Hiroto Hatakeyama

6.2k total citations · 1 hit paper
82 papers, 4.9k citations indexed

About

Hiroto Hatakeyama is a scholar working on Molecular Biology, Biomaterials and Immunology. According to data from OpenAlex, Hiroto Hatakeyama has authored 82 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 22 papers in Biomaterials and 14 papers in Immunology. Recurrent topics in Hiroto Hatakeyama's work include RNA Interference and Gene Delivery (49 papers), Advanced biosensing and bioanalysis techniques (34 papers) and Nanoparticle-Based Drug Delivery (22 papers). Hiroto Hatakeyama is often cited by papers focused on RNA Interference and Gene Delivery (49 papers), Advanced biosensing and bioanalysis techniques (34 papers) and Nanoparticle-Based Drug Delivery (22 papers). Hiroto Hatakeyama collaborates with scholars based in Japan, United States and Spain. Hiroto Hatakeyama's co-authors include Hideyoshi Harashima, Hidetaka Akita, Yusuke Sato, Yu Sakurai, Golam Kibria, Mamoru Hyodo, Noritaka Ohga, Kyoko Hida, Yukio Nagasaki and Motoi Oishi and has published in prestigious journals such as Nucleic Acids Research, Accounts of Chemical Research and ACS Nano.

In The Last Decade

Hiroto Hatakeyama

79 papers receiving 4.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma

2010 543 citations Hiroto Hatakeyama, Hidetaka Akita et al. Advanced Drug Delivery Reviews profile →

Peers

Hiroto Hatakeyama

BIOMA

IMMUN

Priya Karmali United States

Jeremy D. Heidel United States

Cong‐Fei Xu China

Gerben A. Koning Netherlands

Qiang Cheng China

Roy van der Meel Netherlands

Steven M. Ansell United States

Du Cheng China

Sean C. Semple Canada

Xiangrui Liu China

Priya Karmali United States

Hiroto Hatakeyama

2.8k ×0.8

1.6k ×0.8

BIOMA

1.2k ×1.0

585 ×1.1

532 ×1.1

IMMUN

Citations per year, relative to Hiroto Hatakeyama Hiroto Hatakeyama (= 1×) peers Priya Karmali

Countries citing papers authored by Hiroto Hatakeyama

Since Specialization

Citations

This map shows the geographic impact of Hiroto Hatakeyama's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroto Hatakeyama with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroto Hatakeyama more than expected).

Fields of papers citing papers by Hiroto Hatakeyama

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroto Hatakeyama. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroto Hatakeyama. The network helps show where Hiroto Hatakeyama may publish in the future.

Co-authorship network of co-authors of Hiroto Hatakeyama

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroto Hatakeyama. A scholar is included among the top collaborators of Hiroto Hatakeyama based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroto Hatakeyama. Hiroto Hatakeyama is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hatakeyama, Hiroto, et al.. (2025). Buffer compositions strongly impact the in vitro assessment of CYP fraction metabolized using human liver microsomes or expressed isoenzymes. Drug Metabolism and Pharmacokinetics. 62. 101480–101480.

Yasuda, Susumu, Ruoming Duan, Masaharu Ohashi, et al.. (2025). Cholesterol depletion suppresses thermal necrosis resistance by alleviating an increase in membrane fluidity. Scientific Reports. 15(1). 10133–10133. 1 indexed citations

Yoshioka, Hideki, et al.. (2025). Adjuvant Chemotherapy for Gastric Cancer may Worsen Prognosis in Elderly Women: Retrospective Analysis of Individual Patient Data from the CLASSIC Study. Journal of Gastrointestinal Cancer. 56(1). 142–142.

Liu, Yi, et al.. (2024). Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines. Biological and Pharmaceutical Bulletin. 47(3). 698–707. 4 indexed citations

Tanaka, Hiroki, et al.. (2023). Reactivation of Anticancer Immunity by Resetting Interorgan Crosstalk in Immune‐Suppressive Cells with a Nanoparticulated Anti‐Inflammatory Drug. Small. 19(16). e2205131–e2205131. 1 indexed citations

Tanaka, Hiroki, Yuta Nakai, Kota Tange, et al.. (2023). Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds. Pharmaceutics. 15(12). 2702–2702. 5 indexed citations

Abo, Hirohito, et al.. (2022). Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor. Journal for ImmunoTherapy of Cancer. 10(12). e005657–e005657. 5 indexed citations

Hatakeyama, Hiroto, et al.. (2021). Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis. International Journal of Molecular Sciences. 22(16). 9028–9028. 3 indexed citations

Aoki, Shigeki, et al.. (2021). Investigation of energy metabolic dynamism in hyperthermia-resistant ovarian and uterine cancer cells under heat stress. Scientific Reports. 11(1). 14726–14726. 12 indexed citations

10.

Cao, Qizhen, Wanqin Wang, Min Zhou, et al.. (2020). Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine Nanotechnology Biology and Medicine. 25. 102169–102169. 30 indexed citations

11.

Court, Karem A., Hiroto Hatakeyama, Sherry Y. Wu, et al.. (2017). HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer. Molecular Cancer Therapeutics. 16(5). 966–976. 45 indexed citations

12.

Huang, Yan, Lenard M. Lichtenberger, Morgan Taylor, et al.. (2016). Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. Molecular Cancer Therapeutics. 15(12). 2894–2904. 42 indexed citations

13.

Nakamura, Takashi, Yusuke Sato, Yuki Fujiwara, et al.. (2016). A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells. Journal of Controlled Release. 225. 183–191. 100 indexed citations

14.

Kibria, Golam, Hiroto Hatakeyama, & Hideyoshi Harashima. (2013). Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system. Archives of Pharmacal Research. 37(1). 4–15. 139 indexed citations

15.

Takara, Kazuhiro, Hiroto Hatakeyama, Golam Kibria, et al.. (2012). Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy. Journal of Controlled Release. 162(1). 225–232. 88 indexed citations

16.

Sato, Yusuke, Hiroto Hatakeyama, Yu Sakurai, et al.. (2012). A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. Journal of Controlled Release. 163(3). 267–276. 265 indexed citations

17.

Akita, Hidetaka, Hiroto Hatakeyama, & Hideyoshi Harashima. (2010). siRNA delivery by multifunctional envelope-type nano device (MEND). Drug Delivery System. 25(6). 590–597.

18.

Hatakeyama, Hiroto, Hidetaka Akita, & Hideyoshi Harashima. (2010). A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma. Advanced Drug Delivery Reviews. 63(3). 152–160. 543 indexed citations breakdown →

19.

Hatakeyama, Hiroto, Hidetaka Akita, Kentaro Kogure, & Hideyoshi Harashima. (2009). A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device. PubMed. 119. 197–230. 10 indexed citations

20.

Nakamura, N., Yoshihiro Shidoji, Yuichi Yamada, et al.. (1995). Induction of Apoptosis by Acyclic Retinoid in the Human Hepatoma-Derived Cell Line, HuH-7. Biochemical and Biophysical Research Communications. 207(1). 382–388. 83 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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