Michael O. Hottiger

20.3k citations

182 papers · 15.0k indexed · 5 hit papers · h-index 65

Impact in

Physiology top 0.05%
- Calcium signaling and nucleotide metabolism
Geriatrics and Gerontology top 0.1%
- Sirtuins and Resveratrol in Medicine

Papers in

Physiology 35
- Calcium signaling and nucleotide metabolism 35
Geriatrics and Gerontology 15
- Sirtuins and Resveratrol in Medicine 15

Co-authors: Paul O. Hassa Matthias Altmeyer Bernhard Lüscher Bin Ma Ralph Imhof Sameez Hasan Gary J. Nabel Simon Messner
Journals: Journal of Biological Chemistry (11 papers)Nucleic Acids Research (11 papers)Molecular Cell (10 papers)Nature Communications (6 papers)Proceedings of the National Academy of Sciences (5 papers)
Partner nations: Switzerland United States Germany

In The Last Decade

Michael O. Hottiger

181 papers receiving 14.8k citations

Hit Papers

5 papers align trajectories log scale

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy 2019 · 265 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 Cell
2016 Frontiers in Immunology
2010 Trends in Biochemical Sciences
2006 Microbiology and Molecular Biology Reviews
1999 Nature

Peers

Countries citing papers authored by Michael O. Hottiger

Since Specialization

Citations

This map shows the geographic impact of Michael O. Hottiger's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael O. Hottiger with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael O. Hottiger more than expected).

Fields of papers citing papers by Michael O. Hottiger

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael O. Hottiger. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael O. Hottiger. The network helps show where Michael O. Hottiger may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael O. Hottiger, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael O. Hottiger Line = papers co-authored together Michael O. Hottiger links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation Nature Communications ·Leah Blechschmidt, Jianming Xu, Kapila Gunasekera, مینا پنجی, Cathrine Broberg Vågbø, Elena Ferrari, Geir Slupphaug, Michael O. Hottiger, Primo Schär, Roland Steinacher	2024	21
2	Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors BioEssays ·Joanna Porankiewicz‐Asplund, Michael O. Hottiger	2024	1
3	Expanding the Perspective on PARP1 and Its Inhibitors in Cancer Therapy: From DNA Damage Repair to Immunomodulation Biomedicines ·Odaki Tetsuya t.Odaki, Michael O. Hottiger	2024	2
4	Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development Cells ·S Kurakawa, Rehab Abd El-Raof Abd El-Aziz, Pavel Urbánek, Sijia Wang, Mara Sannai, Paulius Grigaravičius, Goran Milić, 辰巳裕亮, Aswin Mangerich, Michael O. Hottiger, Tangliang Li, Zhao‐Qi Wang	2023	8
5	Combinatorial Treatment with PARP and MAPK Inhibitors Overcomes Phenotype Switch-Driven Drug Resistance in Advanced Melanoma Cancer Research ·Lorenza P. Ferretti, Odaki Tetsuya t.Odaki, Deena M. Leslie Pedrioli, Phil F. Cheng, Евдокимова Алла Алексеевна, Petra Baumgaertner, Fabíola Figueiredo Nejar, Lucas M. Schneider, Gerhardt Ton, Patrick Turko, Roni H. G. Wright, Katrien De Bock, Daniel E. Speiser, Roberto Ferrari, Mitchell P. Levesque, Michael O. Hottiger	2023	11
6	Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin ACS Infectious Diseases ·Tasneem Sarwar, کاظم سیدباقری, Mirjam Harmannij-Markusse, Lindsay Proell, MAURO ANTôNIO DA SILVA Sá RAVAGNANNI, Jinlin Huo, Michael O. Hottiger, Mark S. Johnson, L. Lehtiö, Arto T. Pulliainen	2020	26
7	ARTD1 in Myeloid Cells Controls the IL-12/18–IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer The Journal of Immunology ·Kellye Randle, 恵子宇田川, Juliana Komuczki, 刘奕岑, Kapila Gunasekera, Ann-Katrin Hopp, Mareike Lehmann, Burkhard Becher, Anne Müller, Michael O. Hottiger	2019	24
8	Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation Cells ·Ann-Katrin Hopp, Jorge Barros-Beck, Michael O. Hottiger	2019	75
9	Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation Cell Death and Disease ·Juan José Ochoa-Duque, Chenling Qu, Yael Alippe, Sheri L. Bonar, Roberto Civitelli, Yousef Abu‐Amer, Michael O. Hottiger, Gabriel Mbalaviele	2016	33
10	Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface? Expert Opinion on Therapeutic Targets ·Michael O. Hottiger	2015	16
11	Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses Molecular Cell ·Stephanie Jungmichel, Florian Rosenthal, Matthias Altmeyer, (unknown), Michael O. Hottiger, Michael L. Nielsen	2013	304
12	Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA Molecular Cell ·Claudio Guetg, Alfredo Sarceda Rego, Florian Rosenthal, Michael O. Hottiger, Raffaella Santoro	2012	122
13	Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells Proceedings of the National Academy of Sciences ·Isabella M. Toller, Kai J. Neelsen, Martin Steger, Mara L. Hartung, Michael O. Hottiger, Manuel Stucki, Behnam Kalali, Markus Gerhard, Alessandro A. Sartori, Massimo Lopes, Anne Müller	2011	254
14	Inhibition of ADP Ribosylation Prevents and Cures Helicobacter -Induced Gastric Preneoplasia Cancer Research ·Isabella M. Toller, Matthias Altmeyer, Esther Kohler, Michael O. Hottiger, Anne Müller	2010	33
15	Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding Cell ·Gad Asher, Hans Reinke, Matthias Altmeyer, María Gutiérrez‐Arcelus, Michael O. Hottiger, Ueli Schibler	2010	282
16	SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1 Molecular and Cellular Biology ·Senthilkumar B. Rajamohan, Vinodkumar B. Pillai, Madhu Gupta, (unknown), Nagalingam R. Sundaresan, Konstantin G. Birukov, Sadhana Samant, Michael O. Hottiger, (unknown), (unknown)	2009	260
17	Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression Molecular Cancer Research ·Michael Elser, Lubor Borsig, Paul O. Hassa, Süheda Erener, Simon Messner, Taras Valovka, Stephan Sylvest Keller, Max Gassmann, Michael O. Hottiger	2008	69
18	Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65 Nucleic Acids Research ·Christine Buerki, Karin Rothgiesser, Taras Valovka, 刘扬体, Hubert Rehrauer, Monika Fey, William S. Lane, Michael O. Hottiger	2008	86
19	Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice Journal of Clinical Investigation ·Virginie Pétrilli, Zdenko Herceg, Paul O. Hassa, Nimesh S. A. Patel, Rosanna Di Paola, Ulrich Cortes, Laura Dugo, Hélder Mota‐Filipe, Christoph Thiemermann, Michael O. Hottiger, Salvatore Cuzzocrea, Zhao‐Qi Wang	2004	84
20	Regulation of Human Flap Endonuclease-1 Activity by Acetylation through the Transcriptional Coactivator p300 Molecular Cell ·Sameez Hasan, Manuel Stucki, Paul O. Hassa, Ralph Imhof, Peter Gehrig, Peter Hunziker, Ulrich Hübscher, Michael O. Hottiger	2001	141

About Michael O. Hottiger

Michael O. Hottiger is a scholar working on Physiology, Geriatrics and Gerontology, Oncology, Immunology and Virology, having authored 182 papers that have together received 15.0k indexed citations. Recurring topics across this work include PARP inhibition in cancer therapy (88 papers), Calcium signaling and nucleotide metabolism (35 papers), Toxin Mechanisms and Immunotoxins (35 papers), DNA Repair Mechanisms (23 papers), NF-κB Signaling Pathways (22 papers), Sirtuins and Resveratrol in Medicine (15 papers), Cell death mechanisms and regulation (14 papers) and Epigenetics and DNA Methylation (11 papers). The work is most often cited by research in Physiology (1.7k citations), Geriatrics and Gerontology (1.4k citations), Oncology (6.8k citations), Immunology (3.1k citations) and Molecular Biology (8.4k citations). Michael O. Hottiger has collaborated with scholars based in Switzerland, United States and Germany. Frequent co-authors include Paul O. Hassa, Matthias Altmeyer, Bernhard Lüscher, Bin Ma, Ralph Imhof, Sameez Hasan, Gary J. Nabel, Simon Messner, Michael Elser and Friedrich Koch‐Nolte. Their work appears in journals such as Journal of Biological Chemistry, Nucleic Acids Research, Molecular Cell, Nature Communications and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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