Edward Seto

29.8k total citations · 12 hit papers
170 papers, 23.9k citations indexed

About

Edward Seto is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Edward Seto has authored 170 papers receiving a total of 23.9k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Molecular Biology, 34 papers in Oncology and 19 papers in Genetics. Recurrent topics in Edward Seto's work include Histone Deacetylase Inhibitors Research (103 papers), Protein Degradation and Inhibitors (48 papers) and Epigenetics and DNA Methylation (38 papers). Edward Seto is often cited by papers focused on Histone Deacetylase Inhibitors Research (103 papers), Protein Degradation and Inhibitors (48 papers) and Epigenetics and DNA Methylation (38 papers). Edward Seto collaborates with scholars based in United States, Canada and China. Edward Seto's co-authors include Michele A. Glozak, Wen‐Ming Yang, Xiang‐Jiao Yang, Nilanjan Sengupta, Thomas Shenk, Yixuan Li, Xiang-Jiao Yang, Xiaohong Zhang, X-J Yang and James Davie and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Edward Seto

168 papers receiving 23.5k citations

Hit Papers

Acetylation and deacetyla... 1991 2026 2002 2014 2005 1997 2008 2016 1991 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Acetylation and deacetylation of non-histone proteins
    2005 1.3k citations Michele A. Glozak, Nilanjan Sengupta et al. profile →
  2. A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
    1997 1.1k citations Wen‐Ming Yang, Edward Seto et al. profile →
  3. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
    2008 968 citations Edward Seto et al. profile →
  4. HDACs and HDAC Inhibitors in Cancer Development and Therapy
    2016 942 citations Yixuan Li, Edward Seto Cold Spring Harbor Perspectives in Medicine profile →
  5. Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein
    1991 932 citations Edward Seto et al. profile →
  6. Histone deacetylases and cancer
    2007 836 citations Michele A. Glozak, Edward Seto profile →
  7. Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
    1997 822 citations Wen‐Ming Yang, Edward Seto et al. profile →
  8. Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications
    2008 805 citations Edward Seto et al. profile →
  9. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
    2007 794 citations Edward Seto et al. profile →
  10. Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90
    2005 644 citations Edward Seto et al. Journal of Biological Chemistry profile →
  11. HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin
    2007 588 citations Zhigang Yuan, John M. Koomen et al. profile →
  12. Histone deacetylases, transcriptional control, and cancer
    2000 525 citations Edward Seto et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Edward Seto 19.6k 5.0k 2.9k 2.5k 2.0k 170 23.9k
Eric W.‐F. Lam 15.3k 0.8× 5.4k 1.1× 1.7k 0.6× 3.5k 1.4× 1.5k 0.7× 298 23.1k
René H. Medema 24.0k 1.2× 8.2k 1.6× 1.9k 0.7× 1.7k 0.7× 1.1k 0.5× 235 29.6k
Boudewijn Burgering 17.6k 0.9× 3.9k 0.8× 1.2k 0.4× 2.4k 1.0× 1.4k 0.7× 155 22.7k
Nissim Hay 20.2k 1.0× 4.9k 1.0× 1.6k 0.5× 3.0k 1.2× 2.2k 1.1× 160 27.9k
Chunaram Choudhary 12.7k 0.6× 3.2k 0.6× 848 0.3× 1.3k 0.5× 2.0k 1.0× 86 16.0k
Ronald T. Hay 19.5k 1.0× 6.6k 1.3× 3.3k 1.1× 4.4k 1.7× 2.3k 1.1× 247 24.3k
Bernhard Lüscher 9.1k 0.5× 4.9k 1.0× 1.0k 0.3× 3.0k 1.2× 932 0.5× 191 14.4k
Brendan D. Manning 22.0k 1.1× 3.9k 0.8× 1.6k 0.5× 3.5k 1.4× 3.6k 1.7× 118 30.9k
Saadi Khochbin 14.0k 0.7× 2.7k 0.5× 1.9k 0.7× 848 0.3× 952 0.5× 203 16.5k
Junjie Chen 26.9k 1.4× 9.8k 1.9× 4.0k 1.4× 1.7k 0.7× 1.7k 0.9× 387 32.5k

Countries citing papers authored by Edward Seto

Since Specialization
Citations

This map shows the geographic impact of Edward Seto's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward Seto with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward Seto more than expected).

Fields of papers citing papers by Edward Seto

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward Seto. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward Seto. The network helps show where Edward Seto may publish in the future.

Co-authorship network of co-authors of Edward Seto

This figure shows the co-authorship network connecting the top 25 collaborators of Edward Seto. A scholar is included among the top collaborators of Edward Seto based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Edward Seto. Edward Seto is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhou, Shuyan, Chunyan Hou, Changmin Peng, et al.. (2025). Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB–Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer. Cancer Research. 85(9). 1708–1724. 2 indexed citations
2.
Peng, Changmin, et al.. (2024). Abstract 2395 HDAC11's de-fatty acylation of SF3B2 could provide new understanding of RNA splicing regulation and Liver Cancer progression. Journal of Biological Chemistry. 300(3). 107087–107087.
3.
Ling, Hongbo, Yixuan Li, Changmin Peng, Shengyu Yang, & Edward Seto. (2024). HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression. NAR Cancer. 6(2). zcae018–zcae018. 6 indexed citations
4.
Jameel, Muhammad, Zhuqing Li, Shuyan Zhou, et al.. (2024). TFAP2C-DDR1 axis regulates resistance to CDK4/6 inhibitor in breast cancer. Cancer Letters. 610. 217356–217356.
5.
Emmons, Michael F., Richard L. Bennett, Alberto Riva, et al.. (2023). HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis. Nature Communications. 14(1). 7759–7759. 16 indexed citations
6.
Li, Yixuan, Xiangyang Zhang, Shaoqi Zhu, et al.. (2020). HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. Cancer Research. 80(16). 3265–3278. 36 indexed citations
7.
Heim, Cortney E., Megan E. Bosch, Kelsey J. Yamada, et al.. (2020). Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection. Nature Microbiology. 5(10). 1271–1284. 168 indexed citations
8.
Cao, Ji, Lei Sun, Pornpun Aramsangtienchai, et al.. (2019). HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences. 116(12). 5487–5492. 132 indexed citations
9.
Emmons, Michael F., Fernanda Faião‐Flores, Ritin Sharma, et al.. (2019). HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy. Cancer Research. 79(11). 2947–2961. 52 indexed citations
10.
Wang, Michael, Fengdong Cheng, Jie Chen, et al.. (2017). A Novel Role for Histone Deacetylase 10 (HDAC10) in the Regulation of PD-L1 Expression and Immune Tolerance Mediated By Antigen Presenting Cells (APCs). Blood. 130. 3561–3561. 2 indexed citations
11.
Li, Yixuan & Edward Seto. (2016). HDACs and HDAC Inhibitors in Cancer Development and Therapy. Cold Spring Harbor Perspectives in Medicine. 6(10). a026831–a026831. 942 indexed citations breakdown →
12.
Villagra, Alejandro, Eva Sahakian, & Edward Seto. (2016). Preparation and Biochemical Analysis of Classical Histone Deacetylases. Methods in enzymology on CD-ROM/Methods in enzymology. 573. 161–181. 1 indexed citations
13.
Lienlaf, Maritza, Patricio Perez-Villarroel, Tessa Knox, et al.. (2016). Essential role of HDAC6 in the regulation of PD‐L1 in melanoma. Molecular Oncology. 10(5). 735–750. 136 indexed citations
14.
Yuan, Zhigang, Alejandro Villagra, Lirong Peng, et al.. (2010). The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions. Molecular and Cellular Biology. 30(12). 3004–3015. 95 indexed citations
15.
Sengupta, Nilanjan, et al.. (2006). Histone Deacetylase 8 Safeguards the Human Ever-Shorter Telomeres 1B (hEST1B) Protein from Ubiquitin-Mediated Degradation. Molecular and Cellular Biology. 26(19). 7342–7342. 2 indexed citations
16.
Sengupta, Nilanjan & Edward Seto. (2004). Regulation of histone deacetylase activities. Journal of Cellular Biochemistry. 93(1). 57–67. 284 indexed citations
17.
Osborne, Aaron, Hongquan Zhang, Wen‐Ming Yang, Edward Seto, & George Blanck. (2001). Histone Deacetylase Activity Represses Gamma Interferon-Inducible HLA-DR Gene Expression following the Establishment of a DNase I-Hypersensitive Chromatin Conformation. Molecular and Cellular Biology. 21(19). 6495–6506. 36 indexed citations
18.
Yao, Yali, Wen‐Ming Yang, & Edward Seto. (2001). Regulation of Transcription Factor YY1 by Acetylation and Deacetylation. Molecular and Cellular Biology. 21(17). 5979–5991. 367 indexed citations
19.
Westling, Jennifer, et al.. (1999). trans Repression of the Human Metallothionein IIA Gene Promoter by PZ120, a Novel 120-Kilodalton Zinc Finger Protein. Molecular and Cellular Biology. 19(1). 680–689. 20 indexed citations
20.
Lai, Albert, Joseph M. Lee, Wen‐Ming Yang, et al.. (1999). RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins. Molecular and Cellular Biology. 19(10). 6632–6641. 144 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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