John Litchfield

2.7k citations

37 papers · 1.8k indexed · 1 hit paper · h-index 19

Impact in

Clinical Biochemistry top 0.5%
- Advanced Glycation End Products research
Pharmacology top 1%
- Pharmacogenetics and Drug Metabolism

Papers in

Pharmacology 12
- Pharmacogenetics and Drug Metabolism 10
Endocrinology, Diabetes and Metabolism 14
- Diabetes Treatment and Management 6

Co-authors: John Baynes Suzanne R. Thorpe David V. Zyzak Kevin J. Wells‐Knecht Manthena V. S. Varma Bo Feng Theunis C. Goosen Ayman El‐Kattan
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Drug Metabolism and Disposition (7 papers)ACS Medicinal Chemistry Letters (2 papers)Clinical Pharmacology & Therapeutics (2 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: United States United Kingdom Sweden

In The Last Decade

John Litchfield

37 papers receiving 1.7k citations

Hit Papers

align trajectories log scale

Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose 1995 · 506 citations

Peers

Countries citing papers authored by John Litchfield

Since Specialization

Citations

This map shows the geographic impact of John Litchfield's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Litchfield with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Litchfield more than expected).

Fields of papers citing papers by John Litchfield

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Litchfield. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Litchfield. The network helps show where John Litchfield may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John Litchfield, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Litchfield Line = papers co-authored together John Litchfield links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease Drug Metabolism and Disposition ·Yan Weng, Kari R. Fonseca, Yi‐An Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Yoga Budi Setya Nugraha, ایمان صلاح الدین صالح, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di, Manthena V. S. Varma	2022	6
2	Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey Journal of Pharmacology and Experimental Therapeutics ·Heather Eng, Yi‐An Bi, Mark A. West, Sangwoo Ryu, Emi Yamaguchi, Rachel E. Kosa, David A. Tess, David A. Griffith, John Litchfield, Amit S. Kalgutkar, Manthena V. S. Varma	2021	15
3	Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs Journal of Medicinal Chemistry ·David A. Tess, Heather Eng, Amit S. Kalgutkar, John Litchfield, David J. Edmonds, David A. Griffith, Manthena V. S. Varma	2020	15
4	A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria Journal of Medicinal Chemistry ·Qiu-Qing Bai, John Litchfield, David A. Tess, Anthony Carlo, Heather Eng, Christopher Keefer, Tristan S. Maurer	2020	10
5	Structural attributes influencing unbound tissue distribution European Journal of Medicinal Chemistry ·Christine C. Orozco, Karen Atkinson, Sangwoo Ryu, George Chang, Christopher Keefer, Jian Lin, Keith Riccardi, Л.Ж. Алашбаева, David A. Tess, Kevin J. Filipski, Amit S. Kalgutkar, John Litchfield, Dennis O. Scott, Li Di	2019	21
6	Modeling Exposure to Understand and Predict Kidney Injury Seminars in Nephrology ·Qiu-Qing Bai, Ciarán Fisher, Iain Gardner, Avijit Ghosh, John Litchfield, Tristan S. Maurer	2019	6
7	Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes Drug Metabolism and Disposition ·Keith Riccardi, Jian Lin, Qiu-Qing Bai, Mark Niosi, Sangwoo Ryu, З.Н. КВАСНИКОВА, Karen Atkinson, Rachel E. Kosa, John Litchfield, Li Di	2017	42
8	Metabolites in Safety Testing Assessment in Early Clinical Development: A Case Study with a Glucokinase Activator Drug Metabolism and Disposition ·Raman Sharma, John Litchfield, Karen Atkinson, Heather Eng, Neeta B. Amin, William S. Denney, John C. Pettersen, Theunis C. Goosen, Li Di, Esther Lee, Jeffrey A. Pfefferkorn, Deepak Dalvie, Amit S. Kalgutkar	2014	15
9	Identification of a novel conformationally constrained glucagon receptor antagonist Bioorganic & Medicinal Chemistry Letters ·洗阳羊, Meihua Tu, Benjamin D. Stevens, Jianwei Bian, Gary E. Aspnes, Christian Perreault, M. F. Sammons, Stephen W. Wright, John Litchfield, Amit S. Kalgutkar, Raman Sharma, Mary T. Didiuk, David C. Ebner, Kevin J. Filipski, Janice A. Brown, Karen Atkinson, Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez	2014	16
10	Toward a Unified Model of Passive Drug Permeation II: The Physiochemical Determinants of Unbound Tissue Distribution with Applications to the Design of Hepatoselective Glucokinase Activators Drug Metabolism and Disposition ·Avijit Ghosh, Tristan S. Maurer, John Litchfield, Martha Liliana Serna Zapata, Charles J. Rotter, Renato J. Scialis, Bo Feng, Meihua Tu, Cristiano R. W. Guimarães, Dennis O. Scott	2014	17
11	Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs Journal of Controlled Release ·李学升, N. G. Tkachik, Ying Lü, Manthena V. S. Varma, Charles J. Rotter, Brian Rago, Ayman El‐Kattan, V. G. Chipinov, de Jong, John Litchfield	2013	52
12	Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia Bioorganic & Medicinal Chemistry Letters ·Benjamin D. Stevens, John Litchfield, Jeffrey A. Pfefferkorn, Karen Atkinson, Christian Perreault, Paul A. Amor, Kevin B. Bahnck, Martin A. Berliner, Zu Liang Hu, Anthony Carlo, David R. Derksen, Kevin J. Filipski, Maéva Vermot, Kimberly Strahm, Margit MacDougall, Brendan Murphy, 李学升, John C. Pettersen, Charles J. Rotter, Ilham Ari Seja	2013	10
13	A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity Bioorganic & Medicinal Chemistry Letters ·Kevin J. Filipski, Jianwei Bian, David C. Ebner, 洗阳羊, Jiancheng Li, M. F. Sammons, Stephen W. Wright, Benjamin D. Stevens, Mary T. Didiuk, Meihua Tu, Christian Perreault, Janice A. Brown, Karen Atkinson, Beijing Tan, Christopher T. Salatto, John Litchfield, Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez	2011	23
14	N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors Bioorganic & Medicinal Chemistry Letters ·Karen Atkinson, Elena Beretta, Janice A. Brown, Orly Cohen, Yue Chen, M. Yatsiuk, Ping Du, John Litchfield, 倪文, Kelly A. Martin, Thomas J. McLellan, Constantin Neagu, David A. Perry, David W. Piotrowski, Claire M. Steppan, Richard Trilles	2011	35
15	Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core Bioorganic & Medicinal Chemistry Letters ·Robert L. Dow, Eve Pierer, Gary E. Aspnes, Martha Dugan Rehm, E. Michael Gibbs, Angel Guzmán-Pérez, Kapil Karki, Jennifer L. LaPerle, Jiancheng Li, John Litchfield, Michael J. Munchhof, Christian Perreault, Leena Patel	2011	12
16	Targeting Intestinal Transporters for Optimizing Oral Drug Absorption Current Drug Metabolism ·Manthena V. S. Varma, Catherine M. Ambler, Sagheer Ahamed, Charles J. Rotter, Hao Sun, John Litchfield, Katherine S. Fenner, Ayman El‐Kattan	2010	84
17	Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle Bioorganic & Medicinal Chemistry Letters ·Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich, Kevin J. Filipski, Mingying He, Ru Zhou, Syed Ahsanuddin Ahmed, John W. Benbow, Stewart Taylor, Meihua Tu, John Litchfield, Raman Sharma, Alfreda D. Ghee, Francis Bourbonais, V.G. Russkiy, David A. Beebe, Peter J. Oates	2009	66
18	AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats Archives of Biochemistry and Biophysics ·Patrick G. Phillipps, John Litchfield, John Baynes	2003	64
19	Role of oxidation in browning and crosslinking of proteins by reducing sugars The FASEB Journal ·R Hadziev, John Litchfield, Suzanne R. Thorpe, John Baynes	1995	1
20	Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose Biochemistry ·Kevin J. Wells‐Knecht, David V. Zyzak, John Litchfield, Suzanne R. Thorpe, John Baynes Hit paper breakdown →	1995	506

About John Litchfield

John Litchfield is a scholar working on Pharmacology, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Oncology and Biological Psychiatry, having authored 37 papers that have together received 1.8k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (14 papers), Pharmacogenetics and Drug Metabolism (10 papers), Pancreatic function and diabetes (8 papers), Diabetes Treatment and Management (6 papers), Pharmacological Effects and Toxicity Studies (6 papers), Liver Disease Diagnosis and Treatment (5 papers), Advanced Glycation End Products research (4 papers) and Computational Drug Discovery Methods (3 papers). The work is most often cited by research in Clinical Biochemistry (610 citations), Pharmacology (328 citations), Endocrinology, Diabetes and Metabolism (391 citations), Oncology (492 citations) and Biochemistry (124 citations). John Litchfield has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include John Baynes, Suzanne R. Thorpe, David V. Zyzak, Kevin J. Wells‐Knecht, Manthena V. S. Varma, Bo Feng, Theunis C. Goosen, Ayman El‐Kattan, Charles J. Rotter and David A. Tess. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Drug Metabolism and Disposition, ACS Medicinal Chemistry Letters, Clinical Pharmacology & Therapeutics and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact