John C. McKew

3.5k citations

68 papers · 2.1k indexed · 1 hit paper · h-index 24

Impact in

Physiology top 5%
- Lysosomal Storage Disorders Research
Biochemistry top 5%

Papers in

Physiology 4
- Lysosomal Storage Disorders Research 5
Genetics 7
- Chronic Lymphocytic Leukemia Research 3

Co-authors: Wei Zheng Natasha Thorne Seameen Dehdashti Noel Southall James D. ClarkWei SunCatherine Z. Chen Marina W. H. Shen
Journals: Journal of Medicinal Chemistry (5 papers)SLAS DISCOVERY (4 papers)The Journal of Organic Chemistry (4 papers)Scientific Reports (3 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)
Partner nations: United States Canada China

In The Last Decade

John C. McKew

68 papers receiving 2.1k citations

Hit Papers

align trajectories log scale

Phenotypic screens as a renewed approach for drug discovery 2013 · 300 citations

Peers

Countries citing papers authored by John C. McKew

Since Specialization

Citations

This map shows the geographic impact of John C. McKew's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John C. McKew with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John C. McKew more than expected).

Fields of papers citing papers by John C. McKew

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John C. McKew. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John C. McKew. The network helps show where John C. McKew may publish in the future.

Co-authors

The 25 scholars most cited alongside John C. McKew, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John C. McKew Line = papers co-authored together John C. McKew links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency Scientific Reports ·Coral Capó, Ahmed Alanazi, Giulia Sagona, Raffaele Mazziotti, Leonardo Lupori, Elisa Cerri, Elena Putignano, Mark T. Butt, Nuria Canillo, John C. McKew, M. Alessandri, Roberta Battini, Giovanni Cioni, Tommaso Pizzorusso, Laura Baroncelli	2020	14
2	Safety, pharmacokinetics and sialic acid production after oral administration of N -acetylmannosamine (ManNAc) to subjects with GNE myopathy Molecular Genetics and Metabolism ·Xin Xu, Amy Q. Wang, Lea Latham, Paolo Vitali, Carla Ciccone, May Christine V. Malicdan, Barry R. Goldspiel, Pramod Terse, James C. Cradock, N. Nora Yang, Selwyn C. Yorke, John C. McKew, William A. Gahl, Marjan Huizing, Nuria Carrillo	2017	44
3	An open source pharma roadmap PLoS Medicine ·Manica Balasegaram, Peter Kolb, John C. McKew, Νικόλαος Κωνσταντινίδης, Piero Olliaro, Tomasz Sablinski, J.R.C. Silva, Matthew H. Todd, Els Torreele, John Wilbanks	2017	15
4	High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress Stem Cells Translational Medicine ·Natasha Thorne, Nasir Malik, Sonia Shah, Jean J. Zhao, Johann-Wolfgang Metzger, Francis Aguisanda, Noel Southall, Menghang Xia, John C. McKew, Mahendra S. Rao, Wei Zheng	2016	32
5	In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents Bioorganic & Medicinal Chemistry Letters ·Paresma Patel, Wei Sun, Julie A. Carmean Elizabeth H. Diament, Xiuli Huang, Philip E.J. Sanderson, Takeshi Tanaka, John C. McKew, Anton Simeonov, Kim C. Williamson, Wei Zheng, Wenwei Huang	2016	10
6	High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1 Scientific Reports ·Mengqiao Wang, Miao Xu, Yan Long, Sonia Fargue, Noel Southall, Xin Hu, John C. McKew, Christopher J. Danpure, Wei Zheng	2016	22
7	Quantitative hydrophilic interaction chromatography–mass spectrometry analysis of N-acetylneuraminic acid and N-acetylmannosamine in human plasma Journal of Chromatography B ·Yifan Shi, Xin Xu, Janardan Singh, Michael Zhang, Yinghe Li, YANG JiHua, Selwyn C. Yorke, N. Nora Yang, John C. McKew, William A. Gahl, Marjan Huizing, Nuria Carrillo, Danish Khan	2015	20
8	New Financial and Research Models for Pediatric Orphan Drug Development: Focus on the NCATS TRND Program Pharmaceutical Medicine ·John Paul Shen, Gurmit Grewal, A. Ramos-Buades, John C. McKew	2014	3
9	Chemical signatures and new drug targets for gametocytocidal drug development Scientific Reports ·Wei Sun, Takeshi Tanaka, Joe Howlett, Wenwei Huang, Noel Southall, Ruili Huang, Seameen Dehdashti, John C. McKew, Kim C. Williamson, Wei Zheng	2014	86
10	A High-Throughput Screening Assay for Determining Cellular Levels of Total Tau Protein Current Alzheimer Research ·Seameen Dehdashti, Wei Zheng, Joel R. Gever, Robert S. Wilhelm, Ðắc-Trung Nguyễn, G. Sitta Sittampalam, John C. McKew, Christopher P. Austin, Stanley B. Prusiner	2013	18
11	A quantitative high throughput assay for identifying gametocytocidal compounds Molecular and Biochemical Parasitology ·Takeshi Tanaka, Seameen Dehdashti, Ðắc-Trung Nguyễn, John C. McKew, Wei Zheng, Kim C. Williamson	2013	45
12	A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions Analytical and Bioanalytical Chemistry ·Seameen Dehdashti, Jenny Tran, Ðắc-Trung Nguyễn, John C. McKew, Peter R. Williamson, Wei Zheng	2013	10
13	NIH TRND program: successes in preclinical therapeutic development Trends in Pharmacological Sciences ·John C. McKew, A. Ramos-Buades	2012	5
14	δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders Journal of Biological Chemistry ·Miao Xu, Ke Liu, Manju Swaroop, Forbes D. Porter, Rohini Sidhu, Fawwaz Fadlurohman, Daniel S. Ory, Juan Marugán, Jingbo Xiao, Noel Southall, William J. Pavan, Cristin Davidson, Steven U. Walkley, Alan T. Remaley, Ulrich Baxa, Wei Sun, John C. McKew, Christopher P. Austin, Wei Zheng	2012	97
15	The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid Neuropharmacology ·Cheryl Nickerson‐Nutter, Debra G. Goodwin, Marina W. H. Shen, Fithriyah Shalihah, Weili Duan, Tarek A. Samad, John C. McKew, Katherine L. Lee, Margaret M. Zaleska, Névéna Mollova, James D. Clark	2010	5
16	Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties Bioorganic & Medicinal Chemistry ·Steven J. Kirincich, Jason Xiang, Neal Green, Steve Tam, Hui Yang, Jaechul Shim, Marina W. H. Shen, James D. Clark, John C. McKew	2009	24
17	Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors Analytical Biochemistry ·Manjunath Ramarao, Marina W. H. Shen, Elizabeth Murphy, Weili Duan, Yajuan Zhao, John C. McKew, Katherine L. Lee, Paresh Thakker, Mark L. Behnke, James D. Clark	2008	6
18	β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action Bioorganic & Medicinal Chemistry ·Jason Xiang, Manus Ipek, Vipin Suri, May Tam, Yuzhe Xing, Nelson Huang, Yanling Zhang, James F. Tobin, Tarek S. Mansour, John C. McKew	2007	98
19	Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy Bioorganic & Medicinal Chemistry ·Katherine L. Lee, Mark L. Behnke, Megan A. Foley, Lih-Ren Chen, Weiheng Wang, D Sun, Jill Nunez, Steve Tam, Névéna Mollova, Xin Xu, Marina W. H. Shen, Manjunath Ramarao, Debra G. Goodwin, Cheryl Nickerson‐Nutter, William M. Abraham, Cara Williams, James D. Clark, John C. McKew	2007	26
20	Structure–activity relationships of indole cytosolic phospholipase A 2 α inhibitors: substrate mimetics Bioorganic & Medicinal Chemistry Letters ·John C. McKew, Frank Lovering, James D. Clark, Jean E. Bemis, Yibin Xiang, Marina W. H. Shen, Wen Zhang, Juan Carlos Álvarez, Diane Joseph‐McCarthy	2003	18

About John C. McKew

John C. McKew is a scholar working on Physiology, Genetics, Cell Biology, Organic Chemistry and Pharmacology, having authored 68 papers that have together received 2.1k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (8 papers), Lysosomal Storage Disorders Research (5 papers), Muscle metabolism and nutrition (4 papers), Computational Drug Discovery Methods (4 papers), Inflammatory Myopathies and Dermatomyositis (4 papers), Synthesis and biological activity (3 papers), Chronic Lymphocytic Leukemia Research (3 papers) and Pharmacogenetics and Drug Metabolism (3 papers). The work is most often cited by research in Physiology (96 citations), Biochemistry (125 citations), Organic Chemistry (433 citations), Molecular Biology (933 citations) and Pharmacology (117 citations). John C. McKew has collaborated with scholars based in United States, Canada and China. Frequent co-authors include Wei Zheng, Natasha Thorne, Seameen Dehdashti, Noel Southall, James D. Clark, Wei Sun, Catherine Z. Chen, Marina W. H. Shen, Anu Mahadevan and Mario D. González. Their work appears in journals such as Journal of Medicinal Chemistry, SLAS DISCOVERY, The Journal of Organic Chemistry, Scientific Reports and Bioorganic & Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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