Leonard Guarente

70.8k total citations · 32 hit papers
205 papers, 55.1k citations indexed

About

Leonard Guarente is a scholar working on Molecular Biology, Geriatrics and Gerontology and Physiology. According to data from OpenAlex, Leonard Guarente has authored 205 papers receiving a total of 55.1k indexed citations (citations by other indexed papers that have themselves been cited), including 120 papers in Molecular Biology, 95 papers in Geriatrics and Gerontology and 79 papers in Physiology. Recurrent topics in Leonard Guarente's work include Sirtuins and Resveratrol in Medicine (95 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (53 papers). Leonard Guarente is often cited by papers focused on Sirtuins and Resveratrol in Medicine (95 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (53 papers). Leonard Guarente collaborates with scholars based in United States, Canada and Japan. Leonard Guarente's co-authors include Shin‐ichiro Imai, Matt Kaeberlein, David Sinclair, Gil Blander, Marcia C. Haigis, Heidi A. Tissenbaum, Christopher M. Armstrong, Su-Ju Lin, Hung-Chun Chang and Pierre‐Antoine Defossez and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Leonard Guarente

205 papers receiving 54.1k citations

Hit Papers

Transcriptional silencing and longevity protein Sir2... 1983 2026 1997 2011 2000 2001 2001 1999 2004 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    2000 2.8k citations Shin‐ichiro Imai, Leonard Guarente et al. Nature profile →
  2. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    2001 2.2k citations Shin‐ichiro Imai, Leonard Guarente et al. Cell profile →
  3. Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
    2001 1.8k citations Shin‐ichiro Imai, Leonard Guarente et al. Cell profile →
  4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    1999 1.7k citations Leonard Guarente et al. profile →
  5. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    2004 1.6k citations Leonard Guarente et al. Nature profile →
  6. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    2001 1.5k citations Leonard Guarente et al. Nature profile →
  7. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    2011 1.4k citations Eric L. Bell, Leonard Guarente et al. Nature profile →
  8. Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
    2000 1.4k citations Su-Ju Lin, Pierre‐Antoine Defossez et al. Science profile →
  9. The Sir2 Family of Protein Deacetylases
    2004 1.3k citations Leonard Guarente et al. profile →
  10. Extrachromosomal rDNA Circles— A Cause of Aging in Yeast
    1997 1.2k citations David Sinclair, Leonard Guarente Cell profile →
  11. Mammalian SIRT1 Represses Forkhead Transcription Factors
    2004 1.1k citations Leonard Guarente et al. Cell profile →
  12. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
    2008 1.1k citations Leonard Guarente et al. Cell profile →
  13. Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
    2006 1.1k citations Leonard Guarente et al. profile →
  14. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
    2007 1.0k citations Leonard Guarente et al. Molecular and Cellular Biology profile →
  15. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
    2006 930 citations Leonard Guarente et al. Cell profile →
  16. The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
    2013 926 citations Leonard Guarente et al. Cell profile →
  17. SIRT1 and other sirtuins in metabolism
    2014 899 citations Hung-Chun Chang, Leonard Guarente profile →
  18. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    2002 857 citations Su-Ju Lin, Pierre‐Antoine Defossez et al. Nature profile →
  19. Calorie restriction, SIRT1 and metabolism: understanding longevity
    2005 820 citations Leonard Guarente et al. profile →
  20. [12] High-efficiency transformation of yeast by electroporation
    1991 738 citations Leonard Guarente et al. profile →
  21. Molecular Biology of Aging
    1999 669 citations David Sinclair, Leonard Guarente et al. Cell profile →
  22. Calorie Restriction— the SIR2 Connection
    2005 638 citations Leonard Guarente et al. Cell profile →
  23. SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
    2009 616 citations Leonard Guarente et al. Cell profile →
  24. Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site
    1983 594 citations Leonard Guarente et al. Cell profile →
  25. Sir2 links chromatin silencing, metabolism, and aging
    2000 590 citations Leonard Guarente profile →
  26. SIRT1 transgenic mice show phenotypes resembling calorie restriction
    2007 587 citations Leonard Guarente et al. Aging Cell profile →
  27. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
    2005 585 citations Leonard Guarente et al. profile →
  28. SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
    2007 523 citations Leonard Guarente et al. profile →
  29. Two neurons mediate diet-restriction-induced longevity in C. elegans
    2007 519 citations Leonard Guarente et al. Nature profile →
  30. SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
    2013 479 citations Hung-Chun Chang, Leonard Guarente Cell profile →
  31. The multifaceted functions of sirtuins in cancer
    2015 376 citations Leonard Guarente et al. profile →
  32. Human trials exploring anti-aging medicines
    2024 106 citations Leonard Guarente, David Sinclair et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Leonard Guarente United States 106 28.9k 21.8k 17.1k 10.5k 9.2k 205 55.1k
Pere Puigserver United States 72 25.8k 0.9× 8.3k 0.4× 22.3k 1.3× 8.6k 0.8× 1.4k 0.2× 121 43.8k
Rafael de Cabo United States 95 13.6k 0.5× 6.2k 0.3× 14.8k 0.9× 4.0k 0.4× 5.6k 0.6× 344 33.2k
Shin‐ichiro Imai United States 49 8.3k 0.3× 11.0k 0.5× 6.9k 0.4× 5.2k 0.5× 1.7k 0.2× 103 21.3k
Raúl Mostoslavsky United States 53 9.8k 0.3× 9.6k 0.4× 6.3k 0.4× 5.4k 0.5× 1.6k 0.2× 90 20.8k
C. Ronald Kahn United States 143 36.9k 1.3× 2.9k 0.1× 26.6k 1.6× 13.6k 1.3× 2.3k 0.2× 515 74.9k
Manuel Serrano Spain 81 31.1k 1.1× 2.9k 0.1× 16.2k 0.9× 4.6k 0.4× 5.2k 0.6× 271 52.5k
Vilhelm A. Bohr United States 104 30.2k 1.0× 2.8k 0.1× 8.0k 0.5× 3.9k 0.4× 2.3k 0.3× 539 42.0k
Anne Brunet United States 79 26.6k 0.9× 2.8k 0.1× 6.0k 0.3× 3.0k 0.3× 5.7k 0.6× 144 38.7k
Ana María Cuervo United States 112 21.1k 0.7× 2.5k 0.1× 12.3k 0.7× 30.4k 2.9× 2.4k 0.3× 252 52.5k
David Ron United States 118 40.5k 1.4× 1.8k 0.1× 6.4k 0.4× 22.2k 2.1× 2.7k 0.3× 266 74.6k

Countries citing papers authored by Leonard Guarente

Since Specialization
Citations

This map shows the geographic impact of Leonard Guarente's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leonard Guarente with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leonard Guarente more than expected).

Fields of papers citing papers by Leonard Guarente

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leonard Guarente. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leonard Guarente. The network helps show where Leonard Guarente may publish in the future.

Co-authorship network of co-authors of Leonard Guarente

This figure shows the co-authorship network connecting the top 25 collaborators of Leonard Guarente. A scholar is included among the top collaborators of Leonard Guarente based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leonard Guarente. Leonard Guarente is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Holmes, Holly E., et al.. (2020). Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm. International Journal of Toxicology. 39(4). 307–320. 9 indexed citations
2.
Igarashi, Masaki, Eric O. Williams, Frank Jaksch, et al.. (2019). NAD + supplementation rejuvenates aged gut adult stem cells. Aging Cell. 18(3). e12935–e12935. 104 indexed citations
3.
Dellinger, Ryan W., et al.. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. SHILAP Revista de lepidopterología. 3(1). 17–17. 133 indexed citations
4.
Satoh, Akiko, Shin‐ichiro Imai, & Leonard Guarente. (2017). The brain, sirtuins, and ageing. Nature reviews. Neuroscience. 18(6). 362–374. 149 indexed citations
5.
Gage, Fred H., Leonard Guarente, & Amy J. Wagers. (2016). Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends in Molecular Medicine. 22(8). 633–634. 4 indexed citations
6.
Chang, Hung-Chun & Leonard Guarente. (2014). SIRT1 and other sirtuins in metabolism. DSpace@MIT (Massachusetts Institute of Technology). 5 indexed citations
7.
Li, Yu, Kimberly Wong, Amber Giles, et al.. (2014). Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. DSpace@MIT (Massachusetts Institute of Technology). 1 indexed citations
8.
Guarente, Leonard. (2014). Aging Research—Where Do We Stand and Where Are We Going?. Cell. 159(1). 15–19. 47 indexed citations
9.
Fendt, Sarah‐Maria, Eric L. Bell, Mark A. Keibler, et al.. (2013). Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism. Cancer Research. 73(14). 4429–4438. 7 indexed citations
10.
Guarente, Leonard. (2006). Sirtuins as potential targets for metabolic syndrome. Nature. 444(7121). 868–874. 359 indexed citations
11.
Lin, Su-Ju, Pierre‐Antoine Defossez, & Leonard Guarente. (2000). Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae. Science. 289(5487). 2126–2128. 1411 indexed citations breakdown →
12.
Park, Peter U., Pierre‐Antoine Defossez, & Leonard Guarente. (1999). Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in Saccharomyces cerevisiae. Molecular and Cellular Biology. 19(5). 3848–3856. 125 indexed citations
13.
Kennedy, Brian K., Monica Gotta, David Sinclair, et al.. (1997). Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae. Cell. 89(3). 381–391. 301 indexed citations
14.
Guarente, Leonard. (1996). Do Changes in Chromosomes Cause Aging?. Cell. 86(1). 9–12. 45 indexed citations
15.
Horiuchi, Junjiro, Neal Silverman, Gregory A. Marcus, & Leonard Guarente. (1995). ADA3, a Putative Transcriptional Adaptor, Consists of Two Separable Domains and Interacts with ADA2 and GCN5 in a Trimeric Complex. Molecular and Cellular Biology. 15(3). 1203–1209. 151 indexed citations
16.
17.
Forsburg, Susan L. & Leonard Guarente. (1988). Mutational Analysis of Upstream Activation Sequence 2 of the CYC1 Gene of Saccharomyces cerevisiae : a HAP2-HAP3 -Responsive Site. Molecular and Cellular Biology. 8(2). 647–654. 44 indexed citations
18.
Hahn, Steven, Jennifer L. Pinkham, Randy Wei, Rebecca L. Miller, & Leonard Guarente. (1988). The HAP3 Regulatory Locus of Saccharomyces cerevisiae Encodes Divergent Overlapping Transcripts. Molecular and Cellular Biology. 8(2). 655–663. 40 indexed citations
19.
Prezant, Toni R., Karl Pfeifer, & Leonard Guarente. (1987). Organization of the Regulatory Region of the Yeast CYC7 Gene: Multiple Factors Are Involved in Regulation. Molecular and Cellular Biology. 7(9). 3252–3259. 15 indexed citations
20.
Kim, Kwangsoo, M S Rosenkrantz, & Leonard Guarente. (1986). Saccharomyces cerevisiae Contains Two Functional Citrate Synthase Genes. Molecular and Cellular Biology. 6(6). 1936–1942. 130 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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