Edward Seto

29.8k total citations · 12 hit papers
170 papers, 23.9k citations indexed

About

Edward Seto is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Edward Seto has authored 170 papers receiving a total of 23.9k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Molecular Biology, 34 papers in Oncology and 19 papers in Genetics. Recurrent topics in Edward Seto's work include Histone Deacetylase Inhibitors Research (103 papers), Protein Degradation and Inhibitors (48 papers) and Epigenetics and DNA Methylation (38 papers). Edward Seto is often cited by papers focused on Histone Deacetylase Inhibitors Research (103 papers), Protein Degradation and Inhibitors (48 papers) and Epigenetics and DNA Methylation (38 papers). Edward Seto collaborates with scholars based in United States, Canada and China. Edward Seto's co-authors include Michele A. Glozak, Wen‐Ming Yang, Xiang‐Jiao Yang, Nilanjan Sengupta, Thomas Shenk, Yixuan Li, Xiang-Jiao Yang, Xiaohong Zhang, X-J Yang and James Davie and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Edward Seto

168 papers receiving 23.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Acetylation and deacetylation of non-histone proteins

2005 1.3k citations Michele A. Glozak, Nilanjan Sengupta et al. profile →
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 1.1k citations Wen‐Ming Yang, James Davie et al. profile →
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

2008 968 citations Edward Seto et al. profile →
HDACs and HDAC Inhibitors in Cancer Development and Therapy

2016 942 citations Yixuan Li, Edward Seto Cold Spring Harbor Perspectives in Medicine profile →
Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein

1991 932 citations Edward Seto et al. profile →
Histone deacetylases and cancer

2007 836 citations Michele A. Glozak, Edward Seto profile →
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 822 citations Wen‐Ming Yang, James Davie et al. profile →
Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

2008 805 citations Edward Seto et al. profile →
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

2007 794 citations Edward Seto et al. profile →
Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

2005 644 citations Edward Seto et al. Journal of Biological Chemistry profile →
HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

2007 588 citations Zhigang Yuan, John M. Koomen et al. profile →
Histone deacetylases, transcriptional control, and cancer

2000 525 citations Edward Seto et al. profile →

Peers

Countries citing papers authored by Edward Seto

Since Specialization

Citations

This map shows the geographic impact of Edward Seto's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward Seto with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward Seto more than expected).

Fields of papers citing papers by Edward Seto

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward Seto. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward Seto. The network helps show where Edward Seto may publish in the future.

Co-authorship network of co-authors of Edward Seto

This figure shows the co-authorship network connecting the top 25 collaborators of Edward Seto. A scholar is included among the top collaborators of Edward Seto based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Edward Seto. Edward Seto is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB–Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer 2025 ·Cancer Research ·Shuyan Zhou, (unknown), (unknown), Chunyan Hou, (unknown), Changmin Peng, Yunxiao Meng, (unknown), Muhammad Jameel, (unknown), Edward Seto, Min Shen, Matthew D. Hall, Junfeng Ma, X. Cynthia, Shunqiang Li, Wenge Zhu	2
2	Abstract 2395 HDAC11's de-fatty acylation of SF3B2 could provide new understanding of RNA splicing regulation and Liver Cancer progression 2024 ·Journal of Biological Chemistry ·(unknown), Changmin Peng, (unknown), Hening Lin, Edward Seto	0
3	HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis 2023 ·Nature Communications ·Michael F. Emmons, Richard L. Bennett, Alberto Riva, (unknown), Larissa Anastácio da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphné Dupéré-Richer, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter Forsyth, Jonathan D. Licht, Keiran S.M. Smalley	16
4	EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function 2021 ·Cell Death and Disease ·(unknown), Hongbo Ling, (unknown), (unknown), Mary Kay H. Pflum, Edward Seto	17
5	HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma 2020 ·Cancer Research ·Yixuan Li, Xiangyang Zhang, Shaoqi Zhu, (unknown), Weiqun Peng, Antonia R. Sepulveda, Edward Seto	36
6	Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection 2020 ·Nature Microbiology ·Cortney E. Heim, Megan E. Bosch, Kelsey J. Yamada, Amy L. Aldrich, Sujata S. Chaudhari, David Klinkebiel, Casey M. Gries, Abdulelah A. Alqarzaee, Yixuan Li, Vinai C. Thomas, Edward Seto, Adam R. Karpf, Tammy Kielian	168
7	HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2 2019 ·Proceedings of the National Academy of Sciences ·Ji Cao, Lei Sun, Pornpun Aramsangtienchai, Nicole A. Spiegelman, Xiaoyu Zhang, Weishan Huang, Edward Seto, Hening Lin	132
8	HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy 2019 ·Cancer Research ·Michael F. Emmons, Fernanda Faião‐Flores, Ritin Sharma, Ram Thapa, Jane L. Messina, Jürgen C. Becker, Dirk Schadendorf, Edward Seto, Vernon K. Sondak, John M. Koomen, Y. Ann Chen, Eric K. Lau, Lixin Wan, Jonathan D. Licht, Keiran S.M. Smalley	52
9	A Novel Role for Histone Deacetylase 10 (HDAC10) in the Regulation of PD-L1 Expression and Immune Tolerance Mediated By Antigen Presenting Cells (APCs) 2017 ·Blood ·Michael Wang, Fengdong Cheng, Jie Chen, Yixuan Li, (unknown), Mitchell R. Smith, Edward Seto, Eduardo M. Sotomayor	2
10	HDACs and HDAC Inhibitors in Cancer Development and Therapy breakdown → 2016 ·Cold Spring Harbor Perspectives in Medicine ·Yixuan Li, Edward Seto	942
11	Histone Deacetylase Activity Assay 2015 ·Methods in molecular biology ·Lirong Peng, Zhigang Yuan, Edward Seto	9
12	The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions 2010 ·Molecular and Cellular Biology ·Zhigang Yuan, Alejandro Villagra, Lirong Peng, Domenico Coppola, Michele A. Glozak, Eduardo M. Sotomayor, Jiandong Chen, William S. Lane, Edward Seto	95
13	Histone Deacetylase 8 Safeguards the Human Ever-Shorter Telomeres 1B (hEST1B) Protein from Ubiquitin-Mediated Degradation 2006 ·Molecular and Cellular Biology ·(unknown), Nilanjan Sengupta, Alejandro Villagra, Natalie Rezai‐Zadeh, Edward Seto	2
14	Regulation of histone deacetylase activities 2004 ·Journal of Cellular Biochemistry ·Nilanjan Sengupta, Edward Seto	284
15	Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1 2003 ·Genes & Development ·Natalie Rezai‐Zadeh, Xiaohong Zhang, Farès Namour, György Fejér, Yu‐Der Wen, Yali Yao, Ildikó Győry, Kenneth L. Wright, Edward Seto	153
16	Histone Deacetylase Activity Represses Gamma Interferon-Inducible HLA-DR Gene Expression following the Establishment of a DNase I-Hypersensitive Chromatin Conformation 2001 ·Molecular and Cellular Biology ·Aaron Osborne, Hongquan Zhang, Wen‐Ming Yang, Edward Seto, George Blanck	36
17	Regulation of Transcription Factor YY1 by Acetylation and Deacetylation 2001 ·Molecular and Cellular Biology ·Yali Yao, Wen‐Ming Yang, Edward Seto	367
18	trans Repression of the Human Metallothionein IIA Gene Promoter by PZ120, a Novel 120-Kilodalton Zinc Finger Protein 1999 ·Molecular and Cellular Biology ·(unknown), Jennifer Westling, Edward Seto	20
19	RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins 1999 ·Molecular and Cellular Biology ·Albert Lai, Joseph M. Lee, Wen‐Ming Yang, James A. DeCaprio, William G. Kaelin, Edward Seto, Philip E. Branton	144
20	Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family 1997 ·Journal of Biological Chemistry ·Wen‐Ming Yang, Yali Yao, Jian-Min Sun, James Davie, Edward Seto	385

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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