Jun Ninomiya‐Tsuji

12.2k citations

99 papers · 10.4k · 2 hit papers · h-index 49

Impact in

Cancer Research top 0.5%
- NF-κB Signaling Pathways
Aging top 0.5%

Papers in

Cancer Research 51
- NF-κB Signaling Pathways 49
Immunology 39
- Immune Response and Inflammation 30
- interferon and immune responses 16

Co-authors: Kunihiro Matsumoto (51 shared papers)Hiroshi Shibuyà (8 shared papers)Kazuya Kishimoto (2 shared papers)Giichi Takaesu (11 shared papers)Atsushi Hiyama (2 shared papers)Tohru Ishitani (5 shared papers)Shizuo Akira (8 shared papers)Satoshi Kishida (5 shared papers)
Journals: Journal of Biological Chemistry (21 papers)Experimental Cell Research (8 papers)Molecular and Cellular Biology (7 papers)Proceedings of the National Academy of Sciences (4 papers)Nature (4 papers)
Partner nations: Japan United States United Kingdom

In The Last Decade

Jun Ninomiya‐Tsuji

98 papers receiving 10.2k citations

Jun Ninomiya‐Tsuji's Hit Papers

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Essential function for the kinase TAK1 in innate and adaptive immune responses 2005 · 836 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2005 Nature Immunology
1999 Nature

Peers

Countries citing papers authored by Jun Ninomiya‐Tsuji

Since Specialization

Citations

This map shows the geographic impact of Jun Ninomiya‐Tsuji's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jun Ninomiya‐Tsuji with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jun Ninomiya‐Tsuji more than expected).

Fields of papers citing papers by Jun Ninomiya‐Tsuji

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jun Ninomiya‐Tsuji. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jun Ninomiya‐Tsuji. The network helps show where Jun Ninomiya‐Tsuji may publish in the future.

Co-authors

The 25 scholars most cited alongside Jun Ninomiya‐Tsuji, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jun Ninomiya‐Tsuji Line = papers co-authored together Jun Ninomiya‐Tsuji links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 99 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway Nature ·Jun Ninomiya‐Tsuji, Kazuya Kishimoto, Atsushi Hiyama, Jun‐ichiro Inoue, Zhaodan Cao, Kunihiro Matsumoto Hit paper breakdown →	1999	1055
2	Essential function for the kinase TAK1 in innate and adaptive immune responses Nature Immunology ·Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya‐Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi Hit paper breakdown →	2005	836
3	TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway Molecular Cell ·Giichi Takaesu, Satoshi Kishida, Atsushi Hiyama, Toshihiro Yamaguchi, Hiroshi Shibuyà, Kenji Irie, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto	2000	524
4	The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF Nature ·Tohru Ishitani, Jun Ninomiya‐Tsuji, Shin‐ichi Nagai, Michiru Nishita, Marc D. Meneghini, Nick Barker, Marian L. Waterman, Bruce A. Bowerman	1999	517
5	The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca 2+ Pathway To Antagonize Wnt/β-Catenin Signaling Molecular and Cellular Biology ·Tohru Ishitani, Satoshi Kishida, Junko Hyodo‐Miura, Naoto Ueno, Jun Yasuda, Marian L. Waterman, Hiroshi Shibuyà, Randall T. Moon	2002	460
6	Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression Journal of Biological Chemistry ·Hiroshi Hanafusa, Jun Ninomiya‐Tsuji, Norihisa Masuyama, Michiru Nishita, Jun–ichi Fujisawa, Hiroshi Shibuyà, Kunihiro Matsumoto, Eisuke Nishida	1999	399
7	A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase Journal of Biological Chemistry ·Jun Ninomiya‐Tsuji, Taisuke Kajino, Koichiro Ono, Toshihiko Ohtomo, Masahiko Matsumoto, Masashi Shiina, Masahiko Mihara, Masayuki Tsuchiya	2003	371
8	TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway Journal of Molecular Biology ·Giichi Takaesu, Rama Mohan Surabhi, Kyu-Jin Park, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto, Richard B. Gaynor	2003	348
9	Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6 Molecular and Cellular Biology ·Junko Mizukami, Giichi Takaesu, Hiroyuki Akatsuka, Hiroaki Sakurai, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto, Naoki Sakurai	2002	253
10	Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol Molecular and Cellular Biology ·Zhengfan Jiang, Jun Ninomiya‐Tsuji, Youcun Qian, Kunihiro Matsumoto, Xiaoxia Li	2002	247
11	TAK1 control of cell death Cell Death and Differentiation ·September R. Mihaly, Jun Ninomiya‐Tsuji, Sho Morioka	2014	243
12	MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans Nature ·Marc D. Meneghini, Tohru Ishitani, J. Clayton Carter, Naoki Hisamoto, Jun Ninomiya‐Tsuji, Christopher J. Thorpe, Danielle R. Hamill, Kunihiro Matsumoto	1999	237
13	Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling The EMBO Journal ·Tohru Ishitani, Giichi Takaesu, Jun Ninomiya‐Tsuji, Hiroshi Shibuyà, Richard B. Gaynor, Kunihiro Matsumoto	2003	237
14	TAK1 Mitogen-activated Protein Kinase Kinase Kinase Is Activated by Autophosphorylation within Its Activation Loop Journal of Biological Chemistry ·Kazuya Kishimoto, Kunihiro Matsumoto, Jun Ninomiya‐Tsuji	2000	228
15	IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc Cell ·Hiroshi Shibuyà, Mitsutoshi Yoneyama, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto, Tadatsugu Taniguchi	1992	222
16	AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart Circulation Research ·Ji Li, Edward Joseph Miller, Jun Ninomiya‐Tsuji, Raymond R. Russell, Lawrence H. Young	2005	197
17	Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling Molecular and Cellular Biology ·Tohru Ishitani, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto	2003	187
18	IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB Journal of Biological Chemistry ·Youcun Qian, Mairead Commane, Jun Ninomiya‐Tsuji, Kunihiro Matsumoto, Xiaoxia Li	2001	184
19	Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proceedings of the National Academy of Sciences ·Jun Ninomiya‐Tsuji, S. Nomoto, Hideyo Yasuda, Steven I. Reed, Kunihiro Matsumoto	1991	178
20	Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway Molecular and Cellular Biology ·Giichi Takaesu, Jun Ninomiya‐Tsuji, Satoshi Kishida, Xiaoxia Li, George Robert Stark, Kunihiro Matsumoto	2001	172

About Jun Ninomiya‐Tsuji

Jun Ninomiya‐Tsuji is a scholar working on Cancer Research, Immunology, Molecular Biology, Oncology and Genetics, having authored 99 papers that have together received 10.4k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (49 papers), Immune Response and Inflammation (30 papers), interferon and immune responses (16 papers), TGF-β signaling in diseases (9 papers), Cytokine Signaling Pathways and Interactions (9 papers), Cell death mechanisms and regulation (9 papers), Virus-based gene therapy research (9 papers) and Cell Adhesion Molecules Research (6 papers). The work is most often cited by research in Cancer Research (3.6k citations), Aging (339 citations), Immunology (3.7k citations), Molecular Biology (6.1k citations) and Oncology (1.6k citations). Jun Ninomiya‐Tsuji has collaborated with scholars based in Japan, United States and United Kingdom. Frequent co-authors include Kunihiro Matsumoto, Hiroshi Shibuyà, Kazuya Kishimoto, Giichi Takaesu, Atsushi Hiyama, Tohru Ishitani, Shizuo Akira, Satoshi Kishida, Zhaodan Cao and Jun‐ichiro Inoue. Their work appears in journals such as Journal of Biological Chemistry, Experimental Cell Research, Molecular and Cellular Biology, Proceedings of the National Academy of Sciences and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Jun Ninomiya‐Tsuji

Jun Ninomiya‐Tsuji's Hit Papers

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Fields of papers citing papers by Jun Ninomiya‐Tsuji

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About Jun Ninomiya‐Tsuji

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