Luigi Puglielli

5.5k total citations · 1 hit paper
79 papers, 4.1k citations indexed

About

Luigi Puglielli is a scholar working on Molecular Biology, Physiology and Cell Biology. According to data from OpenAlex, Luigi Puglielli has authored 79 papers receiving a total of 4.1k indexed citations (citations by other indexed papers that have themselves been cited), including 38 papers in Molecular Biology, 29 papers in Physiology and 28 papers in Cell Biology. Recurrent topics in Luigi Puglielli's work include Endoplasmic Reticulum Stress and Disease (24 papers), Alzheimer's disease research and treatments (22 papers) and Genetics and Neurodevelopmental Disorders (13 papers). Luigi Puglielli is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (24 papers), Alzheimer's disease research and treatments (22 papers) and Genetics and Neurodevelopmental Disorders (13 papers). Luigi Puglielli collaborates with scholars based in United States, Italy and Chile. Luigi Puglielli's co-authors include Dora M. Kovacs, Rudolph E. Tanzi, Claudio Costantini, Mariana Pehar, Mary Cabell Jonas, Mi Hee Ko, Carlos B. Hirschberg, Laura Ingano, Heidi Scrable and Flavio Nervi and has published in prestigious journals such as Journal of Biological Chemistry, Journal of Clinical Investigation and Nature Communications.

In The Last Decade

Luigi Puglielli

77 papers receiving 4.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Alzheimer's disease: the cholesterol connection

2003 676 citations Luigi Puglielli, Dora M. Kovacs et al. profile →

Peers

Luigi Puglielli

PHYSI

SURGE

ONCOL

David A. Sanan United States

Dora M. Kovacs United States

María Dolores Ledesma Spain

Hagit Eldar-Finkelman Israel

Chunjiang Yu United States

Toshihiko Murayama Japan

Khalid Matrougui United States

S. Høyer Denmark

Toshiyasu Sasaoka Japan

Stephen J. Gardell United States

David A. Sanan United States

Luigi Puglielli

2.1k ×1.1

1.6k ×1.0

PHYSI

1.3k ×1.3

SURGE

469 ×0.7

219 ×0.4

ONCOL

Citations per year, relative to Luigi Puglielli Luigi Puglielli (= 1×) peers David A. Sanan

Countries citing papers authored by Luigi Puglielli

Since Specialization

Citations

This map shows the geographic impact of Luigi Puglielli's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Luigi Puglielli with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Luigi Puglielli more than expected).

Fields of papers citing papers by Luigi Puglielli

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Luigi Puglielli. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Luigi Puglielli. The network helps show where Luigi Puglielli may publish in the future.

Co-authorship network of co-authors of Luigi Puglielli

This figure shows the co-authorship network connecting the top 25 collaborators of Luigi Puglielli. A scholar is included among the top collaborators of Luigi Puglielli based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Luigi Puglielli. Luigi Puglielli is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Clark, Josef P., Timothy W. Rhoads, Kevin W. Eliceiri, et al.. (2025). Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging. Nature Communications. 16(1). 2053–2053. 5 indexed citations

Gu, Ting‐Jia, Daniel G. Delafield, Michael J. Rigby, et al.. (2024). sn-Position-Resolved Quantification of Aminophospholipids by Isotopic N,N-Dimethyl Leucine Labeling and High-Resolution Ion Mobility Mass Spectrometry. Analytical Chemistry. 96(50). 20098–20106. 1 indexed citations

Delafield, Daniel G., et al.. (2024). Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics. Nature Communications. 15(1). 6252–6252. 11 indexed citations

Cappelletti, Pamela, Nicola Salvatore Orefice, Michael J. Rigby, et al.. (2024). miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia. Molecular Neurobiology. 62(2). 2573–2586. 5 indexed citations

Xu, Shuling, Daniel G. Delafield, Michael J. Rigby, et al.. (2023). CHRISTMAS: Chiral Pair Isobaric Labeling Strategy for Multiplexed Absolute Quantitation of Enantiomeric Amino Acids. Analytical Chemistry. 95(50). 18504–18513. 5 indexed citations

Zhang, Hua, Yuan Liu, Lauren Fields, et al.. (2023). Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging. Nature Communications. 14(1). 5185–5185. 59 indexed citations

Rigby, Michael J., Nicola Salvatore Orefice, M Ma, et al.. (2022). SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype. Brain Communications. 4(1). fcac002–fcac002. 10 indexed citations

Rigby, Michael J., Nicola Salvatore Orefice, M Ma, et al.. (2021). Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Brain. 145(2). 500–516. 12 indexed citations

Thomas, Diana D.H., Yajing Peng, Aurelia Lugea, et al.. (2020). Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis. Cellular and Molecular Gastroenterology and Hepatology. 11(3). 725–738. 15 indexed citations

10.

Peng, Yajing, Mi Jin Kim, Rikki Hullinger, et al.. (2016). Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse. Brain. 139(3). 937–952. 31 indexed citations

11.

Ding, Yun, Cosma Dellisanti, Mi Hee Ko, Cynthia Czajkowski, & Luigi Puglielli. (2014). The Endoplasmic Reticulum-based Acetyltransferases, ATase1 and ATase2, Associate with the Oligosaccharyltransferase to Acetylate Correctly Folded Polypeptides. Journal of Biological Chemistry. 289(46). 32044–32055. 21 indexed citations

12.

Pehar, Mariana & Luigi Puglielli. (2012). Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833(3). 686–697. 37 indexed citations

13.

Bendlin, Barbara B., Cynthia M. Carlsson, Sterling C. Johnson, et al.. (2012). CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease. PLoS ONE. 7(6). e37720–e37720. 70 indexed citations

14.

Huttunen, Henri J., Luigi Puglielli, Blake C. Ellis, Laura Ingano, & Dora M. Kovacs. (2008). Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells. Journal of Molecular Neuroscience. 37(1). 6–15. 23 indexed citations

15.

Ko, Mi Hee & Luigi Puglielli. (2007). The Sterol Carrier Protein SCP-x/Pro-SCP-2 Gene Has Transcriptional Activity and Regulates the Alzheimer Disease γ-Secretase. Journal of Biological Chemistry. 282(27). 19742–19752. 21 indexed citations

16.

Puglielli, Luigi, Avi L. Friedlich, Kenneth D.R. Setchell, et al.. (2005). Alzheimer disease β-amyloid activity mimics cholesterol oxidase. Journal of Clinical Investigation. 115(9). 2556–2563. 116 indexed citations

17.

Hutter‐Paier, Birgit, Henri J. Huttunen, Luigi Puglielli, et al.. (2004). The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Neuron. 44(2). 227–238. 221 indexed citations

18.

Sturla, Laura, Luigi Puglielli, Michela Tonetti, et al.. (2001). Impairment of the Golgi GDP-l-Fucose Transport and Unresponsiveness to Fucose Replacement Therapy in LAD II Patients. Pediatric Research. 49(4). 537–542. 55 indexed citations

19.

Puglielli, Luigi & Dora M. Kovacs. (2001). Alzheimer disease: 100 years later. Revista médica de Chile. 129(5). 569–75. 3 indexed citations

20.

Núñez, Lucı́a, Ludwig Amigo, Geltrude Mingrone, et al.. (1995). Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis.. Gut. 37(3). 422–426. 16 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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