Richard O. Hynes

99.3k total citations · 36 hit papers
365 papers, 73.6k citations indexed

About

Richard O. Hynes is a scholar working on Immunology and Allergy, Molecular Biology and Cell Biology. According to data from OpenAlex, Richard O. Hynes has authored 365 papers receiving a total of 73.6k indexed citations (citations by other indexed papers that have themselves been cited), including 217 papers in Immunology and Allergy, 172 papers in Molecular Biology and 95 papers in Cell Biology. Recurrent topics in Richard O. Hynes's work include Cell Adhesion Molecules Research (217 papers), Cellular Mechanics and Interactions (66 papers) and Protease and Inhibitor Mechanisms (55 papers). Richard O. Hynes is often cited by papers focused on Cell Adhesion Molecules Research (217 papers), Cellular Mechanics and Interactions (66 papers) and Protease and Inhibitor Mechanisms (55 papers). Richard O. Hynes collaborates with scholars based in United States, United Kingdom and France. Richard O. Hynes's co-authors include Helen Rayburn, Alexandra Naba, Denisa D. Wagner, Jack Lawler, John W. Tamkun, Kenneth M. Yamada, Joy T. Yang, Antonia T. Destree, Charles A. Whittaker and Jun‐Lin Guan and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Richard O. Hynes

362 papers receiving 71.2k citations

Hit Papers

Integrins: Versatility, m... 1973 2026 1990 2008 1992 2002 2005 2000 1982 2.5k 5.0k 7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Integrins: Versatility, modulation, and signaling in cell adhesion
    1992 8.4k citations Richard O. Hynes profile →
  2. Integrins
    2002 6.9k citations Richard O. Hynes profile →
  3. Complete Replication of Hepatitis C Virus in Cell Culture
    2005 1.9k citations Brett D. Lindenbach, Matthew J. Evans et al. Science profile →
  4. Genomic analysis of metastasis reveals an essential role for RhoC
    2000 1.2k citations Richard O. Hynes et al. profile →
  5. Fibronectins: multifunctional modular glycoproteins.
    1982 1.2k citations Richard O. Hynes et al. profile →
  6. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
    1993 1.0k citations Richard O. Hynes et al. profile →
  7. Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo
    1998 961 citations Richard O. Hynes et al. profile →
  8. The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
    2011 903 citations Alexandra Naba, Steven A. Carr et al. profile →
  9. Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
    2011 892 citations Richard O. Hynes, Alexandra Naba profile →
  10. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    1993 883 citations Richard O. Hynes et al. profile →
  11. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons
    1992 768 citations Richard O. Hynes et al. profile →
  12. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
    1999 734 citations Richard O. Hynes et al. profile →
  13. The extracellular matrix: Tools and insights for the “omics” era
    2015 729 citations Alexandra Naba, Charles A. Whittaker et al. profile →
  14. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin
    1986 687 citations Richard O. Hynes et al. profile →
  15. Three different fibronectin mRNAs arise by alternative splicing within the coding region
    1983 660 citations Richard O. Hynes et al. profile →
  16. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development
    1995 629 citations Richard O. Hynes et al. profile →
  17. Cell surface proteins and malignant transformation
    1976 626 citations Richard O. Hynes profile →
  18. Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere
    2002 592 citations Charles A. Whittaker, Richard O. Hynes profile →
  19. β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    1999 591 citations Denise Crowley, Richard O. Hynes et al. profile →
  20. Developmental Defects in Mouse Embryos Lacking N-Cadherin
    1997 586 citations Richard O. Hynes et al. profile →
  21. CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism
    2002 583 citations Richard O. Hynes et al. profile →
  22. Embryonic mesodermal defects in α5 integrin-deficient mice
    1993 582 citations Richard O. Hynes et al. profile →
  23. The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation
    1999 579 citations Richard O. Hynes et al. profile →
  24. Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis
    1973 574 citations Richard O. Hynes Proceedings of the National Academy of Sciences profile →
  25. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
    2000 563 citations Richard O. Hynes et al. profile →
  26. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1
    1990 542 citations Richard O. Hynes et al. profile →
  27. Self-complementary oligopeptide matrices support mammalian cell attachment
    1995 540 citations Richard O. Hynes et al. profile →
  28. Molecular Biology of Fibronectin
    1985 539 citations Richard O. Hynes profile →
  29. Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins
    1998 516 citations Denise Crowley, Richard O. Hynes et al. profile →
  30. Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases
    1998 513 citations Richard O. Hynes et al. profile →
  31. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.
    1986 505 citations Richard O. Hynes et al. profile →
  32. Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
    2002 502 citations Richard O. Hynes et al. profile →
  33. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
    2012 466 citations John M. Lamar, Patrick Stern et al. Proceedings of the National Academy of Sciences profile →
  34. Platelets guide the formation of early metastatic niches
    2014 423 citations Shahinoor Begum, Richard O. Hynes et al. Proceedings of the National Academy of Sciences profile →
  35. 10 nm filaments in normal and transformed cells
    1978 415 citations Richard O. Hynes et al. profile →
  36. Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells
    2019 291 citations Chenxi Tian, Daniel Öhlund et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Richard O. Hynes United States 132 33.4k 31.3k 18.6k 11.8k 11.4k 365 73.6k
Erkki Ruoslahti United States 152 43.8k 1.3× 31.7k 1.0× 18.7k 1.0× 9.2k 0.8× 13.2k 1.2× 466 91.3k
Kenneth M. Yamada United States 140 28.8k 0.9× 24.4k 0.8× 25.4k 1.4× 5.9k 0.5× 9.3k 0.8× 701 71.9k
David A. Cheresh United States 109 28.3k 0.8× 18.3k 0.6× 7.6k 0.4× 6.5k 0.6× 10.6k 0.9× 245 48.7k
Rupert Timpl Germany 124 20.4k 0.6× 22.7k 0.7× 14.4k 0.8× 4.2k 0.4× 8.3k 0.7× 526 49.4k
Timothy A. Springer United States 153 26.0k 0.8× 43.0k 1.4× 10.6k 0.6× 43.4k 3.7× 4.8k 0.4× 536 91.5k
Mark H. Ginsberg United States 108 16.5k 0.5× 21.4k 0.7× 12.8k 0.7× 6.2k 0.5× 3.9k 0.3× 359 41.6k
Judah Folkman United States 141 62.8k 1.9× 10.9k 0.3× 10.0k 0.5× 8.3k 0.7× 29.5k 2.6× 395 105.2k
Zena Werb United States 151 45.6k 1.4× 12.3k 0.4× 11.5k 0.6× 18.5k 1.6× 33.6k 2.9× 416 110.4k
Joan S. Brugge United States 111 25.6k 0.8× 7.4k 0.2× 9.5k 0.5× 5.2k 0.4× 5.1k 0.4× 259 41.9k
Martin A. Schwartz United States 107 22.6k 0.7× 12.4k 0.4× 19.2k 1.0× 4.4k 0.4× 4.0k 0.3× 409 46.8k

Countries citing papers authored by Richard O. Hynes

Since Specialization
Citations

This map shows the geographic impact of Richard O. Hynes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard O. Hynes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard O. Hynes more than expected).

Fields of papers citing papers by Richard O. Hynes

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard O. Hynes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard O. Hynes. The network helps show where Richard O. Hynes may publish in the future.

Co-authorship network of co-authors of Richard O. Hynes

This figure shows the co-authorship network connecting the top 25 collaborators of Richard O. Hynes. A scholar is included among the top collaborators of Richard O. Hynes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard O. Hynes. Richard O. Hynes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Tian, Chenxi, Daniel Öhlund, Steffen Rickelt, et al.. (2020). Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer Research. 80(7). 1461–1474. 128 indexed citations
2.
Hebert, Jess D., Samuel A. Myers, Alexandra Naba, et al.. (2020). Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Cancer Research. 80(7). 1475–1485. 90 indexed citations
3.
Rickelt, Steffen, Miyeko Mana, Charles A. Whittaker, et al.. (2019). Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. Clinical Cancer Research. 26(6). 1277–1287. 11 indexed citations
4.
Li, Ran, Jess D. Hebert, Hao Xing, et al.. (2016). Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Research. 77(2). 279–290. 78 indexed citations
5.
Oudin, Madeleine J., Oliver Jonas, Tatsiana Kosciuk, et al.. (2016). Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression. Cancer Discovery. 6(5). 516–531. 155 indexed citations
6.
Chen, Michelle B., John M. Lamar, Ran Li, Richard O. Hynes, & Roger D. Kamm. (2016). Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade. Cancer Research. 76(9). 2513–2524. 133 indexed citations
7.
Hebert, Jess D., Alexandra Boussommier-Calleja, Richard O. Hynes, et al.. (2016). Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. DSpace@MIT (Massachusetts Institute of Technology). 22 indexed citations
8.
Heilmann, Silja, Kajan Ratnakumar, Erin M. Langdon, et al.. (2015). A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Research. 75(20). 4272–4282. 84 indexed citations
9.
Yang, Liquan, Guangchun Chen, Glynis Scott, et al.. (2011). GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Research. 71(16). 5558–5568. 3 indexed citations
10.
Liu, Hui, Shao‐En Ong, Kwabena Badu-Nkansah, et al.. (2011). CUB-domain–containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proceedings of the National Academy of Sciences. 108(4). 1379–1384. 79 indexed citations
11.
Xu, Lei, Shahinoor Begum, Marc Barry, et al.. (2010). GPR56 Plays varying roles in endogenous cancer progression. Clinical & Experimental Metastasis. 27(4). 241–249. 2 indexed citations
12.
Sobolev, Olga, Patrick Stern, Adam Lacy‐Hulbert, & Richard O. Hynes. (2009). Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors. Cancer Research. 69(6). 2531–2539. 14 indexed citations
13.
Xu, Lei, Steven S. Shen, Yujin Hoshida, et al.. (2008). Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases. Molecular Cancer Research. 6(5). 760–769. 195 indexed citations
14.
Hynes, Richard O.. (2007). Abstract. Journal of Thrombosis and Haemostasis. 5. PLEN–M3.
15.
Lacy‐Hulbert, Adam, Aileen M. Smith, Hamid Tissire, et al.. (2007). Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins. Proceedings of the National Academy of Sciences. 104(40). 15823–15828. 181 indexed citations
16.
Xu, Lei & Richard O. Hynes. (2007). GPR56 and TG2: Possible Roles in Suppression of Tumor Growth by the Microenvironment. Cell Cycle. 6(2). 160–165. 45 indexed citations
17.
Xu, Lei, et al.. (2006). GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proceedings of the National Academy of Sciences. 103(24). 9023–9028. 227 indexed citations
18.
Lindenbach, Brett D., Matthew J. Evans, Andrew J. Syder, et al.. (2005). Complete Replication of Hepatitis C Virus in Cell Culture. Science. 309(5734). 623–626. 1850 indexed citations breakdown →
19.
Wong, Sunny Y., Herbert Haack, Denise Crowley, et al.. (2005). Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis. Cancer Research. 65(21). 9789–9798. 129 indexed citations
20.
Ni, Heyu, Peter S.T. Yuen, Jane E. Trevithick, et al.. (2003). Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proceedings of the National Academy of Sciences. 100(5). 2415–2419. 165 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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