James Chen

19.0k total citations · 8 hit papers
227 papers, 14.2k citations indexed

About

James Chen is a scholar working on Molecular Biology, Cell Biology and Genetics. According to data from OpenAlex, James Chen has authored 227 papers receiving a total of 14.2k indexed citations (citations by other indexed papers that have themselves been cited), including 106 papers in Molecular Biology, 25 papers in Cell Biology and 20 papers in Genetics. Recurrent topics in James Chen's work include Hedgehog Signaling Pathway Studies (32 papers), Epigenetics and DNA Methylation (23 papers) and Developmental Biology and Gene Regulation (13 papers). James Chen is often cited by papers focused on Hedgehog Signaling Pathway Studies (32 papers), Epigenetics and DNA Methylation (23 papers) and Developmental Biology and Gene Regulation (13 papers). James Chen collaborates with scholars based in United States, Canada and China. James Chen's co-authors include Philip A. Beachy, Jussi Taipale, Michael K. Cooper, Sibo Feng, Hongtao Yu, Surajit Sinha, Stuart L. Schreiber, Andrew W. Brauer, Tapan Maiti and Keith E. Young and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

James Chen

211 papers receiving 13.9k citations

Hit Papers

Inhibition of Hedgehog signaling by direct binding of cyc... 1994 2026 2004 2015 2002 2000 1994 2002 1994 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    2002 1.2k citations James Chen, Philip A. Beachy et al. profile →
  2. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    2000 1.1k citations James Chen, Philip A. Beachy et al. Nature profile →
  3. Structural basis for the binding of proline-rich peptides to SH3 domains
    1994 880 citations James Chen et al. profile →
  4. Small molecule modulation of Smoothened activity
    2002 817 citations James Chen, Philip A. Beachy et al. profile →
  5. Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions
    1994 715 citations James Chen et al. Science profile →
  6. Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
    2002 632 citations James Chen, Philip A. Beachy et al. Science profile →
  7. Organic wastewater treatment by a single-atom catalyst and electrolytically produced H2O2
    2020 572 citations Zhiping Feng, James Chen et al. profile →
  8. Stromal response to Hedgehog signaling restrains pancreatic cancer progression
    2014 386 citations James Chen, Philip A. Beachy et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
James Chen United States 54 10.1k 2.1k 1.9k 1.5k 1.1k 227 14.2k
Nicholas D. Socci United States 74 13.5k 1.3× 3.1k 1.5× 1.8k 0.9× 1.1k 0.7× 2.1k 1.9× 158 21.6k
Yaping Liu China 45 5.0k 0.5× 2.1k 1.0× 830 0.4× 1.3k 0.9× 659 0.6× 209 11.1k
David W. Speicher United States 72 12.6k 1.2× 2.3k 1.1× 1.2k 0.6× 3.6k 2.3× 462 0.4× 278 19.3k
Antony W. Burgess Australia 65 9.1k 0.9× 5.3k 2.6× 1.3k 0.7× 1.0k 0.7× 802 0.8× 258 16.6k
Andrew Emili Canada 66 16.3k 1.6× 1.2k 0.6× 2.2k 1.1× 1.6k 1.0× 1.4k 1.3× 257 21.9k
Michael P. Washburn United States 78 21.3k 2.1× 2.5k 1.2× 1.8k 0.9× 2.2k 1.4× 463 0.4× 260 27.8k
Anne E. Carpenter United States 58 11.0k 1.1× 1.6k 0.8× 1.2k 0.6× 2.1k 1.4× 238 0.2× 166 19.8k
Alnawaz Rehemtulla United States 65 5.1k 0.5× 2.2k 1.1× 1.2k 0.6× 663 0.4× 510 0.5× 232 13.1k
William G. Richards United States 65 9.5k 0.9× 3.4k 1.7× 1.8k 0.9× 755 0.5× 287 0.3× 249 20.5k
Gianni Cesareni Italy 59 11.4k 1.1× 1.1k 0.6× 1.5k 0.8× 1.8k 1.1× 661 0.6× 188 13.9k

Countries citing papers authored by James Chen

Since Specialization
Citations

This map shows the geographic impact of James Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James Chen more than expected).

Fields of papers citing papers by James Chen

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James Chen. The network helps show where James Chen may publish in the future.

Co-authorship network of co-authors of James Chen

This figure shows the co-authorship network connecting the top 25 collaborators of James Chen. A scholar is included among the top collaborators of James Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James Chen. James Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Sakata‐Kato, Tomoyo, et al.. (2025). Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors. ChemistryOpen. 14(5). e202500119–e202500119. 1 indexed citations
2.
Liang, Hao, et al.. (2024). Catalytic asymmetric synthesis of meta benzene isosteres. Nature. 633(8028). 90–95. 10 indexed citations
3.
MacKay, Matthew, et al.. (2023). Abstract P5-05-08: Dual ctDNA and tissue sequencing improves detection of actionable variants in breast cancer patients. Cancer Research. 83(5_Supplement). P5–5. 1 indexed citations
4.
Feng, Zhiping, Daniel Fernández, Alison E. Ondrus, et al.. (2022). Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nature Chemical Biology. 18(10). 1065–1075. 40 indexed citations
5.
King, Kylie, Susan Russell, Laveniya Satgunaseelan, et al.. (2022). “MYH9 mutation and squamous cell cancer of the tongue in a young adult: a novel case report”. Diagnostic Pathology. 17(1). 23–23. 6 indexed citations
6.
Chen, James, et al.. (2020). Lanthanide-Based Optical Probes of Biological Systems. Cell chemical biology. 27(8). 921–936. 77 indexed citations
7.
Chen, James, et al.. (2020). Design Method for Tunable Planar Bandpass Filters With Single-Bias Control and Wide Tunable Frequency Range. IEEE Transactions on Circuits & Systems II Express Briefs. 68(1). 221–225. 17 indexed citations
8.
9.
Monette, Patrick, et al.. (2018). Autoregulation of the Streptococcus mutans SloR Metalloregulator Is Constitutive and Driven by an Independent Promoter. Journal of Bacteriology. 200(14). 12 indexed citations
10.
Oo, Zay Yar, Alexander J. Stevenson, Sebastian Walpole, et al.. (2018). Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clinical Cancer Research. 24(12). 2901–2912. 17 indexed citations
11.
Chen, James, et al.. (2018). A Viable LoRa Framework for Smart Cities. Journal of the Association for Information Systems. 2 indexed citations
12.
Gutzman, Jennifer H., et al.. (2018). Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biology Open. 7(11). 20 indexed citations
13.
Yao, Qingqiang, Bo Wei, Nancy Liu, et al.. (2014). Chondrogenic Regeneration Using Bone Marrow Clots and a Porous Polycaprolactone-Hydroxyapatite Scaffold by Three-Dimensional Printing. Tissue Engineering Part A. 21(7-8). 1388–1397. 39 indexed citations
14.
Chen, James. (2011). The Emergence of China in the Middle East. 1. 4 indexed citations
15.
16.
Tso, Cho-Lea, Peter Shintaku, James Chen, et al.. (2006). Primary Glioblastomas Express Mesenchymal Stem-Like Properties. Molecular Cancer Research. 4(9). 607–619. 184 indexed citations
17.
Chen, Wei, Xiu-Rong Ren, Christopher Nelson, et al.. (2004). Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2. Science. 306(5705). 2257–2260. 221 indexed citations
18.
Tsukamoto, Norifumi, James Chen, & Akira Yoshida. (1998). Enhanced Expressions of Glucose-6-Phosphate Dehydrogenase and Cytosolic Aldehyde Dehydrogenase and Elevation of Reduced Glutathione Level in Cyclophosphamide-Resistant Human Leukemia Cells. Blood Cells Molecules and Diseases. 24(2). 231–238. 23 indexed citations
19.
Chen, James, et al.. (1994). A User-Centered Approach to Adaptive Hypertext Based on an Information Relevance Model. 16 indexed citations
20.
Chen, James, et al.. (1992). TPF dump analyzer: a system to provide expert assistance to analysts in solving run-time program exceptions by deriving program intention from a TPF assembly language program. Innovative Applications of Artificial Intelligence. 71–88. 3 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Breakdown of academic impact, for papers by Nicholas D. Socci Breakdown of academic impact, for papers by Yaping Liu Breakdown of academic impact, for papers by David W. Speicher Breakdown of academic impact, for papers by Antony W. Burgess Breakdown of academic impact, for papers by Andrew Emili Breakdown of academic impact, for papers by Michael P. Washburn Breakdown of academic impact, for papers by Anne E. Carpenter Breakdown of academic impact, for papers by Alnawaz Rehemtulla Breakdown of academic impact, for papers by William G. Richards Breakdown of academic impact, for papers by Gianni Cesareni
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