Antonı́n Holý

15.0k total citations · 2 hit papers
587 papers, 12.5k citations indexed

About

Antonı́n Holý is a scholar working on Molecular Biology, Organic Chemistry and Infectious Diseases. According to data from OpenAlex, Antonı́n Holý has authored 587 papers receiving a total of 12.5k indexed citations (citations by other indexed papers that have themselves been cited), including 352 papers in Molecular Biology, 242 papers in Organic Chemistry and 200 papers in Infectious Diseases. Recurrent topics in Antonı́n Holý's work include HIV/AIDS drug development and treatment (197 papers), Biochemical and Molecular Research (185 papers) and DNA and Nucleic Acid Chemistry (119 papers). Antonı́n Holý is often cited by papers focused on HIV/AIDS drug development and treatment (197 papers), Biochemical and Molecular Research (185 papers) and DNA and Nucleic Acid Chemistry (119 papers). Antonı́n Holý collaborates with scholars based in Czechia, Belgium and Switzerland. Antonı́n Holý's co-authors include Erik De Clercq, Ivan Rosenberg, Ivan Votruba, Jan Balzarini, Milena Masojı́dková, Hana Dvořáková, Robert Snoeck, Takashi Sakuma, Lieve Naesens and Graciela Andreï and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Antonı́n Holý

574 papers receiving 11.9k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A novel selective broad-spectrum anti-DNA virus agent

1986 649 citations Erik De Clercq, Antonı́n Holý et al. Nature profile →
Acyclic nucleoside phosphonates: a key class of antiviral drugs

2005 559 citations Erik De Clercq, Antonı́n Holý profile →

Peers

Countries citing papers authored by Antonı́n Holý

Since Specialization

Citations

This map shows the geographic impact of Antonı́n Holý's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Antonı́n Holý with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Antonı́n Holý more than expected).

Fields of papers citing papers by Antonı́n Holý

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Antonı́n Holý. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Antonı́n Holý. The network helps show where Antonı́n Holý may publish in the future.

Co-authorship network of co-authors of Antonı́n Holý

This figure shows the co-authorship network connecting the top 25 collaborators of Antonı́n Holý. A scholar is included among the top collaborators of Antonı́n Holý based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Antonı́n Holý. Antonı́n Holý is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Influence of Acyclic Nucleoside Phosphonate Antivirals on Gene Expression of Chemokine Receptors CCR5 and CXCR4 2015 ·Folia Biologica ·(unknown), Antonı́n Holý, Zdeňek Zı́dek	2
2	A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity 2013 ·PLoS Pathogens ·Jan Balzarini, Graciela Andreï, E Balestra, Dana Huskens, Christophe Vanpouille, Andrea Introini, Sonia Zicari, Sandra Liekens, Robert Snoeck, Antonı́n Holý, Carlo Federico Perno, Leonid Margolis, Dominique Schols	20
3	An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli 2012 ·Bioorganic & Medicinal Chemistry ·Jiří Blažek, Petr Jansa, Ondřej Baszczyňski, Martin Kaiser, Miroslav Otmar, Marcela Krečmerová, (unknown), Antonı́n Holý, Blanka Králová	8
4	Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP 2011 ·Pharmaceutical Research ·Kateřina Vávrová, Petra Kovařı́ková, Barbora Školová, (unknown), Jaroslav Roh, (unknown), Antonı́n Holý, Alexandr Hrabálek	6
5	6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs 2011 ·Current Topics in Medicinal Chemistry ·John de Jersey, Antonı́n Holý, Dana Hocková, Lieve Naesens, Dianne T. Keough, Luke W. Guddat	36
6	Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3- d ]pyrimidin-2(3 H )-one base 2010 ·Canadian Journal of Chemistry ·Zlatko Janeba, Antonı́n Holý, Radek Pohl, Robert Snoeck, Graciela Andreï, Erik De Clercq, Jan Balzarini	15
7	Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine 2008 ·Biochemical Pharmacology ·Lieve Naesens, Graciela Andreï, Ivan Votruba, Marcela Krečmerová, Antonı́n Holý, Johan Neyts, Erik De Clercq, Robert Snoeck	20
8	In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2- (phosphonomethoxy) propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450 2008 ·Physiological Research ·Eva Anzenbacherová, Pavel Anzenbacher, Zdeňek Zı́dek, (unknown), Eva Kmonı́čková, (unknown), Jana Nekvindová, (unknown), Antonı́n Holý	4
9	Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates 2007 ·European Journal of Pharmacology ·Zdeňek Zı́dek, Eva Kmonı́čková, Antonı́n Holý	8
10	Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. 2006 ·PubMed ·(unknown), (unknown), Jana Nekvindová, Eva Anzenbacherová, (unknown), Pavel Anzenbacher, Zdeňek Zı́dek, Antonı́n Holý	4
11	Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine 2006 ·European Journal of Pharmacology ·Eva Kmonı́čková, (unknown), Antonı́n Holý, Zdeňek Zı́dek	16
12	Determination of acid–base dissociation constants of amino‐ and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis 2006 ·Electrophoresis ·Veronika Šolı́nová, Václav Kašička, Dušan Koval, Michal Česnek, Antonı́n Holý	34
13	Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir 2006 ·Xenobiotica ·Jana Nekvindová, Vlastimil Mašek, (unknown), Eva Anzenbacherová, Pavel Anzenbacher, Zdeňek Zı́dek, Antonı́n Holý	18
14	Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection 2005 ·Nature ·Koert J. Stittelaar, Johan Neyts, Lieve Naesens, Geert van Amerongen, (unknown), Antonı́n Holý, Erik De Clercq, Hubert G.M. Niesters, Edwin Fries, (unknown), Paul Mulder, B A van der Zeijst, Albert D. M. E. Osterhaus	166
15	Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages 2005 ·Bioorganic & Medicinal Chemistry ·Michal Česnek, Antonı́n Holý, Milena Masojı́dková, Zdeňek Zı́dek	14
16	Activity of the (R)-Enantiomers of 9-(2-Phosphonylmethoxypropyl)-Adenine and 9-(2-Phosphonylmethoxypropyl)-2,6-diaminopurine against Human Immunodeficiency Virus in Different Human Cell Systems 1996 ·Biochemical and Biophysical Research Communications ·Jan Balzarini, Stefano Aquaro, Carlo Federico Perno, Myriam Witvrouw, Antonı́n Holý, Erik De Clercq	77
17	Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice 1993 ·Journal of Medical Virology ·Lieve Naesens, Johan Neyts, Jan Balzarini, Antonı́n Holý, Ivan Rosenberg, Erik De Clercq	25
18	Synthesis of 1-(3-azido-2,3-dideoxy-β- d -allofuranosyl)thymine, 1-(2,3-dideoxy-β- d -allofuranosyl)thymine, and 1-(2,3-dideoxy-β- d - erythro -hex-2-enofuranosyl)thymine 1992 ·Carbohydrate Research ·Hubert Hřebabecký, Antonı́n Holý	11
19	Inhibitory effects of 9-(2,3-dihydroxypropyl) adenine and 3-(adenin-9-yl)-2-hydroxypropanoic acid 2-methylpropylester on potato virus X replication 1988 ·Antiviral Research ·Gottfried Schuster, Antonı́n Holý	4
20	Conversion of 2‐mercaptopyrimidine intoS‐(pyrimidin‐2‐yl)‐cysteine in growingEscherichia coli cells 1972 ·FEBS Letters ·Ivan Votruba, Antonı́n Holý, (unknown)	25

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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