Carl‐Henrik Heldin

76.4k total citations · 24 hit papers
494 papers, 62.7k citations indexed

About

Carl‐Henrik Heldin is a scholar working on Molecular Biology, Oncology and Immunology and Allergy. According to data from OpenAlex, Carl‐Henrik Heldin has authored 494 papers receiving a total of 62.7k indexed citations (citations by other indexed papers that have themselves been cited), including 387 papers in Molecular Biology, 133 papers in Oncology and 70 papers in Immunology and Allergy. Recurrent topics in Carl‐Henrik Heldin's work include TGF-β signaling in diseases (150 papers), Cell Adhesion Molecules Research (70 papers) and Protein Kinase Regulation and GTPase Signaling (54 papers). Carl‐Henrik Heldin is often cited by papers focused on TGF-β signaling in diseases (150 papers), Cell Adhesion Molecules Research (70 papers) and Protein Kinase Regulation and GTPase Signaling (54 papers). Carl‐Henrik Heldin collaborates with scholars based in Sweden, Belgium and Japan. Carl‐Henrik Heldin's co-authors include Bengt Westermark, Aristidis Moustakas, Peter ten Dijke, Kohei Miyazono, Lena Claesson‐Welsh, Åke Wasteson, Arne Östman, Kristian Pietras, Ulf Hellman and Kristofer Rubin and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Carl‐Henrik Heldin

492 papers receiving 61.0k citations

Hit Papers

Mechanism of Action and I... 1982 2026 1996 2011 1999 2004 1997 1994 1995 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
    1999 2.0k citations Carl‐Henrik Heldin, Bengt Westermark profile →
  2. High interstitial fluid pressure — an obstacle in cancer therapy
    2004 1.7k citations Carl‐Henrik Heldin, Arne Östman et al. profile →
  3. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
    1997 1.6k citations Jan L. Christian, Susumu Itoh et al. profile →
  4. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
    1994 1.4k citations Johannes Waltenberger, Agneta Siegbahn et al. Journal of Biological Chemistry profile →
  5. Dimerization of cell surface receptors in signal transduction
    1995 1.4k citations Carl‐Henrik Heldin profile →
  6. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
    1983 1.3k citations Åke Wasteson, Bengt Westermark et al. profile →
  7. Non-Smad TGF-β signals
    2005 920 citations Aristidis Moustakas, Carl‐Henrik Heldin profile →
  8. Smad regulation in TGF-β signal transduction
    2001 787 citations Aristidis Moustakas, Carl‐Henrik Heldin et al. profile →
  9. Growth factors: Mechanism of action and relation to oncogenes
    1984 738 citations Carl‐Henrik Heldin, Bengt Westermark profile →
  10. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
    1986 684 citations Christer Betsholtz, Carl‐Henrik Heldin et al. profile →
  11. Improvement of an "In-Gel" Digestion Procedure for the Micropreparation of Internal Protein Fragments for Amino Acid Sequencing
    1995 679 citations Ulf Hellman, Carl‐Henrik Heldin et al. profile →
  12. The regulation of TGFβ signal transduction
    2009 660 citations Aristidis Moustakas, Carl‐Henrik Heldin Development profile →
  13. Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression
    2007 647 citations Aristidis Moustakas, Carl‐Henrik Heldin profile →
  14. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
    1989 619 citations Kohei Miyazono, Ulf Hellman et al. profile →
  15. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
    1994 613 citations Peter ten Dijke, Carl‐Henrik Heldin et al. Journal of Biological Chemistry profile →
  16. Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor
    1982 596 citations Bengt Westermark, Åke Wasteson et al. profile →
  17. Specificity, diversity, and regulation in TGF‐β superfamily signaling
    1999 566 citations Carl‐Henrik Heldin, Peter ten Dijke et al. profile →
  18. Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.
    1988 563 citations Kohei Miyazono, Ulf Hellman et al. Journal of Biological Chemistry profile →
  19. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.
    1992 558 citations Carl‐Henrik Heldin, Bengt Westermark et al. PubMed profile →
  20. Co-localization of NG2 proteoglycan and PDGF ?-receptor on O2A progenitor cells in the developing rat brain
    1996 554 citations Carl‐Henrik Heldin et al. profile →
  21. Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition
    2009 542 citations Carl‐Henrik Heldin, Maréne Landström et al. profile →
  22. Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer
    1998 514 citations Susumu Itoh, Carl‐Henrik Heldin et al. Journal of Biological Chemistry profile →
  23. Signaling Receptors for TGF-β Family Members
    2016 498 citations Carl‐Henrik Heldin, Aristidis Moustakas profile →
  24. Targeting the PDGF signaling pathway in tumor treatment
    2013 390 citations Carl‐Henrik Heldin profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Carl‐Henrik Heldin Sweden 132 41.7k 14.1k 8.9k 6.7k 5.9k 494 62.7k
Rik Derynck United States 118 38.9k 0.9× 17.3k 1.2× 8.8k 1.0× 4.2k 0.6× 5.6k 0.9× 211 57.0k
Kohei Miyazono Japan 123 41.5k 1.0× 12.8k 0.9× 8.3k 0.9× 3.6k 0.5× 4.8k 0.8× 463 57.4k
Jean Paul Thiery France 108 34.1k 0.8× 19.4k 1.4× 11.7k 1.3× 9.5k 1.4× 4.5k 0.8× 553 55.8k
Axel Ullrich Germany 97 32.2k 0.8× 23.0k 1.6× 6.8k 0.8× 4.6k 0.7× 8.3k 1.4× 257 55.6k
Peter ten Dijke Netherlands 130 40.4k 1.0× 12.5k 0.9× 6.9k 0.8× 3.7k 0.6× 4.7k 0.8× 487 57.0k
Anita B. Roberts United States 120 31.6k 0.8× 10.4k 0.7× 5.6k 0.6× 3.7k 0.6× 6.2k 1.1× 288 53.4k
Christer Betsholtz Sweden 100 28.8k 0.7× 7.9k 0.6× 6.2k 0.7× 6.5k 1.0× 4.6k 0.8× 327 52.3k
Harold L. Moses United States 103 24.6k 0.6× 14.7k 1.0× 6.6k 0.7× 3.4k 0.5× 4.9k 0.8× 317 41.0k
J. Silvio Gutkind United States 121 33.7k 0.8× 11.5k 0.8× 5.8k 0.6× 7.8k 1.2× 6.9k 1.2× 582 52.2k
Harold F. Dvorak United States 101 24.4k 0.6× 10.0k 0.7× 10.0k 1.1× 3.7k 0.5× 7.0k 1.2× 279 47.8k

Countries citing papers authored by Carl‐Henrik Heldin

Since Specialization
Citations

This map shows the geographic impact of Carl‐Henrik Heldin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Carl‐Henrik Heldin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Carl‐Henrik Heldin more than expected).

Fields of papers citing papers by Carl‐Henrik Heldin

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Carl‐Henrik Heldin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Carl‐Henrik Heldin. The network helps show where Carl‐Henrik Heldin may publish in the future.

Co-authorship network of co-authors of Carl‐Henrik Heldin

This figure shows the co-authorship network connecting the top 25 collaborators of Carl‐Henrik Heldin. A scholar is included among the top collaborators of Carl‐Henrik Heldin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Carl‐Henrik Heldin. Carl‐Henrik Heldin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Tzavlaki, Kalliopi, Anita Morén, Yukihide Watanabe, et al.. (2023). The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial‐mesenchymal transition. Journal of Cellular Physiology. 238(4). 790–812. 1 indexed citations
2.
3.
Papoutsoglou, Panagiotis, Anita Morén, Fredrik Pontén, et al.. (2021). The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling. Oncogene. 40(21). 3748–3765. 18 indexed citations
4.
Caja, Laia, Artur Mezheyeuski, Sijia Liu, et al.. (2021). The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma. Cell Death and Disease. 12(10). 932–932. 4 indexed citations
5.
Zhang, Yanyu, Jessica Cedervall, Anahita Hamidi, et al.. (2020). Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis. Cancer Research. 80(16). 3345–3358. 66 indexed citations
6.
Thijssen, Victor L., Patrycja Nowak‐Sliwinska, Katrin Deumelandt, et al.. (2018). Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth. The Journal of Pathology. 246(4). 447–458. 75 indexed citations
7.
Okita, Yukari, Chen Chen, Hiroyuki Suzuki, et al.. (2017). The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. Science Signaling. 10(474). 62 indexed citations
8.
Christian, Jan L. & Carl‐Henrik Heldin. (2017). The TGFβ superfamily in Lisbon: navigating through development and disease. Development. 144(24). 4476–4480. 2 indexed citations
9.
Heldin, Carl‐Henrik. (2008). 9 TGF-β Signaling from Receptors to Smads. Cold Spring Harbor Monograph Archive. 50. 259–285. 3 indexed citations
10.
Micke, Patrick, Kai Kappert, Mitsuhiro Ohshima, et al.. (2007). In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma. Journal of Investigative Dermatology. 127(6). 1516–1523. 49 indexed citations
11.
Kallin, Anders, Lene E. Johannessen, Patrice D. Cani, et al.. (2007). SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55γ. Journal of Lipid Research. 48(7). 1628–1636. 44 indexed citations
12.
Valdimarsdóttir, Guðrún, Marie‐José Goumans, Fumiko Itoh, et al.. (2006). Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells. BMC Cell Biology. 7(1). 16–16. 51 indexed citations
13.
Persson, C., Tobias Sjöblom, Arnoud Groen, et al.. (2004). Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases. Proceedings of the National Academy of Sciences. 101(7). 1886–1891. 107 indexed citations
14.
Johnell, Matilda, Brit B. Sørensen, Lars C. Petersen, Carl‐Henrik Heldin, & Agneta Siegbahn. (2004). Regulation of chemotaxis by the cytoplasmic domain of tissue factor. Thrombosis and Haemostasis. 93(1). 27–34. 25 indexed citations
15.
Chiara, Federica, Subal Bishayee, Carl‐Henrik Heldin, & Jean‐Baptiste Demoulin. (2004). Autoinhibition of the Platelet-derived Growth Factor β-Receptor Tyrosine Kinase by Its C-terminal Tail. Journal of Biological Chemistry. 279(19). 19732–19738. 46 indexed citations
16.
Hulth, Anders, et al.. (1996). Effect of transforming growth factor‐β and platelet‐derived growth factor‐BB on articular cartilage in rats. Journal of Orthopaedic Research®. 14(4). 547–553. 52 indexed citations
17.
Waltenberger, Johannes, Kensuke Usuki, Bengt Fellström, Keiko Funa, & Carl‐Henrik Heldin. (1992). Platelet‐derived endothelial cell growth factor Pharmacokinetics, organ distribution and degradation after intravenous administration in rats. FEBS Letters. 313(2). 129–132. 13 indexed citations
18.
Risau, Werner, Hannes C. A. Drexler, Vladimir Mironov, et al.. (1992). Platelet-Derived Growth Factor is AngiogenicIn Vivo. Growth Factors. 7(4). 261–266. 223 indexed citations
19.
Miyazono, Kohei, Kensuke Usuki, & Carl‐Henrik Heldin. (1991). Platelet-derived endothelial cell growth factor. PubMed. 3(3). 207–217. 45 indexed citations
20.
Wasteson, Åke, Bengt Glimelius, Christer Busch, et al.. (1977). Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells. Thrombosis Research. 11(3). 309–321. 84 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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