Steven C. Ley

10.4k citations

84 papers · 8.7k · 3 hit papers · h-index 45

Impact in

Immunology top 0.2%
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- interferon and immune responses
- Immunotherapy and Immune Responses
Cancer Research top 0.5%
- NF-κB Signaling Pathways

Papers in

Immunology 58
- Immune Response and Inflammation 26
- T-cell and B-cell Immunology 17
- Immune Cell Function and Interaction 13
- interferon and immune responses 12
Molecular Biology 34
- Glycosylation and Glycoproteins Research 10

Co-authors: J. Simon C. Arthur (3 shared papers)Anthony I. Magee (4 shared papers)Peter W. Janes (2 shared papers)Sören Beinke (4 shared papers)Panagiotis S. Kabouridis (4 shared papers)Julia Janzen (13 shared papers)Shao‐Cong Sun (1 shared paper)Michaël J. Crumpton (7 shared papers)
Journals: European Journal of Immunology (9 papers)The Journal of Immunology (8 papers)Journal of Biological Chemistry (8 papers)Proceedings of the National Academy of Sciences (7 papers)Molecular and Cellular Biology (6 papers)
Partner nations: United Kingdom United States Tanzania

In The Last Decade

Steven C. Ley

84 papers receiving 8.5k citations

Steven C. Ley's Hit Papers

align trajectories log scale

Mitogen-activated protein kinases in innate immunity 2013 · 1.5k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2013 Nature reviews. Immunology
2004 Biochemical Journal
1999 The Journal of Cell Biology

Peers

Countries citing papers authored by Steven C. Ley

Since Specialization

Citations

This map shows the geographic impact of Steven C. Ley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven C. Ley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven C. Ley more than expected).

Fields of papers citing papers by Steven C. Ley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven C. Ley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven C. Ley. The network helps show where Steven C. Ley may publish in the future.

Co-authors

The 25 scholars most cited alongside Steven C. Ley, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Steven C. Ley Line = papers co-authored together Steven C. Ley links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 84 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Mitogen-activated protein kinases in innate immunity Nature reviews. Immunology ·J. Simon C. Arthur, Steven C. Ley Hit paper breakdown →	2013	1455
2	Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor The Journal of Cell Biology ·Peter W. Janes, Steven C. Ley, Anthony I. Magee Hit paper breakdown →	1999	706
3	Functions of NF-κB1 and NF-κB2 in immune cell biology Biochemical Journal ·Sören Beinke, Steven C. Ley Hit paper breakdown →	2004	515
4	The role of lipid rafts in T cell antigen receptor (TCR) signalling Seminars in Immunology ·Peter W. Janes, Steven C. Ley, Anthony I. Magee, Panagiotis S. Kabouridis	2000	376
5	Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes European Journal of Immunology ·Panagiotis S. Kabouridis, Julia Janzen, Anthony L. Magee, Steven C. Ley	2000	305
6	New insights into NF-κB regulation and function Trends in Immunology ·Shao‐Cong Sun, Steven C. Ley	2008	266
7	Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase. The EMBO Journal ·Andrés Salmerón, Tahir Ahmad, Graeme W. Carlile, Darryl Pappin, Radha P. Narsimhan, Steven C. Ley	1996	263
8	Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) Proceedings of the National Academy of Sciences ·Matthew E. Cockman, David E. Lancaster, Ineke Stolze, Kirsty S. Hewitson, M.A. McDonough, Mathew L. Coleman, C.H. Coles, Xiaohong Yu, Ronald T. Hay, Steven C. Ley, Christopher W. Pugh, Neil J. Oldham, Norma Masson, Christopher J. Schofield, Peter J. Ratcliffe	2006	237
9	Isoforms of 14‐3‐3 protein can form homo‐ and heterodimers in vivo and in vitro: implications for function as adapter proteins FEBS Letters ·David H. Jones, Steven C. Ley, Alastair Aitken	1995	215
10	TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105 Nature ·Monica Belich, (unknown), Leland H. Johnston, Steven C. Ley	1999	186
11	Expression, biological activities and mechanisms of action of A20 (TNFAIP3) Biochemical Pharmacology ·Lynn Verstrepen, Kelly Verhelst, Geert Loo, Isabelle Carpentier, Steven C. Ley, Rudi Beyaert	2010	179
12	Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by IκB Kinase-Induced Proteolysis of NF-κB1 p105 Molecular and Cellular Biology ·S. Beinke, Megan J. Robinson, Margaret Hugunin, Steven C. Ley	2004	176
13	Immortalized B lymphocytes produce B-cell growth factor Nature ·John Gordon, Steven C. Ley, M.D. Melamed, Leonard S. English, N. C. Hughes‐Jones	1984	161
14	Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes. The Journal of Cell Biology ·Steven C. Ley, Mark Marsh, C. R. Bebbington, K Proudfoot, Peter Jordan	1994	161
15	Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif Biochemical Journal ·Manfred Koegl, Philippe Zlatkine, Steven C. Ley, Sara A. Courtneidge, Anthony I. Magee	1994	141
16	TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells The Journal of Experimental Medicine ·Frank J. Kaiser, Dorthe Cook, Stamatia Papoutsopoulou, Ricardo Rajsbaum, Xuemei Wu, Huei-Ting Yang, Susan Grant, Paola Ricciardi‐Castagnoli, Philip N. Tsichlis, Steven C. Ley, Anne O’Garra	2009	138
17	IκB kinase regulation of the TPL‐2/ERK MAPK pathway Immunological Reviews ·Thorsten Gantke, Srividya Sriskantharajah, Michael I. Sadowski, Steven C. Ley	2012	126
18	βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932 Molecular and Cellular Biology ·Valérie Lang, Julia Janzen, Gregory Zvi Fischer, Yasmina Soneji, Sören Beinke, Andrés Salmerón, Hamish Allen, Ronald T. Hay, Yinon Ben‐Neriah, Steven C. Ley	2002	116
19	Direct Phosphorylation of NF-κB1 p105 by the IκB Kinase Complex on Serine 927 Is Essential for Signal-induced p105 Proteolysis Journal of Biological Chemistry ·Andrés Salmerón, Julia Janzen, Yasmina Soneji, Nancy J. Bump, Joanne Kamens, Hamish Allen, Steven C. Ley	2001	115
20	Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase Cell Research ·Thorsten Gantke, Srividya Sriskantharajah, Steven C. Ley	2010	112

About Steven C. Ley

Steven C. Ley is a scholar working on Immunology, Molecular Biology, Cancer Research, Oncology and Radiology, Nuclear Medicine and Imaging, having authored 84 papers that have together received 8.7k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (32 papers), Immune Response and Inflammation (26 papers), T-cell and B-cell Immunology (17 papers), Cytokine Signaling Pathways and Interactions (16 papers), Monoclonal and Polyclonal Antibodies Research (15 papers), Immune Cell Function and Interaction (13 papers), interferon and immune responses (12 papers) and Glycosylation and Glycoproteins Research (10 papers). The work is most often cited by research in Immunology (4.1k citations), Cancer Research (2.0k citations), Molecular Biology (4.0k citations), Oncology (1.4k citations) and Immunology and Allergy (310 citations). Steven C. Ley has collaborated with scholars based in United Kingdom, United States and Tanzania. Frequent co-authors include J. Simon C. Arthur, Anthony I. Magee, Peter W. Janes, Sören Beinke, Panagiotis S. Kabouridis, Julia Janzen, Shao‐Cong Sun, Michaël J. Crumpton, Thorsten Gantke and Monica Belich. Their work appears in journals such as European Journal of Immunology, The Journal of Immunology, Journal of Biological Chemistry, Proceedings of the National Academy of Sciences and Molecular and Cellular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Steven C. Ley

Steven C. Ley's Hit Papers

Peers

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Fields of papers citing papers by Steven C. Ley

All Works

About Steven C. Ley

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