Leonard Guarente

264 total papers · 70.6k total citations
205 papers, 54.9k citations indexed

About

Leonard Guarente is a scholar working on Molecular Biology, Geriatrics and Gerontology and Physiology. According to data from OpenAlex, Leonard Guarente has authored 205 papers receiving a total of 54.9k indexed citations (citations by other indexed papers that have themselves been cited), including 120 papers in Molecular Biology, 95 papers in Geriatrics and Gerontology and 79 papers in Physiology. Recurrent topics in Leonard Guarente's work include Sirtuins and Resveratrol in Medicine (95 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (53 papers). Leonard Guarente is often cited by papers focused on Sirtuins and Resveratrol in Medicine (95 papers), Genetics, Aging, and Longevity in Model Organisms (53 papers) and Adipose Tissue and Metabolism (53 papers). Leonard Guarente collaborates with scholars based in United States, Canada and Japan. Leonard Guarente's co-authors include Shin‐ichiro Imai, Matt Kaeberlein, David Sinclair, Gil Blander, Marcia C. Haigis, Heidi A. Tissenbaum, Christopher M. Armstrong, Su-Ju Lin, Hung-Chun Chang and Pierre‐Antoine Defossez and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Leonard Guarente

205 papers receiving 53.9k citations

Hit Papers

Transcriptional silencing... 1983 2026 1997 2011 2000 2001 2001 1999 2004 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation benchmark for papers published in the same subfield and year, or reaches the top citation threshold in at least one of its specific research topics.

  1. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    2000 2.8k citations Shin‐ichiro Imai, Christopher M. Armstrong et al. Nature profile →
  2. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    2001 2.2k citations Homayoun Vaziri, Scott Dessain et al. Cell profile →
  3. Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
    2001 1.8k citations Jianyuan Luo, Anatoly Nikolaev et al. Cell profile →
  4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    1999 1.7k citations Matt Kaeberlein, Mitch McVey et al. Genes & Development profile →
  5. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    2004 1.6k citations Frédéric Picard, Acharawan Topark‐Ngarm et al. Nature profile →
  6. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    2001 1.5k citations Heidi A. Tissenbaum, Leonard Guarente Nature profile →
  7. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    2011 1.4k citations Christian M. Metallo, Paulo A. Gameiro et al. Nature profile →
  8. Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
    2000 1.4k citations Su-Ju Lin, Pierre‐Antoine Defossez et al. Science profile →
  9. The Sir2 Family of Protein Deacetylases
    2004 1.3k citations Gil Blander, Leonard Guarente Annual Review of Biochemistry profile →
  10. Extrachromosomal rDNA Circles— A Cause of Aging in Yeast
    1997 1.2k citations David Sinclair, Leonard Guarente Cell profile →
  11. Mammalian SIRT1 Represses Forkhead Transcription Factors
    2004 1.1k citations Maria Carla Motta, Nullin Divecha et al. Cell profile →
  12. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
    2008 1.1k citations Yasukazu Nakahata, Milota Kaluzová et al. Cell profile →
  13. Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
    2006 1.1k citations Marcia C. Haigis, Leonard Guarente Genes & Development profile →
  14. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
    2007 1.0k citations David B. Lombard, Frederick W. Alt et al. Molecular and Cellular Biology profile →
  15. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
    2006 928 citations Marcia C. Haigis, Raúl Mostoslavsky et al. Cell profile →
  16. The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
    2013 916 citations Laurent Mouchiroud, Riekelt H. Houtkooper et al. Cell profile →
  17. SIRT1 and other sirtuins in metabolism
    2014 892 citations Hung-Chun Chang, Leonard Guarente Trends in Endocrinology and Metabolism profile →
  18. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    2002 857 citations Su-Ju Lin, Matt Kaeberlein et al. Nature profile →
  19. Calorie restriction, SIRT1 and metabolism: understanding longevity
    2005 819 citations Laura Bordone, Leonard Guarente Nature Reviews Molecular Cell Biology profile →
  20. [12] High-efficiency transformation of yeast by electroporation
    1991 737 citations Daniel M. Becker, Leonard Guarente Methods in enzymology on CD-ROM/Methods in enzymology profile →
  21. Molecular Biology of Aging
    1999 669 citations F. Brad Johnson, David Sinclair et al. Cell profile →
  22. Calorie Restriction— the SIR2 Connection
    2005 638 citations Leonard Guarente, Frédéric Picard Cell profile →
  23. SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
    2009 614 citations Takashi Nakagawa, Marcia C. Haigis et al. Cell profile →
  24. Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site
    1983 594 citations Leonard Guarente, Thomas L. Mason Cell profile →
  25. Sir2 links chromatin silencing, metabolism, and aging
    2000 589 citations Leonard Guarente Genes & Development profile →
  26. SIRT1 transgenic mice show phenotypes resembling calorie restriction
    2007 587 citations Laura Bordone, Dena E. Cohen et al. Aging Cell profile →
  27. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
    2005 585 citations Laura Bordone, Maria Carla Motta et al. PLoS Biology profile →
  28. SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
    2007 522 citations Xiaoling Li, Songwen Zhang et al. Molecular Cell profile →
  29. Two neurons mediate diet-restriction-induced longevity in C. elegans
    2007 518 citations Nicholas A. Bishop, Leonard Guarente Nature profile →
  30. SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
    2013 476 citations Hung-Chun Chang, Leonard Guarente Cell profile →
  31. The multifaceted functions of sirtuins in cancer
    2015 375 citations Angeliki Chalkiadaki, Leonard Guarente Nature reviews. Cancer profile →
  32. Human trials exploring anti-aging medicines
    2024 94 citations Leonard Guarente, David Sinclair et al. Cell Metabolism profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Leonard Guarente 28.8k 21.7k 17.1k 10.5k 9.2k 205 54.9k
Eric Verdin 24.8k 0.9× 10.8k 0.5× 10.9k 0.6× 8.0k 0.8× 1.4k 0.2× 279 47.4k
Pere Puigserver 25.8k 0.9× 8.3k 0.4× 22.3k 1.3× 8.6k 0.8× 1.4k 0.2× 121 43.7k
Rafael de Cabo 13.6k 0.5× 6.2k 0.3× 14.8k 0.9× 4.0k 0.4× 5.6k 0.6× 344 33.0k
Shin‐ichiro Imai 8.3k 0.3× 10.9k 0.5× 6.8k 0.4× 5.2k 0.5× 1.7k 0.2× 102 21.2k
C. Ronald Kahn 36.9k 1.3× 2.8k 0.1× 26.6k 1.6× 13.6k 1.3× 2.3k 0.2× 515 74.6k
Manuel Serrano 30.9k 1.1× 2.9k 0.1× 16.0k 0.9× 4.6k 0.4× 5.1k 0.6× 270 52.1k
Kun‐Liang Guan 57.7k 2.0× 2.9k 0.1× 7.2k 0.4× 14.2k 1.4× 1.7k 0.2× 422 88.6k
Anne Brunet 26.5k 0.9× 2.8k 0.1× 5.9k 0.3× 3.0k 0.3× 5.6k 0.6× 143 38.5k
Vilhelm A. Bohr 30.1k 1.0× 2.8k 0.1× 8.0k 0.5× 3.9k 0.4× 2.3k 0.3× 539 41.7k
Ana María Cuervo 21.0k 0.7× 2.5k 0.1× 12.3k 0.7× 30.2k 2.9× 2.3k 0.3× 251 52.1k

Countries citing papers authored by Leonard Guarente

Since Specialization
Citations

This map shows the geographic impact of Leonard Guarente's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leonard Guarente with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leonard Guarente more than expected).

Fields of papers citing papers by Leonard Guarente

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leonard Guarente. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leonard Guarente. The network helps show where Leonard Guarente may publish in the future.

Co-authorship network of co-authors of Leonard Guarente

This figure shows the co-authorship network connecting the top 25 collaborators of Leonard Guarente. A scholar is included among the top collaborators of Leonard Guarente based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leonard Guarente. Leonard Guarente is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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