Jack Uetrecht

12.1k total citations · 1 hit paper
199 papers, 8.8k citations indexed

About

Jack Uetrecht is a scholar working on Pharmacology, Immunology and Pharmacology. According to data from OpenAlex, Jack Uetrecht has authored 199 papers receiving a total of 8.8k indexed citations (citations by other indexed papers that have themselves been cited), including 71 papers in Pharmacology, 62 papers in Immunology and 47 papers in Pharmacology. Recurrent topics in Jack Uetrecht's work include Drug-Induced Hepatotoxicity and Protection (51 papers), Pharmacogenetics and Drug Metabolism (41 papers) and Blood disorders and treatments (36 papers). Jack Uetrecht is often cited by papers focused on Drug-Induced Hepatotoxicity and Protection (51 papers), Pharmacogenetics and Drug Metabolism (41 papers) and Blood disorders and treatments (36 papers). Jack Uetrecht collaborates with scholars based in Canada, United States and Japan. Jack Uetrecht's co-authors include Nasir Zahid, Imir G. Metushi, Neil H. Shear, Dean J. Naisbitt, Chia Hsin Ju, Adam J. Shuhendler, Lina Cui, Kanyi Pu, Jianghong Rao and Simon R. Knowles and has published in prestigious journals such as The Lancet, Journal of the American Chemical Society and Annals of Internal Medicine.

In The Last Decade

Jack Uetrecht

199 papers receiving 8.5k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

2014 538 citations Jack Uetrecht et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Jack Uetrecht	3.4k	1.8k	1.7k	1.4k	1.4k	199	8.8k
Edward T. Morgan	3.7k 1.1×	781 0.4×	2.3k 1.3×	723 0.5×	2.0k 1.5×	120	7.7k
Miki Nakajima	4.7k 1.4×	1.1k 0.6×	4.5k 2.6×	363 0.3×	3.0k 2.2×	267	11.0k
Dean J. Naisbitt	1.5k 0.5×	3.6k 2.0×	859 0.5×	1.5k 1.1×	677 0.5×	200	6.9k
Neil R. Kitteringham	1.8k 0.5×	819 0.5×	3.1k 1.8×	542 0.4×	937 0.7×	92	7.3k
Noriaki Shimada	2.4k 0.7×	521 0.3×	1.8k 1.0×	332 0.2×	1.4k 1.0×	207	9.6k
Sidney D. Nelson	6.5k 1.9×	782 0.4×	2.9k 1.7×	322 0.2×	2.4k 1.7×	213	10.8k
Caroline F. Thorn	2.0k 0.6×	826 0.5×	2.2k 1.3×	285 0.2×	1.3k 0.9×	58	6.9k
Hong‐Hao Zhou	1.7k 0.5×	833 0.5×	3.6k 2.1×	408 0.3×	1.4k 1.0×	258	7.8k
Patrick Maurel	6.6k 1.9×	795 0.4×	3.3k 2.0×	342 0.2×	3.9k 2.8×	205	12.8k
Tsuyoshi Yokoi	7.2k 2.1×	1.6k 0.9×	6.2k 3.6×	525 0.4×	4.8k 3.4×	369	16.2k

Countries citing papers authored by Jack Uetrecht

Since Specialization

Citations

This map shows the geographic impact of Jack Uetrecht's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jack Uetrecht with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jack Uetrecht more than expected).

Fields of papers citing papers by Jack Uetrecht

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jack Uetrecht. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jack Uetrecht. The network helps show where Jack Uetrecht may publish in the future.

Co-authorship network of co-authors of Jack Uetrecht

This figure shows the co-authorship network connecting the top 25 collaborators of Jack Uetrecht. A scholar is included among the top collaborators of Jack Uetrecht based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jack Uetrecht. Jack Uetrecht is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Shinozawa, Tadahiro, Kazumasa Miyamoto, K. Scott Baker, et al.. (2025). TAK-994 mechanistic investigation into drug-induced liver injury. Toxicological Sciences. 204(2). 143–153. 2 indexed citations

Bonneil, Éric, et al.. (2024). Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis. Journal of Pharmacology and Experimental Therapeutics. 388(3). 827–845. 3 indexed citations

Balzani, Eleonora, Mohd H. Abdul‐Aziz, J. Turgeon, et al.. (2024). Propofol and Fentanyl Pharmacokinetics and Pharmacodynamics in Extracorporeal Membrane Oxygenation. Annals of the American Thoracic Society. 22(1). 121–129. 1 indexed citations

Uetrecht, Jack. (2023). A review of the mechanisms of valproate-induced liver injury with an emphasis on the role of reactive metabolites discovered by Tom Baillie. Medicinal Chemistry Research. 32(9). 1995–2000. 3 indexed citations

Uetrecht, Jack, et al.. (2023). The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis. International Journal of Molecular Sciences. 24(2). 1243–1243. 13 indexed citations

Brandt, Christian, Lynanne McGuire, & Jack Uetrecht. (2021). Severe cutaneous adverse reaction associated with antiseizure medications: Diagnosis, management, and prevention. Epilepsy & Behavior. 117. 107844–107844. 6 indexed citations

Metushi, Imir G., M. Anthony Hayes, & Jack Uetrecht. (2014). Treatment of PD‐1−/− mice with amodiaquine and anti‐CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients. Hepatology. 61(4). 1332–1342. 112 indexed citations

Metushi, Imir G., et al.. (2013). Hepatic effects of aminoglutethimide: A model aromatic amine. Journal of Immunotoxicology. 12(1). 24–32. 3 indexed citations

Sharma, Amy & Jack Uetrecht. (2013). Bioactivation of drugs in the skin: relationship to cutaneous adverse drug reactions. Drug Metabolism Reviews. 46(1). 1–18. 22 indexed citations

10.

Mannargudi, Baskar, David McNally, William Reynolds, & Jack Uetrecht. (2009). Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis. Drug Metabolism and Disposition. 37(9). 1806–1818. 11 indexed citations

11.

Uetrecht, Jack, et al.. (2007). Changes In Gene Expression Induced by Tienilic Acid and Sulfamethoxazole: Testing the Danger Hypothesis. Journal of Immunotoxicology. 4(4). 253–266. 10 indexed citations

12.

Furst, Sylvia M., et al.. (1995). Covalent binding of carbamazepine oxidative metabolites to neutrophils.. Drug Metabolism and Disposition. 23(5). 590–594. 30 indexed citations

13.

Nakamura, Hideki, Jack Uetrecht, Alastair E. Cribb, et al.. (1995). In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity.. Journal of Pharmacology and Experimental Therapeutics. 274(3). 1099–1104. 30 indexed citations

14.

Liu, Zhichao & Jack Uetrecht. (1995). Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.. Journal of Pharmacology and Experimental Therapeutics. 275(3). 1476–1483. 148 indexed citations

15.

Uetrecht, Jack, et al.. (1994). Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone-induced agranulocytosis.. Journal of Pharmacology and Experimental Therapeutics. 270(3). 865–872. 36 indexed citations

16.

Uetrecht, Jack, Neil H. Shear, & Nasir Zahid. (1993). N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system.. Drug Metabolism and Disposition. 21(5). 830–834. 41 indexed citations

17.

Uetrecht, Jack, Nasir Zahid, Neil H. Shear, & W. Douglas Biggar. (1988). Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells.. Journal of Pharmacology and Experimental Therapeutics. 245(1). 274–279. 110 indexed citations

18.

Rieder, Michael J., Jack Uetrecht, Neil H. Shear, & Stephen P. Spielberg. (1988). Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides.. Journal of Pharmacology and Experimental Therapeutics. 244(2). 724–728. 130 indexed citations

19.

Uetrecht, Jack, Brian J. Sweetman, Raymond L. Woosley, & J A Oates. (1984). Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes.. Drug Metabolism and Disposition. 12(1). 77–81. 41 indexed citations

20.

Freeman, Richard W., Jack Uetrecht, Raymond L. Woosley, J A Oates, & Raymond D. Harbison. (1981). Covalent binding of procainamide in vitro and in vivo to hepatic protein in mice.. Drug Metabolism and Disposition. 9(3). 188–192. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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