Hiroshi Shibuyà

15.6k citations

136 papers · 12.1k indexed · 5 hit papers · h-index 49

Molecular Biology top 0.5%
Immunology top 1%
Cancer Research top 0.5%
Oncology top 1%
Surgery top 2%

Co-authors: Kunihiro Matsumoto Naoto Ueno Eisuke Nishida Kenji Irie Tadatsugu Taniguchi Toshihiro Yamaguchi Kyoko Shirakabe Jun Ninomiya‐Tsuji
Topics: Thyroid Cancer Diagnosis and Treatment (21 papers)Wnt/β-catenin signaling in development and cancer (19 papers)Cancer-related gene regulation (18 papers)
Cited by: Cancer Research Molecular Biology Immunology
Journals: Nature Science Cell
Partner nations: Japan United States Canada

In The Last Decade

Hiroshi Shibuyà

130 papers receiving 11.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 1.2k citations Kyoko Shirakabe, Hiroshi Shibuyà et al. profile →
The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway

2003 605 citations Bisei Ohkawara, Hiroshi Shibuyà et al. Genes to Cells profile →
TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway

2000 511 citations Hiroshi Shibuyà, Jun Ninomiya‐Tsuji et al. Molecular Cell profile →
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

1999 507 citations Jun Ninomiya‐Tsuji, Michiru Nishita et al. profile →
TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 505 citations Hiroshi Shibuyà, Kyoko Shirakabe et al. profile →

Peers

Countries citing papers authored by Hiroshi Shibuyà

Since Specialization

Citations

This map shows the geographic impact of Hiroshi Shibuyà's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroshi Shibuyà with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroshi Shibuyà more than expected).

Fields of papers citing papers by Hiroshi Shibuyà

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroshi Shibuyà. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroshi Shibuyà. The network helps show where Hiroshi Shibuyà may publish in the future.

Co-authorship network of co-authors of Hiroshi Shibuyà

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroshi Shibuyà. A scholar is included among the top collaborators of Hiroshi Shibuyà based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroshi Shibuyà. Hiroshi Shibuyà is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression 2023 ·Journal of Biological Chemistry ·Michiru Nishita,Koki Kamizaki,(unknown),(unknown),(unknown),Hiroshi Shibuyà,Kunio Matsumoto,Yasuhiro Minami	3
2	WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID 2020 ·Communications Biology ·Atsushi Sato,(unknown),Toshiyasu Goto,Hiroyuki Masuno,Hiroyuki Kagechika,Nobuyuki Tanaka,Hiroshi Shibuyà	18
3	Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway 2018 ·PLoS ONE ·Atsushi Sato,Hiroshi Shibuyà	9
4	WNK4 is an essential effector of anterior formation in FGF signaling 2013 ·Genes to Cells ·(unknown),Toshiyasu Goto,Atsushi Sato,Hiroshi Shibuyà	3
5	Prognosis and Prognostic Factors for Distant Metastases and Tumor Mortality in Follicular Thyroid Carcinoma 2011 ·Thyroid ·Kiminori Sugino,Koichi Ito,Mitsuji Nagahama,Wataru Kitagawa,Hiroshi Shibuyà,Keiko Ohkuwa,Yukiko Yano,Takashi Uruno,Junko Akaishi,Kaori Kameyama,Kunihiko Ito	86
6	TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling 2010 ·Molecular Cell ·Yukihide Watanabe,Susumu Itoh,Toshiyasu Goto,Eriko Ohnishi,Masako Inamitsu,Fumiko Itoh,Kiyotoshi Satoh,Eliza Wiercinska,Weiwen Yang,Liang Shi,Aya Tanaka,Naoko Nakano,A. Mieke Mommaas,Hiroshi Shibuyà,Peter ten Dijke,Mitsuyasu Kato	124
7	Caenorhabditis elegans WNK–STE20 pathway regulates tube formation by modulating ClC channel activity 2007 ·EMBO Reports ·Naoki Hisamoto,Tetsuo Moriguchi,Seiichi Urushiyama,Shohei Mitani,Hiroshi Shibuyà,Kunihiro Matsumoto	31
8	Molecular Pathogenesis of Pseudohypoaldosteronism Type II: Generation and Analysis of a Wnk4 Knockin Mouse Model 2007 ·Cell Metabolism ·Sung‐Sen Yang,Tetsuji Morimoto,Tatemitsu Rai,Motoko Chiga,Eisei Sohara,Mayuko Ohno,Keiko Uchida,Shih‐Hua Lin,Tetsuo Moriguchi,Hiroshi Shibuyà,Yoshiaki Kondo,Sei Sasaki,Shinichi Uchida	255
9	NARF, an Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF) 2006 ·Journal of Biological Chemistry ·Misato Yamada,Junji Ohnishi,Bisei Ohkawara,Shun‐ichiro Iemura,Kiyotoshi Satoh,Junko Hyodo‐Miura,(unknown),Tohru Natsume,Hiroshi Shibuyà	116
10	Dok‐3 sequesters Grb2 and inhibits the Ras‐Erk pathway downstream of protein‐tyrosine kinases 2006 ·Genes to Cells ·Miyuki Honma,Osamu Higuchi,Masaki Shirakata,Tomoharu Yasuda,Hiroshi Shibuyà,Shun‐ichiro Iemura,Tohru Natsume,Yuji Yamanashi	33
11	Negative regulation of Wnt signalling by HMG2L1, a novel NLK‐binding protein 2003 ·Genes to Cells ·Misato Yamada,Bisei Ohkawara,Naoya Ichimura,Junko Hyodo‐Miura,Seiichi Urushiyama,Kyoko Shirakabe,Hiroshi Shibuyà	29
12	Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis 2002 ·Mechanisms of Development ·Yoshihiro Komatsu,Hiroshi Shibuyà,Naoki Takeda,Jun Ninomiya‐Tsuji,Teruhito Yasui,Kenji Miyado,Tomohisa Sekimoto,Naoto Ueno,Kunihiro Matsumoto,Gen Yamada	81
13	Cloning and Characterization of a Rat Ortholog of MMP-23 (Matrix Metalloproteinase-23), a Unique Type of Membrane-Anchored Matrix Metalloproteinase and Conditioned Switching of Its Expression during the Ovarian Follicular Development 2001 ·Molecular Endocrinology ·Junji Ohnishi,(unknown),(unknown),(unknown),(unknown),Hitoshi Matsui,Atsushi P. Kimura,Hirofumi Sawa,Kazuhisa Nakayama,Hiroshi Shibuyà,Kazuo Nagashima,Takayuki Takahashi	36
14	TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development 2000 ·Molecular and Cellular Biology ·Yoshihiro Takatsu,Makoto Nakamura,Mark Stapleton,Maria C. Danos,Kunihiro Matsumoto,Michael B. O’Connor,Hiroshi Shibuyà,Naoto Ueno	116
15	A BMP-Inducible Gene, Dlx5, Regulates Osteoblast Differentiation and Mesoderm Induction 1999 ·Developmental Biology ·Katsuyoshi Miyama,Gen Yamada,Takamasa Yamamoto,Chiyo Takagi,Kenji Miyado,Miho Sakai,Naoto Ueno,Hiroshi Shibuyà	164
16	Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver 1997 ·Hepatology ·Hiroshi Shibuyà	60
17	Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver 1997 ·Hepatology ·Hiroshi Shibuyà,Nobuhiro Ohkohchi,(unknown),S. Satomi	59
18	Photodynamic Diagnosis for Early Stage Lung Cancer with Photofrin^\|^reg; and Excimer dye laser Fluorescence Image Analyzer 1996 ·Nippon Laser Igakkaishi ·(unknown),(unknown),(unknown),Yutaka Yamamoto,Hiroshi Shibuyà,Shinya Okada,(unknown),(unknown),Katsuo Aizawa,(unknown),(unknown)	0
19	Experimental Photodynamic Diagnosis of Malignant Tumor Using New Photosensitizer 1996 ·Nippon Laser Igakkaishi ·Kinya Furukawa,Tetsuya Okunaka,Hiroshi Shibuyà,(unknown),Norihiko Ikeda,Chimori Konaka,Harubumi Kato	0
20	Functional Dissection of p56 ^lck , a Protein Tyrosine Kinase Which Mediates Interleukin-2-Induced Activation of the c- fos Gene 1994 ·Molecular and Cellular Biology ·Hiroshi Shibuyà,Kazuyoshi Kohu,Kyoko Yamada,Edward L. Barsoumian,Roger M. Perlmutter,Tadatsugu Taniguchi	5

About Hiroshi Shibuyà

Hiroshi Shibuyà is a scholar working on Aging, Endocrinology, Diabetes and Metabolism and Molecular Biology, having authored 136 papers that have together received 12.1k indexed citations. Recurring topics across this work include Thyroid Cancer Diagnosis and Treatment (21 papers), Wnt/β-catenin signaling in development and cancer (19 papers) and Cancer-related gene regulation (18 papers). The work is most often cited by research in Cancer Research (1.9k citations), Molecular Biology (8.0k citations) and Immunology (2.3k citations). Hiroshi Shibuyà has collaborated with scholars based in Japan, United States and Canada. Frequent co-authors include Kunihiro Matsumoto, Naoto Ueno, Eisuke Nishida, Kenji Irie, Tadatsugu Taniguchi, Toshihiro Yamaguchi, Kyoko Shirakabe, Jun Ninomiya‐Tsuji, Michiru Nishita and Isao Oishi. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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