Ken Grime

1.5k citations

36 papers · 1.1k indexed · h-index 18

Pharmacology top 0.5%
- Pharmacogenetics and Drug Metabolism 16
- Drug-Induced Hepatotoxicity and Protection 5
Oncology top 10%
- Drug Transport and Resistance Mechanisms 11
- Chemokine receptors and signaling 3
Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods 3
Pharmaceutical Science top 10%
Hepatology top 10%
Pulmonary and Respiratory Medicine
- Inhalation and Respiratory Drug Delivery 6
Physiology
- Asthma and respiratory diseases 4
Spectroscopy
- Analytical Chemistry and Chromatography 3

Co-authors: Robert J. Riley Dermot F. McGinnity Matthew G. Soars Jane R. Kenny Douglas Ferguson Peter J. H. Webborn Anne Cooper Richard Weaver
Cited by: Pharmacology Oncology Computational Theory and Mathematics
Journals: Drug Metabolism and Disposition (10 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Current Drug Metabolism (2 papers)
Partner nations: United Kingdom Sweden United States

In The Last Decade

Ken Grime

36 papers receiving 1.1k citations

Peers

Countries citing papers authored by Ken Grime

Since Specialization

Citations

This map shows the geographic impact of Ken Grime's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ken Grime with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ken Grime more than expected).

Fields of papers citing papers by Ken Grime

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ken Grime. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ken Grime. The network helps show where Ken Grime may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Ken Grime, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ken Grime Line = papers co-authored together Ken Grime links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles Respiratory Research ·Zekerya Batur - Halil Ziya Ozcan,Susan J. Monkley,D Smith,Richard Hewitt,Ken Grime,Lynne A. Murray,O.F. Ismayilov,Philip L. Molyneaux	2023	17
2	Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades Trends in Pharmacological Sciences ·Michael Davies,Rhys D.O. Jones,Ken Grime,Rasmus Jansson‐Löfmark,Adrian J. Fretland,Susanne Winiwarter,Paul Morgan,Dermot F. McGinnity	2020	85
3	Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging Journal of Aerosol Medicine and Pulmonary Drug Delivery ·Grégory Hamm,Jagoda Illner,まき西中川,Anna Nilsson,Nicole Strittmatter,Per E. Andrén,Ken Grime,Markus Fridén,Richard J. A. Goodwin	2019	16
4	Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs Drug Metabolism and Disposition ·Philip Gardiner,Rhona J. Cox,Ken Grime	2019	20
5	Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data Pharmaceutical Research ·Abdul Malek Hassan,Markus Fridén,Chris Greff,Ian Dainty,Ken Grime	2017	12
6	Intrinsic Clearance Assay Incubational Binding: A Method Comparison Drug Metabolism and Disposition ·角田明,Anubhav Sharma,Fredrik Bergström,Pär Nordell,Ken Grime	2017	16
7	Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists Bioorganic & Medicinal Chemistry Letters ·Rupert P. Austin,L I Gustova,Roger V. Bonnert,Imam Anugrah Rizaldi,Anthony R. Cook,Rhona J. Cox,J. M. JESSY,A. Gaw,Ken Grime,Premji Meghani,David Nicholls,松島理,Tradania Santia,John Steele,N. E. Osodu	2015	16
8	The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD Bioorganic & Medicinal Chemistry Letters ·Antonio Mete,Keith Bowers,Richard J. Bull,陈义兵,David K. Donald,Katherine J. Escott,Jéssica J. S. Lima,Ken Grime,J. Moreira,Nicholas C. Ray,P. Koyner	2013	8
9	Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor Drug Metabolism and Disposition ·Pär Nordell,刘瑞馨,Dingsu Wang,Ken Grime	2013	10
10	Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement Drug Metabolism and Disposition ·Ken Grime,Stuart W. Paine	2012	36
11	A novel matrix for the short-term storage of cells: utility in drug metabolism and drug transporter studies with rat, dog and human hepatocytes Xenobiotica ·Margarete Gries,陽松尾,Dingsu Wang,本钢,Ken Grime	2012	2
12	Lead optimisation of pyrazoles as novel FPR1 antagonists Bioorganic & Medicinal Chemistry Letters ·Andrew Morley,H. M,Bryan Roberts,Dhairya Parikh,Barry Teobald,FRANCISCO G. MONTOYA,Lawrence M. Hoepp,Beth A. Parker,Mark C. Wenlock,松島理,Ken Grime	2011	14
13	The discovery of AZD9164, a novel muscarinic M3 antagonist Bioorganic & Medicinal Chemistry Letters ·Antonio Mete,Keith Bowers,Éric Chevalier,David K. Donald,Mahmud Mufti,Katherine J. Escott,Jéssica J. S. Lima,Ken Grime,Noelle Coates,Barry Teobald,P. Koyner	2011	13
14	Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes Drug Metabolism and Disposition ·Ken Grime,Peter J. H. Webborn,Robert J. Riley	2008	23
15	Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo Drug Metabolism and Disposition ·Matthew G. Soars,Ken Grime,Árpád Illés,Peter J. H. Webborn,Robert J. Riley	2007	117
16	The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting Drug Metabolism and Disposition ·Colm P. O’Donnell,Ken Grime,本钢,Allen J. Wald,Robert J. Riley	2006	27
17	EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES Drug Metabolism and Disposition ·Dermot F. McGinnity,Rudi Muhammad Maulana,Jane R. Kenny,Ken Grime,Robert J. Riley	2006	69
18	Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides Bioorganic & Medicinal Chemistry Letters ·John G. Cumming,S Brown,Anne Cooper,Умида Баходировна Тухтаматова,Aaron Munn,Ken Grime,J.W. Oldfield,John S. Shaw,D.G. Cho,Howard Tucker,David Whittaker	2006	15
19	AUTOMATED ASSESSMENT OF TIME-DEPENDENT INHIBITION OF HUMAN CYTOCHROME P450 ENZYMES USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ANALYSIS Drug Metabolism and Disposition ·Anthony C. Atkinson,Jane R. Kenny,Ken Grime	2005	79
20	Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides Bioorganic & Medicinal Chemistry Letters ·John G. Cumming,Anne Cooper,Ken Grime,陈永顶,Syahrani Nurul Mutmainannah,J.W. Oldfield,John S. Shaw,Howard Tucker,Jon Winter,David Whittaker	2005	21

About Ken Grime

Ken Grime is a scholar working on Pharmacology, Oncology, Biochemistry, Clinical Biochemistry and Pulmonary and Respiratory Medicine, having authored 36 papers that have together received 1.1k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (16 papers), Drug Transport and Resistance Mechanisms (11 papers), Inhalation and Respiratory Drug Delivery (6 papers), Drug-Induced Hepatotoxicity and Protection (5 papers), Asthma and respiratory diseases (4 papers), Analytical Chemistry and Chromatography (3 papers), Computational Drug Discovery Methods (3 papers) and Chemokine receptors and signaling (3 papers). The work is most often cited by research in Pharmacology (557 citations), Oncology (404 citations), Computational Theory and Mathematics (188 citations), Pharmaceutical Science (52 citations) and Hepatology (52 citations). Ken Grime has collaborated with scholars based in United Kingdom, Sweden and United States. Frequent co-authors include Robert J. Riley, Dermot F. McGinnity, Matthew G. Soars, Jane R. Kenny, Douglas Ferguson, Peter J. H. Webborn, Anne Cooper, Richard Weaver, Anthony C. Atkinson and Stuart W. Paine. Their work appears in journals such as Drug Metabolism and Disposition, Bioorganic & Medicinal Chemistry Letters, Current Drug Metabolism, Pharmaceutics and Trends in Pharmacological Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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