Heather Eng

3.9k citations

41 papers · 865 indexed · h-index 17

Pharmacology top 2%
- Pharmacogenetics and Drug Metabolism 16
- Drug-Induced Hepatotoxicity and Protection 5
Microbiology top 10%
Toxicology top 10%
Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods 7
Oncology
- Drug Transport and Resistance Mechanisms 10
Surgery
- Pancreatic function and diabetes 5
Endocrinology, Diabetes and Metabolism
- Diabetes Treatment and Management 4
Molecular Biology
- Receptor Mechanisms and Signaling 4
- Chemical Synthesis and Analysis 3

Co-authors: Amit S. Kalgutkar R. Scott Obach Raman Sharma Thomas S. McDonald Li Di Manthena V. S. Varma Chris Limberakis Angela Wolford
Cited by: Pharmacology Microbiology Toxicology
Journals: Drug Metabolism and Disposition (16 papers)Xenobiotica (4 papers)Journal of Medicinal Chemistry (3 papers)
Partner nations: United States China United Kingdom

In The Last Decade

Heather Eng

39 papers receiving 848 citations

Peers

Countries citing papers authored by Heather Eng

Since Specialization

Citations

This map shows the geographic impact of Heather Eng's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Heather Eng with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Heather Eng more than expected).

Fields of papers citing papers by Heather Eng

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Heather Eng. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Heather Eng. The network helps show where Heather Eng may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Heather Eng, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Heather Eng Line = papers co-authored together Heather Eng links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Absorption, distribution, metabolism, and excretion tactics toward the expedited discovery and development of the severe acute respiratory syndrome coronavirus-2 main protease inhibitor nirmatrelvir Drug Metabolism and Disposition ·Amit S. Kalgutkar,Heather Eng,Alyssa Dantonio,Eugene P. Kadar,E. Gushchin,Gregory S. Walker,Britton Boras,Christoph Kolckhorst	2025	0
2	Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine Xenobiotica ·C. Battella,Heather Eng,Zhengang Sun,Joseph Tillotson,Krista L. Dobo,Amit S. Kalgutkar	2025	0
3	Development of a sensitive LC-MS/MS assay to support human microdose study for an oral agonist of the GLP-1 receptor Bioanalysis ·Eugene P. Kadar,Heather Eng,Amit S. Kalgutkar,Christopher L. Holliman,Kaciane K. B. Oliveira	2024	1
4	Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir Xenobiotica ·T.C. Singhal,Heather Eng,Qingyi Yang,S.N. Yaseneva,Laura J. Byrnes,Alyssa Dantonio,Graham M. West,Li Di,Amit S. Kalgutkar	2023	3
5	Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans Drug Metabolism and Disposition ·Heather Eng,Alyssa Dantonio,Eugene P. Kadar,R. Scott Obach,Li Di,Jian Lin,Nandini C. Patel,Britton Boras,Gregory S. Walker,Jonathan J. Novak,Emi Kimoto,Ravi Shankar Prasad Singh,Amit S. Kalgutkar	2022	77
6	Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development Clinical Pharmacology & Therapeutics ·Ravi Shankar Prasad Singh,Gregory S. Walker,Eugene P. Kadar,Loretta M. Cox,Heather Eng,Raman Sharma,Arthur Bergman,Lien Van Eyck,Frances Hackman,Sima S. Toussi,Amit S. Kalgutkar,R. Scott Obach	2022	15
7	Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes Drug Metabolism and Disposition ·Elaine Tseng,Heather Eng,Jian Lin,Matthew A. Cerny,David A. Tess,Theunis C. Goosen,R. Scott Obach	2021	27
8	Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants Drug Metabolism and Disposition ·Heather Eng,Elaine Tseng,Matthew A. Cerny,Theunis C. Goosen,R. Scott Obach	2021	21
9	Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey Journal of Pharmacology and Experimental Therapeutics ·Heather Eng,Yi‐An Bi,Mark A. West,Sangwoo Ryu,Emi Yamaguchi,Rachel E. Kosa,David A. Tess,David A. Griffith,John Litchfield,Amit S. Kalgutkar,Manthena V. S. Varma	2021	15
10	Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria European Journal of Drug Metabolism and Pharmacokinetics ·M. Liu,Heather Eng,Nuryahyania Daniyati,Manthena V. S. Varma,Angela L. Slitt	2021	12
11	Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs Journal of Medicinal Chemistry ·David A. Tess,Heather Eng,Amit S. Kalgutkar,John Litchfield,David J. Edmonds,David A. Griffith,Manthena V. S. Varma	2020	15
12	6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol Drug Metabolism and Disposition ·Kimberly Lapham,Jian Lin,Jonathan J. Novak,Christine C. Orozco,Mark Niosi,Li Di,Theunis C. Goosen,Sangwoo Ryu,Keith Riccardi,Heather Eng,Kimberly O. Cameron,Amit S. Kalgutkar	2018	5
13	Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK) Journal of Medicinal Chemistry ·Tim F. Ryder,Matthew F. Calabrese,Gregory S. Walker,Kimberly O. Cameron,Allan R. Reyes,Kris A. Borzilleri,Jake Delmore,Russell Miller,Ravi G. Kurumbail,Jessica Ward,Daniel W. Kung,Janice A. Brown,David J. Edmonds,Heather Eng,Angela Wolford,Amit S. Kalgutkar	2018	18
14	Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes Drug Metabolism and Disposition ·Heather Eng,R. Scott Obach	2016	5
15	In Vitro – In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein–Cannulated Monkey Journal of Pharmaceutical Sciences ·Patrick Trapa,Kevin Beaumont,Karen Atkinson,Heather Eng,Amanda King‐Ahmad,Dennis O. Scott,Tristan S. Maurer,Li Di	2016	7
16	Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes Drug Metabolism and Disposition ·Heather Eng,Raman Sharma,Angela Wolford,Li Di,Roger B. Ruggeri,Leonard Buckbinder,Edward L. Conn,Deepak Dalvie,Amit S. Kalgutkar	2016	8
17	The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide–Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy Drug Metabolism and Disposition ·Heather Eng,Renato J. Scialis,Charles J. Rotter,Jun Lin,Sarah Lazzaro,Manthena V. S. Varma,Li Di,Bo Feng,Mark A. West,Amit S. Kalgutkar	2016	23
18	Metabolites in Safety Testing Assessment in Early Clinical Development: A Case Study with a Glucokinase Activator Drug Metabolism and Disposition ·Raman Sharma,John Litchfield,Karen Atkinson,Heather Eng,Neeta B. Amin,William S. Denney,John C. Pettersen,Theunis C. Goosen,Li Di,Esther Lee,Jeffrey A. Pfefferkorn,Deepak Dalvie,Amit S. Kalgutkar	2014	15
19	Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor Drug Metabolism and Disposition ·Heather Eng,Raman Sharma,Thomas S. McDonald,David J. Edmonds,Jean‐Philippe Fortin,Xianping Li,Benjamin D. Stevens,David A. Griffith,Chris Limberakis,Whitney M. Nolte,David A. Price,TeckDong Chung,Amit S. Kalgutkar	2013	20
20	Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes Drug Metabolism and Disposition ·Phillip D. Yates,Heather Eng,Li Di,R. Scott Obach	2012	24

About Heather Eng

Heather Eng is a scholar working on Pharmacology, Pharmacology, Computational Theory and Mathematics, Oncology and Endocrinology, Diabetes and Metabolism, having authored 41 papers that have together received 865 indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (16 papers), Drug Transport and Resistance Mechanisms (10 papers), Computational Drug Discovery Methods (7 papers), Drug-Induced Hepatotoxicity and Protection (5 papers), Pancreatic function and diabetes (5 papers), Diabetes Treatment and Management (4 papers), Receptor Mechanisms and Signaling (4 papers) and Chemical Synthesis and Analysis (3 papers). The work is most often cited by research in Pharmacology (230 citations), Microbiology (60 citations), Toxicology (32 citations), Computational Theory and Mathematics (133 citations) and Oncology (176 citations). Heather Eng has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Amit S. Kalgutkar, R. Scott Obach, Raman Sharma, Thomas S. McDonald, Li Di, Manthena V. S. Varma, Chris Limberakis, Angela Wolford, Jian Lin and Jonathan Bauman. Their work appears in journals such as Drug Metabolism and Disposition, Xenobiotica, Journal of Medicinal Chemistry, Journal of Pharmacology and Experimental Therapeutics and Organic Letters.

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