David A. Beebe

5.1k citations

18 papers · 3.9k indexed · 1 hit paper · h-index 13

Impact in

Clinical Biochemistry top 0.1%
- Advanced Glycation End Products research
Endocrinology, Diabetes and Metabolism top 1%
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease

Papers in

Cell Biology 7
- Aldose Reductase and Taurine 6
Endocrinology, Diabetes and Metabolism 7
- Diabetes Treatment and Management 4
- Diet, Metabolism, and Disease 2

Co-authors: Peter J. Oates Michael Brownlee Takeshi Matsumura Mark A. Yorek Takeshi Nishikawa Xue Du Ida Giardino Diane Edelstein
Journals: Journal of Medicinal Chemistry (5 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Cellular and Molecular Gastroenterology and Hepatology (2 papers)Journal of Translational Medicine (1 paper)Journal of Hepatology (1 paper)
Partner nations: United States Germany Japan

In The Last Decade

David A. Beebe

18 papers receiving 3.8k citations

Hit Papers

align trajectories log scale

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage 2000 · 3.4k citations

Peers

Countries citing papers authored by David A. Beebe

Since Specialization

Citations

This map shows the geographic impact of David A. Beebe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David A. Beebe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David A. Beebe more than expected).

Fields of papers citing papers by David A. Beebe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David A. Beebe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David A. Beebe. The network helps show where David A. Beebe may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David A. Beebe, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David A. Beebe Line = papers co-authored together David A. Beebe links everyone, so they are left out of the graph.

All Works

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18 of 18 papers shown

#	Work
1	GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner Cellular and Molecular Gastroenterology and Hepatology ·Kathleen R. Smith, H. Löw, Melissa Miller, Cui Lijiang, C B Ortiz, MICHAEL MAHON, Dongmei Li, Jabeen Zahida, Youngwook Ahn, David A. Beebe, Kenneth L. Kelly, Trenton T. Ross, Kendra K. Bence, Iona C. Hamlett	2023	5
2	Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems Cellular and Molecular Gastroenterology and Hepatology ·Trenton T. Ross, Collin Crowley, Kenneth L. Kelly, Anthony Rinaldi, David A. Beebe, Matthew P. Lech, Robert V. Martinez, Santos Carvajal‐Gonzalez, Magalie Boucher, Jabeen Zahida, Jeffrey Morin, Alan Opsahl, Ahmad Reza Katouzian, Kendra K. Bence, Jeffrey A. Pfefferkorn, William P. Esler	2020	69
3	The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes Metabolism ·Melissa A. Linden, Trenton T. Ross, David A. Beebe, Matthew Gorgoglione, Karyn L. Hamilton, Benjamin F. Miller, Barry Braun, William P. Esler	2019	18
4	PS-109-Partial inhibition of de novo lipogenesis with the acetyl-CoA carboxylase inhibitor PF-05221304 does not increase circulating triglycerides in humans and is sufficient to lower steatosis in rats Journal of Hepatology ·William P. Esler, Trenton T. Ross, Arthur Bergman, Collin Crowley, Muhanad A. Althbaiti, David A. Beebe, Jeffrey A. Pfefferkorn, Neeta B. Amin	2019	2
5	Effects of age on noninvasive assessments of vascular function in nonhuman primates: implications for translational drug discovery Journal of Translational Medicine ·Delvin R. Knight, Andrew H. Smith, Richard L. Schroeder, Chunli Huang, David A. Beebe, Sharon Sokolowski, Miao Wang	2013	4
6	1-((3S,4S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes Bioorganic & Medicinal Chemistry Letters ·Kim Andrews, David A. Beebe, John W. Benbow, 松川正明, Shawn D. Doran, Hui Yu, Shenping Liu, R. Kirk McPherson, Constantin Neagu, Janice C. Parker, David W. Piotrowski, Kaylin Harbin, Judith L. Treadway, Maria A. VanVolkenberg, William J. Zembrowski	2011	16
7	Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle Bioorganic & Medicinal Chemistry Letters ·Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich, Kevin J. Filipski, Mingying He, Ru Zhou, Syed Ahsanuddin Ahmed, John W. Benbow, Stewart Taylor, Meihua Tu, John Litchfield, Raman Sharma, Alfreda D. Ghee, Francis Bourbonais, V.G. Russkiy, David A. Beebe, Peter J. Oates	2009	66
8	Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of Type 2 diabetes Bioorganic & Medicinal Chemistry Letters ·John W. Benbow, Zhie Wu, Jiri Aubrecht, David A. Beebe, Annette Mann, Shawn D. Doran, V.P. Dzhevinsky, Hui Yu, 拓也下原, Janice C. Parker, Judith L. Treadway, Maria A. VanVolkenberg, William J. Zembrowski	2009	6
9	A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners Journal of Medicinal Chemistry ·Banavara L. Mylari, N. Neri, David A. Beebe, Edward L. Conn, James B. Coutcher, Michael S. Dina, Melissa O’Gorman, Michael C. Linhares, William H. Martin, Peter J. Oates, David A. Tess, Clara E. Taft, William J. Zembrowski	2005	53
10	X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase Structure ·Thomas Pauly, J.L. Ekstrom, David A. Beebe, Boris A. Chrunyk, David Cunningham, Matthew C. Griffor, Ajith V. Kamath, Joao Cardoso das Neves Neto, Bárbara Marín, W. Lisch, Timothy A. Subashi, David J. Wasilko, Paul Watts, Banavara L. Mylari, Peter J. Oates, Paul D. Adams, Virginia L. Rath	2003	85
11	A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one Journal of Medicinal Chemistry ·Banavara L. Mylari, N. Neri, David A. Beebe, Edward L. Conn, James B. Coutcher, Michael S. Dina, Melissa O’Gorman, Michael C. Linhares, William H. Martin, Peter J. Oates, David A. Tess, Clara E. Taft, William J. Zembrowski	2003	63
12	SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711 Bioorganic & Medicinal Chemistry Letters ·Margaret Y. Chu‐Moyer, William E. Ballinger, David A. Beebe, James B. Coutcher, Wesley Day, Jiancheng Li, Peter J. Oates, Ernst Cassirer	2002	5
13	A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action: 1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol Journal of Medicinal Chemistry ·Banavara L. Mylari, Peter J. Oates, William J. Zembrowski, David A. Beebe, Edward L. Conn, James B. Coutcher, Melissa O’Gorman, Michael C. Linhares, Clara E. Taft	2002	12
14	Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines Journal of Medicinal Chemistry ·Margaret Y. Chu‐Moyer, William E. Ballinger, David A. Beebe, Richard Berger, James B. Coutcher, Wesley Day, Jiancheng Li, Banavara L. Mylari, Peter J. Oates, Ernst Cassirer	2001	40
15	Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide Journal of Medicinal Chemistry ·Banavara L. Mylari, Peter J. Oates, David A. Beebe, Ming Yu, James B. Coutcher, Michael S. Dina, William J. Zembrowski	2001	20
16	Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature ·Takeshi Nishikawa, Diane Edelstein, Xue Du, Sho‐ichi Yamagishi, Takeshi Matsumura, Yasufumi Kaneda, Mark A. Yorek, David A. Beebe, Peter J. Oates, Hans‐Peter Hammes, Ida Giardino, Michael Brownlee Hit paper breakdown →	2000	3428
17	Nishikawa T, Du Edelstein DXL & Yamagishi S et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature404: 787-790 Takeshi Nishikawa, Diane Edelstein, Xue Du, Satoru Yamagishi, Takeshi Matsumura, Yasufumi Kaneda, Mark A. Yorek, David A. Beebe, Peter J. Oates, HP Hammes, Ida Giardino, Michael Brownlee	2000	17
18	Reversible inhibition of estrogen receptor activation by molybdate. Journal of Biological Chemistry ·R.E. Müller, A. Traish, David A. Beebe, Herbert H. Wotiz	1982	36

About David A. Beebe

David A. Beebe is a scholar working on Cell Biology, Endocrinology, Diabetes and Metabolism, Pharmacology, Clinical Biochemistry and Biochemistry, having authored 18 papers that have together received 3.9k indexed citations. Recurring topics across this work include Aldose Reductase and Taurine (6 papers), Cannabis and Cannabinoid Research (5 papers), Pancreatic function and diabetes (5 papers), Diabetes Treatment and Management (4 papers), Liver Disease Diagnosis and Treatment (2 papers), Diet, Metabolism, and Disease (2 papers), Peptidase Inhibition and Analysis (2 papers) and Peroxisome Proliferator-Activated Receptors (2 papers). The work is most often cited by research in Clinical Biochemistry (1.4k citations), Endocrinology, Diabetes and Metabolism (991 citations), Physiology (1.1k citations), Biochemistry (249 citations) and Nephrology (226 citations). David A. Beebe has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Peter J. Oates, Michael Brownlee, Takeshi Matsumura, Mark A. Yorek, Takeshi Nishikawa, Xue Du, Ida Giardino, Diane Edelstein, Yasufumi Kaneda and Sho‐ichi Yamagishi. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Cellular and Molecular Gastroenterology and Hepatology, Journal of Translational Medicine and Journal of Hepatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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