Thomas R. Cech

51.5k citations

354 papers · 40.1k indexed · 21 hit papers · h-index 105

Impact in

Aging top 0.05%
Molecular Biology top 0.02%
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery

Papers in

Molecular Biology 326
- RNA and protein synthesis mechanisms 176
- RNA modifications and cancer 133
- RNA Research and Splicing 67
- Advanced biosensing and bioanalysis techniques 61
- DNA and Nucleic Acid Chemistry 45
- DNA Repair Mechanisms 43
Physiology 105
- Telomeres, Telomerase, and Senescence 104

Co-authors: Arthur J. Zaug Elaine R. Podell Joachim Lingner Peter Baumann Paula J. Grabowski Toru Nakamura Anne R. Gooding Daniel Herschlag
Journals: Biochemistry (42 papers)Cell (32 papers)Science (30 papers)Nucleic Acids Research (29 papers)Proceedings of the National Academy of Sciences (25 papers)
Partner nations: United States United Kingdom Australia

In The Last Decade

Thomas R. Cech

351 papers receiving 39.1k citations

Hit Papers

15 papers align trajectories log scale

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization 2021 · 172 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2021 Nature Reviews Molecular Cell Biology
2017 Science Advances
2016 Cell
2007 Nature
2002 Nature
2001 Science
1997 Science
1997 Science
1996 Science
1991 Nature
1989 Science
1988 Gene
1987 Science
1987 Nucleic Acids Research
1986 Science
1986 Annual Review of Biochemistry
1986 Cell
1986 Annual Review of Biochemistry
1985 Proceedings of the National Academy of Sciences
1982 Cell
1981 Cell

Peers

Countries citing papers authored by Thomas R. Cech

Since Specialization

Citations

This map shows the geographic impact of Thomas R. Cech's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas R. Cech with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas R. Cech more than expected).

Fields of papers citing papers by Thomas R. Cech

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas R. Cech. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas R. Cech. The network helps show where Thomas R. Cech may publish in the future.

Co-authors

The 25 scholars most cited alongside Thomas R. Cech, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas R. Cech Line = papers co-authored together Thomas R. Cech links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication Nucleic Acids Research ·Guanhui Wu, 吴卓颐 Wu Zhuoyi, Daniel T. Youmans, Nausica Arnoult, Thomas R. Cech	2025	0
2	POT1 recruits and regulates CST-Polα/primase at human telomeres Cell ·J Landois, Hiroyuki Takai, Arthur J. Zaug, 中田雅弘, Thomas R. Cech, Thomas Walz, Titia de Lange	2024	8
3	Structural basis for inactivation of PRC2 by G-quadruplex RNA Science ·H K Nakayama, Anne R. Gooding, Raagini Jawa, Ronald Rye, Anne L. Robertson, Kemal Akbar Muharam, Leonard I. Zon, Trista E. North, Vignesh Kasinath, Thomas R. Cech	2023	43
4	Reconstitution of a telomeric replicon organized by CST Nature ·Arthur J. Zaug, Karen J. Goodrich, Marco Monari, Cinthya Ivonne Mota Hernández, Thomas R. Cech	2022	35
5	CST does not evict elongating telomerase but prevents initiation by ssDNA binding Nucleic Acids Research ·Arthur J. Zaug, Ci Ji Lim, 项文新, 文春傑, Karen J. Goodrich, Deborah S. Wuttke, Thomas R. Cech	2021	22
6	Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers Molecular Cancer Research ·Josh Lewis Stern, Grace N. Hibshman, Kevin Hu, 恒男小池, James C. Costello, William Kim, Pablo Tamayo, Thomas R. Cech, Franklin W. Huang	2020	20
7	The structure of human CST reveals a decameric assembly bound to telomeric DNA Science ·Ci Ji Lim, Shuang Liang, Arthur J. Zaug, Karen J. Goodrich, Fernando Crespo Díaz, Deborah S. Wuttke, Thomas R. Cech	2020	68
8	Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines Proceedings of the National Academy of Sciences ·Teisha J. Rowland, Gabrijela Dumbović, Yuichi Jono, John L. Rinn, Thomas R. Cech	2019	30
9	Regulation of histone methylation by automethylation of PRC2 Genes & Development ·Xueyin Wang, Yicheng Long, Richard D. Paucek, Anne R. Gooding, Thomas Lee, Brett F. Mayhew, Thomas R. Cech	2019	56
10	Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2 eLife ·Yicheng Long, Ben Bolaños, Brenda Letícia Andrade de Melo Maia, Wei Liu, Karen J. Goodrich, Xin Yang, Siming Chen, Anne R. Gooding, Karen A. Maegley, K.S. Gajiwala, Alexei Brooun, Thomas R. Cech, Xin Liu	2017	78
11	Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects Nature Structural & Molecular Biology ·Siddharth Shukla, Jens C. Schmidt, Katherine C. Goldfarb, Thomas R. Cech, Roy Parker	2016	88
12	Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT Nucleic Acids Research ·Linghe Xi, Thomas R. Cech	2014	106
13	Many disease-associated variants of hTERT retain high telomerase enzymatic activity Nucleic Acids Research ·Arthur J. Zaug, Sharon M. Crary, Lauren Barry, 学白石, Thomas R. Cech	2013	56
14	RNA worlds : from life's origins to diversity in gene regulation John F. Atkins, Raymond F. Gesteland, Thomas R. Cech	2011	84
15	Yeast telomerase RNA: A flexible scaffold for protein subunits Proceedings of the National Academy of Sciences ·David C. Zappulla, Thomas R. Cech	2004	180
16	Sharing Publication-Related Data and Materials: Responsibilities of Authorship in the Life Sciences PLANT PHYSIOLOGY ·Thomas R. Cech, Sean R. Eddy, David Eisenberg, Karen Hersey, J. Rudis-jicinsky, George Poste, Natasha V. Raikhel, Richard H. Scheller, Feilong Dong, A Mathiot, (unknown)	2003	92
17	Evolution of Tetrahymena ribozyme mutants with increased structural stability Nature Structural Biology ·Feng Guo, Thomas R. Cech	2002	36
18	13 Building a Catalytic Active Site Using Only RNA Cold Spring Harbor Monograph Archive ·Thomas R. Cech, Barbara L. Golden	1999	11
19	4 Telomere Proteins Cold Spring Harbor Monograph Archive ·Guowei Fang, Thomas R. Cech	1995	2
20	11 Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P Cold Spring Harbor Monograph Archive ·Thomas R. Cech	1993	70

About Thomas R. Cech

Thomas R. Cech is a scholar working on Molecular Biology, Physiology, Aging, Ecology and Parasitology, having authored 354 papers that have together received 40.1k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (176 papers), RNA modifications and cancer (133 papers), Telomeres, Telomerase, and Senescence (104 papers), RNA Research and Splicing (67 papers), Advanced biosensing and bioanalysis techniques (61 papers), Bacteriophages and microbial interactions (56 papers), DNA and Nucleic Acid Chemistry (45 papers) and DNA Repair Mechanisms (43 papers). The work is most often cited by research in Aging (1.6k citations), Molecular Biology (35.3k citations), Physiology (10.9k citations), Ecology (3.7k citations) and Cancer Research (2.2k citations). Thomas R. Cech has collaborated with scholars based in United States, United Kingdom and Australia. Frequent co-authors include Arthur J. Zaug, Elaine R. Podell, Joachim Lingner, Peter Baumann, Paula J. Grabowski, Toru Nakamura, Anne R. Gooding, Daniel Herschlag, Jennifer A. Doudna and Brenda Bass. Their work appears in journals such as Biochemistry, Cell, Science, Nucleic Acids Research and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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