George Chang

7.3k total citations · 3 hit papers
55 papers, 6.2k citations indexed

About

George Chang is a scholar working on Pharmacology, Computational Theory and Mathematics and Oncology. According to data from OpenAlex, George Chang has authored 55 papers receiving a total of 6.2k indexed citations (citations by other indexed papers that have themselves been cited), including 20 papers in Pharmacology, 18 papers in Computational Theory and Mathematics and 16 papers in Oncology. Recurrent topics in George Chang's work include Pharmacogenetics and Drug Metabolism (19 papers), Computational Drug Discovery Methods (18 papers) and Drug Transport and Resistance Mechanisms (13 papers). George Chang is often cited by papers focused on Pharmacogenetics and Drug Metabolism (19 papers), Computational Drug Discovery Methods (18 papers) and Drug Transport and Resistance Mechanisms (13 papers). George Chang collaborates with scholars based in United States, Sweden and Switzerland. George Chang's co-authors include Wayne C. Guida, W. Clark Still, Thomas F. Hendrickson, Craig E. Caufield, Nigel G. J. Richards, F. MOHAMADI, Rob M. J. Liskamp, Mark A. Lipton, Martin Saunders and Yun Wu and has published in prestigious journals such as Journal of the American Chemical Society, Biochemical and Biophysical Research Communications and Journal of Medicinal Chemistry.

In The Last Decade

George Chang

53 papers receiving 5.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 3.5k citations George Chang et al. profile →
An internal-coordinate Monte Carlo method for searching conformational space

1989 959 citations George Chang et al. profile →
Conformations of cycloheptadecane. A comparison of methods for conformational searching

1990 436 citations George Chang et al. profile →

Peers

Countries citing papers authored by George Chang

Since Specialization

Citations

This map shows the geographic impact of George Chang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George Chang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George Chang more than expected).

Fields of papers citing papers by George Chang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George Chang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George Chang. The network helps show where George Chang may publish in the future.

Co-authorship network of co-authors of George Chang

This figure shows the co-authorship network connecting the top 25 collaborators of George Chang. A scholar is included among the top collaborators of George Chang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with George Chang. George Chang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes 2024 ·The AAPS Journal ·Jianhua Liu, (unknown), (unknown), Anthony Carlo, Woodrow Burchett, (unknown), (unknown), Joy C. Yang, Ye Che, George Chang, Matthew D. Troutman, Li Di	3
2	Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery 2024 ·The AAPS Journal ·Sam Zhang, Christine C. Orozco, (unknown), (unknown), Anthony Carlo, George Chang, David A. Tess, Christopher Keefer, Li Di	0
3	In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes 2023 ·The AAPS Journal ·David A. Tess, George Chang, Christopher Keefer, Anthony Carlo, Rhys Jones, Li Di	26
4	Comparison of Tumor Binding Across Tumor Types and Cell Lines to Support Free Drug Considerations for Oncology Drug Discovery 2023 ·Journal of Pharmaceutical Sciences ·(unknown), Sangwoo Ryu, Woodrow Burchett, Carl D. Davis, Rhys D.O. Jones, Sam Zhang, (unknown), George Chang, Li Di	1
5	Rare case of multifocal extradural and intramedullary neurosarcoidosis without pulmonary involvement: a case report and literature review 2021 ·Spinal Cord Series and Cases ·(unknown), (unknown), (unknown), (unknown), Shailen Shah, George Chang, (unknown), (unknown)	1
6	Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods 2020 ·Journal of Pharmaceutical Sciences ·(unknown), David A. Tess, Woodrow Burchett, George Chang, Nathaniel A. Woody, Christopher Keefer, Christine C. Orozco, Jian Lin, (unknown), Shinji Yamazaki, Rhys D.O. Jones, Li Di	20
7	Prediction of fraction unbound in microsomal and hepatocyte incubations – a comparison of methods across industry data sets (by the IQ in silico ADME working group) 2019 ·The Novartis Repository (Novartis) ·Bernard Faller, Susanne Winiwarter, George Chang, Prashant Desai, (unknown), (unknown), Christopher Keefer, Fabio Broccatelli	1
8	Structural attributes influencing unbound tissue distribution 2019 ·European Journal of Medicinal Chemistry ·Christine C. Orozco, Karen Atkinson, Sangwoo Ryu, George Chang, Christopher Keefer, Jian Lin, Keith Riccardi, (unknown), David A. Tess, Kevin J. Filipski, Amit S. Kalgutkar, John Litchfield, Dennis O. Scott, Li Di	21
9	Evaluation of Fraction Unbound Across 7 Tissues of 5 Species 2019 ·Journal of Pharmaceutical Sciences ·Sangwoo Ryu, David A. Tess, George Chang, Christopher Keefer, Woodrow Burchett, (unknown), Jonathan J. Novak, (unknown), Karen Atkinson, Keith Riccardi, Li Di	23
10	Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines 2018 ·Drug Metabolism and Disposition ·Keith Riccardi, Sangwoo Ryu, Jian Lin, Phillip D. Yates, David A. Tess, Rui Li, (unknown), (unknown), (unknown), George Chang, Li Di	34
11	In-Silico Extraction of Design Ideas Using MMPA-by-QSAR and its Application on ADME Endpoints 2018 ·Journal of Chemical Information and Modeling ·Alexios Koutsoukas, George Chang, Christopher Keefer	9
12	Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility 2013 ·Xenobiotica ·Amit S. Kalgutkar, Kosea S. Frederick, Heather L. Hatch, Catherine M. Ambler, David A. Perry, Ravi S. Garigipati, George Chang, Bruce A. Lefker, Ronald W. Clark, Lee A. Morehouse, Omar L. Francone, Xiao Hu	2
13	Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design 2012 ·European Journal of Medicinal Chemistry ·Li Di, Christopher Keefer, Dennis O. Scott, Timothy J. Strelevitz, George Chang, Yi‐An Bi, Yurong Lai, (unknown), Katherine S. Fenner, Matthew D. Troutman, R. Scott Obach	98
14	Species Independence in Brain Tissue Binding Using Brain Homogenates 2011 ·Drug Metabolism and Disposition ·Li Di, John P. Umland, George Chang, Youping Huang, (unknown), Dennis O. Scott, Matthew D. Troutman, Theodore E. Liston	114
15	Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state 2010 ·Expert Opinion on Drug Metabolism & Toxicology ·Bo Feng, (unknown), George Chang, Manthena V. S. Varma	75
16	Assessment ofin silicomodels for fraction of unbound drug in human liver microsomes 2010 ·Expert Opinion on Drug Metabolism & Toxicology ·Hua Gao, Stefanus J. Steyn, George Chang, Jing Lin	24
17	CP-346086 2003 ·Journal of Lipid Research ·Charles E. Chandler, (unknown), (unknown), (unknown), Stephen F. Petras, George Chang, John Vincent, H. James Harwood	149
18	Biosynthesis and Secretion of Growth Factor Proteins by Kidney Cells from DES-Treated Syrian Hamsters 1993 ·Biochemical and Biophysical Research Communications ·(unknown), Robert W. Brueggemeier, George Chang, Yi‐Chia Lin	4
19	Linear free energy relationship studies of enzyme active site binding: thymidylate synthase 1988 ·Journal of Medicinal Chemistry ·George Chang, (unknown), Charles J. Decedue, Jan Balzarini, Erik De Clercq, Mathias P. Mertes	4
20	Underground pumped hydro storage - An evaluation of the concept 1979 ·Intersociety Energy Conversion Engineering Conference ·(unknown), George Chang, (unknown)	1

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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