Kevin M. Ryan

41.9k citations

115 papers · 11.8k indexed · 7 hit papers · h-index 53

Molecular Biology top 0.5%
Epidemiology top 0.5%
Oncology top 0.5%
Cancer Research top 0.5%
Cell Biology top 0.5%

Co-authors: Karen H. Vousden Jim O’Prey Simon Wilkinson Mathias T. Rosenfeldt Andrew C. Phillips Jayanta Debnath Noor Gammoh Diane Crighton
Topics: Autophagy in Disease and Therapy (55 papers)Cancer-related Molecular Pathways (36 papers)Cell death mechanisms and regulation (19 papers)
Cited by: Cancer Research Physiology Epidemiology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: United Kingdom United States Ireland

In The Last Decade

Kevin M. Ryan

114 papers receiving 11.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

2006 1.1k citations Diane Crighton, Simon Wilkinson et al. profile →
Autophagy and autophagy-related pathways in cancer

2023 804 citations Kevin M. Ryan et al. profile →
p53 and metabolism

2009 780 citations Karen H. Vousden, Kevin M. Ryan profile →
Role of NF-κB in p53-mediated programmed cell death

2000 652 citations Kevin M. Ryan et al. profile →
Regulation and function of the p53 tumor suppressor protein

2001 591 citations Kevin M. Ryan et al. profile →
p53 status determines the role of autophagy in pancreatic tumour development

2013 576 citations Mathias T. Rosenfeldt, Jim O’Prey et al. profile →
Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

2018 393 citations Joel S. Riley, Giovanni Quarato et al. The EMBO Journal profile →

Peers

Countries citing papers authored by Kevin M. Ryan

Since Specialization

Citations

This map shows the geographic impact of Kevin M. Ryan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kevin M. Ryan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kevin M. Ryan more than expected).

Fields of papers citing papers by Kevin M. Ryan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kevin M. Ryan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kevin M. Ryan. The network helps show where Kevin M. Ryan may publish in the future.

Co-authorship network of co-authors of Kevin M. Ryan

This figure shows the co-authorship network connecting the top 25 collaborators of Kevin M. Ryan. A scholar is included among the top collaborators of Kevin M. Ryan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kevin M. Ryan. Kevin M. Ryan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy 2023 ·The Journal of Cell Biology ·(unknown),Joanne Durgan,David G. McEwan,(unknown),Kevin M. Ryan,Oliver Florey	51
2	LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner 2023 ·Cell Death and Disease ·Elżbieta Kania,Jaclyn S. Long,David G. McEwan,Kirsten Welkenhuyzen,Rita La Rovere,Tomas Luyten,J. C. Halpin,Evy Lobbestael,Veerle Baekelandt,Geert Bultynck,Kevin M. Ryan,Jan B. Parys	10
3	ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis 2022 ·Proceedings of the National Academy of Sciences ·Jaclyn S. Long,Elżbieta Kania,David G. McEwan,Valentin J.A. Barthet,(unknown),Marcus J.G.W. Ladds,(unknown),Kevin M. Ryan	19
4	Glycan degradation promotes macroautophagy 2022 ·Proceedings of the National Academy of Sciences ·Alice D. Baudot,Victoria M.-Y. Wang,(unknown),Jim O’Prey,Jaclyn S. Long,Viola Paulus-Hock,Sérgio Lilla,David M. Thomson,(unknown),(unknown),Colin Nixon,Miep Helfrich,Douglas Strathdee,Judith A. Pratt,Francesco Marchesi,Sara Zanivan,Kevin M. Ryan	7
5	Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver 2021 ·Science Advances ·Valentin J.A. Barthet,(unknown),Marcus J.G.W. Ladds,(unknown),Christos Kiourtis,Alice D. Baudot,(unknown),Barbara Zunino,Miryam Müller,Stephanie May,Colin Nixon,Jaclyn S. Long,Thomas G. Bird,Kevin M. Ryan	33
6	Prolonged elevation of D‐dimer levels in convalescent COVID‐19 patients is independent of the acute phase response 2021 ·Journal of Thrombosis and Haemostasis ·Liam Townsend,Helen Fogarty,Adam H. Dyer,Ignacio Martín‐Loeches,Ciarán Bannan,Parthiban Nadarajan,Colm Bergin,Cliona O’Farrelly,Niall Conlon,Nollaig M. Bourke,Soracha E. Ward,Mary Byrne,Kevin M. Ryan,Niamh O’Connell,Jamie M. O’Sullivan,Clíona Ní Cheallaigh,James S. O’Donnell	120
7	D-mannose suppresses macrophage IL-1β production 2020 ·Nature Communications ·Simone Torretta,Alessandra Scagliola,Luisa Ricci,Francesco Mainini,Sabrina Di Marco,Ivan Cuccovillo,Anna Kajaste‐Rudnitski,David Sumpton,Kevin M. Ryan,Simone Cardaci	163
8	MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma 2019 ·Cancer Research ·Maria I. New,Tim Van Acker,Jun-Ichi Sakamaki,Ming Jiang,Rebecca E. Saunders,Jaclyn S. Long,Victoria M.-Y. Wang,Axel Behrens,Joana Cerveira,Padhmanand Sudhakar,Tamás Korcsmáros,Harold B.J. Jefferies,Kevin M. Ryan,Michael Howell,Sharon A. Tooze	29
9	Targeting quiescent leukemic stem cells using second generation autophagy inhibitors 2018 ·Leukemia ·Pablo Baquero,(unknown),Arunima Mukhopadhyay,(unknown),Rebecca Mitchell,O. Porta Olivares,(unknown),Mary T. Scott,Karen Dunn,Michael C. Nicastri,Jeffrey D. Winkler,Alison M. Michie,Kevin M. Ryan,Christina Halsey,Eyal Gottlieb,Erin P. Keaney,Leon O. Murphy,Ravi K. Amaravadi,Tessa L. Holyoake,G. Vignir Helgason	95
10	MCL-1 is a prognostic indicator and drug target in breast cancer 2018 ·Cell Death and Disease ·Kirsteen J. Campbell,Sandeep Dhayade,Nicola Ferrari,Andrew H. Sims,Emma Johnson,Susan Mason,(unknown),Kevin M. Ryan,Gabriela Kalna,Joanne Edwards,Stephen W. G. Tait,Karen Blyth	144
11	Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosisbreakdown → 2018 ·The EMBO Journal ·Joel S. Riley,Giovanni Quarato,Catherine Cloix,Jonathan Lopez,Jim O’Prey,Matthew Pearson,James Chapman,Hiromi Sesaki,Leo M. Carlin,João F. Passos,Ann P. Wheeler,Andrew Oberst,Kevin M. Ryan,Stephen W. G. Tait	393
12	Retrograde signaling from autophagy modulates stress responses 2017 ·Science Signaling ·Hans‐Uwe Simon,Robert R. Friis,Stephen W. G. Tait,Kevin M. Ryan	64
13	Application of CRISPR/Cas9 to Autophagy Research 2016 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Jim O’Prey,Jun-Ichi Sakamaki,Alice D. Baudot,Mark New,Tim Van Acker,Sharon A. Tooze,Jaclyn S. Long,Kevin M. Ryan	28
14	Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1 2013 ·Cancer Discovery ·Anni Laine,Harri Sihto,Christophé Côme,Mathias T. Rosenfeldt,Aleksandra Zwolińska,Minna Niemelä,Anchit Khanna,Edward K. L. Chan,Veli‐Matti Kähäri,Pirkko‐Liisa Kellokumpu‐Lehtinen,Owen J. Sansom,Gérard I. Evan,Melissa R. Junttila,Kevin M. Ryan,Jean‐Christophe Marine,Heikki Joensuu,Jukka Westermarck	101
15	MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity 2011 ·Cell Cycle ·(unknown),(unknown),Arnaud Vigneron,Kevin M. Ryan,Karen H. Vousden	47
16	Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1 2010 ·Cancer Research ·G. Vignir Helgason,Jim O’Prey,Kevin M. Ryan	8
17	c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells 2009 ·Cancer Research ·Séverine Lorin,(unknown),(unknown),Sylvie Souquère,Gérard Pierron,Kevin M. Ryan,Patrice Codogno,Mojgan Djavaheri‐Mergny	67
18	DRAM Links Autophagy to p53 and Programmed Cell Death 2007 ·Autophagy ·Diane Crighton,Simon Wilkinson,Kevin M. Ryan	168
19	Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells 2004 ·Cancer Research ·Weiguang Wang,James T. Cassidy,Vincent O’Brien,Kevin M. Ryan,Elaina Collie–Duguid	95
20	Pulmonary lymphangioleiomyomatosis complicated by pregnancy. 1986 ·PubMed ·(unknown),(unknown),Kevin M. Ryan	34

About Kevin M. Ryan

Kevin M. Ryan is a scholar working on Epidemiology, Oncology and Physiology, having authored 115 papers that have together received 11.8k indexed citations. Recurring topics across this work include Autophagy in Disease and Therapy (55 papers), Cancer-related Molecular Pathways (36 papers) and Cell death mechanisms and regulation (19 papers). The work is most often cited by research in Cancer Research (2.3k citations), Physiology (643 citations) and Epidemiology (4.3k citations). Kevin M. Ryan has collaborated with scholars based in United Kingdom, United States and Ireland. Frequent co-authors include Karen H. Vousden, Jim O’Prey, Simon Wilkinson, Mathias T. Rosenfeldt, Andrew C. Phillips, Jayanta Debnath, Noor Gammoh, Diane Crighton, Mary K. Ernst and Nancy R. Rice. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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