James D. Clark

8.7k total citations · 3 hit papers
77 papers, 6.3k citations indexed

About

James D. Clark is a scholar working on Molecular Biology, Oncology and Immunology. According to data from OpenAlex, James D. Clark has authored 77 papers receiving a total of 6.3k indexed citations (citations by other indexed papers that have themselves been cited), including 32 papers in Molecular Biology, 17 papers in Oncology and 17 papers in Immunology. Recurrent topics in James D. Clark's work include Protein Kinase Regulation and GTPase Signaling (18 papers), Cytokine Signaling Pathways and Interactions (13 papers) and Pain Mechanisms and Treatments (11 papers). James D. Clark is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (18 papers), Cytokine Signaling Pathways and Interactions (13 papers) and Pain Mechanisms and Treatments (11 papers). James D. Clark collaborates with scholars based in United States, Canada and Japan. James D. Clark's co-authors include John L. Knopf, Lih‐Ling Lin, Ronald Kriz, Lisa A. Sultzman, Jean‐Baptiste Telliez, Chakkodabylu S. Ramesha, Alice Lin, Eric A. Nalefski, Mark E. Flanagan and Andrea R. Schievella and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

James D. Clark

76 papers receiving 6.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 1.5k citations James D. Clark, Lih‐Ling Lin et al. Cell profile →
Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

2014 460 citations James D. Clark, Jean‐Baptiste Telliez et al. profile →
The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.

2016 305 citations James D. Clark, Jean‐Baptiste Telliez et al. PubMed profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James D. Clark United States	34	3.2k	1.3k	979	817	712	77	6.3k
Lih‐Ling Lin United States	29	3.8k 1.2×	1.3k 1.1×	756 0.8×	743 0.9×	645 0.9×	50	6.0k
Kenneth E. Bernstein United States	55	5.5k 1.7×	1.1k 0.8×	1.0k 1.1×	1.2k 1.4×	287 0.4×	193	11.1k
Yoshihide Kanaoka United States	49	2.5k 0.8×	2.0k 1.6×	2.4k 2.5×	577 0.7×	365 0.5×	93	6.8k
Ronald L. Magolda United States	29	3.0k 1.0×	728 0.6×	493 0.5×	950 1.2×	411 0.6×	69	5.6k
Paul H. Naccache Canada	56	4.2k 1.3×	3.7k 2.9×	1.3k 1.3×	798 1.0×	851 1.2×	168	8.1k
Juan Miguel Redondo Spain	51	3.8k 1.2×	1.4k 1.2×	617 0.6×	875 1.1×	357 0.5×	135	6.7k
Hirotoshi Tanaka Japan	46	4.2k 1.3×	1.0k 0.8×	1.0k 1.0×	1.2k 1.5×	510 0.7×	175	8.0k
Werner Schlegel Switzerland	51	4.9k 1.5×	970 0.8×	1.1k 1.1×	656 0.8×	801 1.1×	206	8.6k
Catherine A. Reardon United States	47	2.9k 0.9×	2.0k 1.6×	1.9k 2.0×	624 0.8×	350 0.5×	132	7.7k
Belinda Willard United States	46	3.3k 1.0×	854 0.7×	700 0.7×	497 0.6×	546 0.8×	189	6.3k

Countries citing papers authored by James D. Clark

Since Specialization

Citations

This map shows the geographic impact of James D. Clark's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James D. Clark with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James D. Clark more than expected).

Fields of papers citing papers by James D. Clark

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James D. Clark. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James D. Clark. The network helps show where James D. Clark may publish in the future.

Co-authorship network of co-authors of James D. Clark

This figure shows the co-authorship network connecting the top 25 collaborators of James D. Clark. A scholar is included among the top collaborators of James D. Clark based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James D. Clark. James D. Clark is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Murray, George, Jason A. Bubier, Belinda S. Harris, et al.. (2023). An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response. G3 Genes Genomes Genetics. 13(8). 5 indexed citations

Irvine, Karen‐Amanda, Christopher M. Peters, Elena M. Vazey, Adam R. Ferguson, & James D. Clark. (2022). Activation of the Locus Coeruleus Mediated by Designer Receptor Exclusively Activated by Designer Drug Restores Descending Nociceptive Inhibition after Traumatic Brain Injury in Rats. Journal of Neurotrauma. 39(13-14). 964–978. 3 indexed citations

Page, Karen, Mayte Suárez‐Fariñas, Maria Suprun, et al.. (2020). Molecular and Cellular Responses to the TYK2/JAK1 Inhibitor PF-06700841 Reveal Reduction of Skin Inflammation in Plaque Psoriasis. Journal of Investigative Dermatology. 140(8). 1546–1555.e4. 42 indexed citations

Gerstenberger, Brian S., Mary Ellen Banker, James D. Clark, et al.. (2020). Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences. Scientific Reports. 10(1). 8974–8974. 7 indexed citations

Mostafavi, Sara, Hideyuki Yoshida, Devapregasan Moodley, et al.. (2016). Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 164(3). 564–578. 202 indexed citations

Angst, Martin S., Laura C. Lazzeroni, Nicholas Phillips, et al.. (2012). Aversive and Reinforcing Opioid Effects. Anesthesiology. 117(1). 22–37. 53 indexed citations

Zheng, Ming, David L. Dill, James D. Clark, & Gary Peltz. (2012). Computational genetic discoveries that could improve perioperative medicine. Current Opinion in Anaesthesiology. 25(4). 428–433. 1 indexed citations

Ronninger, Marcus, Yongjing Guo, Klementy Shchetynsky, et al.. (2012). The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls. Genome Medicine. 4(1). 2–2. 26 indexed citations

Hewson, Christopher A., Sheena Patel, Luigino Calzetta, et al.. (2011). Preclinical Evaluation of an Inhibitor of Cytosolic Phospholipase A2α for the Treatment of Asthma. Journal of Pharmacology and Experimental Therapeutics. 340(3). 656–665. 30 indexed citations

10.

Bloom, Laird, et al.. (2010). A Human CXCL13-Induced Actin Polymerization Assay Measured by Fluorescence Plate Reader. Assay and Drug Development Technologies. 8(1). 73–84. 3 indexed citations

11.

Kirincich, Steven J., Jason Xiang, Neal Green, et al.. (2009). Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties. Bioorganic & Medicinal Chemistry. 17(13). 4383–4405. 24 indexed citations

12.

Whalen, K., Holly Legault, Andrew Hill, et al.. (2008). In vitroallergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A_2αovercomes the asthma‐associated response. Clinical & Experimental Allergy. 38(10). 1590–1605. 12 indexed citations

13.

Ramarao, Manjunath, Marina W. H. Shen, Elizabeth Murphy, et al.. (2008). Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors. Analytical Biochemistry. 383(2). 217–225. 6 indexed citations

14.

Ramarao, Manjunath, Elizabeth Murphy, Marina W. H. Shen, et al.. (2005). A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening. Analytical Biochemistry. 343(1). 143–151. 51 indexed citations

15.

Marušić, Suzana, Michael W. Leach, Jeffrey W. Pelker, et al.. (2005). Cytosolic phospholipase A2α–deficient mice are resistant to experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 202(6). 841–851. 123 indexed citations

16.

McKew, John C., Frank Lovering, James D. Clark, et al.. (2003). Structure–activity relationships of indole cytosolic phospholipase A 2 α inhibitors: substrate mimetics. Bioorganic & Medicinal Chemistry Letters. 13(24). 4501–4504. 18 indexed citations

17.

Stepkowski, Stanislaw M., Robert A. Kirken, Barton W Trawick, et al.. (2002). Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common ??-chain-dependent cytokine signals1. Transplantation. 73(8). 1227–1235. 5 indexed citations

18.

Xu, Guangyi, Thomas McDonagh, Hsiang‐Ai Yu, et al.. (1998). Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A 2 1 1Edited by J. Karn. Journal of Molecular Biology. 280(3). 485–500. 91 indexed citations

19.

Clark, James D., Andrea R. Schievella, Eric A. Nalefski, & Lih‐Ling Lin. (1995). Cytosolic phospholipase A2. PubMed. 12(2-3). 83–117. 431 indexed citations

20.

Clark, James D., Lih‐Ling Lin, Ronald Kriz, et al.. (1991). A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP. Cell. 65(6). 1043–1051. 1487 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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