Natilie Hosea

2.5k citations

21 papers · 1.5k indexed · h-index 16

Pharmacology top 0.5%
- Pharmacogenetics and Drug Metabolism 10
- Cholinesterase and Neurodegenerative Diseases 5
Pharmacology top 2%
- Pharmacogenetics and Drug Metabolism 10
- Cholinesterase and Neurodegenerative Diseases 5
Oncology top 5%
- Drug Transport and Resistance Mechanisms 4
Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods 7
Pediatrics, Perinatology and Child Health top 10%
Genetics
- Estrogen and related hormone effects 3
Spectroscopy
- Analytical Chemistry and Chromatography 3
Plant Science
- Pesticide Exposure and Toxicity 3
Organic Chemistry
- Chemical Reaction Mechanisms 3

Co-authors: F. Peter Guengerich Palmer Taylor Harvey Alan Berman Grover P. Miller Zoran Radić Bill J. Smith Megan Gibbs Hannah M. Jones
Cited by: Pharmacology Oncology
Journals: Journal of Clinical Oncology (1 paper)Biochemistry (4 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)
Partner nations: United States United Kingdom Japan

In The Last Decade

Natilie Hosea

21 papers receiving 1.5k citations

Peers

Countries citing papers authored by Natilie Hosea

Since Specialization

Citations

This map shows the geographic impact of Natilie Hosea's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Natilie Hosea with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Natilie Hosea more than expected).

Fields of papers citing papers by Natilie Hosea

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Natilie Hosea. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Natilie Hosea. The network helps show where Natilie Hosea may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Natilie Hosea, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Natilie Hosea Line = papers co-authored together Natilie Hosea links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Intermittent Oral Coadministration of a Gamma Secretase Inhibitor with Dexamethasone Mitigates Intestinal Goblet Cell Hyperplasia in Rats Toxicologic Pathology ·Shirley A. Aguirre,Ling Liu,Natilie Hosea,Wesley Scott,Jeffrey R. May,Leigh Ann Burns‐Naas,Sophia Randolph,Robert H. Denlinger,Bora Han	2013	4
2	Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding BMC Genomics ·Zhou Zhu,Manli Shi,Wenyue Hu,Heather Estrella,Jon Engebretsen,Tim Nichols,David M. Briere,Natilie Hosea,Gerrit Los,Paul A. Rejto,Andrea Fanjul	2012	7
3	Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo,Susan E. Kephart,Martha A. Ornelas,Javier González,Angelica Linton,Mason Pairish,Asako Nagata,S.E. Greasley,Jeff Elleraas,Natilie Hosea,Jon Engebretsen,Andrea Fanjul	2011	11
4	Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling Clinical Pharmacokinetics ·Hannah M. Jones,Iain Gardner,Wendy T. Collard,Phil Stanley,Penny Oxley,Natilie Hosea,David R. Plowchalk,Steve S. Gernhardt,Jing Lin,Maurice Dickins,S. Ravi Rahavendran,Barry Jones,Kenny J. Watson,Henry Pertinez,Vikas Kumar,Susan Cole	2011	79
5	Drug Design Tools - In Silico, In Vitro and In Vivo ADME/PK Prediction and Interpretation: Is PK in Monkey An Essential Part of a Good Human PK Prediction? Current Topics in Medicinal Chemistry ·Natilie Hosea	2011	3
6	Phase I study of PF-04554878, a second-generation focal adhesion kinase (FAK) inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology ·Suzanne F. Jones,Geoffrey I. Shapiro,Johanna C. Bendell,E. X. Chen,P. Bedard,J. M. Cleary,Shuchi S. Pandya,Kristen J. Pierce,Brett E. Houk,Natilie Hosea,K. S. Zandi,W. G. Roberts,S. Martin Shreeve,Lillian L. Siu	2011	10
7	Evaluation of Selective γ-Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design Molecular Cancer Therapeutics ·Ping Wei,Marlena Walls,Ming Qiu,Richard Ding,Robert H. Denlinger,Anthony Wong,Kosta Tsaparikos,Jitesh P. Jani,Natilie Hosea,Michelle Sands,Sophia Randolph,Tod Smeal	2010	158
8	N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275 Bioorganic & Medicinal Chemistry Letters ·Michael Siu,Theodore Johnson,Yong Wang,Sajiv K. Nair,Wendy Taylor,Stephan J. Cripps,Jean Matthews,Martin P. Edwards,Thomas Pauly,Jacques Ermolieff,Arturo Castro,Natilie Hosea,Amy LaPaglia,Andrea Fanjul,Jennifer E. Vogel	2009	35
9	Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches The Journal of Clinical Pharmacology ·Natilie Hosea,Wendy T. Collard,Susan Cole,Tristan S. Maurer,Rick X. Fang,Hannah M. Jones,Shefali Kakar,Yasuhiro Nakai,Bill J. Smith,Rob Webster,Kevin Beaumont	2009	205
10	Demonstration of Proof of Mechanism and Pharmacokinetics and Pharmacodynamic Relationship with 4′-Cyano-biphenyl-4-sulfonic Acid (6-Amino-pyridin-2-yl)-amide (PF-915275), an Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1, in Cynomolgus Monkeys Journal of Pharmacology and Experimental Therapeutics ·Balkrishen Bhat,Natilie Hosea,Andrea Fanjul,Jocelyn Herrera,Justin Chapman,F.W. Thalacker,Paul M. Stewart,Paul A. Rejto	2007	47
11	Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration Drug Metabolism and Disposition ·Xingrong Liu,Bill J. Smith,Cuiping Chen,Ernesto Callegari,Stacey L. Becker,Xi Chen,Julie Cianfrogna,Angela C. Doran,Shawn D. Doran,John P. Gibbs,Natilie Hosea,Jianhua Liu,Frederick Nelson,Mark A. Szewc,Jeffrey Van Deusen	2006	129
12	Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding Journal of Pharmacology and Experimental Therapeutics ·Xingrong Liu,Bill J. Smith,Cuiping Chen,Ernesto Callegari,Stacey L. Becker,Xi Chen,Julie Cianfrogna,Angela C. Doran,Shawn D. Doran,John P. Gibbs,Natilie Hosea,Jianhua Liu,Frederick Nelson,Mark A. Szewc,Jeffery Van Deusen	2005	136
13	Factors Affecting the Clinical Development of Cytochrome P450 3A Substrates Clinical Pharmacokinetics ·Megan Gibbs,Natilie Hosea	2003	49
14	Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4 Biochemistry ·Natilie Hosea,Grover P. Miller,F. Peter Guengerich	2000	201
15	Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity Chemico-Biological Interactions ·Palmer Taylor,Lilly Wong,Zoran Radić,Igor F. Tsigelny,Roger J. M. Brüggemann,Natilie Hosea,Harvey Alan Berman	1999	20
16	Oxidation of Nonionic Detergents by Cytochrome P450 Enzymes Archives of Biochemistry and Biophysics ·Natilie Hosea,F. Peter Guengerich	1998	32
17	Reconstitution Premixes for Assays Using Purified Recombinant Human Cytochrome P450, NADPH-Cytochrome P450 Reductase, and Cytochromeb5 Archives of Biochemistry and Biophysics ·Peter Shaw,Natilie Hosea,David V. Thompson,Janean M. Lenius,F. Peter Guengerich	1997	80
18	Aspartate 74 as a Primary Determinant in Acetylcholinesterase Governing Specificity to Cationic Organophosphonates Biochemistry ·Natilie Hosea,Zoran Radić,Igor F. Tsigelny,Harvey Alan Berman,Daniel M. Quinn,Palmer Taylor	1996	60
19	Structural bases for the specificity of cholinesterase catalysis and inhibition Toxicology Letters ·Palmer Taylor,Zoran Radić,Natilie Hosea,Shelley Camp,P. Marchot,Harvey Alan Berman	1995	83
20	Specificity and Orientation of Trigonal Carboxyl Esters and Tetrahedral Alkylphosphonyl Esters in Cholinesterases Biochemistry ·Natilie Hosea,Harvey Alan Berman,Palmer Taylor	1995	87

About Natilie Hosea

Natilie Hosea is a scholar working on Pharmacology, Computational Theory and Mathematics and Pharmacology, having authored 21 papers that have together received 1.5k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (10 papers), Computational Drug Discovery Methods (7 papers), Cholinesterase and Neurodegenerative Diseases (5 papers), Drug Transport and Resistance Mechanisms (4 papers), Estrogen and related hormone effects (3 papers), Analytical Chemistry and Chromatography (3 papers), Pesticide Exposure and Toxicity (3 papers) and Chemical Reaction Mechanisms (3 papers). The work is most often cited by research in Pharmacology (549 citations), Pharmacology (414 citations) and Oncology (487 citations). Natilie Hosea has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include F. Peter Guengerich, Palmer Taylor, Harvey Alan Berman, Grover P. Miller, Zoran Radić, Bill J. Smith, Megan Gibbs, Hannah M. Jones, Susan Cole and Wendy T. Collard. Their work appears in journals such as Journal of Clinical Oncology, Biochemistry and Journal of Pharmacology and Experimental Therapeutics.

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