Solomon H. Snyder

178.5k citations

1.0k papers · 143.6k indexed · 74 hit papers · h-index 200

Molecular Biology top 0.01%
Cellular and Molecular Neuroscience top 0.01%
Physiology top 0.01%
Biochemistry top 0.01%
Endocrine and Autonomic Systems top 0.01%

Co-authors: David S. Bredt Ian Creese Candace B. Pert Ted M. Dawson Bindu D. Paul David R. Burt Henry I. Yamamura Stephen J. Peroutka
Topics: Neuroscience and Neuropharmacology Research (224 papers)Receptor Mechanisms and Signaling (201 papers)Neuropeptides and Animal Physiology (142 papers)
Cited by: Cellular and Molecular Neuroscience Biochemistry Endocrine and Autonomic Systems
Journals: Nature Science New England Journal of Medicine
Partner nations: United States Poland United Kingdom

In The Last Decade

Solomon H. Snyder

997 papers receiving 137.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 2.9k citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 2.0k citations Solomon H. Snyder et al. profile →
H ₂ S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

2008 2.0k citations Guangdong Yang, Lingyun Wu et al. Science profile →
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 1.7k citations Solomon H. Snyder et al. Science profile →
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 1.6k citations Ted M. Dawson, Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Opiate Receptor: Demonstration in Nervous Tissue

1973 1.6k citations Solomon H. Snyder et al. Science profile →
Carbon Monoxide: a Putative Neural Messenger

1993 1.3k citations Solomon H. Snyder et al. Science profile →
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 1.2k citations Solomon H. Snyder et al. profile →
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

2001 1.2k citations Solomon H. Snyder et al. profile →
Handbook of Psychopharmacology

1988 1.1k citations Solomon H. Snyder et al. profile →
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol

1979 1.1k citations Solomon H. Snyder et al. profile →
Targeted disruption of the neuronal nitric oxide synthase gene

1993 1.1k citations Ted M. Dawson, Solomon H. Snyder et al. profile →
Muscarinic Cholinergic Binding in Rat Brain

1974 1.1k citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
H ₂ S Signals Through Protein S-Sulfhydration

2009 1.0k citations Asif K. Mustafa, Moataz M. Gadalla et al. Science Signaling profile →
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 1.0k citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 993 citations Solomon H. Snyder et al. Science profile →
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 965 citations Adele M. Snowman, Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
d -Serine is an endogenous ligand for the glycine site of the N -methyl- d -aspartate receptor

2000 961 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 944 citations Valina L. Dawson, Ted M. Dawson et al. Science profile →
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 941 citations Roxanne K. Barrow, Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Biliverdin reductase: A major physiologic cytoprotectant

2002 889 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Nitric Oxide: First in a New Class of Neurotransmitters

1992 884 citations Solomon H. Snyder Science profile →
NOVELNEURALMODULATORS

2003 883 citations Solomon H. Snyder et al. profile →
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

2005 871 citations Makoto R. Hara, Sangwon F. Kim et al. profile →
Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 856 citations Solomon H. Snyder et al. Science profile →
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 771 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
H2S signalling through protein sulfhydration and beyond

2012 722 citations Bindu D. Paul, Solomon H. Snyder profile →
Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 719 citations Solomon H. Snyder et al. Science profile →
A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 705 citations Ted M. Dawson, Valina L. Dawson et al. profile →
The Biotin Switch Method for the Detection of S -Nitrosylated Proteins

2001 696 citations Solomon H. Snyder et al. profile →
Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 681 citations Solomon H. Snyder et al. Science profile →
Serine racemase: A glial enzyme synthesizing d -serine to regulate glutamate- N -methyl- d -aspartate neurotransmission

1999 674 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

1968 666 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Nitric oxide, a novel biologic messenger

1992 654 citations Solomon H. Snyder et al. profile →
Drugs, Neurotransmitters, and Schizophrenia

1974 644 citations Solomon H. Snyder et al. Science profile →
Generation of superoxide by purified brain nitric oxide synthase.

1992 615 citations Solomon H. Snyder et al. profile →
Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

2012 609 citations Nilkantha Sen, Bindu D. Paul et al. profile →
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1999 606 citations Lynda D. Hester, Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.

1986 606 citations Solomon H. Snyder et al. profile →
Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 604 citations Solomon H. Snyder et al. Science profile →
Adenosine receptors and behavioral actions of methylxanthines.

1981 590 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 585 citations Solomon H. Snyder et al. profile →
Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 575 citations Solomon H. Snyder et al. profile →
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 564 citations Solomon H. Snyder et al. profile →
Two Distinct Central Serotonin Receptors with Different Physiological Functions

1981 549 citations Solomon H. Snyder et al. Science profile →
Nitric oxide as a neuronal messenger

1991 548 citations Solomon H. Snyder et al. profile →
Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1975 541 citations Solomon H. Snyder et al. profile →
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 530 citations Solomon H. Snyder et al. profile →
Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 515 citations Solomon H. Snyder et al. profile →
A huntingtin-associated protein enriched in brain with implications for pathology

1995 512 citations Solomon H. Snyder et al. profile →
Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

2011 510 citations Asif K. Mustafa, Gautam Sikka et al. Circulation Research profile →
Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 509 citations Solomon H. Snyder et al. profile →
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

2018 506 citations Michael D. Kornberg, Pavan Bhargava et al. Science profile →
Beta Adrenergic Receptor Binding in Membrane Preparations from Mammalian Brain

1976 501 citations Solomon H. Snyder et al. profile →
Distinct cholecystokinin receptors in brain and pancreas.

1980 499 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System

1974 497 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.

1987 496 citations Solomon H. Snyder et al. profile →
HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN¹

1973 487 citations Solomon H. Snyder et al. profile →
Binding Characteristics of a Radiolabeled Agonist and Antagonist at Central Nervous System Alpha Noradrenergic Receptors

1977 474 citations Solomon H. Snyder et al. profile →
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 470 citations Ted M. Dawson, Solomon H. Snyder et al. profile →
Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 461 citations Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →
A sensitive and specific fluorescence assay for tissue serotonin

1965 461 citations Solomon H. Snyder et al. profile →
Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 456 citations Solomon H. Snyder et al. profile →
Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines

1981 446 citations Solomon H. Snyder et al. profile →
Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

1970 443 citations Solomon H. Snyder et al. profile →
Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 427 citations Solomon H. Snyder profile →
Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 416 citations Solomon H. Snyder et al. Science profile →
Properties of [3H]Haloperidol and [3H]Dopamine Binding Associated with Dopamine Receptors in Calf Brain Membranes

1976 398 citations Solomon H. Snyder et al. profile →
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS

1994 359 citations Ted M. Dawson, Solomon H. Snyder et al. Science profile →
Amine Synthesis in Regenerating Rat Liver: Extremely Rapid Turnover of Ornithine Decarboxylase

1969 352 citations Solomon H. Snyder et al. profile →
Control of Hydroxyindole O-Methyltransferase Activity in the Rat Pineal Gland by Environmental Lighting

1965 316 citations Solomon H. Snyder et al. profile →
Regulators of the transsulfuration pathway

2018 260 citations Solomon H. Snyder, Bindu D. Paul et al. profile →
Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

2021 195 citations Adele M. Snowman, Thomas W. Sedlak et al. Proceedings of the National Academy of Sciences profile →
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

2021 167 citations Bindu D. Paul, Solomon H. Snyder et al. Proceedings of the National Academy of Sciences profile →

Peers

Countries citing papers authored by Solomon H. Snyder

Since Specialization

Citations

This map shows the geographic impact of Solomon H. Snyder's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Solomon H. Snyder with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Solomon H. Snyder more than expected).

Fields of papers citing papers by Solomon H. Snyder

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Solomon H. Snyder. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Solomon H. Snyder. The network helps show where Solomon H. Snyder may publish in the future.

Co-authorship network of co-authors of Solomon H. Snyder

This figure shows the co-authorship network connecting the top 25 collaborators of Solomon H. Snyder. A scholar is included among the top collaborators of Solomon H. Snyder based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Solomon H. Snyder. Solomon H. Snyder is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Mammalian D-Cysteine controls insulin secretion in the pancreas 2024 ·Molecular Metabolism ·Robin Roychaudhuri,(unknown),Soumyaroop Bhattacharya,Harry Saavedra,Hangnoh Lee,(unknown),Moataz M. Gadalla,L. Mario Amzel,Peixin Yang,Solomon H. Snyder	2
2	Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling 2022 ·Science Signaling ·Chirag Vasavda,(unknown),Jason Liew,(unknown),Ryan S. Dhindsa,(unknown),Anthony Lin,Robert Tokhunts,(unknown),Adele M. Snowman,(unknown),(unknown),Cristian Ripoli,Claudio Grassi,Eugenio Barone,Michael D. Kornberg,Xinzhong Dong,Bindu D. Paul,Solomon H. Snyder	6
3	D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain 2021 ·Proceedings of the National Academy of Sciences ·(unknown),Maged M. Harraz,(unknown),Adarsha P. Malla,Chirag Vasavda,Moataz M. Gadalla,Michael D. Kornberg,Solomon H. Snyder,Robin Roychaudhuri	54
4	Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis 2019 ·Proceedings of the National Academy of Sciences ·Urbain Weyemi,Bindu D. Paul,(unknown),Adarsha P. Malla,Myriem Boufraqech,Maged M. Harraz,William M. Bonner,Solomon H. Snyder	24
5	MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus 2019 ·Proceedings of the National Academy of Sciences ·James Meixiong,Chirag Vasavda,Solomon H. Snyder,Xinzhong Dong	109
6	The glutathione cycle shapes synaptic glutamate activity 2019 ·Proceedings of the National Academy of Sciences ·Thomas W. Sedlak,Bindu D. Paul,(unknown),Lynda D. Hester,Adele M. Snowman,Yu Taniguchi,Atsushi Kamiya,Solomon H. Snyder,Akira Sawa	113
7	Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunitybreakdown → 2018 ·Science ·Michael D. Kornberg,Pavan Bhargava,Paul M. Kim,Vasanta Putluri,Adele M. Snowman,Nagireddy Putluri,Peter A. Calabresi,Solomon H. Snyder	506
8	Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade 2016 ·Proceedings of the National Academy of Sciences ·Prasun Guha,Maged M. Harraz,Solomon H. Snyder	49
9	S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis 2012 ·Proceedings of the National Academy of Sciences ·B Selvakumar,Meagan A. Jenkins,Natasha K. Hussain,Richard L. Huganir,Stephen F. Traynelis,Solomon H. Snyder	78
10	Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channelsbreakdown → 2011 ·Circulation Research ·Asif K. Mustafa,Gautam Sikka,Sadia K. Gazi,Jochen Steppan,Sung Mee Jung,Anil K. Bhunia,Viachaslau Barodka,(unknown),Roxanne K. Barrow,Rui Wang,L. Mario Amzel,Dan E. Berkowitz,Solomon H. Snyder	510
11	Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB 2011 ·Proceedings of the National Academy of Sciences ·David Maag,Micah J. Maxwell,Douglas A. Hardesty,Katie Boucher,Namrata Choudhari,(unknown),(unknown),(unknown),(unknown),Risheng Xu,Phillip B. Storm,Adolfo Saiardi,Solomon H. Snyder,Adam Resnick	88
12	H ₂ S mediates O ₂ sensing in the carotid body 2010 ·Proceedings of the National Academy of Sciences ·Yingjie Peng,Jayasri Nanduri,Gayatri Raghuraman,Dangjai Souvannakitti,Moataz M. Gadalla,Ganesh K. Kumar,Solomon H. Snyder,Nanduri R. Prabhakar	308
13	H ₂ S Signals Through Protein S-Sulfhydrationbreakdown → 2009 ·Science Signaling ·Asif K. Mustafa,Moataz M. Gadalla,Nilkantha Sen,Seyun Kim,Weitong Mu,Sadia K. Gazi,Roxanne K. Barrow,Guangdong Yang,Rui Wang,Solomon H. Snyder	1023
14	S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors 2009 ·Proceedings of the National Academy of Sciences ·B Selvakumar,Richard L. Huganir,Solomon H. Snyder	61
15	Bilirubin and glutathione have complementary antioxidant and cytoprotective roles 2009 ·Proceedings of the National Academy of Sciences ·Thomas W. Sedlak,(unknown),Daniel S. Higginson,Bindu D. Paul,Krishna R. Juluri,Solomon H. Snyder	430
16	H ₂ S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyasebreakdown → 2008 ·Science ·Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang	2004
17	Antipsychotic drug-induced weight gain mediated by histamine H ₁ receptor-linked activation of hypothalamic AMP-kinase 2007 ·Proceedings of the National Academy of Sciences ·Sangwon F. Kim,Alex S. Huang,Adele M. Snowman,Cory Teuscher,Solomon H. Snyder	316
18	Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event 2007 ·Proceedings of the National Academy of Sciences ·Rashna Bhandari,Adolfo Saiardi,Yousef Ahmadibeni,Adele M. Snowman,Adam Resnick,Troels Zakarias Kristiansen,Henrik Molina,Akhilesh Pandey,J. Kent Werner,Krishna R. Juluri,Yong Xu,Glenn D. Prestwich,Keykavous Parang,Solomon H. Snyder	182
19	Neuroprotection by pharmacologic blockade of the GAPDH death cascade 2006 ·Proceedings of the National Academy of Sciences ·Makoto R. Hara,Bobby Thomas,Matthew B. Cascio,Byoung-Il Bae,Lynda D. Hester,Valina L. Dawson,Ted M. Dawson,Akira Sawa,Solomon H. Snyder	191
20	Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity 2005 ·Proceedings of the National Academy of Sciences ·Adam Resnick,Adele M. Snowman,(unknown),K. Joseph Hurt,Solomon H. Snyder,Adolfo Saiardi	101

About Solomon H. Snyder

Solomon H. Snyder is a scholar working on Cellular and Molecular Neuroscience, Biochemistry and Endocrine and Autonomic Systems, having authored 1.0k papers that have together received 143.6k indexed citations. Recurring topics across this work include Neuroscience and Neuropharmacology Research (224 papers), Receptor Mechanisms and Signaling (201 papers) and Neuropeptides and Animal Physiology (142 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (59.1k citations), Biochemistry (17.7k citations) and Endocrine and Autonomic Systems (11.1k citations). Solomon H. Snyder has collaborated with scholars based in United States, Poland and United Kingdom. Frequent co-authors include David S. Bredt, Ian Creese, Candace B. Pert, Ted M. Dawson, Bindu D. Paul, David R. Burt, Henry I. Yamamura, Stephen J. Peroutka, Samie R. Jaffrey and Charles J. Lowenstein. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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