Jack W. Szostak

58.6k citations

364 papers · 45.2k indexed · 31 hit papers · h-index 99

Co-authors: Andrew D. Ellington Terry L. Orr‐Weaver Rodney Rothstein Elizabeth H. Blackburn David P. Bartel David Sloan Wilson Andrew W. Murray David Huizenga
Topics: RNA and protein synthesis mechanisms (217 papers)Origins and Evolution of Life (128 papers)DNA and Nucleic Acid Chemistry (108 papers)
Cited by: Molecular Biology Astronomy and Astrophysics Aging
Journals: Nature Science Cell
Partner nations: United States China Japan

In The Last Decade

Jack W. Szostak

361 papers receiving 43.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

In vitro selection of RNA molecules that bind specific ligands

1990 7.9k citations Jack W. Szostak et al. profile →
The double-strand-break repair model for recombination

1983 2.1k citations Jack W. Szostak et al. profile →
Yeast transformation: a model system for the study of recombination.

1981 1.3k citations Jack W. Szostak et al. Proceedings of the National Academy of Sciences profile →
Synthesizing life

2001 1.2k citations Jack W. Szostak et al. profile →
A DNA Aptamer That Binds Adenosine and ATP

1995 1.1k citations Jack W. Szostak et al. profile →
In Vitro Selection of Functional Nucleic Acids

1999 957 citations David Sloan Wilson, Jack W. Szostak profile →
RNA-peptide fusions for the in vitro selection of peptides and proteins

1997 816 citations Richard W. Roberts, Jack W. Szostak Proceedings of the National Academy of Sciences profile →
A mutant with a defect in telomere elongation leads to senescence in yeast

1989 758 citations Jack W. Szostak et al. profile →
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

2006 710 citations Jack W. Szostak et al. profile →
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

1992 675 citations Jack W. Szostak et al. profile →
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division

2003 634 citations Jack W. Szostak et al. Science profile →
THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 570 citations Jack W. Szostak et al. profile →
Template-directed synthesis of a genetic polymer in a model protocell

2008 531 citations Jack W. Szostak et al. profile →
An RNA motif that binds ATP

1993 480 citations Jack W. Szostak et al. profile →
Double-strand breaks at an initiation site for meiotic gene conversion

1989 475 citations Jack W. Szostak et al. profile →
Cloning yeast telomeres on linear plasmid vectors

1982 465 citations Jack W. Szostak et al. profile →
Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site

1991 463 citations Jack W. Szostak et al. profile →
[14] Genetic applications of yeast transformation with linear and gapped plasmids

1983 446 citations Jack W. Szostak et al. Methods in enzymology on CD-ROM/Methods in enzymology profile →
DNA sequences of telomeres maintained in yeast

1984 439 citations Jack W. Szostak et al. profile →
Functional proteins from a random-sequence library

2001 400 citations Anthony D. Keefe, Jack W. Szostak profile →
Coupled Growth and Division of Model Protocell Membranes

2009 376 citations Jack W. Szostak et al. Journal of the American Chemical Society profile →
Yeast recombination: the association between double-strand gap repair and crossing-over.

1983 374 citations Jack W. Szostak et al. Proceedings of the National Academy of Sciences profile →
Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae

1980 363 citations Jack W. Szostak et al. profile →
A DNA metalloenzyme with DNA ligase activity

1995 352 citations Jack W. Szostak et al. profile →
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA

1991 341 citations Jack W. Szostak et al. profile →
Pedigree analysis of plasmid segregation in yeast

1983 337 citations Jack W. Szostak et al. profile →
Construction of artificial chromosomes in yeast

1983 337 citations Jack W. Szostak et al. profile →
The Emergence of Competition Between Model Protocells

2004 316 citations Richard W. Roberts, Jack W. Szostak et al. Science profile →
The guanosine binding site of the Tetrahymena ribozyme

1989 314 citations Jack W. Szostak et al. profile →
Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences

1995 294 citations Jack W. Szostak et al. Science profile →
Structural conventions for group I introns

1987 261 citations Jack W. Szostak et al. Nucleic Acids Research profile →

Peers

Countries citing papers authored by Jack W. Szostak

Since Specialization

Citations

This map shows the geographic impact of Jack W. Szostak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jack W. Szostak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jack W. Szostak more than expected).

Fields of papers citing papers by Jack W. Szostak

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jack W. Szostak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jack W. Szostak. The network helps show where Jack W. Szostak may publish in the future.

Co-authorship network of co-authors of Jack W. Szostak

This figure shows the co-authorship network connecting the top 25 collaborators of Jack W. Szostak. A scholar is included among the top collaborators of Jack W. Szostak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jack W. Szostak. Jack W. Szostak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Nonenzymatic RNA copying with a potentially primordial genetic alphabet 2025 ·Proceedings of the National Academy of Sciences ·(unknown),Xiwen Jia,(unknown),Jack W. Szostak	0
2	Overcoming nucleotide bias in the nonenzymatic copying of RNA templates 2024 ·Nucleic Acids Research ·Daniel Duzdevich,Christopher E. Carr,(unknown),(unknown),Jack W. Szostak	4
3	Constraints on the emergence of RNA through non-templated primer extension with mixtures of potentially prebiotic nucleotides 2024 ·Nucleic Acids Research ·Xiwen Jia,Stephanie J. Zhang,Lijun Zhou,Jack W. Szostak	2
4	RNA‐Catalyzed RNA Ligation within Prebiotically Plausible Model Protocells** 2023 ·Chemistry - A European Journal ·Saurja DasGupta,Stephanie J. Zhang,Merrick Pierson Smela,Jack W. Szostak	7
5	Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides 2022 ·Proceedings of the National Academy of Sciences ·(unknown),Saurja DasGupta,Tom H. Wright,(unknown),Jack W. Szostak	15
6	Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides 2022 ·Nucleic Acids Research ·(unknown),Jack W. Szostak	16
7	Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying 2022 ·Proceedings of the National Academy of Sciences ·Stephanie J. Zhang,Daniel Duzdevich,Dian Ding,Jack W. Szostak	35
8	Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension 2021 ·Nucleic Acids Research ·Daniel Duzdevich,Christopher E. Carr,Dian Ding,Stephanie J. Zhang,Travis Walton,Jack W. Szostak	19
9	In search of the RNA world on Mars 2021 ·Geobiology ·(unknown),Lin Jin,Jack W. Szostak,J. W. Head,M. T. Zuber	9
10	Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates 2021 ·Nucleic Acids Research ·Dian Ding,Lijun Zhou,(unknown),Jack W. Szostak	22
11	Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase 2020 ·Proceedings of the National Academy of Sciences ·Victor S. Lelyveld,Wen Zhang,Jack W. Szostak	9
12	Deep sequencing of non-enzymatic RNA primer extension 2020 ·Nucleic Acids Research ·Daniel Duzdevich,Christopher E. Carr,Jack W. Szostak	22
13	Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA 2018 ·Proceedings of the National Academy of Sciences ·(unknown),Derek K. O’Flaherty,Lijun Zhou,Victor S. Lelyveld,Jack W. Szostak	41
14	Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells 2013 ·Science ·Katarzyna P. Adamala,Jack W. Szostak	251
15	In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors 2012 ·Journal of the American Chemical Society ·(unknown),Matthew C. T. Hartman,Kristopher Josephson,Jack W. Szostak	203
16	Single-Molecule Imaging of an in Vitro -Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics 2009 ·Journal of the American Chemical Society ·(unknown),Jack W. Szostak,Antoine M. van Oijen	35
17	A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene 2006 ·Science ·Kourosh Salehi‐Ashtiani,Andrej Lupták,Alexander Litovchick,Jack W. Szostak	205
18	Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose 2005 ·Proceedings of the National Academy of Sciences ·(unknown),Jack W. Szostak	105
19	The use of mRNA display to select high-affinity protein-binding peptides 2001 ·Proceedings of the National Academy of Sciences ·David Sloan Wilson,Anthony D. Keefe,Jack W. Szostak	315
20	[19] Optimized synthesis of RNA-protein fusions for in vitro protein selection 2000 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Rihe Liu,Jeffrey E. Barrick,Jack W. Szostak,Richard W. Roberts	131

About Jack W. Szostak

Jack W. Szostak is a scholar working on Astronomy and Astrophysics, Molecular Biology and Cellular and Molecular Neuroscience, having authored 364 papers that have together received 45.2k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (217 papers), Origins and Evolution of Life (128 papers) and DNA and Nucleic Acid Chemistry (108 papers). The work is most often cited by research in Molecular Biology (39.9k citations), Astronomy and Astrophysics (7.3k citations) and Aging (678 citations). Jack W. Szostak has collaborated with scholars based in United States, China and Japan. Frequent co-authors include Andrew D. Ellington, Terry L. Orr‐Weaver, Rodney Rothstein, Elizabeth H. Blackburn, David P. Bartel, David Sloan Wilson, Andrew W. Murray, David Huizenga, Richard W. Roberts and Franklin W. Stahl. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

You can learn more about the impact of Jack W. Szostak by visiting their Pantheon page.

Explore authors with similar magnitude of impact