Leonard Μ. Neckers

10.4k citations

100 papers · 8.1k indexed · 3 hit papers · h-index 47

Co-authors: Theodor W. Schulte Won Gun An Monica G. Marcu Mikhail V. Blagosklonny Edward G. Mimnaugh Jane B. Trepel Michel Simon Emin Maltepe
Topics: Heat shock proteins research (37 papers)Toxin Mechanisms and Immunotoxins (13 papers)Ubiquitin and proteasome pathways (10 papers)
Cited by: Molecular Biology Cancer Research Immunology
Journals: Nature New England Journal of Medicine Proceedings of the National Academy of Sciences
Partner nations: United States Japan Germany

In The Last Decade

Leonard Μ. Neckers

99 papers receiving 7.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 713 citations Leonard Μ. Neckers et al. profile →
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 592 citations Rosemary Watt, Leonard Μ. Neckers et al. profile →
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

2002 543 citations Jennifer S. Isaacs, Yunjin Jung et al. Journal of Biological Chemistry profile →

Peers

Countries citing papers authored by Leonard Μ. Neckers

Since Specialization

Citations

This map shows the geographic impact of Leonard Μ. Neckers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leonard Μ. Neckers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leonard Μ. Neckers more than expected).

Fields of papers citing papers by Leonard Μ. Neckers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leonard Μ. Neckers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leonard Μ. Neckers. The network helps show where Leonard Μ. Neckers may publish in the future.

Co-authorship network of co-authors of Leonard Μ. Neckers

This figure shows the co-authorship network connecting the top 25 collaborators of Leonard Μ. Neckers. A scholar is included among the top collaborators of Leonard Μ. Neckers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leonard Μ. Neckers. Leonard Μ. Neckers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid 2023 ·Cancer Discovery ·Anderson R. Frank,(unknown),Spencer D. Shelton,Jiwoong Kim,Gordon M. Stott,Leonard Μ. Neckers,Yang Xie,Noelle S. Williams,Prashant Mishra,David G. McFadden	12
2	Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer 2023 ·PNAS Nexus ·(unknown),Ryo Ishida,(unknown),(unknown),(unknown),Jonathan H. Shrimp,(unknown),Stephen J. Ralph,Ian C. T. Nisbet,Murali Cherukuri,Jason E. Gestwicki,Leonard Μ. Neckers	5
3	Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription 2021 ·Molecular Cancer Therapeutics ·Lixia Liu,(unknown),(unknown),(unknown),Jinxin Zhang,(unknown),(unknown),Xueqiong Zhou,(unknown),Hongjun Yang,Leonard Μ. Neckers,Fei Zou,Xuemei Chen	18
4	Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function 2020 ·Journal of Thrombosis and Haemostasis ·Joseph W. Jackson,(unknown),Kristin Beebe,Andy D. Tran,Jane B. Trepel,Jason E. Gestwicki,Brian S. J. Blagg,Shuichi Ohkubo,Leonard Μ. Neckers	10
5	Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer 2018 ·Cancer Research ·Michael A. Moses,Yeong Sang Kim,(unknown),Nobu Oshima,(unknown),Kristin Beebe,(unknown),Sunmin Lee,Abbey D. Zuehlke,Hao Shao,William E. Bingman,Vineet Kumar,Sanjay V. Malhotra,Nancy L. Weigel,Jason E. Gestwicki,Jane B. Trepel,Leonard Μ. Neckers	97
6	Synthesis of a stable and orally bioavailable englerin analogue 2016 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Cody J. Peer,Zhenwu Li,(unknown),Sima Hayavi,Florian J. Sulzmaier,Joe W. Ramos,Carole Sourbier,Leonard Μ. Neckers,William D. Figg,John A. Beutler,William J. Chain	10
7	Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity 2014 ·Clinical Cancer Research ·Salim Khiati,Ilaria Dalla Rosa,Carole Sourbier,Xuefei Ma,V. Ashutosh Rao,Leonard Μ. Neckers,Hongliang Zhang,Yves Pommier	101
8	Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer 2014 ·Pharmaceutical Development and Technology ·Liang Su,(unknown),Dong Liang,Jeffrey C. Sivils,Leonard Μ. Neckers,Marc B. Cox,Huan Xie	10
9	Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response 2012 ·Proceedings of the National Academy of Sciences ·Stéphanie Solier,Kurt W. Kohn,Bradley T. Scroggins,Wanping Xu,Jane B. Trepel,Leonard Μ. Neckers,Yves Pommier	74
10	Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer 2012 ·Breast Cancer Research ·Qing Cheng,Jeffrey T. Chang,Joseph Geradts,Leonard Μ. Neckers,Timothy Haystead,Neil L. Spector,H. Kim Lyerly	133
11	Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma 2010 ·Molecular Pharmacology ·Hyesik Kong,Sunmin Lee,Kristin Beebe,Bradley T. Scroggins,Gopal N. Gupta,Min-Jung Lee,Yunjin Jung,Jane B. Trepel,Leonard Μ. Neckers	18
12	A systematic protocol for the characterization of Hsp90 modulators 2010 ·Bioorganic & Medicinal Chemistry ·Robert L. Matts,Gary Brandt,Yuanming Lu,Anshuman Dixit,Mehdi Mollapour,(unknown),Alison C. Donnelly,Leonard Μ. Neckers,Gennady M. Verkhivker,Brian S. J. Blagg	72
13	Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells 2009 ·Cancer Research ·(unknown),Maja Mandić,Jennifer Taylor,(unknown),Amy Wesa,Leonard Μ. Neckers,Walter J. Storkus	30
14	Mechanisms of Disease: the role of heat-shock protein 90 in genitourinary malignancy 2006 ·Nature Clinical Practice Urology ·Jean‐Baptiste Lattouf,Ramaprasad Srinivasan,Peter A. Pinto,W. Marston Linehan,Leonard Μ. Neckers	29
15	The C-Terminal Half of Heat Shock Protein 90 Represents a Second Site for Pharmacologic Intervention in Chaperone Function 2003 ·Current Cancer Drug Targets ·Monica G. Marcu,Leonard Μ. Neckers	19
16	Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathwaybreakdown → 2002 ·Journal of Biological Chemistry ·Jennifer S. Isaacs,Yunjin Jung,Edward G. Mimnaugh,Alfredo Martı́nez,Frank Cuttitta,Leonard Μ. Neckers	543
17	Abstracts from the Third Annual NIH Symposium on Therapeutic Oligonucleotides 1999 ·Antisense and Nucleic Acid Drug Development ·Yoon S. Cho‐Chung,Serge L. Beaucage,Víctor E. Márquez,Leonard Μ. Neckers,Paul F. Torrence	14
18	Expression of PAX3 in Ewing's Sarcoma Family of Tumors 1997 ·Biochemical and Molecular Medicine ·Theodor W. Schulte,Jeffrey A. Toretsky,(unknown),Lee J. Helman,Leonard Μ. Neckers	31
19	Bovine Serum Albumin Is a Major Oligonucleotide-Binding Protein Found on the Surface of Cultured Cells 1995 ·PubMed ·Daniel A. Geselowitz,Leonard Μ. Neckers	46
20	Transcriptional Inactivation of c-myc and the Transferrin Receptor in Dibutyryl Cyclic AMP-Treated HL-60 Cells 1987 ·Molecular and Cellular Biology ·Jane B. Trepel,Oscar R. Colamonici,Kathleen Kelly,Gisela Schwab,Rosemary Watt,Edward A. Sausville,Elaine S. Jaffe,Leonard Μ. Neckers	50

About Leonard Μ. Neckers

Leonard Μ. Neckers is a scholar working on Molecular Biology, Immunology and Toxicology, having authored 100 papers that have together received 8.1k indexed citations. Recurring topics across this work include Heat shock proteins research (37 papers), Toxin Mechanisms and Immunotoxins (13 papers) and Ubiquitin and proteasome pathways (10 papers). The work is most often cited by research in Molecular Biology (6.0k citations), Cancer Research (1.3k citations) and Immunology (1.3k citations). Leonard Μ. Neckers has collaborated with scholars based in United States, Japan and Germany. Frequent co-authors include Theodor W. Schulte, Won Gun An, Monica G. Marcu, Mikhail V. Blagosklonny, Edward G. Mimnaugh, Jane B. Trepel, Michel Simon, Emin Maltepe, Jennifer S. Isaacs and David O. Toft. Their work appears in journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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