David Gius

17.2k total citations · 6 hit papers
148 papers, 13.7k citations indexed

About

David Gius is a scholar working on Molecular Biology, Geriatrics and Gerontology and Epidemiology. According to data from OpenAlex, David Gius has authored 148 papers receiving a total of 13.7k indexed citations (citations by other indexed papers that have themselves been cited), including 98 papers in Molecular Biology, 40 papers in Geriatrics and Gerontology and 28 papers in Epidemiology. Recurrent topics in David Gius's work include Sirtuins and Resveratrol in Medicine (40 papers), Mitochondrial Function and Pathology (21 papers) and Redox biology and oxidative stress (20 papers). David Gius is often cited by papers focused on Sirtuins and Resveratrol in Medicine (40 papers), Mitochondrial Function and Pathology (21 papers) and Redox biology and oxidative stress (20 papers). David Gius collaborates with scholars based in United States, South Korea and Japan. David Gius's co-authors include Douglas R. Spitz, Seong‐Hoon Park, Athanassios Vassilopoulos, Özkan Özden, Kheem S. Bisht, Jian Jian Li, J. Daniel Pennington, Chu‐Xia Deng, Edouard I. Azzam and Haiyan Jiang and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

David Gius

146 papers receiving 13.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

2010 735 citations Mitchell C. Coleman, J. Daniel Pennington et al. profile →
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

2008 665 citations Wenqiang Yu, David Gius et al. profile →
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

2010 647 citations Krish Patel, Kheem S. Bisht et al. profile →
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

2004 559 citations Douglas R. Spitz, Jian Jian Li et al. profile →
Circadian Clock NAD ⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

2013 507 citations David Gius et al. profile →
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

2015 354 citations David Gius et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
David Gius United States	65	8.0k	3.4k	2.6k	2.4k	2.4k	148	13.7k
Joseph A. Baur United States	53	6.8k 0.9×	5.2k 1.5×	1.1k 0.4×	2.4k 1.0×	5.0k 2.1×	116	16.0k
David B. Lombard United States	45	6.6k 0.8×	4.8k 1.4×	1.1k 0.4×	3.3k 1.4×	3.7k 1.5×	83	12.7k
Shazib Pervaiz Singapore	58	5.9k 0.7×	1.2k 0.3×	1.5k 0.6×	1.0k 0.4×	921 0.4×	176	9.9k
Marcia C. Haigis United States	65	13.7k 1.7×	6.6k 1.9×	5.7k 2.2×	5.5k 2.3×	5.3k 2.2×	128	24.7k
Antonello Mai Italy	63	9.0k 1.1×	1.8k 0.5×	940 0.4×	1.8k 0.8×	1.1k 0.5×	393	14.2k
Orian S. Shirihai United States	63	11.2k 1.4×	795 0.2×	1.7k 0.6×	4.4k 1.8×	3.9k 1.6×	163	16.8k
Dudley W. Lamming United States	48	5.5k 0.7×	2.9k 0.8×	593 0.2×	2.0k 0.8×	3.9k 1.6×	97	11.9k
Lucia Altucci Italy	62	9.9k 1.2×	1.1k 0.3×	1.5k 0.6×	1.0k 0.4×	736 0.3×	321	14.5k
Kaikobad Irani United States	53	6.4k 0.8×	673 0.2×	1.5k 0.6×	947 0.4×	2.7k 1.1×	117	11.5k
Matthew D. Hirschey United States	44	6.1k 0.8×	4.5k 1.3×	1.1k 0.4×	2.8k 1.2×	4.7k 2.0×	82	11.9k

Countries citing papers authored by David Gius

Since Specialization

Citations

This map shows the geographic impact of David Gius's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Gius with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Gius more than expected).

Fields of papers citing papers by David Gius

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Gius. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Gius. The network helps show where David Gius may publish in the future.

Co-authorship network of co-authors of David Gius

This figure shows the co-authorship network connecting the top 25 collaborators of David Gius. A scholar is included among the top collaborators of David Gius based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Gius. David Gius is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Xu, Guogang, Yucheng Gao, Sung‐Jen Wei, et al.. (2025). Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet. Free Radical Biology and Medicine. 232. 260–268. 2 indexed citations

Horikoshi, Nobuo, et al.. (2022). Manganese Superoxide Dismutase Acetylation and Regulation of Protein Structure in Breast Cancer Biology and Therapy. Antioxidants. 11(4). 635–635. 7 indexed citations

Gao, Yucheng, et al.. (2021). MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism. International Journal of Biological Sciences. 17(5). 1203–1216. 12 indexed citations

Beilhartz, Greg L., et al.. (2020). An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth. Proceedings of the National Academy of Sciences. 117(29). 16938–16948. 28 indexed citations

He, Chenxia, Jeanne M. Danes, Peter C. Hart, et al.. (2019). SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proceedings of the National Academy of Sciences. 116(47). 23534–23541. 54 indexed citations

Zou, Xianghui, Yueming Zhu, Seong‐Hoon Park, et al.. (2017). SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth. Cancer Research. 77(15). 3990–3999. 74 indexed citations

Park, Seong‐Hoon, Özkan Özden, Guoxiang Liu, et al.. (2016). SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth. Cancer Research. 76(13). 3802–3812. 105 indexed citations

Liu, Rui, Ming Fan, Demet Candas, et al.. (2015). CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Molecular Cancer Therapeutics. 14(9). 2090–2102. 84 indexed citations

Coleman, Mitchell C., Alicia K. Olivier, Kranti A. Mapuskar, et al.. (2013). Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3. Antioxidants and Redox Signaling. 20(9). 1423–1435. 31 indexed citations

10.

Vassilopoulos, Athanassios, J. Daniel Pennington, Þorkell Andrésson, et al.. (2013). SIRT3 Deacetylates ATP Synthase F ₁ Complex Proteins in Response to Nutrient- and Exercise-Induced Stress. Antioxidants and Redox Signaling. 21(4). 551–564. 144 indexed citations

11.

Nguyen, Phuongmai, Hengmi Cui, Kheem S. Bisht, et al.. (2008). CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region. Cancer Research. 68(14). 5546–5551. 39 indexed citations

12.

Sun, Lunching, Lei Huang, Phuongmai Nguyen, et al.. (2008). DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation. Cancer Research. 68(8). 2726–2735. 41 indexed citations

13.

Nguyen, Phuongmai, Gil Bar‐Sela, Lunching Sun, et al.. (2008). BAT3 and SET1A Form a Complex with CTCFL/BORIS To Modulate H3K4 Histone Dimethylation and Gene Expression. Molecular and Cellular Biology. 28(21). 6720–6729. 79 indexed citations

14.

Gius, David, Eric Y. Chuang, Sheng Feng, et al.. (2007). Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates. Cancer Research. 67(15). 7113–7123. 76 indexed citations

15.

Waes, Carter Van, Angela A. Chang, Peter F. Lebowitz, et al.. (2005). Inhibition of nuclear factor-κB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma. International Journal of Radiation Oncology*Biology*Physics. 63(5). 1400–1412. 93 indexed citations

16.

Smart, Dee Dee, C. Matthew Bradbury, C. Norman Coleman, & David Gius. (2004). Ionizing radiation alters localization and phosphorylation of caveolin-1 in glioblastoma cells and blood-brain barrier endothelium.. Cancer Research. 64. 724–724. 1 indexed citations

17.

Gius, David. (2004). Redox-Sensitive Signaling Factors and Antioxidants: How Tumor Cells Respond to Ionizing Radiation. Journal of Nutrition. 134(11). 3213S–3214S. 19 indexed citations

18.

Ohiro, Yoichi, Igor Garkavtsev, Shinichiro Kobayashi, et al.. (2002). A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF). FEBS Letters. 524(1-3). 163–171. 103 indexed citations

19.

Aft, Rebecca, et al.. (2002). Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death. British Journal of Cancer. 87(7). 805–812. 244 indexed citations

20.

Bradbury, C. Matthew, Douglas R. Spitz, & David Gius. (2001). Thioredoxin reductase is a novel cytoplasmic signaling factor regulating radiation-induced AP-1 DNA-binding activity and gene expression via active cysteine residues. Free Radical Biology and Medicine. 31(10). 128. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact