Kai Chen

16.2k citations

204 papers · 11.3k indexed · 8 hit papers · h-index 55

Impact in

Organic Chemistry top 0.2%
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
Biological Psychiatry top 1%

Papers in ⓘ

Organic Chemistry 71
- Catalytic C–H Functionalization Methods 42
- Cyclopropane Reaction Mechanisms 33
- Synthesis and Catalytic Reactions 22
- Catalytic Cross-Coupling Reactions 18
Molecular Biology 53
- Receptor Mechanisms and Signaling 17

Co-authors: Frances H. Arnold (16 shared papers)Jean C. Shih (56 shared papers)Bing‐Feng Shi (20 shared papers)Clarence W. Rowley (6 shared papers)S. B. Jennifer Kan (5 shared papers)Shuo‐Qing Zhang (10 shared papers)Marco Bortolato (6 shared papers)Qi Zhang (7 shared papers)
Journals: Chemical Communications (9 papers)Journal of Biological Chemistry (8 papers)Journal of the American Chemical Society (6 papers)Angewandte Chemie International Edition (6 papers)Journal of Fluid Mechanics (6 papers)
Partner nations: United States China Italy

In The Last Decade

Kai Chen

197 papers receiving 11.1k citations

Hit Papers

8 papers align trajectories log scale

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein 2024 · 54 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Nature Biotechnology
2020 Nature Catalysis
2018 Nature
2018 Science
2017 Nature
2016 Science
2012 Journal of Nonlinear Science
1995 Science

Peers

Countries citing papers authored by Kai Chen

Since Specialization

Citations

This map shows the geographic impact of Kai Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kai Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kai Chen more than expected).

Fields of papers citing papers by Kai Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kai Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kai Chen. The network helps show where Kai Chen may publish in the future.

Co-authors

The 25 scholars most cited alongside Kai Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Kai Chen Line = papers co-authored together Kai Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 204 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA Science ·Olivier Cases, Isabelle Seif, Joseph Grimsby, Patrícia Gaspar, Kai Chen, S. Pournin, Ulrike Müller, Michel Aguet, Charles Babinet, Jean C. Shih, Edward De Maeyer Hit paper breakdown →	1995	916
2	Engineering new catalytic activities in enzymes Nature Catalysis ·Kai Chen, Frances H. Arnold Hit paper breakdown →	2020	623
3	Variants of Dynamic Mode Decomposition: Boundary Condition, Koopman, and Fourier Analyses Journal of Nonlinear Science ·Kai Chen, Jonathan H. Tu, Clarence W. Rowley Hit paper breakdown →	2012	506
4	Monoamine oxidase inactivation: From pathophysiology to therapeutics Advanced Drug Delivery Reviews ·Marco Bortolato, Kai Chen, Jean C. Shih	2008	499
5	Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life Science ·S. B. Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold Hit paper breakdown →	2016	447
6	Stereoselective Synthesis of Chiral α‐Amino‐β‐Lactams through Palladium(II)‐Catalyzed Sequential Monoarylation/Amidation of C(sp³)H Bonds Angewandte Chemie International Edition ·Qi Zhang, Kai Chen, Wei‐Hao Rao, Yuejun Zhang, Fa‐Jie Chen, Bing‐Feng Shi	2013	307
7	Pd(ii)-catalyzed alkoxylation of unactivated C(sp3)–H and C(sp2)–H bonds using a removable directing group: efficient synthesis of alkyl ethers Chemical Science ·Fa‐Jie Chen, Sheng Zhao, Fang Hu, Kai Chen, Qi Zhang, Shuo‐Qing Zhang, Bing‐Feng Shi	2013	283
8	Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization Nature ·Ruijie K. Zhang, Kai Chen, Xiongyi Huang, Lena Wohlschlager, Hans Renata, Frances H. Arnold Hit paper breakdown →	2018	257
9	Genetically programmed chiral organoborane synthesis Nature ·S. B. Jennifer Kan, Xiongyi Huang, Yosephine Gumulya, Kai Chen, Frances H. Arnold Hit paper breakdown →	2017	241
10	Increased stress response and β–phenylethylamine in MAOB–deficient mice Nature Genetics ·Joseph Grimsby, Miklós Tóth, Kai Chen, Takeshi Kumazawa, Lori K. Klaidman, James D. Adams, Farouk Karoum, Judit Gál, Jean C. Shih	1997	202
11	Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids Chemical Science ·Kai Chen, Fang Hu, Shuo‐Qing Zhang, Bing‐Feng Shi	2013	194
12	The light field stereoscope ACM Transactions on Graphics ·Fu‐Chung Huang, Kai Chen, Gordon Wetzstein	2015	193
13	Enzymatic construction of highly strained carbocycles Science ·Kai Chen, Xiongyi Huang, S. B. Jennifer Kan, Ruijie K. Zhang, Frances H. Arnold Hit paper breakdown →	2018	188
14	Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp³)–H Bonds: Scope and Mechanistic Studies Journal of the American Chemical Society ·Qi Zhang, Xue‐Song Yin, Kai Chen, Shuo‐Qing Zhang, Bing‐Feng Shi	2015	182
15	Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts Antioxidants and Redox Signaling ·Nina Kaludercic, Andrea Carpi, Takahiro Nagayama, Vidhya Sivakumaran, Guangshuo Zhu, Edwin W. Lai, Djahida Bedja, Agnese De Mario, Kai Chen, Kathleen L. Gabrielson, Merry L. Lindsey, Karel Pacák, Eiki Takimoto, Jean C. Shih, David A. Kass, Fabio Di Lisa, Nazareno Paolocci	2013	139
16	Divergent and Stereoselective Synthesis of β‐Silyl‐α‐Amino Acids through Palladium‐Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C−H Bonds Angewandte Chemie International Edition ·Yue‐Jin Liu, Yanhua Liu, Zhuo‐Zhuo Zhang, Sheng‐Yi Yan, Kai Chen, Bing‐Feng Shi	2016	136
17	Sulfonamide‐Promoted Palladium(II)‐Catalyzed Alkylation of Unactivated Methylene C(sp ³ )H Bonds with Alkyl Iodides Angewandte Chemie International Edition ·Kai Chen, Bing‐Feng Shi	2014	130
18	Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1 Journal of Biological Chemistry ·Xiao‐Ming Ou, Kai Chen, Jean C. Shih	2006	126
19	Rhodium(II)‐Catalyzed Intramolecular Cycloisomerizations of Methylenecyclopropanes with N‐Sulfonyl 1,2,3‐Triazoles Angewandte Chemie International Edition ·Kai Chen, Zi‐Zhong Zhu, Yongsheng Zhang, Xiang‐Ying Tang, Min Shi	2014	124
20	A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior Journal of Biological Chemistry ·Kai Chen, Daniel P. Holschneider, Weihua Wu, Igor Rebrin, Jean C. Shih	2004	120

About Kai Chen

Kai Chen is a scholar working on Organic Chemistry, Molecular Biology, Cellular and Molecular Neuroscience, Electrical and Electronic Engineering and Neurology, having authored 204 papers that have together received 11.3k indexed citations. Recurring topics across this work include Catalytic C–H Functionalization Methods (42 papers), Cyclopropane Reaction Mechanisms (33 papers), Neurotransmitter Receptor Influence on Behavior (28 papers), Synthesis and Catalytic Reactions (22 papers), Catalytic Cross-Coupling Reactions (18 papers), Receptor Mechanisms and Signaling (17 papers), Parkinson's Disease Mechanisms and Treatments (15 papers) and Fluid Dynamics and Turbulent Flows (13 papers). The work is most often cited by research in Organic Chemistry (4.3k citations), Biological Psychiatry (314 citations), Cellular and Molecular Neuroscience (1.8k citations), Inorganic Chemistry (985 citations) and Behavioral Neuroscience (245 citations). Kai Chen has collaborated with scholars based in United States, China and Italy. Frequent co-authors include Frances H. Arnold, Jean C. Shih, Bing‐Feng Shi, Clarence W. Rowley, S. B. Jennifer Kan, Shuo‐Qing Zhang, Marco Bortolato, Qi Zhang, Jonathan H. Tu and Xiongyi Huang. Their work appears in journals such as Chemical Communications, Journal of Biological Chemistry, Journal of the American Chemical Society, Angewandte Chemie International Edition and Journal of Fluid Mechanics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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