Patrick Brassil

1.9k citations

28 papers · 1.2k indexed · h-index 18

Impact in

Pharmacology top 2%
- Pharmacogenetics and Drug Metabolism
Cancer Research top 10%
- NF-κB Signaling Pathways

Papers in ⓘ

Pharmacology 9
- Pharmacogenetics and Drug Metabolism 7
Toxicology 3
- Bioactive Compounds and Antitumor Agents 3

Co-authors: James R. Burke (3 shared papers)Wendy Clarke (3 shared papers)Kurt R. Gregor (2 shared papers)Mark A. Pattoli (2 shared papers)Yuping Qiu (2 shared papers)Kim W. McIntyre (2 shared papers)John F. MacMaster (1 shared paper)Xiaoxia Yang (1 shared paper)
Journals: Journal of Medicinal Chemistry (4 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Drug Metabolism Reviews (2 papers)Biochemical Pharmacology (2 papers)Cancer Research (2 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Patrick Brassil

28 papers receiving 1.1k citations

Peers

Countries citing papers authored by Patrick Brassil

Since Specialization

Citations

This map shows the geographic impact of Patrick Brassil's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Brassil with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Brassil more than expected).

Fields of papers citing papers by Patrick Brassil

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Brassil. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Brassil. The network helps show where Patrick Brassil may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick Brassil, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick Brassil Line = papers co-authored together Patrick Brassil links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 28 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice Journal of Biological Chemistry ·James R. Burke, Mark A. Pattoli, Kurt R. Gregor, Patrick Brassil, John F. MacMaster, Kim W. McIntyre, Xiaoxia Yang, Violetta S. Iotzova, Wendy Clarke, Joann Strnad, Yuping Qiu, F. Christopher Zusi	2003	439
2	Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity Journal of Medicinal Chemistry ·Folkert Reck, Richard A. Alm, Patrick Brassil, Joseph P. Newman, Boudewijn L DeJonge, Charles J. Eyermann, Gloria A. Breault, John Breen, Janelle Comita-Prevoir, M Cronin, Hajnalka E. Davis, David E. Ehmann, Vincent Galullo, Bolin Geng, Tyler Grebe, Marshall Morningstar, P Craig Walker, Barry R. Hayter, Stewart L. Fisher	2011	86
3	Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK_a: Antibacterial Agents with an Improved Safety Profile Journal of Medicinal Chemistry ·Folkert Reck, Richard A. Alm, Patrick Brassil, Joseph Newman, Paul J. Ciaccio, John McNulty, Herbert Barthlow, Kosalaram Goteti, John Breen, Janelle Comita-Prevoir, M Cronin, David E. Ehmann, Bolin Geng, Andrew A. Godfrey, Stewart L. Fisher	2012	65
4	Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme Journal of Crohn s and Colitis ·William J. Sandborn, Deanna D. Nguyen, David T. Beattie, Patrick Brassil, W. D. Krey, Jacky Woo, Eva Situ, Reuben Sana, Erik Sandvik, M. Teresa Pulido‐Rios, Raj Bhandari, Jonathan A. Leighton, Ravi Ganeshappa, David L. Boyle, Brihad Abhyankar, Melanie A. Kleinschek, Richard Graham, Julián Panés	2020	65
5	Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells Drug Metabolism and Disposition ·Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser, Robert J. Riley	2009	64
6	Biotransformation and bioactivation reactions of alicyclic amines in drug molecules Drug Metabolism Reviews ·Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick Brassil, David L. Bourdet	2014	60
7	Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization Journal of Medicinal Chemistry ·Gregory S. Basarab, Patrick Brassil, P. Doig, Vincent Galullo, Howard B. Haimes, Günther Kern, Amy Kutschke, John McNulty, Virna Schuck, Gregory G. Stone, Madhusudhan Gowravaram	2014	44
8	The right compound in the right assay at the right time: an integrated discovery DMPK strategy Drug Metabolism Reviews ·Peter Ballard, Patrick Brassil, Khanh Bui, Hugues Dolgos, Carl Petersson, Anders Tunek, Peter J. H. Webborn	2012	37
9	Reaction Phenotyping: Current Industry Efforts to Identify Enzymes Responsible for Metabolizing Drug Candidates The AAPS Journal ·Timothy W. Harper, Patrick Brassil	2008	33
10	BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A2 That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models Journal of Pharmacology and Experimental Therapeutics ·James R. Burke, Lynda B. Davern, Paul Stanley, Kurt R. Gregor, Jacques Banville, Roger Rémillard, John W. Russell, Patrick Brassil, Mark R. Witmer, Graham Johnson, Jeffrey Tredup, Kenneth M. Tramposch	2001	27
11	Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents Cancer Chemotherapy and Pharmacology ·Kosalaram Goteti, C. Edwin Garner, Lucas Utley, Jing Dai, Susan Ashwell, Demetri T. Moustakas, Mithat Gönen, Gary K. Schwartz, Steven E. Kern, Sonya Zabludoff, Patrick Brassil	2009	26
12	Synthesis and structure–activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors Bioorganic & Medicinal Chemistry Letters ·Makonen Belema, Amy Bunker, Van N. Nguyen, Françis Beaulieu, Carl Ouellet, Yuping Qiu, Yunhui Zhang, Alain Martel, James R. Burke, Kim W. McIntyre, Mark A. Pattoli, Connie Daloisio, Kathleen M. Gillooly, Wendy Clarke, Patrick Brassil, F. Chris Zusi, Dolatrai M. Vyas	2007	26
13	Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy Journal of Inflammation ·David T. Beattie, M. Teresa Pulido‐Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie A. Kleinschek, Sharath S. Hegde	2017	21
14	Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors Journal of Medicinal Chemistry ·Bin Yang, Melissa M. Vasbinder, Alexander W. Hird, Qibin Su, Haixia Wang, Yan Yu, Dorin Toader, Paul D. Lyne, Jon Read, J. Breed, Stephanos Ioannidis, Chun Deng, Michael Grondine, Nancy DeGrace, David Whitston, Patrick Brassil, James W. Janetka	2018	20
15	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Vibha Oza, Susan Ashwell, Patrick Brassil, J. Breed, Jaychandran Ezhuthachan, Chun Deng, Michael Grondine, Candice L. Horn, DongFang Liu, Paul D. Lyne, Nicholas J. Newcombe, Martin Pass, Jon Read, Mei Su, Dorin Toader, Dingwei Yu, Yan Yu, Sonya Zabludoff	2012	19
16	Estimation of Human Drug Clearance Using Multiexponential Techniques The Journal of Clinical Pharmacology ·Kosalaram Goteti, Patrick Brassil, Steven S. Good, C. Edwin Garner	2008	18
17	Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130 Pharmacology Biochemistry and Behavior ·Matthew T. Taber, Robert Wright, Thaddeus F. Molski, Wendy Clarke, Patrick Brassil, Derek J. Denhart, Ronald J. Mattson, Nicholas J. Lodge	2005	17
18	Expression and distribution of cholesterol 7α-hydroxylase in rat liver Biochemical Pharmacology ·Patrick Brassil, Robert J. Edwards, Donald S. Davies	1995	17
19	Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists Bioorganic & Medicinal Chemistry ·Shuanghua Hu, Yazhong Huang, Yong‐Jin Wu, Huan He, Katherine A. Grant-Young, Robert L. Bertekap, Valerie Whiterock, Patrick Brassil, Kimberley A. Lentz, Prasanna Sivaprakasam, David R. Langley, Ryan S. Westphal, Paul M. Scola	2014	17
20	Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Thomas Schulz, Renate Thiel, Diether Neubert, Patrick Brassil, Timothy Schulz-Utermoehl, Alan R. Boobis, Robert J. Edwards	2001	17

About Patrick Brassil

Patrick Brassil is a scholar working on Pharmacology, Toxicology, Molecular Medicine, Oncology and Molecular Biology, having authored 28 papers that have together received 1.2k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (7 papers), Cancer therapeutics and mechanisms (6 papers), Drug Transport and Resistance Mechanisms (4 papers), Computational Drug Discovery Methods (3 papers), Bioactive Compounds and Antitumor Agents (3 papers), Cancer-related Molecular Pathways (3 papers), Synthesis and biological activity (2 papers) and Analytical Chemistry and Chromatography (2 papers). The work is most often cited by research in Pharmacology (189 citations), Cancer Research (256 citations), Toxicology (54 citations), Molecular Medicine (73 citations) and Oncology (272 citations). Patrick Brassil has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include James R. Burke, Wendy Clarke, Kurt R. Gregor, Mark A. Pattoli, Yuping Qiu, Kim W. McIntyre, John F. MacMaster, Xiaoxia Yang, Joann Strnad and F. Christopher Zusi. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Drug Metabolism Reviews, Biochemical Pharmacology and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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