Titia de Lange

51.9k total citations · 24 hit papers
180 papers, 38.8k citations indexed

About

Titia de Lange is a scholar working on Molecular Biology, Physiology and Plant Science. According to data from OpenAlex, Titia de Lange has authored 180 papers receiving a total of 38.8k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Molecular Biology, 136 papers in Physiology and 29 papers in Plant Science. Recurrent topics in Titia de Lange's work include Telomeres, Telomerase, and Senescence (136 papers), DNA Repair Mechanisms (97 papers) and CRISPR and Genetic Engineering (38 papers). Titia de Lange is often cited by papers focused on Telomeres, Telomerase, and Senescence (136 papers), DNA Repair Mechanisms (97 papers) and CRISPR and Genetic Engineering (38 papers). Titia de Lange collaborates with scholars based in United States, Netherlands and United Kingdom. Titia de Lange's co-authors include Agata Smogorzewska, Bas van Steensel, Wilhelm Palm, Hiroyuki Takai, Dominique Broccoli, Jan Karlseder, Agnel Sfeir, Eros Lazzerini Denchi, Alessandro Bianchi and Giulia Celli and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Titia de Lange

178 papers receiving 38.2k citations

Hit Papers

Shelterin: the protein co... 1987 2026 2000 2013 2005 1999 1998 2008 2003 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Shelterin: the protein complex that shapes and safeguards human telomeres
    2005 2.3k citations Titia de Lange Genes & Development profile →
  2. Mammalian Telomeres End in a Large Duplex Loop
    1999 1.9k citations Jack D. Griffith, Laurey Comeau et al. Cell profile →
  3. TRF2 Protects Human Telomeres from End-to-End Fusions
    1998 1.4k citations Titia de Lange et al. Cell profile →
  4. How Shelterin Protects Mammalian Telomeres
    2008 1.4k citations Titia de Lange et al. profile →
  5. DNA Damage Foci at Dysfunctional Telomeres
    2003 1.1k citations Hiroyuki Takai, Titia de Lange et al. profile →
  6. Control of telomere length by the human telomeric protein TRF1
    1997 994 citations Titia de Lange et al. Nature profile →
  7. p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
    1999 869 citations Titia de Lange et al. Science profile →
  8. Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
    2009 788 citations Agnel Sfeir, Dirk Hockemeyer et al. Cell profile →
  9. Protection of mammalian telomeres
    2002 754 citations Titia de Lange profile →
  10. Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2
    1997 743 citations Titia de Lange et al. profile →
  11. Structure and variability of human chromosome ends.
    1990 689 citations Titia de Lange et al. profile →
  12. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    2007 682 citations Eros Lazzerini Denchi, Titia de Lange Nature profile →
  13. Telomerase activity in normal and malignant hematopoietic cells.
    1995 648 citations Titia de Lange et al. profile →
  14. How Telomeres Solve the End-Protection Problem
    2009 637 citations Titia de Lange Science profile →
  15. Regulation of Telomerase by Telomeric Proteins
    2004 636 citations Titia de Lange et al. profile →
  16. Senescence Induced by Altered Telomere State, Not Telomere Loss
    2002 627 citations Titia de Lange et al. Science profile →
  17. Control of Human Telomere Length by TRF1 and TRF2
    2000 617 citations Alessandro Bianchi, Titia de Lange et al. profile →
  18. A Human Telomeric Protein
    1995 567 citations Titia de Lange et al. Science profile →
  19. Shelterin-Mediated Telomere Protection
    2018 566 citations Titia de Lange profile →
  20. POT1 as a terminal transducer of TRF1 telomere length control
    2003 540 citations Diego Loayza, Titia de Lange Nature profile →
  21. Telomeres in cancer: tumour suppression and genome instability
    2017 498 citations John Maciejowski, Titia de Lange profile →
  22. 53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection
    2013 465 citations Michal Zimmermann, Francisca Lottersberger et al. Science profile →
  23. Chromothripsis and Kataegis Induced by Telomere Crisis
    2015 456 citations John Maciejowski, Titia de Lange et al. Cell profile →
  24. Definition of regions in human c-myc that are involved in transformation and nuclear localization.
    1987 409 citations Titia de Lange et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Titia de Lange United States 97 29.5k 26.0k 4.9k 4.8k 3.5k 180 38.8k
Fabrizio d’Adda di Fagagna Italy 51 11.5k 0.4× 7.8k 0.3× 652 0.1× 1.6k 0.3× 2.8k 0.8× 97 18.0k
Gregg B. Morin Canada 34 8.5k 0.3× 7.2k 0.3× 869 0.2× 1.1k 0.2× 1.3k 0.4× 93 13.2k
Olivia M. Pereira‐Smith United States 43 9.6k 0.3× 6.0k 0.2× 442 0.1× 1.4k 0.3× 3.3k 0.9× 108 14.3k
James E. Haber United States 100 30.1k 1.0× 2.4k 0.1× 5.8k 1.2× 916 0.2× 3.4k 1.0× 345 32.6k
Choy‐Pik Chiu United States 21 7.5k 0.3× 6.1k 0.2× 392 0.1× 1.1k 0.2× 834 0.2× 25 11.8k
Shawn E. Holt United States 34 5.5k 0.2× 6.1k 0.2× 440 0.1× 1.1k 0.2× 1.1k 0.3× 63 9.4k
David Scott United States 34 20.7k 0.7× 736 0.0× 2.1k 0.4× 1.3k 0.3× 1.9k 0.5× 53 24.2k
A. B. Futcher United States 16 5.6k 0.2× 5.7k 0.2× 903 0.2× 1.3k 0.3× 619 0.2× 18 9.3k
Robin C. Allshire United Kingdom 63 13.9k 0.5× 2.4k 0.1× 6.3k 1.3× 617 0.1× 459 0.1× 142 16.5k
Kristian Helin Denmark 103 31.3k 1.1× 1.2k 0.0× 1.3k 0.3× 417 0.1× 9.1k 2.6× 275 37.0k

Countries citing papers authored by Titia de Lange

Since Specialization
Citations

This map shows the geographic impact of Titia de Lange's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Titia de Lange with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Titia de Lange more than expected).

Fields of papers citing papers by Titia de Lange

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Titia de Lange. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Titia de Lange. The network helps show where Titia de Lange may publish in the future.

Co-authorship network of co-authors of Titia de Lange

This figure shows the co-authorship network connecting the top 25 collaborators of Titia de Lange. A scholar is included among the top collaborators of Titia de Lange based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Titia de Lange. Titia de Lange is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Stuart, Alexander, et al.. (2025). Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen. Molecular Cell. 85(24). 4667–4677.e7.
2.
Lange, Titia de. (2025). How Shelterin Orchestrates the Replication and Protection of Telomeres. Cold Spring Harbor Perspectives in Biology. a041685–a041685. 4 indexed citations
3.
Myler, Logan R., Cara K. Vaughan, Kaori Takai, et al.. (2023). DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres. Nature Structural & Molecular Biology. 30(9). 1346–1356. 21 indexed citations
4.
Zinder, John C., Vladimir Svetlov, Martin Bush, et al.. (2022). Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state. Nature Structural & Molecular Biology. 29(8). 813–819. 39 indexed citations
5.
Mirman, Zachary, et al.. (2022). CST/Polα/primase-mediated fill-in synthesis at DSBs. Cell Cycle. 22(4). 379–389. 8 indexed citations
6.
Schmutz, Isabelle, Arjen R. Mensenkamp, Kaori Takai, et al.. (2020). TINF2 is a haploinsufficient tumor suppressor that limits telomere length. eLife. 9. 42 indexed citations
7.
Lange, Titia de, et al.. (2020). Characterization of t-loop formation by TRF2. Nucleus. 11(1). 164–177. 35 indexed citations
8.
Lange, Titia de. (2018). What I got wrong about shelterin. Journal of Biological Chemistry. 293(27). 10453–10456. 7 indexed citations
9.
Yang, Zhe, John Maciejowski, & Titia de Lange. (2017). Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb. Molecular Cancer Research. 15(11). 1579–1586. 40 indexed citations
10.
Schmutz, Isabelle, et al.. (2017). TRF2 binds branched DNA to safeguard telomere integrity. Nature Structural & Molecular Biology. 24(9). 734–742. 62 indexed citations
11.
Takai, Hiroyuki, Emma M. Jenkinson, Shaheen Kabir, et al.. (2016). A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes & Development. 30(7). 812–826. 68 indexed citations
12.
Zimmermann, Michal & Titia de Lange. (2013). 53BP1: pro choice in DNA repair. Trends in Cell Biology. 24(2). 108–117. 279 indexed citations
13.
Wu, Peng, Hiroyuki Takai, & Titia de Lange. (2012). Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell. 150(1). 39–52. 238 indexed citations
14.
Sfeir, Agnel, Shaheen Kabir, Megan van Overbeek, Giulia Celli, & Titia de Lange. (2010). Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal. Science. 327(5973). 1657–1661. 198 indexed citations
15.
Chen, Yong, Yuting Yang, Megan van Overbeek, et al.. (2008). A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins. Science. 319(5866). 1092–1096. 207 indexed citations
16.
Denchi, Eros Lazzerini & Titia de Lange. (2007). Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448(7157). 1068–1071. 682 indexed citations breakdown →
17.
Celli, Giulia, Eros Lazzerini Denchi, & Titia de Lange. (2006). Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biology. 8(8). 885–890. 229 indexed citations
18.
Donigian, Jill R., Megan van Overbeek, Diego Loayza, et al.. (2004). TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres. Journal of Biological Chemistry. 279(45). 47264–47271. 257 indexed citations
19.
Loayza, Diego & Titia de Lange. (2003). POT1 as a terminal transducer of TRF1 telomere length control. Nature. 423(6943). 1013–1018. 540 indexed citations breakdown →
20.
Griffith, Jack D., et al.. (1999). Mammalian Telomeres End in a Large Duplex Loop. Cell. 97(4). 503–514. 1872 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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