Robert K. Semple

19.2k total citations · 3 hit papers
153 papers, 7.6k citations indexed

About

Robert K. Semple is a scholar working on Molecular Biology, Surgery and Genetics. According to data from OpenAlex, Robert K. Semple has authored 153 papers receiving a total of 7.6k indexed citations (citations by other indexed papers that have themselves been cited), including 92 papers in Molecular Biology, 44 papers in Surgery and 39 papers in Genetics. Recurrent topics in Robert K. Semple's work include Metabolism, Diabetes, and Cancer (42 papers), Pancreatic function and diabetes (32 papers) and Adipose Tissue and Metabolism (22 papers). Robert K. Semple is often cited by papers focused on Metabolism, Diabetes, and Cancer (42 papers), Pancreatic function and diabetes (32 papers) and Adipose Tissue and Metabolism (22 papers). Robert K. Semple collaborates with scholars based in United Kingdom, United States and France. Robert K. Semple's co-authors include Stephen O’Rahilly, David B. Savage, Phillip Görden, Elaine Cochran, A. Kemal Topaloğlu, Maria A. Soos, Joshua R. Cook, Ralitsa R. Madsen, Bart Vanhaesebroeck and Isabel Huang‐Doran and has published in prestigious journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Robert K. Semple

144 papers receiving 7.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

PPAR and human metabolic disease

2006 683 citations Robert K. Semple Journal of Clinical Investigation profile →
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

2008 658 citations A. Kemal Topaloğlu, Stephen O’Rahilly et al. profile →
PIK3CA‐related overgrowth spectrum (PROS): Diagnostic and testing eligibility criteria, differential diagnosis, and evaluation

2014 326 citations Kim M. Keppler‐Noreuil, Victoria Parker et al. American Journal of Medical Genetics Part A profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Robert K. Semple United Kingdom	41	4.0k	1.6k	1.5k	1.5k	1.3k	153	7.6k
Anthony N. Hollenberg United States	50	2.9k 0.7×	1.5k 0.9×	1.2k 0.8×	485 0.3×	2.5k 2.0×	115	6.9k
Generoso Andria Italy	46	2.9k 0.7×	1.7k 1.1×	2.3k 1.5×	1.1k 0.7×	284 0.2×	215	8.5k
Mario Serio Italy	48	2.8k 0.7×	851 0.5×	585 0.4×	1.2k 0.8×	1.4k 1.1×	151	8.2k
Mehboob A. Hussain United States	40	2.9k 0.7×	1.3k 0.8×	1.0k 0.7×	2.7k 1.8×	2.2k 1.8×	75	6.2k
Derek LeRoith United States	49	4.1k 1.0×	753 0.5×	1.3k 0.8×	924 0.6×	2.2k 1.8×	123	7.3k
Shuyuan Yeh United States	68	7.0k 1.7×	3.7k 2.3×	457 0.3×	1.4k 1.0×	2.7k 2.1×	204	14.5k
Liam J. Murphy Canada	52	3.4k 0.8×	1.8k 1.1×	961 0.6×	819 0.6×	3.9k 3.1×	159	8.4k
Antonio Cao Italy	53	4.5k 1.1×	2.6k 1.6×	872 0.6×	629 0.4×	611 0.5×	303	12.1k
Jeffrey R. Bender United States	45	2.4k 0.6×	2.0k 1.2×	748 0.5×	623 0.4×	1.3k 1.0×	90	6.7k
Chieko Mineo United States	44	3.6k 0.9×	1.3k 0.8×	1.1k 0.7×	1.7k 1.2×	1.3k 1.0×	106	7.7k

Countries citing papers authored by Robert K. Semple

Since Specialization

Citations

This map shows the geographic impact of Robert K. Semple's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert K. Semple with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert K. Semple more than expected).

Fields of papers citing papers by Robert K. Semple

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert K. Semple. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert K. Semple. The network helps show where Robert K. Semple may publish in the future.

Co-authorship network of co-authors of Robert K. Semple

This figure shows the co-authorship network connecting the top 25 collaborators of Robert K. Semple. A scholar is included among the top collaborators of Robert K. Semple based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Robert K. Semple. Robert K. Semple is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Brierley, Gemma V., Rupa Kumar, Corinne Vigouroux, et al.. (2025). Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance. Nature Communications. 16(1). 9143–9143. 1 indexed citations

Barker, Peter, Keith Burling, Diarmuid Smith, et al.. (2023). Diagnosis and treatment of anti‐insulin antibody‐mediated labile glycaemia in insulin‐treated diabetes. Diabetic Medicine. 40(11). e15194–e15194. 4 indexed citations

Zecchin, Davide, Nicole Knöpfel, Mark Stevenson, et al.. (2023). GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics. Journal of Investigative Dermatology. 144(4). 811–819.e4. 7 indexed citations

Suchacki, Karla J., Lynne Ramage, Calum Gray, et al.. (2023). The serotonin transporter sustains human brown adipose tissue thermogenesis. Nature Metabolism. 5(8). 1319–1336. 17 indexed citations

Atallah, Isis, Dominique McCormick, Montserrat Fraga, et al.. (2022). Partial lipodystrophy, severe dyslipidaemia and insulin resistant diabetes as early signs of Werner syndrome. Journal of clinical lipidology. 16(5). 583–590. 8 indexed citations

Madsen, Ralitsa R., James Longden, Rachel Knox, et al.. (2021). NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells. Disease Models & Mechanisms. 14(3). 5 indexed citations

Douzgou, Sofia, Eulàlia Baselga, Moise Danielpour, et al.. (2021). A standard of care for individuals with PIK3CA ‐related disorders: An international expert consensus statement. Clinical Genetics. 101(1). 32–47. 20 indexed citations

Madsen, Ralitsa R., Rachel Knox, Wayne Pearce, et al.. (2019). Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner. Proceedings of the National Academy of Sciences. 116(17). 8380–8389. 42 indexed citations

Brierley, Gemma V., V. Grasso, Rossella Gaudino, et al.. (2018). Severe insulin resistance in disguise: A familial case of reactive hypoglycemia associated with a novel heterozygous INSR mutation. Pediatric Diabetes. 19(4). 670–674. 8 indexed citations

10.

Brierley, Gemma V., Kenneth Siddle, & Robert K. Semple. (2018). Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models. Diabetologia. 61(7). 1662–1675. 7 indexed citations

11.

Rocha, Nuno, Felicity Payne, Isabel Huang‐Doran, et al.. (2017). The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. Scientific Reports. 7(1). 17593–17593. 24 indexed citations

12.

Gripp, Karen W., Laura Baker, Vinay Kandula, et al.. (2016). Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. American Journal of Medical Genetics Part A. 170(10). 2559–2569. 48 indexed citations

13.

Parker, Victoria E R, Rachel Knox, Zuo‐Feng Zhang, Michael J.O. Wakelam, & Robert K. Semple. (2015). Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options. The Lancet. 385. S77–S77. 14 indexed citations

14.

Payne, Felicity, Rita Colnaghi, Nuno Rocha, et al.. (2014). Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. Journal of Clinical Investigation. 124(9). 4028–4038. 72 indexed citations

15.

Mayson, Sarah E., Victoria Parker, Mark H. Schutta, Robert K. Semple, & Michael R. Rickels. (2012). Severe Insulin Resistance and Hypertriglyceridemia After Childhood Total Body Irradiation. Endocrine Practice. 19(1). 51–58. 27 indexed citations

16.

Hussain, Khalid, Benjamin Challis, Nuno Rocha, et al.. (2011). An Activating Mutation of AKT2 and Human Hypoglycemia. Science. 334(6055). 474–474. 114 indexed citations

17.

Williams, Carmen J., et al.. (2010). Expression of ARL15, a type 2 diabetes risk variant, is increased in cultured human skeletal muscle cells from insulin-resistant type 2 diabetes patients. Diabetologia. 53. 1 indexed citations

18.

Semple, Robert K. & A. Kemal Topaloğlu. (2010). Neurokinin B and Its Receptor in Hypogonadotropic Hypogonadism. Frontiers of hormone research. 39. 133–141. 6 indexed citations

19.

Zhou, Ligang, Gregory M. Sutton, Justin J. Rochford, et al.. (2007). Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4 Receptor Signaling Pathways. Cell Metabolism. 6(5). 398–405. 177 indexed citations

20.

Dinneen, Seán F. & Robert K. Semple. (2002). What's new in … Diabetes prevention and delivery of care. Medicine. 30(1). i–iii. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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