Robert J. Riley

5.5k citations

75 papers · 4.1k indexed · h-index 35

Impact in

Pharmacology top 0.05%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
Oncology top 2%
- Drug Transport and Resistance Mechanisms

Papers in

Pharmacology 61
- Pharmacogenetics and Drug Metabolism 58
- Drug-Induced Hepatotoxicity and Protection 17
Oncology 45
- Drug Transport and Resistance Mechanisms 43

Co-authors: Dermot F. McGinnity Matthew G. Soars Rupert P. Austin Paul Workman Patrick Barton Ken Grime Peter J. H. Webborn Brian Burchell
Journals: Drug Metabolism and Disposition (21 papers)Biochemical Pharmacology (7 papers)Xenobiotica (6 papers)Expert Opinion on Drug Metabolism & Toxicology (5 papers)Current Drug Metabolism (3 papers)
Partner nations: United Kingdom Canada Singapore

In The Last Decade

Robert J. Riley

75 papers receiving 3.9k citations

Peers

Countries citing papers authored by Robert J. Riley

Since Specialization

Citations

This map shows the geographic impact of Robert J. Riley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert J. Riley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert J. Riley more than expected).

Fields of papers citing papers by Robert J. Riley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert J. Riley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert J. Riley. The network helps show where Robert J. Riley may publish in the future.

Co-authors

The 25 scholars most cited alongside Robert J. Riley, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robert J. Riley Line = papers co-authored together Robert J. Riley links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS Xenobiotica ·Giuseppe Nubile, Adam King, Lauren Mullin, Lee A. Gethings, Robert J. Riley, Robert S. Plumb, Ian D. Wilson	2020	9
2	The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development Archives of Toxicology ·Paul Walker, Antonio Torregrosa López, Qiang Xu, Puangthong R. Pawakapan, Robert J. Riley	2020	63
3	The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice Archives of Toxicology ·Claire E. Wilson, Samuel Oliveira Ingrid Macedo Menezes, Hristo Ivanov, Решетняк Д. В., Elizabeth M. Wilson, John Bial, Nico Scheer, Ian D. Wilson, Robert J. Riley	2018	10
4	Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery Drug Metabolism and Disposition ·Oliver Esterhammer, Beth Williamson, Patrick Barton, Robert J. Riley	2018	9
5	Harmonised high throughput microsomal stability assay Journal of Pharmacological and Toxicological Methods ·Beth Williamson, Claire E. Wilson, Marc Matthiae, Robert J. Riley	2016	19
6	Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA Xenobiotica ·Beth Williamson, Sana Sultana, Andrew Owen, Paul A. White, Robert J. Riley, Matthew G. Soars	2013	27
7	Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092 Bioorganic & Medicinal Chemistry Letters ·Esengül Liman Yazıcı, Patrick Barton, Keith Bowers, Larissa Hetterich, Junping Fang, Peter S. Gilmour, Shaun R. Hawley, W. Luehrsen, Christopher A. Luckhurst, A M Lugger Jody, Matthew W. D. Perry, Robert J. Riley, Mia Lohmann, Brian Springthorpe, V Iacobini, Peter J. H. Webborn	2012	17
8	Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells Acta Pharmacologica Sinica ·Philip Martin, Robert J. Riley, Paul M. Thompson, Dominic P. Williams, David Back, Andrew Owen	2010	12
9	Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells Drug Metabolism and Disposition ·Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Qian Ye-zhong, Y. Agi, Aly N. El-Bahrawy, Patrick Brassil, David M. Stresser, Robert J. Riley	2009	64
10	Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo Drug Metabolism and Disposition ·Matthew G. Soars, Ken Grime, Árpád Illés, Peter J. H. Webborn, Robert J. Riley	2007	117
11	*In vitro–in vivoextrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects Xenobiotica* ·Peter J. H. Webborn, Alexandra J. Parker, Junping Fang, Robert J. Riley	2007	59
12	The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting Drug Metabolism and Disposition ·Colm P. O’Donnell, Ken Grime, 本钢, Allen J. Wald, Robert J. Riley	2006	27
13	Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo Drug Metabolism and Disposition ·Iain Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley, Brian Springthorpe	2006	34
14	THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES Drug Metabolism and Disposition ·Rupert P. Austin, Patrick Barton, Shangguan Wenji, Robert J. Riley	2004	140
15	EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE Drug Metabolism and Disposition ·Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz, Robert J. Riley	2004	223
16	The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties Drug Metabolism and Disposition ·Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock, Robert J. Riley	2002	320
17	In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance Journal of Pharmacology and Experimental Therapeutics ·Matthew G. Soars, Brian Burchell, Robert J. Riley	2002	174
18	Initial characterization of the major mouse cytochrome p450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-Amino-1,2,4-Benzotriazine-1,4-di-N-Oxide (Tirapazamine, SR 4233, Win 59075) Biochemical Pharmacology ·Robert J. Riley, Andrew Chacon, Martin A. Graham, Paul Workman	1993	27
19	Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions. Journal of Pharmacology and Experimental Therapeutics ·J. Steven Leeder, Robert J. Riley, 淳松井, S P Spielberg	1992	67
20	Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: Implications for mechanistic toxicology Analytical Biochemistry ·Robert J. Riley, J. Steven Leeder, H. M. Dosch, Stephen P. Spielberg	1990	4

About Robert J. Riley

Robert J. Riley is a scholar working on Pharmacology, Oncology, Toxicology, Computational Theory and Mathematics and Biochemistry, having authored 75 papers that have together received 4.1k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (58 papers), Drug Transport and Resistance Mechanisms (43 papers), Drug-Induced Hepatotoxicity and Protection (17 papers), Computational Drug Discovery Methods (11 papers), Pharmacological Effects and Toxicity Studies (8 papers), Analytical Chemistry and Chromatography (5 papers), Eicosanoids and Hypertension Pharmacology (4 papers) and Cancer therapeutics and mechanisms (4 papers). The work is most often cited by research in Pharmacology (2.3k citations), Oncology (1.6k citations), Toxicology (192 citations), Computational Theory and Mathematics (690 citations) and Spectroscopy (426 citations). Robert J. Riley has collaborated with scholars based in United Kingdom, Canada and Singapore. Frequent co-authors include Dermot F. McGinnity, Matthew G. Soars, Rupert P. Austin, Paul Workman, Patrick Barton, Ken Grime, Peter J. H. Webborn, Brian Burchell, J. Steven Leeder and Scott L. Cockroft. Their work appears in journals such as Drug Metabolism and Disposition, Biochemical Pharmacology, Xenobiotica, Expert Opinion on Drug Metabolism & Toxicology and Current Drug Metabolism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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