Kai Chen

16.2k total citations · 8 hit papers
204 papers, 11.3k citations indexed

About

Kai Chen is a scholar working on Organic Chemistry, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Kai Chen has authored 204 papers receiving a total of 11.3k indexed citations (citations by other indexed papers that have themselves been cited), including 71 papers in Organic Chemistry, 53 papers in Molecular Biology and 37 papers in Cellular and Molecular Neuroscience. Recurrent topics in Kai Chen's work include Catalytic C–H Functionalization Methods (42 papers), Cyclopropane Reaction Mechanisms (33 papers) and Neurotransmitter Receptor Influence on Behavior (28 papers). Kai Chen is often cited by papers focused on Catalytic C–H Functionalization Methods (42 papers), Cyclopropane Reaction Mechanisms (33 papers) and Neurotransmitter Receptor Influence on Behavior (28 papers). Kai Chen collaborates with scholars based in United States, China and Italy. Kai Chen's co-authors include Frances H. Arnold, Jean C. Shih, Bing‐Feng Shi, Clarence W. Rowley, S. B. Jennifer Kan, Marco Bortolato, Shuo‐Qing Zhang, Qi Zhang, Jonathan H. Tu and Xiongyi Huang and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Kai Chen

197 papers receiving 11.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 916 citations Kai Chen et al. Science profile →
Engineering new catalytic activities in enzymes

2020 623 citations Kai Chen, Frances H. Arnold Nature Catalysis profile →
Variants of Dynamic Mode Decomposition: Boundary Condition, Koopman, and Fourier Analyses

2012 506 citations Kai Chen et al. profile →
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life

2016 447 citations S. B. Jennifer Kan, Russell D. Lewis et al. Science profile →
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization

2018 257 citations Kai Chen, Xiongyi Huang et al. profile →
Genetically programmed chiral organoborane synthesis

2017 241 citations S. B. Jennifer Kan, Xiongyi Huang et al. profile →
Enzymatic construction of highly strained carbocycles

2018 188 citations Kai Chen, Xiongyi Huang et al. Science profile →
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein

2024 54 citations Kai Chen, Marena Trinidad et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kai Chen United States	55	4.3k	3.2k	1.8k	985	601	204	11.3k
Robert C. Thompson United States	70	1.0k 0.2×	6.1k 1.9×	3.7k 2.1×	1.8k 1.8×	244 0.4×	362	19.7k
Nobuo Kato Japan	57	1.5k 0.3×	6.7k 2.1×	1.9k 1.1×	265 0.3×	356 0.6×	494	13.6k
Takashi Itoh Japan	56	2.8k 0.7×	3.9k 1.2×	752 0.4×	610 0.6×	202 0.3×	581	13.8k
Hai Lin China	45	435 0.1×	3.3k 1.0×	794 0.5×	579 0.6×	196 0.3×	233	9.3k
David J. Adams Australia	71	1.2k 0.3×	11.7k 3.7×	4.3k 2.4×	148 0.2×	280 0.5×	387	17.9k
Harald Schmidt Germany	91	842 0.2×	9.1k 2.8×	3.7k 2.1×	249 0.3×	612 1.0×	372	29.5k
Tuomas P. J. Knowles United Kingdom	88	2.2k 0.5×	19.2k 6.0×	1.8k 1.1×	177 0.2×	4.0k 6.7×	465	32.9k
Susan T. Weintraub United States	48	538 0.1×	4.1k 1.3×	908 0.5×	311 0.3×	522 0.9×	231	9.0k
Michal Harel Israel	51	2.6k 0.6×	5.9k 1.9×	1.4k 0.8×	122 0.1×	158 0.3×	131	15.6k
David M. Doddrell Australia	46	1.6k 0.4×	2.0k 0.6×	234 0.1×	389 0.4×	151 0.3×	235	9.6k

Countries citing papers authored by Kai Chen

Since Specialization

Citations

This map shows the geographic impact of Kai Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kai Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kai Chen more than expected).

Fields of papers citing papers by Kai Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kai Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kai Chen. The network helps show where Kai Chen may publish in the future.

Co-authorship network of co-authors of Kai Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Kai Chen. A scholar is included among the top collaborators of Kai Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kai Chen. Kai Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Ma, Enbo, Kai Chen, Honglue Shi, et al.. (2025). Directed evolution expands CRISPR–Cas12a genome-editing capacity. Nucleic Acids Research. 53(13). 1 indexed citations

Wang, Ting, Kai Chen, Dali Yin, et al.. (2024). Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective indoleamine 2,3-dioxygenase 1 inhibitors to combat inflammation. Bioorganic Chemistry. 152. 107740–107740. 2 indexed citations

Chen, Kai, et al.. (2024). Engineering self-deliverable ribonucleoproteins for genome editing in the brain. Nature Communications. 15(1). 1727–1727. 24 indexed citations

Wang, Weihan, Kai Chen, George Z. Chen, et al.. (2024). Stereo-NEC: Enhancing Stereo Visual-Inertial SLAM Initialization with Normal Epipolar Constraints. 2691–2697. 5 indexed citations

Chen, Kai & Hang Shi. (2024). Nucleophilic Aromatic Substitution of Halobenzenes and Phenols with Catalysis by Arenophilic π Acids. Accounts of Chemical Research. 57(15). 2194–2206. 19 indexed citations

Chen, Kai, Haiming Xie, & Jun Liu. (2024). Self-healing and mechanically robust poly(thiourea-disulfide) elastomers based on three types of synergistic dynamic bonding. Polymer Chemistry. 15(23). 2370–2376. 8 indexed citations

Chen, Kai, Katarzyna M. Soczek, Erin Doherty, et al.. (2024). Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell. 187(13). 3249–3261.e14. 29 indexed citations

Calvó‐Tusell, Carla, Zhen Liu, Kai Chen, Frances H. Arnold, & Marc Garcia‐Borràs. (2023). Reversing the Enantioselectivity of Enzymatic Carbene N−H Insertion Through Mechanism‐Guided Protein Engineering**. Angewandte Chemie International Edition. 62(35). e202303879–e202303879. 21 indexed citations

Ma, Enbo, Kai Chen, Honglue Shi, et al.. (2022). Improved genome editing by an engineered CRISPR-Cas12a. Nucleic Acids Research. 50(22). 12689–12701. 66 indexed citations

10.

Liu, Zhen, et al.. (2021). Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation. Nature Chemistry. 13(12). 1166–1172. 74 indexed citations

11.

Chen, Kai & Frances H. Arnold. (2020). Engineering new catalytic activities in enzymes. Nature Catalysis. 3(3). 203–213. 623 indexed citations breakdown →

12.

Chen, Kai & Frances H. Arnold. (2020). Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes. Journal of the American Chemical Society. 142(15). 6891–6895. 74 indexed citations

13.

Chen, Kai, Xiongyi Huang, Shuo‐Qing Zhang, et al.. (2019). Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion. Synlett. 30(4). 378–382. 22 indexed citations

14.

Brandenberg, Oliver F., Kai Chen, & Frances H. Arnold. (2019). Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society. 141(22). 8989–8995. 103 indexed citations

15.

Chen, Kai, Shuo‐Qing Zhang, Oliver F. Brandenberg, Xin Hong, & Frances H. Arnold. (2018). Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions. Journal of the American Chemical Society. 140(48). 16402–16407. 114 indexed citations

16.

Knight, Anders M., S. B. Jennifer Kan, Russell D. Lewis, et al.. (2018). Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes. ACS Central Science. 4(3). 372–377. 117 indexed citations

17.

Chen, Kai, et al.. (2017). Dynamic mode decomposition for estimating vortices and lee waves in a stratified wake. Experiments in Fluids. 58(5). 8 indexed citations

18.

Chen, Kai, et al.. (2017). Palladium-catalyzed interannular meta-C–H arylation. Chemical Communications. 53(13). 2166–2169. 37 indexed citations

19.

Chen, Kai, et al.. (2017). Local flow characterization using bioinspired sensory information. Journal of Fluid Mechanics. 818. 366–381. 11 indexed citations

20.

Kan, S. B. Jennifer, Russell D. Lewis, Kai Chen, & Frances H. Arnold. (2016). Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life. Science. 354(6315). 1048–1051. 447 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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