. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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